v3.26.1
Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Astellas
Public Offering
Common Stock
Common Stock
Astellas
Common Stock
Public Offering
Additional Paid-in Capital
Additional Paid-in Capital
Astellas
Additional Paid-in Capital
Public Offering
Accumulated Other Comprehensive Loss
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2024       136,959,446              
Beginning balance at Dec. 31, 2024 $ 1,150,385     $ 14     $ 1,911,872     $ (1,717) $ (759,784)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Vesting of restricted common stock (in shares)       1,297,685              
Exercise of stock options (in shares)       230,803              
Exercise of stock options 1,247           1,247        
Issuance of common stock under employee stock purchase plan (in shares)       398,340              
Issuance of common stock under employee stock purchase plan 1,757           1,757        
Stock-based compensation 26,510           26,510        
Other comprehensive loss (504)                 (504)  
Net income (loss) (231,923)                   (231,923)
Ending balance (in shares) at Jun. 30, 2025       138,886,274              
Ending balance at Jun. 30, 2025 947,472     $ 14     1,941,386     (2,221) (991,707)
Beginning balance (in shares) at Mar. 31, 2025       138,063,698              
Beginning balance at Mar. 31, 2025 1,043,819     $ 14     1,926,529     (1,975) (880,749)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Vesting of restricted common stock (in shares)       286,057              
Exercise of stock options (in shares)       138,179              
Exercise of stock options 649           649        
Issuance of common stock under employee stock purchase plan (in shares)       398,340              
Issuance of common stock under employee stock purchase plan 1,757           1,757        
Stock-based compensation 12,451           12,451        
Other comprehensive loss (246)                 (246)  
Net income (loss) (110,958)                   (110,958)
Ending balance (in shares) at Jun. 30, 2025       138,886,274              
Ending balance at Jun. 30, 2025 $ 947,472     $ 14     1,941,386     (2,221) (991,707)
Beginning balance (in shares) at Dec. 31, 2025 139,474,954     139,474,954              
Beginning balance at Dec. 31, 2025 $ 765,276     $ 14     1,965,090     (2,057) (1,197,771)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost (in shares)         7,239,382 20,294,117          
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost   $ 75,724 $ 162,205   $ 1 $ 2   $ 75,723 $ 162,203    
Vesting of restricted common stock (in shares)       1,680,128              
Vesting of restricted common stock 0                    
Exercise of stock options (in shares)       248,757              
Exercise of stock options 1,614           1,614        
Issuance of common stock under employee stock purchase plan (in shares)       248,333              
Issuance of common stock under employee stock purchase plan 1,356           1,356        
Stock-based compensation 24,478           24,478        
Other comprehensive loss (2,545)                 (2,545)  
Net income (loss) $ (45,615)                   (45,615)
Ending balance (in shares) at Jun. 30, 2026 169,185,671     169,185,671              
Ending balance at Jun. 30, 2026 $ 982,493     $ 17     2,230,464     (4,602) (1,243,386)
Beginning balance (in shares) at Mar. 31, 2026       161,234,058              
Beginning balance at Mar. 31, 2026 812,765     $ 16     2,139,698     (3,483) (1,323,466)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                      
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost (in shares)         7,239,382            
Adjustments of issuance costs and Issuance of common stock related to a follow-on public offering, net of issuance cost   $ 75,724 $ (144)   $ 1     $ 75,723 $ (144)    
Vesting of restricted common stock (in shares)       292,076              
Vesting of restricted common stock 0                    
Exercise of stock options (in shares)       171,822              
Exercise of stock options 1,440           1,440        
Issuance of common stock under employee stock purchase plan (in shares)       248,333              
Issuance of common stock under employee stock purchase plan 1,356           1,356        
Stock-based compensation 12,391           12,391        
Other comprehensive loss (1,119)                 (1,119)  
Net income (loss) $ 80,080                   80,080
Ending balance (in shares) at Jun. 30, 2026 169,185,671     169,185,671              
Ending balance at Jun. 30, 2026 $ 982,493     $ 17     $ 2,230,464     $ (4,602) $ (1,243,386)