v3.26.1
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Operating activities:    
Net income $ 464,364 $ 95,590
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization expense 81,659 68,418
Share-based compensation expenses 260,760 246,287
Acquired in-process research and development 20,518 500
Amortization of research and development cost share liability (58,163) (45,569)
Other items, net 14,412 15,128
Changes in operating assets and liabilities:    
Accounts receivable (192,876) (73,369)
Inventories (118,988) 6,174
Other assets 3,893 (45,316)
Accounts payable (4,657) (35,852)
Accrued expenses and other payables 195,616 75,625
Other liabilities (2,382) 64
Net cash provided by operating activities 664,156 307,680
Investing activities:    
Purchases of property, plant and equipment (68,265) (100,233)
Purchase of intangible assets 0 (20,000)
Proceeds from sale or maturity of investments 5,872 1,800
Purchase of in-process research and development (20,518) (60,000)
Other investing activities (11,952) (10,113)
Net cash used in investing activities (94,863) (188,546)
Financing activities:    
Repayment of long-term loan (24,693) (16,799)
Proceeds from short-term loans 58,204 221,521
Repayment of short-term loans 0 (275,782)
Repayment of sale of future royalties liability (2,556) 0
Payments of withholding taxes from share-based awards 0 (24,195)
Proceeds from option exercises and employee share purchase plan 34,923 96,503
Other financing activities (3,300) 0
Net cash provided by financing activities 62,578 1,248
Effect of foreign exchange rate changes, net 39,156 26,957
Net increase in cash, cash equivalents, and restricted cash 671,027 147,339
Cash, cash equivalents, and restricted cash at beginning of period 4,609,647 2,638,747
Cash, cash equivalents, and restricted cash at end of period 5,280,674 2,786,086
Supplemental cash flow information:    
Cash and cash equivalents 5,098,041 2,756,056
Short-term restricted cash 161,046 15,802
Long-term restricted cash 21,587 14,228
Income taxes paid 67,860 77,033
Interest expense paid 26,320 24,018
Supplemental non-cash information:    
Capital expenditures included in accounts payable and accrued expenses 49,147 57,923
ROU assets obtained in exchange for new operating lease liabilities $ 14,757 $ 18,141