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License and Collaboration Agreements (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended			6 Months Ended		114 Months Ended
	Apr. 28, 2026	Sep. 30, 2025	Jun. 30, 2026	Mar. 31, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Apr. 30, 2024	Jan. 31, 2024
License and Collaboration Agreements
License and collaboration revenue			$ 213,475		$ 5,546	$ 269,843	$ 33,867
Contract asset			3,366			3,366		$ 3,366
Recognized revenue from deferred revenue contract liability			4,400			$ 7,600
Janssen \| Restated Agreement \| FDA approval of ICOTYDE
License and Collaboration Agreements
License and collaboration revenue				$ 50,000
Janssen \| Restated Agreement \| Minimum
License and Collaboration Agreements
Percentage of royalties on net product sales						6.00%
Janssen \| Restated Agreement \| Maximum
License and Collaboration Agreements
Percentage of royalties on net product sales						10.00%
Janssen \| License and collaboration agreement
License and Collaboration Agreements
Proceeds from Milestone Payments						$ 50,000		387,500
Janssen \| License and collaboration agreement \| Phase 3 clinical trial for rusfertide in PV
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable			425,000			425,000		425,000
Janssen \| License and collaboration agreement \| Acceptance of New Drug Application filed by Food And Drug Administration approval for second indication
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable			25,000			25,000		25,000
Janssen \| License and collaboration agreement \| Acceptance of an NDA filing by the FDA for a third indication
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable			35,000			35,000		35,000
Janssen \| License and collaboration agreement \| Food And Drug Administration approval of New Drug Application for second indication
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable			45,000			45,000		45,000
Janssen \| License and collaboration agreement \| FDA approval of an NDA for a third indication
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable			50,000			50,000		50,000
Takeda Pharmaceuticals \| License and collaboration agreement
License and Collaboration Agreements
License and collaboration revenue			213,500			205,700
Proceeds from Milestone Payments		$ 25,000
Non-refundable upfront payment									$ 300,000
Final transaction price										$ 300,000
Revenue recognized upon exercise of opt out right			192,400			192,400
Contract with customer, deferred revenue contract liability			7,600			7,600		7,600
Contract asset			3,400			3,400		3,400
Collaborative agreement, opt-out wind down period	3 months
Initial opt-out payment			200,000			200,000		$ 200,000
Cost reimbursement for post opt-out			5,700			5,700
Revenue recognized			4,400			$ 7,600
Takeda Pharmaceuticals \| License and collaboration agreement \| Annual net Sales Up to 1.5 billion
License and Collaboration Agreements
Milestone revenue	$ 775,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Annual net sales above 1.5 billion
License and Collaboration Agreements
Percentage of royalties on ex-U.S. net sales	29.00%
Takeda Pharmaceuticals \| License and collaboration agreement \| Food And Drug Administration approval Of new drug application for rusfertide in PV
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable										75,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Food And Drug Administration approval Of new drug application for rusfertide in PV \| Exercise of full opt-out right
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable	$ 75,000
Takeda Pharmaceuticals \| License and collaboration agreement \| First regulatory approval in three European countries
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable										15,000
Takeda Pharmaceuticals \| License and collaboration agreement \| First regulatory approval in japan
License and Collaboration Agreements
Upcoming potential development and regulatory milestone payments receivable										10,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Minimum \| Annual net Sales Up to 1.5 billion
License and Collaboration Agreements
Percentage of royalties on ex-U.S. net sales	14.00%
Takeda Pharmaceuticals \| License and collaboration agreement \| Minimum \| Annual net sales above 1.5 billion
License and Collaboration Agreements
Annual net sales	$ 1,500,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Maximum
License and Collaboration Agreements
Additional payment eligible to receive from a collaborative arrangement	200,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Maximum \| Exercise of full opt out right during the initial opt out period
License and Collaboration Agreements
Collaborative arrangement, milestone payment, eligible to receive	$ 200,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Maximum \| Annual net Sales Up to 1.5 billion
License and Collaboration Agreements
Percentage of royalties on ex-U.S. net sales	29.00%
Annual net sales	$ 1,500,000
Takeda Pharmaceuticals \| License and collaboration agreement \| Weighted average \| Annual net Sales Up to 1.5 billion
License and Collaboration Agreements
Percentage of royalties on ex-U.S. net sales	21.00%
Takeda Pharmaceuticals \| License and collaboration agreement \| License And Service \| Exercise of full opt-out right
License and Collaboration Agreements
Profit (loss) share on U.S. profits and losses	50.00%
Takeda Pharmaceuticals \| License and collaboration agreement \| License and Maintenance
License and Collaboration Agreements
Upfront payment										254,100
Takeda Pharmaceuticals \| License and collaboration agreement \| Development Services
License and Collaboration Agreements
Upfront payment										$ 45,900
Takeda Pharmaceuticals \| License and collaboration agreement \| Rusfertide clinical trial supplies
License and Collaboration Agreements
License and collaboration revenue			$ 11,000