<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019dfa35-5f6b-7d41-b354-2b2f701f5a76,g:d19500ff-eb38-4c01-9529-73b180e3d745-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.amd.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="amd-20260627.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019dfa35-6030-7195-a21a-1fb986da2a80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7518-bdb1-ef553cf2513a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019dfa35-6030-7195-a21a-1fb986da2a80" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7518-bdb1-ef553cf2513a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019dfa35-6030-78f1-924d-9e6e84a8802f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019dfa35-6030-7195-a21a-1fb986da2a80" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019dfa35-6030-78f1-924d-9e6e84a8802f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019dfa35-6030-7cb5-8edf-595c225eac3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019dfa35-6030-7c8a-ab8a-b53b9e7dabe6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019dfa35-6030-7cb5-8edf-595c225eac3d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019dfa35-6030-7c8a-ab8a-b53b9e7dabe6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019dfa35-6030-77ac-91e1-6b6130c5b96e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019dfa35-6030-7cb5-8edf-595c225eac3d" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019dfa35-6030-77ac-91e1-6b6130c5b96e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amd_AmortizationOfAcquisitionRelatedIntangiblesOpex_019dfa35-6030-763c-bf36-4933004af256" xlink:href="amd-20260627.xsd#amd_AmortizationOfAcquisitionRelatedIntangiblesOpex"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019dfa35-6030-7cb5-8edf-595c225eac3d" xlink:to="loc_amd_AmortizationOfAcquisitionRelatedIntangiblesOpex_019dfa35-6030-763c-bf36-4933004af256" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d0c-985f-33ae64b57325" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019dfa35-6030-72f0-be50-2fba04fe14db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d0c-985f-33ae64b57325" xlink:to="loc_us-gaap_OperatingIncomeLoss_019dfa35-6030-72f0-be50-2fba04fe14db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_019dfa35-6030-7dcd-824b-b77c6caed659" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d0c-985f-33ae64b57325" xlink:to="loc_us-gaap_InterestExpense_019dfa35-6030-7dcd-824b-b77c6caed659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019dfa35-6030-770f-b821-8f758c92e486" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d0c-985f-33ae64b57325" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019dfa35-6030-770f-b821-8f758c92e486" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7462-b796-b75687bcd29f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d8b-a659-3da73831dcf5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7462-b796-b75687bcd29f" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_019dfa35-6030-7d8b-a659-3da73831dcf5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019dfa35-6030-7664-b1de-2317ac952cdc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7462-b796-b75687bcd29f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019dfa35-6030-7664-b1de-2317ac952cdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019dfa35-6030-75a3-9268-1f8d6157d49c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_019dfa35-6030-7462-b796-b75687bcd29f" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019dfa35-6030-75a3-9268-1f8d6157d49c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019dfa35-6030-7bcb-99c5-cab9a46fe4e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019dfa35-6030-73e3-9a87-c1ccb2ef564b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019dfa35-6030-7bcb-99c5-cab9a46fe4e5" xlink:to="loc_us-gaap_GrossProfit_019dfa35-6030-73e3-9a87-c1ccb2ef564b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019dfa35-6030-70fe-a1cf-6941e2ba8f3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019dfa35-6030-7bcb-99c5-cab9a46fe4e5" xlink:to="loc_us-gaap_OperatingExpenses_019dfa35-6030-70fe-a1cf-6941e2ba8f3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019dfa35-6030-7bda-bf54-86d98083159a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019dfa35-6030-7697-927e-50abd25346cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfGoodsAndServicesSold_019dfa35-6030-7bda-bf54-86d98083159a" xlink:to="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019dfa35-6030-7697-927e-50abd25346cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amd_AmortizationOfAcquisitionRelatedIntangiblesCOGS_019dfa35-6030-71a8-8c1f-ea0907e6153b" xlink:href="amd-20260627.xsd#amd_AmortizationOfAcquisitionRelatedIntangiblesCOGS"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfGoodsAndServicesSold_019dfa35-6030-7bda-bf54-86d98083159a" xlink:to="loc_amd_AmortizationOfAcquisitionRelatedIntangiblesCOGS_019dfa35-6030-71a8-8c1f-ea0907e6153b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019dfa35-6030-78d1-9dab-f95230a98d20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019dfa35-6030-7944-a43c-8902ab9fb136" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019dfa35-6030-78d1-9dab-f95230a98d20" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019dfa35-6030-7944-a43c-8902ab9fb136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019dfa35-6030-7cd9-8b7d-b6e24085f437" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019dfa35-6030-78d1-9dab-f95230a98d20" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019dfa35-6030-7cd9-8b7d-b6e24085f437" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amd.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="amd-20260627.xsd#CondensedConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019dfa35-6030-764b-8244-0a12508e344a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019dfa35-6030-7752-8101-356195990dce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019dfa35-6030-764b-8244-0a12508e344a" xlink:to="loc_us-gaap_NetIncomeLoss_019dfa35-6030-7752-8101-356195990dce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019dfa35-6030-75ac-927f-542dbae013bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019dfa35-6030-764b-8244-0a12508e344a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019dfa35-6030-75ac-927f-542dbae013bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019dfa35-6030-7a59-aae2-d665b0811abd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019dfa35-6030-764b-8244-0a12508e344a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019dfa35-6030-7a59-aae2-d665b0811abd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amd.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="amd-20260627.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019dfa35-6030-7d93-9f03-28d2b91e2e65" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019dfa35-6030-7d93-9f03-28d2b91e2e65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019dfa35-6030-7be2-b8d5-0aa098d904d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:to="loc_us-gaap_ShortTermInvestments_019dfa35-6030-7be2-b8d5-0aa098d904d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019dfa35-6030-7e32-bf3a-bc4e2e2c99b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019dfa35-6030-7e32-bf3a-bc4e2e2c99b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019dfa35-6030-7567-b467-974077bdc115" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:to="loc_us-gaap_InventoryNet_019dfa35-6030-7567-b467-974077bdc115" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019dfa35-6030-74de-ad58-2fd7332a7433" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019dfa35-6030-711d-af92-22fe71512e3e" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019dfa35-6030-74de-ad58-2fd7332a7433" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-78d4-ab27-f57f655e3efc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019dfa35-6030-7a0c-980e-e752daddde3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-78d4-ab27-f57f655e3efc" xlink:to="loc_us-gaap_AccountsPayableCurrent_019dfa35-6030-7a0c-980e-e752daddde3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_019dfa35-6030-7d99-a066-008e212531c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-78d4-ab27-f57f655e3efc" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_019dfa35-6030-7d99-a066-008e212531c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019dfa35-6030-781e-adb5-ae4c7d0e1011" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-78d4-ab27-f57f655e3efc" xlink:to="loc_us-gaap_LongTermDebtCurrent_019dfa35-6030-781e-adb5-ae4c7d0e1011" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019dfa35-6030-7018-8061-67623b1f2969" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-78d4-ab27-f57f655e3efc" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019dfa35-6030-7018-8061-67623b1f2969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019dfa35-6030-7607-9f50-8c0e7c06fc6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_AssetsCurrent_019dfa35-6030-7607-9f50-8c0e7c06fc6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019dfa35-6030-7791-82db-4b07610320be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019dfa35-6030-7791-82db-4b07610320be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019dfa35-6030-7e0b-a9ef-9d394aae88c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_Goodwill_019dfa35-6030-7e0b-a9ef-9d394aae88c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019dfa35-6030-78b4-bee3-ad2767f39fe2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019dfa35-6030-78b4-bee3-ad2767f39fe2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019dfa35-6030-7fb8-bcee-5504d7331484" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019dfa35-6030-7fb8-bcee-5504d7331484" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019dfa35-6030-7c29-b91c-92e69608521a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019dfa35-6030-79f9-beb4-7df939e131d7" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019dfa35-6030-7c29-b91c-92e69608521a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019dfa35-6030-76da-873b-e0bdd17019a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:to="loc_us-gaap_CommonStockValue_019dfa35-6030-76da-873b-e0bdd17019a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019dfa35-6030-71a4-a34e-6d60fe876074" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019dfa35-6030-71a4-a34e-6d60fe876074" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019dfa35-6030-79d0-9c5c-1c3f487fb090" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:to="loc_us-gaap_TreasuryStockValue_019dfa35-6030-79d0-9c5c-1c3f487fb090" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019dfa35-6030-7ed6-ba0b-ceae5b726186" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019dfa35-6030-7ed6-ba0b-ceae5b726186" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019dfa35-6030-74b0-acba-a32d76683ee1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019dfa35-6030-7942-837b-cfc219b807b5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019dfa35-6030-74b0-acba-a32d76683ee1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-7d36-9e36-045047e3f935" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_LiabilitiesCurrent_019dfa35-6030-7d36-9e36-045047e3f935" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019dfa35-6030-7640-b0ba-77f88ac57eec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019dfa35-6030-7640-b0ba-77f88ac57eec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019dfa35-6030-72ad-a120-707841119fa4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019dfa35-6030-72ad-a120-707841119fa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019dfa35-6030-7b29-98f6-560f62cdd2d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019dfa35-6030-7b29-98f6-560f62cdd2d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019dfa35-6030-762a-bd8d-5da9998c6e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019dfa35-6030-762a-bd8d-5da9998c6e2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019dfa35-6030-752e-b7a4-55425c0d8960" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019dfa35-6030-7de1-a16a-1571b75429cd" xlink:to="loc_us-gaap_StockholdersEquity_019dfa35-6030-752e-b7a4-55425c0d8960" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amd.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="amd-20260627.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019dfa35-6031-70ed-be89-bcb32c12a2f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_NetIncomeLoss_019dfa35-6031-70ed-be89-bcb32c12a2f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAdjustmentsToIncomeDiscontinuedOperations_019dfa35-6031-7da5-94ba-3cab51c4ed8c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAdjustmentsToIncomeDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_OtherAdjustmentsToIncomeDiscontinuedOperations_019dfa35-6031-7da5-94ba-3cab51c4ed8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_019dfa35-6031-792b-b85c-f483e387c5a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherDepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_019dfa35-6031-792b-b85c-f483e387c5a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019dfa35-6031-7bce-8f57-b28a1e4f6672" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019dfa35-6031-7bce-8f57-b28a1e4f6672" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019dfa35-6031-79cb-b2af-fb5708bc473b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_ShareBasedCompensation_019dfa35-6031-79cb-b2af-fb5708bc473b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amd_GainsLossesOnLongTermInvestmetnsNet_019dfa35-6031-71bc-9acd-ae914be5d02f" xlink:href="amd-20260627.xsd#amd_GainsLossesOnLongTermInvestmetnsNet"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_amd_GainsLossesOnLongTermInvestmetnsNet_019dfa35-6031-71bc-9acd-ae914be5d02f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019dfa35-6031-7da6-aab8-2bc66904bc90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019dfa35-6031-7da6-aab8-2bc66904bc90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019dfa35-6031-7552-b073-21735329b6e9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019dfa35-6031-7552-b073-21735329b6e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019dfa35-6031-7271-8ab5-06907dbe78f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019dfa35-6031-7271-8ab5-06907dbe78f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019dfa35-6031-765c-96ef-7bfa268e0b38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019dfa35-6031-765c-96ef-7bfa268e0b38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019dfa35-6031-78b2-826c-bb148b5c24ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019dfa35-6031-78b2-826c-bb148b5c24ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019dfa35-6031-7342-817c-0d5bf4761b73" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019dfa35-6031-7342-817c-0d5bf4761b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019dfa35-6031-7bfd-bb84-f04c83157555" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019dfa35-6031-7fc4-9c47-cd38fde19bd7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019dfa35-6031-7bfd-bb84-f04c83157555" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019dfa35-6031-715c-8753-fe99d58183a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019dfa35-6031-7325-b6c1-5ac936345033" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019dfa35-6031-715c-8753-fe99d58183a4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019dfa35-6031-7325-b6c1-5ac936345033" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019dfa35-6031-78f8-b912-f16604f2980c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019dfa35-6031-715c-8753-fe99d58183a4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019dfa35-6031-78f8-b912-f16604f2980c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-743a-86d8-23b76bfefcba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019dfa35-6031-715c-8753-fe99d58183a4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-743a-86d8-23b76bfefcba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f9634-8ea6-708a-b2b9-898a1f7fa885" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019f9634-8ea6-708a-b2b9-898a1f7fa885" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_019f9634-8ea6-7696-a9c4-331553581d80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_019f9634-8ea6-7696-a9c4-331553581d80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_019f9634-8ea6-748f-a89f-04bacdffa52e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_019f9634-8ea6-748f-a89f-04bacdffa52e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_019f9634-8ea6-75b5-9125-26c8253ea888" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_019f9634-8ea6-75b5-9125-26c8253ea888" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_019f9634-8ea6-742c-a8a1-e5f9638e754f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_019f9634-8ea6-742c-a8a1-e5f9638e754f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019f9634-8ea6-7449-b818-42b6eed39049" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f9634-8ea6-71e8-b1cf-ed30dfbb1cc7" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019f9634-8ea6-7449-b818-42b6eed39049" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f964f-4690-7e08-bc53-ab6bc82ebaed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_019f964f-9a5c-7af2-9006-4e5395555671" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f964f-4690-7e08-bc53-ab6bc82ebaed" xlink:to="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_019f964f-9a5c-7af2-9006-4e5395555671" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019f9656-ea14-73c6-9d81-e9a4a2dc95ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f964f-4690-7e08-bc53-ab6bc82ebaed" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019f9656-ea14-73c6-9d81-e9a4a2dc95ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019dfa35-6031-76c4-9f0d-51ea03c274c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019dfa35-6031-76c4-9f0d-51ea03c274c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfCommercialPaper_019dfa35-6031-7bdb-bb9a-34bf41637898" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfCommercialPaper"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_RepaymentsOfCommercialPaper_019dfa35-6031-7bdb-bb9a-34bf41637898" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019dfa35-6031-7a00-b295-9b0d29744405" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019dfa35-6031-7a00-b295-9b0d29744405" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019dfa35-6031-7a36-b3d2-e7ddcce46322" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019dfa35-6031-7a36-b3d2-e7ddcce46322" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019f962c-ef05-7750-84a6-7d7cb7f6afec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019f962c-ef05-7750-84a6-7d7cb7f6afec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f962c-ef05-75b5-bde9-fe3e47ebec6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019dfa35-6031-7517-84ee-8ba702e75e08" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f962c-ef05-75b5-bde9-fe3e47ebec6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019f9634-a7b9-74c0-b483-1d0bb4ab0601" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_019f9634-a7b9-7d94-ba68-3bedcbf77b3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019f9634-a7b9-74c0-b483-1d0bb4ab0601" xlink:to="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_019f9634-a7b9-7d94-ba68-3bedcbf77b3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amd_PaymentsToAcquirePropertyPlantAndEquipmentFromDiscontinuedOperation_019f964a-97e5-724c-8a8c-983c744a5e9b" xlink:href="amd-20260627.xsd#amd_PaymentsToAcquirePropertyPlantAndEquipmentFromDiscontinuedOperation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019f9634-a7b9-74c0-b483-1d0bb4ab0601" xlink:to="loc_amd_PaymentsToAcquirePropertyPlantAndEquipmentFromDiscontinuedOperation_019f964a-97e5-724c-8a8c-983c744a5e9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019dfa35-6031-734b-b280-5ecf9d57f649" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019f964c-3fee-7513-b310-3f502f41925b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019dfa35-6031-734b-b280-5ecf9d57f649" xlink:to="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019f964c-3fee-7513-b310-3f502f41925b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f964c-a7a0-7118-937f-0c6debcfcee5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019dfa35-6031-734b-b280-5ecf9d57f649" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019f964c-a7a0-7118-937f-0c6debcfcee5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amd.com/role/SupplementalBalanceSheetInformationSchedulesDetails" xlink:type="simple" xlink:href="amd-20260627.xsd#SupplementalBalanceSheetInformationSchedulesDetails"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/SupplementalBalanceSheetInformationSchedulesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019dfa35-6031-7e04-bc99-ad4792b241ff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dfa35-6031-7a6f-9fbd-0de462d2f362" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019dfa35-6031-7e04-bc99-ad4792b241ff" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dfa35-6031-7a6f-9fbd-0de462d2f362" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_019dfa35-6031-727b-8930-5c6301c817b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019dfa35-6031-7e04-bc99-ad4792b241ff" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_019dfa35-6031-727b-8930-5c6301c817b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_amd_CustomerProgramAccruals_019dfa35-6031-7b3c-b3c7-4f5d51d3e7d5" xlink:href="amd-20260627.xsd#amd_CustomerProgramAccruals"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019dfa35-6031-7e04-bc99-ad4792b241ff" xlink:to="loc_amd_CustomerProgramAccruals_019dfa35-6031-7b3c-b3c7-4f5d51d3e7d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019dfa35-6031-7f08-bff2-1401ebd13016" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019dfa35-6031-7e04-bc99-ad4792b241ff" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019dfa35-6031-7f08-bff2-1401ebd13016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019dfa35-60e5-7638-b281-f741a055ea57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-60e5-7edd-92d0-ae56dd751dfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019dfa35-60e5-7638-b281-f741a055ea57" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-60e5-7edd-92d0-ae56dd751dfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019dfa35-60e5-76df-bdd5-b9e66894411b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019dfa35-60e5-7638-b281-f741a055ea57" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019dfa35-60e5-76df-bdd5-b9e66894411b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019dfa35-6031-7c20-a713-580813e9e03b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019dfa35-6031-75c9-bcaa-d879fc67e069" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019dfa35-6031-7c20-a713-580813e9e03b" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019dfa35-6031-75c9-bcaa-d879fc67e069" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019dfa35-6031-7bef-b6c7-08712c54bd1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019dfa35-6031-7c20-a713-580813e9e03b" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019dfa35-6031-7bef-b6c7-08712c54bd1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019dfa35-60e5-7771-b09b-6289d4197944" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019dfa35-6031-7c20-a713-580813e9e03b" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019dfa35-60e5-7771-b09b-6289d4197944" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-6031-7024-8937-6bfe958c24ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsGross_019dfa35-6031-7249-a778-13365c7c15b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseholdImprovementsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-6031-7024-8937-6bfe958c24ba" xlink:to="loc_us-gaap_LeaseholdImprovementsGross_019dfa35-6031-7249-a778-13365c7c15b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_019dfa35-6031-7a53-8c4d-71e7c145f327" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MachineryAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-6031-7024-8937-6bfe958c24ba" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_019dfa35-6031-7a53-8c4d-71e7c145f327" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_019dfa35-6031-7d4f-b51e-7d8c6cfc059a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_019dfa35-6031-7024-8937-6bfe958c24ba" xlink:to="loc_us-gaap_ConstructionInProgressGross_019dfa35-6031-7d4f-b51e-7d8c6cfc059a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.amd.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="amd-20260627.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.amd.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019dfa35-60e6-7bea-b72a-8cdaa80ebc8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019dfa35-60e6-7814-9e42-7402a2595bad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019dfa35-60e6-7bea-b72a-8cdaa80ebc8e" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019dfa35-60e6-7814-9e42-7402a2595bad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019dfa35-60e6-7dfd-98d0-7425dad15314" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019dfa35-60e6-7bea-b72a-8cdaa80ebc8e" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019dfa35-60e6-7dfd-98d0-7425dad15314" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019dfa35-60e6-7438-b689-6334d806c13a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019dfa35-60e6-785b-9e97-5712985eee96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019dfa35-60e6-7438-b689-6334d806c13a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019dfa35-60e6-785b-9e97-5712985eee96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019dfa35-60e6-7d20-a7a0-d3aa42eb61a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019dfa35-60e6-7438-b689-6334d806c13a" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019dfa35-60e6-7d20-a7a0-d3aa42eb61a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019dfa35-60e6-70b1-94a0-88e08ad8a7c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019dfa35-60e6-7b5e-bf7d-d8eeb360275d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019dfa35-60e6-70b1-94a0-88e08ad8a7c4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019dfa35-60e6-7b5e-bf7d-d8eeb360275d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019dfa35-60e6-7496-b958-ca44de0b8e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019dfa35-60e6-70b1-94a0-88e08ad8a7c4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019dfa35-60e6-7496-b958-ca44de0b8e4d" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
