Liabilities for Sales of Future Royalties - Schedule of Activity Within Liability Related to Sale of Future Royalties (Details) - USD ($) $ in Millions	6 Months Ended	12 Months Ended
	Jun. 30, 2026	Dec. 31, 2025
Liability For Sale Of Future Royalties [Line Items]
Liability for sale of future royalties at beginning of year	$ 1,216	$ 870
Net proceeds from sale of future royalties		392
Royalty revenue	(57)	(108)
Non-cash interest expense	43	62
Liability for sale of future royalties at end of year	1,202	1,216
2025 OMERS Agreement
Liability For Sale Of Future Royalties [Line Items]
Liability for sale of future royalties at beginning of year	398	0
Net proceeds from sale of future royalties		392
Royalty revenue	0	0
Non-cash interest expense	18	6
Liability for sale of future royalties at end of year	416	398
2022 OMERS Agreement
Liability For Sale Of Future Royalties [Line Items]
Liability for sale of future royalties at beginning of year	452	495
Net proceeds from sale of future royalties		0
Royalty revenue	(41)	(79)
Non-cash interest expense	15	36
Liability for sale of future royalties at end of year	426	452
RPI Finance Trust 2019
Liability For Sale Of Future Royalties [Line Items]
Liability for sale of future royalties at beginning of year	366	375
Net proceeds from sale of future royalties		0
Royalty revenue	(16)	(29)
Non-cash interest expense	10	20
Liability for sale of future royalties at end of year	$ 360	$ 366