Collaborative arrangements effective reduction of expense in research and development expenses.

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- Definition

Payments made under agreement.

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- Definition

Regulatory milestone payments achieved.

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- Definition

Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity.

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License and Research Agreements - Mereo - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended	67 Months Ended
	Jan. 31, 2021	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025	Dec. 31, 2024	Jun. 30, 2026	Dec. 31, 2025
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development		$ 167	$ 165	$ 354	$ 331
Regulatory milestone payments achieved						$ 30	$ 9
License and Collaboration Agreement \| Mereo
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Offset to research and development expense		$ 2	$ 2	$ 2	$ 2
License agreement accounts receivable								$ 1
Payments made under agreement	$ 50