v3.26.1
Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Disaggregation of Revenue [Line Items]        
Total revenues $ 10,054 $ 9,179 $ 18,672 $ 17,328
Repatha        
Disaggregation of Revenue [Line Items]        
Total revenues 953 696 1,829 1,352
Repatha | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 510 361 975 704
Repatha | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 443 335 854 648
Prolia        
Disaggregation of Revenue [Line Items]        
Total revenues 759 1,122 1,486 2,221
Prolia | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 478 745 939 1,465
Prolia | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 281 377 547 756
EVENITY        
Disaggregation of Revenue [Line Items]        
Total revenues 714 518 1,276 960
EVENITY | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 550 395 981 715
EVENITY | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 164 123 295 245
TEPEZZA        
Disaggregation of Revenue [Line Items]        
Total revenues 576 505 1,066 886
TEPEZZA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 520 466 944 831
TEPEZZA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 56 39 122 55
Otezla        
Disaggregation of Revenue [Line Items]        
Total revenues 491 618 922 1,055
Otezla | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 431 512 783 855
Otezla | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 60 106 139 200
ENBREL        
Disaggregation of Revenue [Line Items]        
Total revenues 580 604 900 1,114
ENBREL | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 574 597 888 1,101
ENBREL | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 6 7 12 13
BLINCYTO        
Disaggregation of Revenue [Line Items]        
Total revenues 472 384 887 754
BLINCYTO | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 285 270 506 543
BLINCYTO | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 187 114 381 211
Nplate        
Disaggregation of Revenue [Line Items]        
Total revenues 430 369 842 682
Nplate | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 275 228 558 429
Nplate | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 155 141 284 253
TEZSPIRE        
Disaggregation of Revenue [Line Items]        
Total revenues 486 342 829 627
TEZSPIRE | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 486 342 829 627
TEZSPIRE | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 0 0 0 0
XGEVA        
Disaggregation of Revenue [Line Items]        
Total revenues 352 532 763 1,098
XGEVA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 187 347 415 707
XGEVA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 165 185 348 391
Aranesp        
Disaggregation of Revenue [Line Items]        
Total revenues 352 359 663 699
Aranesp | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 94 107 171 198
Aranesp | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 258 252 492 501
KRYSTEXXA        
Disaggregation of Revenue [Line Items]        
Total revenues 400 349 655 585
KRYSTEXXA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 399 349 654 585
KRYSTEXXA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 1 0 1 0
KYPROLIS        
Disaggregation of Revenue [Line Items]        
Total revenues 314 378 644 702
KYPROLIS | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 201 232 419 448
KYPROLIS | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 113 146 225 254
Vectibix        
Disaggregation of Revenue [Line Items]        
Total revenues 338 305 625 572
Vectibix | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 167 144 303 279
Vectibix | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 171 161 322 293
UPLIZNA        
Disaggregation of Revenue [Line Items]        
Total revenues 335 176 597 267
UPLIZNA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 317 132 563 214
UPLIZNA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 18 44 34 53
IMDELLTRA/IMDYLLTRA        
Disaggregation of Revenue [Line Items]        
Total revenues 288 134 546 215
IMDELLTRA/IMDYLLTRA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 233 107 421 186
IMDELLTRA/IMDYLLTRA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 55 27 125 29
Other products        
Disaggregation of Revenue [Line Items]        
Total revenues 1,697 1,380 3,225 2,855
Other products | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 1,283 990 2,414 2,099
Other products | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 414 390 811 756
Product sales        
Disaggregation of Revenue [Line Items]        
Total revenues 9,537 8,771 17,755 16,644
Product sales | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 6,990 6,324 12,763 11,986
Product sales | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues $ 2,547 $ 2,447 $ 4,992 $ 4,658