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SEGMENT REPORTING
 6 Months Ended
Jun. 30, 2026
Segment Reporting [Abstract]  
SEGMENT REPORTING SEGMENT REPORTING
Operating segments are defined as components of an entity for which separate financial information is available and that is regularly reviewed by the Chief Operating Decision Maker (CODM) in deciding how to allocate resources to an individual segment and in assessing performance. The Company operates as a single reporting segment, focused on the development of MasterKey therapies that target families of oncogenic mutations in patients with cancer.
The Company’s measure of segment profit or loss is net income (loss). The CODM is the chief executive officer (CEO). The CODM manages and allocates resources to the operations of the Company on a total company basis. Managing and allocating resources on a consolidated basis enables the CEO to assess the overall level of resources available and how to best deploy these resources across functions and development projects that are in line with the Company’s strategic goals. Consistent with this decision-making process, the CEO uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. Segment net income (loss) is used to monitor budget versus actual results and in assessing performance of the segment.
The following table is a reconciliation of the significant expense categories to segment net income (loss) regularly provided to the CODM when managing the Company’s single reporting segment:

Three Months Ended
June 30,		Six Months Ended
June 30,

2026

20252026

2025

(in thousands)(in thousands)
License revenue$— $— $— $(70,000)
Program expenses:
Silevertinib (NSCLC) research and development expenses$2,232 $5,518 $5,020 $10,722 
Silevertinib (GBM) research and development expenses2,633 — 4,001 — 
BDTX-4933 research and development expenses— — — 1,018 
Other research programs and development expenses1
— 371 6 933 
Non-program expenses2
3,196 2,997 5,806 6,543 
Personnel-related expenses2,458 2,671 5,470 6,022 
Other segment items3
(614)(996)(1,362)(1,219)
Segment net (income) loss$9,905 $10,561 $18,941 $(45,981)
(1) Includes cross-program consulting expenses; (2) Includes facilities, information technology, legal, intellectual property, and other general and administrative expense; (3) Includes stock-based compensation expense, depreciation, sublease income, investment accretion, interest income, and other (income) expense.