<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e1d7d-3c29-7a2e-bce6-a7195d8ffa76,g:ee232ac4-ecde-437a-a04f-f616a5befdbd-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="zvra-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e1d7d-3cf4-785e-be88-9c1fdec5cfc8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e1d7d-3cf4-785e-be88-9c1fdec5cfc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e1d7d-3cf4-719f-8ba6-add29d3c7387" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e1d7d-3cf4-719f-8ba6-add29d3c7387" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e1d7d-3cf4-7010-bdcd-f3c3de5f124f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e1d7d-3cf4-7010-bdcd-f3c3de5f124f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e1d7d-3cf4-794e-97cc-79f0bf5e9c28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_Goodwill_019e1d7d-3cf4-794e-97cc-79f0bf5e9c28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-70c5-9e21-e484870e3d41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-70c5-9e21-e484870e3d41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e1d7d-3cf4-75cf-84e4-3321ea12e563" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e1d7d-3cf4-75cf-84e4-3321ea12e563" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019e1d7d-3cf4-736e-85ff-8209b0227ad8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_InventoryNoncurrent_019e1d7d-3cf4-736e-85ff-8209b0227ad8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019e1d7d-3cf4-723f-a175-19e5057cb480" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e1d7d-3cf4-7c0c-a11e-9a8faf853386" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019e1d7d-3cf4-723f-a175-19e5057cb480" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019e1d7d-3cf4-7b05-bf0b-b170561b6f42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_PreferredStockValue_019e1d7d-3cf4-7b05-bf0b-b170561b6f42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_019e1d7d-3cf4-7456-b7d5-446214c993ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_CommonStockValueOutstanding_019e1d7d-3cf4-7456-b7d5-446214c993ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e1d7d-3cf4-73e4-bf38-32e49893119c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e1d7d-3cf4-73e4-bf38-32e49893119c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019e1d7d-3cf4-7bd8-88bb-e1082bf1ad36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_TreasuryStockValue_019e1d7d-3cf4-7bd8-88bb-e1082bf1ad36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e1d7d-3cf4-7478-b251-e7fa0fc29883" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e1d7d-3cf4-7478-b251-e7fa0fc29883" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e1d7d-3cf4-72e5-b28f-f67ad9b9f0a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-72d5-8ba0-b74d80107724" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e1d7d-3cf4-72e5-b28f-f67ad9b9f0a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019e1d7d-3cf4-748a-8b73-e9b15153f85a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019e1d7d-3cf4-748a-8b73-e9b15153f85a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e1d7d-3cf4-76ef-9e2e-132dc67e71ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e1d7d-3cf4-76ef-9e2e-132dc67e71ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e1d7d-3cf4-7968-8144-28484c0f1767" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e1d7d-3cf4-7968-8144-28484c0f1767" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_019e1d7d-3cf4-75f3-ad98-6b6a8014e89c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_019e1d7d-3cf4-75f3-ad98-6b6a8014e89c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e1d7d-3cf4-7996-8fec-be7fb336ee46" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e1d7d-3cf4-7ed3-a6e3-adbb95c8ebc7" xlink:to="loc_us-gaap_InventoryNet_019e1d7d-3cf4-7996-8fec-be7fb336ee46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilitiesCurrent_019e1d7d-3cf4-758a-ac50-9b1ef2b6579d" xlink:href="zvra-20260630.xsd#zvra_DiscountAndRebateLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:to="loc_zvra_DiscountAndRebateLiabilitiesCurrent_019e1d7d-3cf4-758a-ac50-9b1ef2b6579d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e1d7d-3cf4-7bc7-bb91-02baed9eaeeb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e1d7d-3cf4-7bc7-bb91-02baed9eaeeb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019e1d7d-3cf4-739e-8f7e-649a33a857e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019e1d7d-3cf4-739e-8f7e-649a33a857e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e1d7d-3cf4-7dd6-8314-ce9c529efc42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_019e1d7d-3cf4-7dd6-8314-ce9c529efc42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019e1d7d-3cf4-79bd-a66f-7aad6b2b559b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-751d-a594-0c00ab79df63" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019e1d7d-3cf4-79bd-a66f-7aad6b2b559b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e1d7d-3cf4-7138-a792-65a6ff19a453" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e1d7d-3cf4-7138-a792-65a6ff19a453" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilitiesNoncurrent_019e1d7d-3cf4-7c18-a17e-a683c7fbe9c6" xlink:href="zvra-20260630.xsd#zvra_DiscountAndRebateLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_zvra_DiscountAndRebateLiabilitiesNoncurrent_019e1d7d-3cf4-7c18-a17e-a683c7fbe9c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-7a6a-8421-20c916a48853" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e1d7d-3cf4-7a6a-8421-20c916a48853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DerivativeAndWarrantLiabilityNoncurrent_019e1d7d-3cf4-7879-a152-5fa01adf7990" xlink:href="zvra-20260630.xsd#zvra_DerivativeAndWarrantLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_zvra_DerivativeAndWarrantLiabilityNoncurrent_019e1d7d-3cf4-7879-a152-5fa01adf7990" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e1d7d-3cf4-7526-a38d-09f987ddde15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e1d7d-3cf4-7526-a38d-09f987ddde15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e1d7d-3cf4-72e3-8b39-888460c9f2c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e1d7d-3cf4-72e3-8b39-888460c9f2c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e1d7d-3cf4-7a53-822f-e7125752477f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e1d7d-3cf4-7d2c-a1c4-7daac9957171" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e1d7d-3cf4-7a53-822f-e7125752477f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e1d7d-3cf4-7763-a415-48748a141d7d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e1d7d-3cf4-7b08-b1d3-135f384e573d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e1d7d-3cf4-7763-a415-48748a141d7d" xlink:to="loc_us-gaap_Liabilities_019e1d7d-3cf4-7b08-b1d3-135f384e573d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e1d7d-3cf4-71a0-9db0-988f3a2a8c95" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e1d7d-3cf4-7763-a415-48748a141d7d" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e1d7d-3cf4-71a0-9db0-988f3a2a8c95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-7417-9d39-93b66b6fe2ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e1d7d-3cf4-7763-a415-48748a141d7d" xlink:to="loc_us-gaap_StockholdersEquity_019e1d7d-3cf4-7417-9d39-93b66b6fe2ab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="zvra-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019e1d7d-3cf4-7b7e-b130-eaa1b41a438a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019e1d7d-3cf4-7b7e-b130-eaa1b41a438a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019e1d7d-3cf4-7d5d-a401-61e8e6468e08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_us-gaap_CostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization_019e1d7d-3cf4-7d5d-a401-61e8e6468e08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019e1d7d-3cf4-7900-9937-fb7e50c26eb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019e1d7d-3cf4-7900-9937-fb7e50c26eb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e1d7d-3cf4-7adb-a199-be062cda0248" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_us-gaap_CostsAndExpenses_019e1d7d-3cf4-7adb-a199-be062cda0248" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019e1d7d-3cf4-717b-847e-4f04be06e0d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019e1d7d-3cf4-717b-847e-4f04be06e0d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019f039a-30fb-70cb-8e59-11c3f49a566f" xlink:href="zvra-20260630.xsd#zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7607-8d3b-fcbb2e98d04c" xlink:to="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019f039a-30fb-70cb-8e59-11c3f49a566f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e1d7d-3cf4-7899-afcc-b71ade33c89a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e1d7d-3cf4-7c13-928b-5adb4a1f393a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e1d7d-3cf4-7899-afcc-b71ade33c89a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e1d7d-3cf4-7c13-928b-5adb4a1f393a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e1d7d-3cf4-75fa-b8cc-e164a0b4bf15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e1d7d-3cf4-7899-afcc-b71ade33c89a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e1d7d-3cf4-75fa-b8cc-e164a0b4bf15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e1d7d-3cf4-7e5c-a849-bec0a6d13117" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e1d7d-3cf4-7e5c-a849-bec0a6d13117" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019e1d7d-3cf4-7a49-b5ba-2cca8e61a5f7" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019e1d7d-3cf4-7a49-b5ba-2cca8e61a5f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfInvestments_019e1d7d-3cf4-7cbf-b929-50c22d5e99b9" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentOfInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_zvra_FairValueAdjustmentOfInvestments_019e1d7d-3cf4-7cbf-b929-50c22d5e99b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_InterestAndOtherIncomeExpenseNet_019e1d7d-3cf4-7e80-97ea-850fb3c75ece" xlink:href="zvra-20260630.xsd#zvra_InterestAndOtherIncomeExpenseNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_zvra_InterestAndOtherIncomeExpenseNet_019e1d7d-3cf4-7e80-97ea-850fb3c75ece" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e1d7d-3cf4-72c6-bb58-2bd7ddd0daff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e1d7d-3cf4-72c6-bb58-2bd7ddd0daff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_019e1d7d-3cf4-71d4-b584-6f01e8167c45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_019e1d7d-3cf4-71d4-b584-6f01e8167c45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019f0399-0842-7485-b978-65d9c0d89698" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7e7b-8606-656eae83fbed" xlink:to="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019f0399-0842-7485-b978-65d9c0d89698" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-709a-9997-c7d29ddbcdb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e1d7d-3cf4-7836-9ada-54a742e93cd0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-709a-9997-c7d29ddbcdb3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e1d7d-3cf4-7836-9ada-54a742e93cd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e1d7d-3cf4-7948-b01e-428f4b5990c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-709a-9997-c7d29ddbcdb3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e1d7d-3cf4-7948-b01e-428f4b5990c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e1d7d-3cf4-7096-b691-f755360bf99a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7560-ab66-42986fae29c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e1d7d-3cf4-7096-b691-f755360bf99a" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e1d7d-3cf4-7560-ab66-42986fae29c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7e94-af6d-c7740eca82c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e1d7d-3cf4-7096-b691-f755360bf99a" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e1d7d-3cf4-7e94-af6d-c7740eca82c1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="zvra-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e1d7d-3cf4-7621-87b8-cc66fe7b0b33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-768b-9c39-a43d3e6adf28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e1d7d-3cf4-7621-87b8-cc66fe7b0b33" xlink:to="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-768b-9c39-a43d3e6adf28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e1d7d-3cf4-7b1a-9d04-29622f8c1dab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e1d7d-3cf4-7621-87b8-cc66fe7b0b33" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e1d7d-3cf4-7b1a-9d04-29622f8c1dab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e1d7d-3cf4-7830-b545-625efd0d7f08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019e1d7d-3cf4-7d5a-8195-f54d996caca4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e1d7d-3cf4-7830-b545-625efd0d7f08" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019e1d7d-3cf4-7d5a-8195-f54d996caca4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e1d7d-3cf4-7710-8e7f-57f21747cd7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019e1d7d-3cf4-7830-b545-625efd0d7f08" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e1d7d-3cf4-7710-8e7f-57f21747cd7c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="zvra-20260630.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://zevra.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_019e1d7d-3cf4-7864-98d9-f97ce4e8dd17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_us-gaap_RepaymentsOfDebt_019e1d7d-3cf4-7864-98d9-f97ce4e8dd17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_019e1d7d-3cf4-7fa6-839c-2aacc7a2766c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_019e1d7d-3cf4-7fa6-839c-2aacc7a2766c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements_019e1d7d-3cf4-723d-a904-f87ffc73836f" xlink:href="zvra-20260630.xsd#zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_zvra_PaymentsOfPrincipalOnInsuranceFinancingArrangements_019e1d7d-3cf4-723d-a904-f87ffc73836f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e1d7d-3cf4-7dc1-9640-166728405160" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e1d7d-3cf4-7dc1-9640-166728405160" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019e1d7d-3cf4-71ac-a2b8-2c56011eb232" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019e1d7d-3cf4-71ac-a2b8-2c56011eb232" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans_019f03c2-50f5-7eb1-852c-cbb5fe898d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-7198-8904-eb84a1d0fb64" xlink:to="loc_us-gaap_ProceedsFromRepaymentOfLoansByEmployeeStockOwnershipPlans_019f03c2-50f5-7eb1-852c-cbb5fe898d3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-75df-a2d3-2d1701c843a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf4-75df-a2d3-2d1701c843a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e1d7d-3cf4-7aeb-80f5-d9b2d0f321d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_ShareBasedCompensation_019e1d7d-3cf4-7aeb-80f5-d9b2d0f321d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019e1d7d-3cf4-792d-b323-7002ee6cee03" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_InventoryWriteDown_019e1d7d-3cf4-792d-b323-7002ee6cee03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_IncomeTaxExpenseBenefitNoncashAdjustment_019e1d7d-3cf4-7e9f-9d47-eba28f326067" xlink:href="zvra-20260630.xsd#zvra_IncomeTaxExpenseBenefitNoncashAdjustment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_IncomeTaxExpenseBenefitNoncashAdjustment_019e1d7d-3cf4-7e9f-9d47-eba28f326067" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e1d7d-3cf4-719f-bce0-d174a7690f89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e1d7d-3cf4-719f-bce0-d174a7690f89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashExpense_019e1d7d-3cf4-7368-883e-829c8bdbdb93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_OtherNoncashExpense_019e1d7d-3cf4-7368-883e-829c8bdbdb93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019e1d7d-3cf4-7056-ab13-dcc994e3fc14" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_FairValueAdjustmentRelatedToWarrantAndCVRLiability_019e1d7d-3cf4-7056-ab13-dcc994e3fc14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019e1d7d-3cf4-784d-be3a-cab018fb0e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019e1d7d-3cf4-784d-be3a-cab018fb0e7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfInvestments_019e1d7d-3cf4-7504-bf16-cf16ea0c5385" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentOfInvestments"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_FairValueAdjustmentOfInvestments_019e1d7d-3cf4-7504-bf16-cf16ea0c5385" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e1d7d-3cf4-7b7d-8f07-a353d193c259" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019e1d7d-3cf4-7b7d-8f07-a353d193c259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentRelatedToDerivativeInstrument_019e1d7d-3cf4-7468-afb4-5f837950bbec" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentRelatedToDerivativeInstrument"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_FairValueAdjustmentRelatedToDerivativeInstrument_019e1d7d-3cf4-7468-afb4-5f837950bbec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium_019e1d7d-3cf4-7dd2-8df1-519256873896" xlink:href="zvra-20260630.xsd#zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_CashPaidToSettleDerivativeInstrumentAndPayoffPremium_019e1d7d-3cf4-7dd2-8df1-519256873896" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_PaymentOfPaidInKindInterest_019e1d7d-3cf4-7117-8685-3bae1539fa31" xlink:href="zvra-20260630.xsd#zvra_PaymentOfPaidInKindInterest"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_PaymentOfPaidInKindInterest_019e1d7d-3cf4-7117-8685-3bae1539fa31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019e1d7d-3cf4-7edf-89d6-0054f04139c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnDispositionOfIntangibleAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_GainLossOnDispositionOfIntangibleAssets_019e1d7d-3cf4-7edf-89d6-0054f04139c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_ConsultingFeesPaidInCommonStock_019e1d7d-3cf4-72c2-a07f-8308645ff0bf" xlink:href="zvra-20260630.xsd#zvra_ConsultingFeesPaidInCommonStock"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_ConsultingFeesPaidInCommonStock_019e1d7d-3cf4-72c2-a07f-8308645ff0bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019e1d7d-3cf4-7799-9251-8885ce285503" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019e1d7d-3cf4-7799-9251-8885ce285503" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_019e1d7d-3cf4-7f95-b399-f2e350d4f967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_019e1d7d-3cf4-7f95-b399-f2e350d4f967" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e1d7d-3cf4-7493-b0d7-9907d6613c16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e1d7d-3cf4-7493-b0d7-9907d6613c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e1d7d-3cf4-709f-8d57-3bd835304b15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e1d7d-3cf4-709f-8d57-3bd835304b15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_019e1d7d-3cf4-7cdd-8b0b-fbbd306a694f" xlink:href="zvra-20260630.xsd#zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="20" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_IncreaseDecreaseInOperatingLeaseRightOfUseAsset_019e1d7d-3cf4-7cdd-8b0b-fbbd306a694f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019e1d7d-3cf4-79f1-a6fd-65f4d109e1b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="21" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019e1d7d-3cf4-79f1-a6fd-65f4d109e1b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_DiscountAndRebateLiabilities_019e1d7d-3cf4-7675-94d9-e11192901529" xlink:href="zvra-20260630.xsd#zvra_DiscountAndRebateLiabilities"/>
    <link:calculationArc order="22" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_DiscountAndRebateLiabilities_019e1d7d-3cf4-7675-94d9-e11192901529" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019e1d7d-3cf4-71c5-963d-b0168a15105d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="23" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019e1d7d-3cf4-71c5-963d-b0168a15105d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019e1d7d-3cf4-70f0-b484-750ef3005f91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="24" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019e1d7d-3cf4-70f0-b484-750ef3005f91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInRoyaltiesPayable_019e1d7d-3cf4-793d-8436-a4ee3e83496f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInRoyaltiesPayable"/>
    <link:calculationArc order="25" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInRoyaltiesPayable_019e1d7d-3cf4-793d-8436-a4ee3e83496f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019f03c5-c5ea-73a7-85b4-4580b1d6f514" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="26" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_019f03c5-c5ea-73a7-85b4-4580b1d6f514" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019f3c04-0a95-7094-8d60-f570f198d65d" xlink:href="zvra-20260630.xsd#zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet"/>
    <link:calculationArc order="27" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_zvra_GainLossOnSaleOfFutureRoyaltiesIntellectualPropertyAndOtherAssetsNet_019f3c04-0a95-7094-8d60-f570f198d65d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f652d-01c4-7035-b975-73e62cd444fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="28" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f652d-01c4-7035-b975-73e62cd444fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019f6530-5044-71f4-8405-c79dfba8aef5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="29" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-790a-b129-d8048b4dd7d5" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019f6530-5044-71f4-8405-c79dfba8aef5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e1d7d-3cf4-7839-a110-0f583001ee99" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-7cd7-9e66-84df44f4ff7b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e1d7d-3cf4-7839-a110-0f583001ee99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e1d7d-3cf4-7cd7-9e66-84df44f4ff7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019e1d7d-3cf4-7016-b9f3-aa1b0ba4a0db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e1d7d-3cf4-7839-a110-0f583001ee99" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019e1d7d-3cf4-7016-b9f3-aa1b0ba4a0db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-748e-b901-61a6ce6217a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e1d7d-3cf4-7839-a110-0f583001ee99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e1d7d-3cf4-748e-b901-61a6ce6217a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-7cef-a120-0a9608ba2bae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e1d7d-3cf4-7839-a110-0f583001ee99" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-7cef-a120-0a9608ba2bae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e1d7d-3cf4-704b-b41b-a63134877427" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e1d7d-3cf4-704b-b41b-a63134877427" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_019e1d7d-3cf4-7c0b-b76d-34eb129edd9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_019e1d7d-3cf4-7c0b-b76d-34eb129edd9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019e1d7d-3cf4-7048-ab02-ac092adaa0c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019e1d7d-3cf4-7048-ab02-ac092adaa0c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_019e1d7d-3cf4-706d-a22e-c64079a29d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:to="loc_us-gaap_ProceedsFromSaleOfIntangibleAssets_019e1d7d-3cf4-706d-a22e-c64079a29d3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_ProceedsFromSaleOfPriorityReviewVoucher_019f03d4-b774-7145-8d42-95395adda403" xlink:href="zvra-20260630.xsd#zvra_ProceedsFromSaleOfPriorityReviewVoucher"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e1d7d-3cf4-760c-a409-fd46cc0fe0b9" xlink:to="loc_zvra_ProceedsFromSaleOfPriorityReviewVoucher_019f03d4-b774-7145-8d42-95395adda403" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/SegmentInformationSegmentReportingInformationbySegmentDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#SegmentInformationSegmentReportingInformationbySegmentDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/SegmentInformationSegmentReportingInformationbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019e1d7d-3cf5-76f4-9a1f-823cbba00c76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_019e1d7d-3cf5-76f4-9a1f-823cbba00c76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e1d7d-3cf5-7fd3-90ca-194abdfaa636" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019e1d7d-3cf5-7fd3-90ca-194abdfaa636" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e1d7d-3cf5-7a09-bc2f-d27a37ba2bfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e1d7d-3cf5-7a09-bc2f-d27a37ba2bfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e1d7d-3cf5-77c8-9e7e-34fc318da473" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e1d7d-3cf5-77c8-9e7e-34fc318da473" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019e1d7d-3cf5-7a83-bad0-bf3d412b6620" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019e1d7d-3cf5-7a83-bad0-bf3d412b6620" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e1d7d-3cf5-7487-98f1-eafa52226bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e1d7d-3cf5-7487-98f1-eafa52226bd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e1d7d-3cf5-787b-9ecf-5e6357b61ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e1d7d-3cf5-787b-9ecf-5e6357b61ad6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e1d7d-3cf5-7159-9c03-e49e2fd6ace3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e1d7d-3cf5-7159-9c03-e49e2fd6ace3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_019f03dc-1b40-7ad2-b4f1-e69cf3ecd933" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e1d7d-3cf5-74c7-87dc-328744adc416" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_019f03dc-1b40-7ad2-b4f1-e69cf3ecd933" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/InventoriesDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_019e1d7d-3cf5-7129-bb7a-96ba9a4fb1d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_019e1d7d-3cf5-7f9f-99d4-10794e8c259f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019e1d7d-3cf5-7129-bb7a-96ba9a4fb1d3" xlink:to="loc_us-gaap_InventoryRawMaterials_019e1d7d-3cf5-7f9f-99d4-10794e8c259f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_019e1d7d-3cf5-707d-a723-89083d4595f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019e1d7d-3cf5-7129-bb7a-96ba9a4fb1d3" xlink:to="loc_us-gaap_InventoryWorkInProcess_019e1d7d-3cf5-707d-a723-89083d4595f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_019e1d7d-3cf5-708a-9dc7-77ff02c2f1d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019e1d7d-3cf5-7129-bb7a-96ba9a4fb1d3" xlink:to="loc_us-gaap_InventoryFinishedGoods_019e1d7d-3cf5-708a-9dc7-77ff02c2f1d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/DebtObligationsScheduleofLongTermDebtDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#DebtObligationsScheduleofLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/DebtObligationsScheduleofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e1d7d-3cf5-7839-83f8-02415926ce91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e1d7d-3cf5-7492-b1c3-c1747e17de81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e1d7d-3cf5-7839-83f8-02415926ce91" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019e1d7d-3cf5-7492-b1c3-c1747e17de81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019e1d7d-3cf5-70a1-98d3-6650bf97b609" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e1d7d-3cf5-7839-83f8-02415926ce91" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019e1d7d-3cf5-70a1-98d3-6650bf97b609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_019e1d7d-3cf5-7bbc-aa3c-4a562786dc46" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e1d7d-3cf5-7839-83f8-02415926ce91" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_019e1d7d-3cf5-7bbc-aa3c-4a562786dc46" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/NetIncomePerShareScheduleofEarningsPerShareBasicandDilutedDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#NetIncomePerShareScheduleofEarningsPerShareBasicandDilutedDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/NetIncomePerShareScheduleofEarningsPerShareBasicandDilutedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7071-a5f9-da280a48da76" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e1d7d-3dad-7f84-97ca-ecc042f0538b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7071-a5f9-da280a48da76" xlink:to="loc_us-gaap_NetIncomeLoss_019e1d7d-3dad-7f84-97ca-ecc042f0538b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_019e1d7d-3dad-7d7b-85cb-83b1aed75d5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7071-a5f9-da280a48da76" xlink:to="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_019e1d7d-3dad-7d7b-85cb-83b1aed75d5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019e1d7d-3dad-7a28-87f7-7e7f6af11452" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7abe-8681-6f0bb296c081" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019e1d7d-3dad-7a28-87f7-7e7f6af11452" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7abe-8681-6f0bb296c081" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_zvra_FairValueAdjustmentOfWarrantsNetOfTax_019e1d7d-3dad-725a-b347-d48049b18ef8" xlink:href="zvra-20260630.xsd#zvra_FairValueAdjustmentOfWarrantsNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_019e1d7d-3dad-7a28-87f7-7e7f6af11452" xlink:to="loc_zvra_FairValueAdjustmentOfWarrantsNetOfTax_019e1d7d-3dad-725a-b347-d48049b18ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e1d7d-3dad-7128-a531-4dc201677fbf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e1d7d-3dad-7fc1-afca-2f91dd2ed6aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e1d7d-3dad-7128-a531-4dc201677fbf" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e1d7d-3dad-7fc1-afca-2f91dd2ed6aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019e1d7d-3dad-7392-be0d-82a09b0a7599" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e1d7d-3dad-7128-a531-4dc201677fbf" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_019e1d7d-3dad-7392-be0d-82a09b0a7599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019e1d7d-3dad-72b6-9da3-bc46fdbd2488" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7d5f-bbd9-6362a519f94b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019e1d7d-3dad-72b6-9da3-bc46fdbd2488" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e1d7d-3dad-7d5f-bbd9-6362a519f94b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019e1d7d-3dad-7032-abe0-8028f16bfd9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_UndistributedEarningsLossAvailableToCommonShareholdersBasic_019e1d7d-3dad-72b6-9da3-bc46fdbd2488" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_019e1d7d-3dad-7032-abe0-8028f16bfd9f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofComponentofLeaseExpensesDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#LeasesScheduleofComponentofLeaseExpensesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofComponentofLeaseExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019e1d7d-3dad-7f25-ba4f-c9d0870b9f84" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubleaseIncome_019e1d7d-3dad-78ec-8c01-ef644310499b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubleaseIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e1d7d-3dad-7f25-ba4f-c9d0870b9f84" xlink:to="loc_us-gaap_SubleaseIncome_019e1d7d-3dad-78ec-8c01-ef644310499b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019e1d7d-3dad-7dca-9370-f6cd778d8747" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e1d7d-3dad-7f25-ba4f-c9d0870b9f84" xlink:to="loc_us-gaap_OperatingLeaseCost_019e1d7d-3dad-7dca-9370-f6cd778d8747" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_019e1d7d-3dad-7d72-a308-e933de3a1e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e1d7d-3dad-7f25-ba4f-c9d0870b9f84" xlink:to="loc_us-gaap_ShortTermLeaseCost_019e1d7d-3dad-7d72-a308-e933de3a1e5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019f03ea-1bd3-73ed-a4aa-7fce7b4a595e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e1d7d-3dad-7f25-ba4f-c9d0870b9f84" xlink:to="loc_us-gaap_VariableLeaseCost_019f03ea-1bd3-73ed-a4aa-7fce7b4a595e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e1d7d-3dad-7015-b141-9d5db1ab5270" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e1d7d-3dad-7e91-a248-237c63ed1527" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e1d7d-3dad-7015-b141-9d5db1ab5270" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e1d7d-3dad-7e91-a248-237c63ed1527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e1d7d-3dad-7a14-8e87-3fb209c35e6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e1d7d-3dad-7015-b141-9d5db1ab5270" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e1d7d-3dad-7a14-8e87-3fb209c35e6c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="zvra-20260630.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-7336-a53f-dd2ef0e14357" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e1d7d-3dad-736b-aee1-7e9c0eca8e66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-7336-a53f-dd2ef0e14357" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e1d7d-3dad-736b-aee1-7e9c0eca8e66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e1d7d-3dad-75d0-92a2-1d9e01302152" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-7336-a53f-dd2ef0e14357" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e1d7d-3dad-75d0-92a2-1d9e01302152" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="zvra-20260630.xsd#LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://zevra.com/role/LeasesScheduleofMaturitiesofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-78a5-95b8-760deaa13f10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e1d7d-3dad-7747-b3f6-23c1557c7ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-78a5-95b8-760deaa13f10" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e1d7d-3dad-7747-b3f6-23c1557c7ffd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e1d7d-3dad-7d5f-8c34-c6a31095cb0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-78a5-95b8-760deaa13f10" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e1d7d-3dad-7d5f-8c34-c6a31095cb0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e1d7d-3dad-7218-8d73-e1aea9e3b753" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-78a5-95b8-760deaa13f10" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e1d7d-3dad-7218-8d73-e1aea9e3b753" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e1d7d-3dad-7c67-aacd-c6642244080d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e1d7d-3dad-78a5-95b8-760deaa13f10" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e1d7d-3dad-7c67-aacd-c6642244080d" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
