3.26.1 html 313 401 1 false 84 0 false 9 false false R1.htm 0000001 - Document - Cover Sheet http://www.biocryst.com/role/Cover Cover Cover 1 false false R2.htm 9952151 - Statement - Condensed Consolidated Balance Sheets Sheet http://www.biocryst.com/role/CondensedConsolidatedBalanceSheets Condensed Consolidated Balance Sheets Statements 2 false false R3.htm 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) Sheet http://www.biocryst.com/role/CondensedConsolidatedBalanceSheetsParenthetical Condensed Consolidated Balance Sheets (Parenthetical) Statements 3 false false R4.htm 9952153 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) Sheet http://www.biocryst.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeLoss Condensed Consolidated Statements of Comprehensive Income (Loss) Statements 4 false false R5.htm 9952154 - Statement - Condensed Consolidated Statements of Cash Flows Sheet http://www.biocryst.com/role/CondensedConsolidatedStatementsofCashFlows Condensed Consolidated Statements of Cash Flows Statements 5 false false R6.htm 9952155 - Statement - Condensed Consolidated Statements of Stockholders' Deficit Sheet http://www.biocryst.com/role/CondensedConsolidatedStatementsofStockholdersDeficit Condensed Consolidated Statements of Stockholders' Deficit Statements 6 false false R7.htm 9952156 - Disclosure - Significant Accounting Policies and Concentrations of Risk Sheet http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRisk Significant Accounting Policies and Concentrations of Risk Notes 7 false false R8.htm 9952157 - Disclosure - Acquisition of Astria Therapeutics, Inc. Sheet http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsInc Acquisition of Astria Therapeutics, Inc. Notes 8 false false R9.htm 9952158 - Disclosure - Revenue Sheet http://www.biocryst.com/role/Revenue Revenue Notes 9 false false R10.htm 9952159 - Disclosure - Fair Value Measurements and Investments Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestments Fair Value Measurements and Investments Notes 10 false false R11.htm 9952160 - Disclosure - Trade Receivables Sheet http://www.biocryst.com/role/TradeReceivables Trade Receivables Notes 11 false false R12.htm 9952161 - Disclosure - Inventory Sheet http://www.biocryst.com/role/Inventory Inventory Notes 12 false false R13.htm 9952162 - Disclosure - Royalty Financing Obligations Sheet http://www.biocryst.com/role/RoyaltyFinancingObligations Royalty Financing Obligations Notes 13 false false R14.htm 9952163 - Disclosure - Debt Sheet http://www.biocryst.com/role/Debt Debt Notes 14 false false R15.htm 9952164 - Disclosure - Lease Obligations Sheet http://www.biocryst.com/role/LeaseObligations Lease Obligations Notes 15 false false R16.htm 9952165 - Disclosure - Stockholders' Equity Sheet http://www.biocryst.com/role/StockholdersEquity Stockholders' Equity Notes 16 false false R17.htm 9952166 - Disclosure - Stock-Based Compensation Sheet http://www.biocryst.com/role/StockBasedCompensation Stock-Based Compensation Notes 17 false false R18.htm 9952167 - Disclosure - Collaborative and Other Relationships Sheet http://www.biocryst.com/role/CollaborativeandOtherRelationships Collaborative and Other Relationships Notes 18 false false R19.htm 9952168 - Disclosure - Workforce Reduction Sheet http://www.biocryst.com/role/WorkforceReduction Workforce Reduction Notes 19 false false R20.htm 9952169 - Disclosure - Segment Information Sheet http://www.biocryst.com/role/SegmentInformation Segment Information Notes 20 false false R21.htm 9952170 - Disclosure - Commitments and Contingencies Sheet http://www.biocryst.com/role/CommitmentsandContingencies Commitments and Contingencies Notes 21 false false R22.htm 9952171 - Disclosure - Net Income (Loss) Per Share Sheet http://www.biocryst.com/role/NetIncomeLossPerShare Net Income (Loss) Per Share Notes 22 false false R23.htm 9952172 - Disclosure - Subsequent Events Sheet http://www.biocryst.com/role/SubsequentEvents Subsequent Events Notes 23 false false R24.htm 995445 - Disclosure - Insider Trading Arrangements Sheet http://xbrl.sec.gov/ecd/role/InsiderTradingArrangements Insider Trading Arrangements Notes 24 false false R25.htm 9955511 - Disclosure - Significant Accounting Policies and Concentrations of Risk (Policies) Sheet http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskPolicies Significant Accounting Policies and Concentrations of Risk (Policies) Policies http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRisk 25 false false R26.htm 9955512 - Disclosure - Acquisition of Astria Therapeutics, Inc. (Tables) Sheet http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsIncTables Acquisition of Astria Therapeutics, Inc. (Tables) Tables http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsInc 26 false false R27.htm 9955513 - Disclosure - Revenue (Tables) Sheet http://www.biocryst.com/role/RevenueTables Revenue (Tables) Tables http://www.biocryst.com/role/Revenue 27 false false R28.htm 9955514 - Disclosure - Fair Value Measurements and Investments (Tables) Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestmentsTables Fair Value Measurements and Investments (Tables) Tables http://www.biocryst.com/role/FairValueMeasurementsandInvestments 28 false false R29.htm 9955515 - Disclosure - Trade Receivables (Tables) Sheet http://www.biocryst.com/role/TradeReceivablesTables Trade Receivables (Tables) Tables http://www.biocryst.com/role/TradeReceivables 29 false false R30.htm 9955516 - Disclosure - Inventory (Tables) Sheet http://www.biocryst.com/role/InventoryTables Inventory (Tables) Tables http://www.biocryst.com/role/Inventory 30 false false R31.htm 9955517 - Disclosure - Royalty Financing Obligations (Tables) Sheet http://www.biocryst.com/role/RoyaltyFinancingObligationsTables Royalty Financing Obligations (Tables) Tables http://www.biocryst.com/role/RoyaltyFinancingObligations 31 false false R32.htm 9955518 - Disclosure - Lease Obligations (Tables) Sheet http://www.biocryst.com/role/LeaseObligationsTables Lease Obligations (Tables) Tables http://www.biocryst.com/role/LeaseObligations 32 false false R33.htm 9955519 - Disclosure - Stockholders' Equity (Tables) Sheet http://www.biocryst.com/role/StockholdersEquityTables Stockholders' Equity (Tables) Tables http://www.biocryst.com/role/StockholdersEquity 33 false false R34.htm 9955520 - Disclosure - Stock-Based Compensation (Tables) Sheet http://www.biocryst.com/role/StockBasedCompensationTables Stock-Based Compensation (Tables) Tables http://www.biocryst.com/role/StockBasedCompensation 34 false false R35.htm 9955521 - Disclosure - Workforce Reduction (Tables) Sheet http://www.biocryst.com/role/WorkforceReductionTables Workforce Reduction (Tables) Tables http://www.biocryst.com/role/WorkforceReduction 35 false false R36.htm 9955522 - Disclosure - Segment Information (Tables) Sheet http://www.biocryst.com/role/SegmentInformationTables Segment Information (Tables) Tables http://www.biocryst.com/role/SegmentInformation 36 false false R37.htm 9955523 - Disclosure - Net Income (Loss) Per Share (Tables) Sheet http://www.biocryst.com/role/NetIncomeLossPerShareTables Net Income (Loss) Per Share (Tables) Tables http://www.biocryst.com/role/NetIncomeLossPerShare 37 false false R38.htm 9955524 - Disclosure - Significant Accounting Policies and Concentrations of Risk (Details) Sheet http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskDetails Significant Accounting Policies and Concentrations of Risk (Details) Details http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskPolicies 38 false false R39.htm 9955525 - Disclosure - Acquisition of Astria Therapeutics, Inc. - Narrative (Details) Sheet http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsIncNarrativeDetails Acquisition of Astria Therapeutics, Inc. - Narrative (Details) Details 39 false false R40.htm 9955526 - Disclosure - Acquisition of Astria Therapeutics, Inc. - Schedule of Consideration Transferred (Details) Sheet http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsIncScheduleofConsiderationTransferredDetails Acquisition of Astria Therapeutics, Inc. - Schedule of Consideration Transferred (Details) Details 40 false false R41.htm 9955527 - Disclosure - Acquisition of Astria Therapeutics, Inc. - Schedule of Separation Costs (Details) Sheet http://www.biocryst.com/role/AcquisitionofAstriaTherapeuticsIncScheduleofSeparationCostsDetails Acquisition of Astria Therapeutics, Inc. - Schedule of Separation Costs (Details) Details 41 false false R42.htm 9955528 - Disclosure - Revenue - Schedule of Revenues (Details) Sheet http://www.biocryst.com/role/RevenueScheduleofRevenuesDetails Revenue - Schedule of Revenues (Details) Details 42 false false R43.htm 9955529 - Disclosure - Revenue - Narrative (Details) Sheet http://www.biocryst.com/role/RevenueNarrativeDetails Revenue - Narrative (Details) Details 43 false false R44.htm 9955530 - Disclosure - Fair Value Measurements and Investments - Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis (Details) Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestmentsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails Fair Value Measurements and Investments - Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis (Details) Details 44 false false R45.htm 9955531 - Disclosure - Fair Value Measurements and Investments - Schedule of Fair Value of the Company's Investments by Type (Details) Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestmentsScheduleofFairValueoftheCompanysInvestmentsbyTypeDetails Fair Value Measurements and Investments - Schedule of Fair Value of the Company's Investments by Type (Details) Details 45 false false R46.htm 9955532 - Disclosure - Fair Value Measurements and Investments - Narrative (Details) Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestmentsNarrativeDetails Fair Value Measurements and Investments - Narrative (Details) Details 46 false false R47.htm 9955533 - Disclosure - Fair Value Measurements and Investments - Schedule of Maturity of Investments (Details) Sheet http://www.biocryst.com/role/FairValueMeasurementsandInvestmentsScheduleofMaturityofInvestmentsDetails Fair Value Measurements and Investments - Schedule of Maturity of Investments (Details) Details 47 false false R48.htm 9955534 - Disclosure - Trade Receivables (Details) Sheet http://www.biocryst.com/role/TradeReceivablesDetails Trade Receivables (Details) Details http://www.biocryst.com/role/TradeReceivablesTables 48 false false R49.htm 9955535 - Disclosure - Inventory (Details) Sheet http://www.biocryst.com/role/InventoryDetails Inventory (Details) Details http://www.biocryst.com/role/InventoryTables 49 false false R50.htm 9955536 - Disclosure - Royalty Financing Obligations - Narrative (Details) Sheet http://www.biocryst.com/role/RoyaltyFinancingObligationsNarrativeDetails Royalty Financing Obligations - Narrative (Details) Details 50 false false R51.htm 9955537 - Disclosure - Royalty Financing Obligations - Schedule of Royalty Financing Obligations (Details) Sheet http://www.biocryst.com/role/RoyaltyFinancingObligationsScheduleofRoyaltyFinancingObligationsDetails Royalty Financing Obligations - Schedule of Royalty Financing Obligations (Details) Details 51 false false R52.htm 9955538 - Disclosure - Debt (Details) Sheet http://www.biocryst.com/role/DebtDetails Debt (Details) Details http://www.biocryst.com/role/Debt 52 false false R53.htm 9955539 - Disclosure - Lease Obligations - Narrative (Details) Sheet http://www.biocryst.com/role/LeaseObligationsNarrativeDetails Lease Obligations - Narrative (Details) Details 53 false false R54.htm 9955540 - Disclosure - Lease Obligations - Schedule of Aggregate Lease Expense Under Operating Leases (Details) Sheet http://www.biocryst.com/role/LeaseObligationsScheduleofAggregateLeaseExpenseUnderOperatingLeasesDetails Lease Obligations - Schedule of Aggregate Lease Expense Under Operating Leases (Details) Details 54 false false R55.htm 9955541 - Disclosure - Lease Obligations - Schedule of Other Supplemental Information Related to Leases (Details) Sheet http://www.biocryst.com/role/LeaseObligationsScheduleofOtherSupplementalInformationRelatedtoLeasesDetails Lease Obligations - Schedule of Other Supplemental Information Related to Leases (Details) Details 55 false false R56.htm 9955542 - Disclosure - Lease Obligations - Schedule of Maturities of Lease Liabilities (Details) Sheet http://www.biocryst.com/role/LeaseObligationsScheduleofMaturitiesofLeaseLiabilitiesDetails Lease Obligations - Schedule of Maturities of Lease Liabilities (Details) Details 56 false false R57.htm 9955543 - Disclosure - Lease Obligations - Schedule of Supplemental Cash Flows (Details) Sheet http://www.biocryst.com/role/LeaseObligationsScheduleofSupplementalCashFlowsDetails Lease Obligations - Schedule of Supplemental Cash Flows (Details) Details 57 false false R58.htm 9955544 - Disclosure - Stockholders' Equity - Narrative (Details) Sheet http://www.biocryst.com/role/StockholdersEquityNarrativeDetails Stockholders' Equity - Narrative (Details) Details 58 false false R59.htm 9955545 - Disclosure - Stockholders' Equity - Schedule of Shares Reserved for Future Issuance (Details) Sheet http://www.biocryst.com/role/StockholdersEquityScheduleofSharesReservedforFutureIssuanceDetails Stockholders' Equity - Schedule of Shares Reserved for Future Issuance (Details) Details 59 false false R60.htm 9955546 - Disclosure - Stock-Based Compensation - Narrative (Details) Sheet http://www.biocryst.com/role/StockBasedCompensationNarrativeDetails Stock-Based Compensation - Narrative (Details) Details 60 false false R61.htm 9955547 - Disclosure - Stock-Based Compensation - Schedule of Share-Based Compensation (Details) Sheet http://www.biocryst.com/role/StockBasedCompensationScheduleofShareBasedCompensationDetails Stock-Based Compensation - Schedule of Share-Based Compensation (Details) Details 61 false false R62.htm 9955548 - Disclosure - Stock-Based Compensation - Schedule of Reconciliation Recurring Basis Fair Value Measurements (Details) Sheet http://www.biocryst.com/role/StockBasedCompensationScheduleofReconciliationRecurringBasisFairValueMeasurementsDetails Stock-Based Compensation - Schedule of Reconciliation Recurring Basis Fair Value Measurements (Details) Details 62 false false R63.htm 9955549 - Disclosure - Stock-Based Compensation - Schedule of Option Activity (Details) Sheet http://www.biocryst.com/role/StockBasedCompensationScheduleofOptionActivityDetails Stock-Based Compensation - Schedule of Option Activity (Details) Details 63 false false R64.htm 9955550 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Unit Activity (Details) Sheet http://www.biocryst.com/role/StockBasedCompensationScheduleofRestrictedStockUnitActivityDetails Stock-Based Compensation - Schedule of Restricted Stock Unit Activity (Details) Details 64 false false R65.htm 9955551 - Disclosure - Collaborative and Other Relationships (Details) Sheet http://www.biocryst.com/role/CollaborativeandOtherRelationshipsDetails Collaborative and Other Relationships (Details) Details http://www.biocryst.com/role/CollaborativeandOtherRelationships 65 false false R66.htm 9955552 - Disclosure - Workforce Reduction - Narrative (Details) Sheet http://www.biocryst.com/role/WorkforceReductionNarrativeDetails Workforce Reduction - Narrative (Details) Details 66 false false R67.htm 9955553 - Disclosure - Workforce Reduction - Schedule of Accrued Liability Activity (Details) Sheet http://www.biocryst.com/role/WorkforceReductionScheduleofAccruedLiabilityActivityDetails Workforce Reduction - Schedule of Accrued Liability Activity (Details) Details 67 false false R68.htm 9955554 - Disclosure - Segment Information - Narrative (Details) Sheet http://www.biocryst.com/role/SegmentInformationNarrativeDetails Segment Information - Narrative (Details) Details 68 false false R69.htm 9955555 - Disclosure - Segment Information - Schedule of Segment Reporting Information, by Segment (Details) Sheet http://www.biocryst.com/role/SegmentInformationScheduleofSegmentReportingInformationbySegmentDetails Segment Information - Schedule of Segment Reporting Information, by Segment (Details) Details 69 false false R70.htm 9955556 - Disclosure - Net Income (Loss) Per Share - Schedule of Earnings Per Share (Details) Sheet http://www.biocryst.com/role/NetIncomeLossPerShareScheduleofEarningsPerShareDetails Net Income (Loss) Per Share - Schedule of Earnings Per Share (Details) Details http://www.biocryst.com/role/NetIncomeLossPerShareTables 70 false false R71.htm 9955557 - Disclosure - Net Income (Loss) Per Share - Schedule of Potential Shares Excluded from Computation of Diluted Net Income (Loss) Per Share (Details) Sheet http://www.biocryst.com/role/NetIncomeLossPerShareScheduleofPotentialSharesExcludedfromComputationofDilutedNetIncomeLossPerShareDetails Net Income (Loss) Per Share - Schedule of Potential Shares Excluded from Computation of Diluted Net Income (Loss) Per Share (Details) Details http://www.biocryst.com/role/NetIncomeLossPerShareTables 71 false false R72.htm 9955558 - Disclosure - Subsequent Event (Details) Sheet http://www.biocryst.com/role/SubsequentEventDetails Subsequent Event (Details) Details http://www.biocryst.com/role/SubsequentEvents 72 false false All Reports Book All Reports bcrx-20260630.htm bcrx-20260630.xsd bcrx-20260630_cal.xml bcrx-20260630_def.xml bcrx-20260630_lab.xml bcrx-20260630_pre.xml http://fasb.org/us-gaap/2026 http://xbrl.sec.gov/dei/2026 http://xbrl.sec.gov/ecd/2026 true true