In February 2026, the Company implemented a strategic restructuring plan designed to reduce operating expenses and focus resources on its highest value drivers. The restructuring plan included a reduction in workforce and the curtailment of certain

operating activities, including UX143 manufacturing activities. As part of the restructuring, the Company reduced its workforce by approximately 10%. The workforce reduction was substantially completed during the first quarter of 2026.

The following table presents the details of the Company’s restructuring charges and amounts paid or settled during the six months ended June 30, 2026 (in millions):


	Employee-Related			Manufacturing Related			Total
Balance as of December 31, 2025	$	—		$	—		$	—
Restructuring expense		8			22			30
Cash settled/ adjustment		(8	)		(22	)		(30	)
Balance as of June 30, 2026	$	—		$	—		$	—

Total restructuring charges recognized on the Condensed Consolidated Statements of Operations during the three and six months ended June 30, 2026 were as below (in millions):


	Three Months Ended		Six Months Ended
	June 30,		June 30,
	2026		2026
Research and development	$	—	$	28
Selling, general and administrative		—		2
Total restructuring expense	$	—	$	30