0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Condensed Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Organization link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Grant Agreements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Collaboration and License Agreements link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Stock-Based Awards link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Net Income (Loss) Per Share link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Stock-Based Awards (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Net Income (Loss) Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Organization (Details) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Fair Value Measurements - Schedule of Financial Assets Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Fair Value Measurements - Schedule of Estimated Fair Value of Significant Unobservable Inputs (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Fair Value Measurements - Schedule of Changes in Estimated Fair Value of Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Grant Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Grant Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Collaboration and License Agreements - License Agreement with Astellas US LLC (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Collaboration and License Agreements - License Agreement with Norgine Pharma UK Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Collaboration and License Agreements - License Agreement with Sanofi (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Collaboration and License Agreements - Alnylam Pharmaceuticals, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Balance Sheet Components - Schedule of Accrued and Other Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Stock-Based Awards - Schedule of Assumptions Used for Estimating the Fair Value of Stock Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stock-Based Awards - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stock-Based Awards - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Net Income (Loss) Per Share - Schedule of Basic and Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Net Income (Loss) Per Share - Schedule of Potentially Dilutive Securities Not Included in Diluted Per Share Calculations (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Income Taxes - Schedule of (Loss) Income Before Benefit from (Provision for) Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Segment Reporting - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Segment Reporting - Schedule of Revenue from External Customers by Geographic Areas (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink