v3.26.1
Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net income (loss) $ (45,615) $ (231,923)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 5,613 5,784
Amortization of premiums on investments, net 716 6,610
Noncash lease expense 2,707 2,358
Change in fair value of equity investments 1,893 (3,000)
Change in estimated fair value of contingent consideration 240 11,010
Payment of contingent consideration in excess of acquisition date fair value 0 (17,140)
Stock-based compensation 24,478 26,510
Non-cash restructuring, long-lived assets impairment and related charges 0 399
Other non-cash items, net 123 59
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 6,059 5,937
Other assets 53 (1,132)
Accounts payable 8,083 7,444
Accrued liabilities and other liabilities (8,831) (7,998)
Operating lease liabilities (4,579) (3,253)
Net cash used in operating activities (9,060) (198,335)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Proceeds from sale of equipment 0 326
Purchases of long-lived assets (422) (4,167)
Purchases of investments (510,473) (366,065)
Maturities and sales of investments 325,588 553,180
Net cash (used in) provided by investing activities (185,307) 183,274
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from exercise of stock options 1,614 1,247
Proceeds from issuance of common stock under ESPP 1,356 1,757
Other financing activities 0 (360)
Net cash provided by financing activities 240,899 2,644
Net increase (decrease) in cash, cash equivalents and restricted cash and cash equivalents 46,532 (12,417)
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period 241,070 318,695
Cash, cash equivalents and restricted cash and cash equivalents at end of period 287,602 306,278
NONCASH INVESTING AND FINANCING ACTIVITIES:    
Obtaining a right-of-use asset in exchange for a lease liability 0 7,591
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:    
Cash and cash equivalents 278,729 211,104
Restricted cash and cash equivalents, current 1,929 88,218
Restricted cash and cash equivalents, noncurrent 6,944 6,956
Total cash, cash equivalents and restricted cash and cash equivalents 287,602 306,278
Public Offering    
CASH FLOWS FROM FINANCING ACTIVITIES:    
Issuance of common stock 162,205 0
Astellas    
CASH FLOWS FROM FINANCING ACTIVITIES:    
Issuance of common stock $ 75,724 $ 0