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operations, diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted, Continuing Operations Weighted Average Number of Shares Outstanding, Diluted, Continuing Operations Clinical Trial Expenses Clinical Trial Expense [Policy Text Block] Clinical Trial Expense [Policy Text Block] REVENUE RECOGNITION Revenue from Contract with Customer [Text Block] Debt instrument, convertible, prior to maturity date Debt Instrument, Convertible, Redemption Option, Scheduled Trading Days Prior To Maturity Date Debt Instrument, Convertible, Redemption Option, Scheduled Trading Days Prior To Maturity Date Milestone payment from collaborator, recognized Collaborative Arrangement, Milestone Payment From Collaborator, Recognized Collaborative Arrangement, Milestone Payment From Collaborator, Recognized Other Payment for (Proceeds from) Other Investing Activity Inventory Increase (Decrease) in Inventories Weighted-average discount rate Operating Lease, Weighted Average Discount Rate, Percent Ligand License Agreement Ligand License Agreement [Member] Ligand License Agreement under which an entity develop, manufacture and commercialize a drug technology which is referred to as DARA. Schedule of Service Based Restricted Stock Activity Nonvested Restricted Stock Shares Activity [Table Text Block] Segment Reporting [Table] Segment Reporting [Table] Royalty guarantees, commitments, amount Royalty Guarantees, Commitments, Amount Sale of Stock [Axis] Sale of Stock [Axis] Cash Flows From Investing Activities: Cash Provided by (Used in) Investing Activity, Continuing Operation [Abstract] Remaining Contractual Term (years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract] Schedule of Weighted-average Remaining Lease Term and Discount Rate Lease, Cost [Table Text Block] Cash Flows From Operating Activities: Cash Provided by (Used in) Operating Activity, Continuing Operation [Abstract] Induced conversion on 2029 Notes Adjustment to Additional Paid-in Capital, Convertible Debt Instrument Issued at Substantial Premium Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] All Trading Arrangements All Trading Arrangements [Member] Less than 12 months, fair value Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Other Performance Measure, Amount Other Performance Measure, Amount Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Operating income (loss) Operating Income (Loss) Current Fiscal Year End Date Current Fiscal Year End Date Proceeds from issuance of debt Proceeds from Issuance of Debt Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member] Entity File Number Entity File Number Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Share based compensation Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Unamortized lease incentives Operating Lease, Incentive, Tenant Improvements Operating Lease, Incentive, Tenant Improvements Schedule of Stock Option Activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Senior Notes Due 2025 and Senior Notes Due 2029 Senior Notes Due 2025, Senior Notes Due 2029 and Senior Notes Due 2032 [Member] Senior Notes Due 2025, Senior Notes Due 2029 and Senior Notes Due 2032 Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Common stock, issued (in shares) Common Stock, Shares, Issued Measure: Measure [Axis] Number of performance obligations Collaborative Arrangement, Number Of Performance Obligations Collaborative Arrangement, Number Of Performance Obligations William E. Rote, Ph.D. [Member] William E. Rote, Ph.D. Accrued royalties Accrued Royalties, Current 12 months or greater, unrealized losses Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Marketable debt securities, available-for-sale, current Debt Securities, Available-for-Sale, Current Equity Components [Axis] Equity Components [Axis] Debt instrument, repurchase amount Debt Instrument, Repurchase Amount Accounts receivable Increase (Decrease) in Accounts Receivable Product and Service [Domain] Product and Service [Domain] Class of Stock [Line Items] Class of Stock [Line Items] Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Entity Interactive Data Current Entity Interactive Data Current Percentage of royalty on net sales receives Collaborative Arrangement, Royalty Percentage On Net Sales Collaborative Arrangement, Royalty Percentage On Net Sales Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Entity Small Business Entity Small Business Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Termination Date Trading Arrangement Termination Date Discontinued Operations Discontinued Operations, Policy [Policy Text Block] Variable interest entity, gain from sale Variable Interest Entity, Gain From Sale Variable Interest Entity, Gain From Sale Subsequent Events [Abstract] Subsequent Events [Abstract] Loss from discontinued operations, net of tax Net loss from discontinued operations Net loss from discontinued operations Loss from discontinued operations Income (Loss) from Discontinued Operations, Net of Tax, Attributable to Parent Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] DIVESTITURES Disposal Groups, Including Discontinued Operations, Disclosure [Text Block] Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] Other current liabilities Other Liabilities, Current Securities of government sponsored entities Securities of government-sponsored entities US Government-sponsored Enterprises Debt Securities [Member] Collaborative Arrangements Collaborative Arrangement, Accounting Policy [Policy Text Block] Other assets Other Assets, Noncurrent Cash Flows From Financing Activities: Cash Provided by (Used in) Financing Activity, Continuing Operation [Abstract] Document Type Document Type Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Accrued expenses Total accrued expenses Accrued Liabilities, Current Fair Value as of Grant Date Award Grant Date Fair Value Repurchase of 2029 convertible senior notes including premium Repayments of Convertible Debt Schedule of Available-for-Sale Marketable Debt Securities in an Unrealized Loss Position Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES Significant Accounting Policies [Text Block] Number of direct-to-patient pharmacies sold to Number of Direct-To-Patient Pharmacies Sold To Number of Direct-To-Patient Pharmacies Sold To Aggregate intrinsic value, exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Arrangement Duration Trading Arrangement Duration Subsequent Event [Line Items] Subsequent Event [Line Items] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Local Phone Number Local Phone Number Entity Address, Postal Zip Code Entity Address, Postal Zip Code Entity Registrant Name Entity Registrant Name Consideration receivable on sale of business (up to) Disposal Group, Including Discontinued Operation, Contingent Consideration Receivable Disposal Group, Including Discontinued Operation, Contingent Consideration Receivable Less than 12 months, unrealized losses Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Schedule of Performance Based Restricted Stock Activity Share-Based Payment Arrangement, Performance Shares, Activity [Table Text Block] Loss from continuing operations before income tax Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Aggregate intrinsic value, vested and expected to vest Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Commitments and Contingencies (See Note 13) Commitments and Contingencies Gross carrying amount Finite-lived intangible assets Intangible Asset, Finite-Lived, before Accumulated Amortization Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Accounting Standards Update and Change in Accounting Principle [Table] Accounting Standards Update and Change in Accounting Principle [Table] Accounts payable Increase (Decrease) in Accounts Payable and Accrued Liabilities Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Executive Category: Executive Category [Axis] Counterparty Name [Axis] Counterparty Name [Axis] Liabilities and Stockholders' Equity Liabilities and Equity [Abstract] Intangible Asset, Finite-Lived, Class [Domain] Intangible Asset, Finite-Lived, Class [Domain] Exercisable (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted-Average Remaining Contractual Term Total inventory Inventory, Net Award Type [Domain] Award Type [Domain] Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount 2026 (remaining) Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] Significant unobservable inputs (Level 3) Fair Value, Inputs, Level 3 [Member] PEO Name PEO Name Debt instrument, convertible, threshold percentage of stock price trigger Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Geographical [Axis] Geographical [Axis] External research and development External Research and Development External Research and Development Deferred revenue Contract with Customer, Liability Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Entity Tax Identification Number Entity Tax Identification Number Royalties and milestones capitalized Royalty Costs And Milestones, Capitalized Royalty Costs And Milestones, Capitalized Total interest expense Interest Expense, Debt Notes payable Notes Payable Marketable debt securities, available-for-sale, noncurrent Debt Securities, Available-for-Sale, Noncurrent Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Exercised (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Cash and cash equivalents, beginning of year Cash and cash equivalents, end of period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Intangible Asset, Finite-Lived [Table] Intangible Asset, Finite-Lived [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Miscellaneous accrued expenses Accrued Liabilities, Miscellaneous, Current Accrued Liabilities, Miscellaneous, Current Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Non-NEOs Non-NEOs [Member] Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Net loss from discontinued operations, basic (in dollars per share) Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share Measurement Frequency [Domain] Measurement Frequency [Domain] Debt Instrument [Axis] Debt Instrument [Axis] Subsequent Event [Table] Subsequent Event [Table] Share based compensation Share-Based Payment Arrangement, Noncash Expense Research and development Accrued Liabilities, Research and Development, Current Accrued Liabilities, Research and Development, Current Disposal Group Name [Axis] Disposal Group Name [Axis] Schedule of Inventory Schedule of Inventory, Current [Table Text Block] LEASES Lessee, Operating Leases [Text Block] Long-term Debt, Type [Domain] Long-Term Debt, Type [Domain] Net loss per common share, basic (in dollars per share) Earnings Per Share, Basic Force majeure event period threshold License Agreement, Force Majeure Event Period Threshold License Agreement, Force Majeure Event Period Threshold Total current assets Assets, Current Statistical Measurement [Axis] Statistical Measurement [Axis] Insider Trading Arrangements [Line Items] Long-term debt, excluding current maturities Long-Term Debt, Excluding Current Maturities Award Type [Axis] Award Type [Axis] Available-for-sale marketable debt securities in an unrealized loss position Debt Securities, Available-for-sale, Unrealized Loss Position, Amortized Cost Debt Securities, Available-for-sale, Unrealized Loss Position, Amortized Cost Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Orphan Technologies Limited Orphan Technologies Limited [Member] Orphan Technologies Limited Accounts receivable, net Accounts Receivable, after Allowance for Credit Loss, Current Issuance of common stock under the equity incentive plan and proceeds from exercise Shares Granted, Value, Share-Based Payment Arrangement, before Forfeiture Unrealized loss on marketable debt securities Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Accumulated deficit Retained Earnings (Accumulated Deficit) Product and Service [Axis] Product and Service [Axis] Debt instrument, convertible, threshold trading days Debt Instrument, Convertible, Threshold Trading Days Milestone payments (up to) Collaborative Arrangement, Contingent Milestone Payments From Collaborator Collaborative Arrangement, Contingent Milestone Payments From Collaborator Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Common Stock Common Stock [Member] Marketable debt securities, at fair value Total available-for-sale marketable debt securities Total available-for-sale marketable debt securities Marketable debt securities, available-for-sale Debt Securities, Available-for-Sale Contingent consideration, liability Business Combination, Contingent Consideration, Liability Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Cover [Abstract] Cover [Abstract] Contractual interest expense Interest Expense, Debt, Excluding Amortization Debt Conversion, Scenario One Debt Conversion, Scenario One [Member] Debt Conversion, Scenario One Concentration risk, percentage Concentration Risk, Percentage Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Equity Awards Adjustments Equity Awards Adjustments [Member] COLLABORATION AND LICENSE AGREEMENTS Collaborative Arrangement Disclosure [Text Block] Total liabilities and stockholders' equity Liabilities and Equity Compensation related costs Accrued Salaries, Current Options Employee Stock Option Share-Based Payment Arrangement, Option [Member] Segments [Axis] Segments [Axis] Other current and non-current liabilities Increase (Decrease) in Other Operating Liabilities Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Accrued interest receivable Interest Receivable, Current Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Tabular List, Table Tabular List [Table Text Block] Additional paid-in capital Additional Paid in Capital PTE. Ltd. PTE. Ltd. [Member] PTE. Ltd. Schedule of Share Based Compensation Expenses Share-Based Payment Arrangement, Cost by Plan [Table Text Block] Purchase of intangible assets Payments to date under terms of agreement Payments to Acquire Intangible Assets Other (expense) income, net Other Nonoperating Income (Expense) Peter Heerma [Member] Peter Heerma Name Awards Close in Time to MNPI Disclosures, Individual Name Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Aggregate intrinsic value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Forfeited/canceled (in shares) Forfeited/canceled (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Proceeds from milestone payment Disposal Group, Including Discontinued Operation, Proceeds From Milestone Payment Disposal Group, Including Discontinued Operation, Proceeds From Milestone Payment Preferred stock, authorized (in shares) Preferred Stock, Shares Authorized Christopher Cline [Member] Christopher Cline Preferred stock $0.0001 par value; 20,000,000 shares authorized; no shares issued and outstanding as of June 30, 2026 and December 31, 2025 Preferred Stock, Value, Issued Adjustment to Compensation: Adjustment to Compensation [Axis] Cost of goods sold Cost of Goods and Service [Policy Text Block] Schedule of Cost of Goods Sold Schedule Of Cost Of Goods Sold [Table Text Block] Schedule Of Cost Of Goods Sold Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Upfront payment Collaborative Arrangement, Upfront Payment Collaborative Arrangement, Upfront Payment Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Total Assets, Fair Value Disclosure Vested and expected to vest (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Discontinued Operations and Disposal Groups [Abstract] Discontinued Operations and Disposal Groups [Abstract] Name Measure Name Accounts payable Accounts Payable, Current Pay vs Performance Disclosure [Line Items] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Other Other Noncash Income (Expense) Debt Instrument [Line Items] Debt Instrument [Line Items] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Additional Paid in Capital Additional Paid-in Capital [Member] Entity Filer Category Entity Filer Category Total, fair value Debt Securities, Available-for-Sale, Unrealized Loss Position Name Trading Arrangement, Individual Name Cash and cash equivalents Cash and Cash Equivalent Raw materials Inventory, Raw Materials, Net of Reserves Operating lease expense Operating Lease, Expense Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Company Selected Measure Amount Company Selected Measure Amount Beginning balance (in shares) Ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number Investments, Debt and Equity Securities [Abstract] Investments, Debt and Equity Securities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Vested and expected to vest (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Lease incentive, tenant improvements Incentive to Lessee Inventory Current inventory Inventory, Gross Elizabeth E. Reed [Member] Elizabeth E. Reed Entity Address, Address Line Two Entity Address, Address Line Two Stock, Class of Stock [Table] Stock, Class of Stock [Table] Accounts and Financing Receivables [Table] Accounts and Financing Receivables [Table] Regulatory Development And Sales Based Milestone Regulatory Development And Sales Based Milestone [Member] Regulatory Development And Sales Based Milestone Current assets: Assets, Current [Abstract] Debt Conversion, Name [Domain] Debt Conversion, Name [Domain] Weighted-average remaining lease term in years Operating Lease, Weighted Average Remaining Lease Term Debt instrument, repurchase amount including accrued and unpaid interest Debt Instrument, Repurchase Amount Including Accrued and Unpaid Interest Debt Instrument, Repurchase Amount Including Accrued and Unpaid Interest Non-PEO NEO Non-PEO NEO [Member] Senior Notes Senior Notes [Member] Entity Address, Address Line One Entity Address, Address Line One Vested (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Income tax benefit (provision) on continuing operations Income tax benefit (provision) Income Tax Expense (Benefit) Foreign currency remeasurement impact Gain (Loss), Foreign Currency Transaction, before Tax Cost of goods sold Total cost of goods sold Cost of Product and Service Sold Award Timing Method Award Timing Method [Text Block] Principles of Consolidation Consolidation, Policy [Policy Text Block] Net increase in cash and cash equivalents Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Other research and development Other Research and Development Expense Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Marketable debt securities, available-for-sale, unrealized gains, noncurrent Debt Securities, Available For Sale Unrealized Gain, Noncurrent Debt Securities, Available For Sale Unrealized Gain, Noncurrent Research and development Total research and development Research and Development Expense (Excluding Acquired in Process Cost) Net loss Net loss Net loss Net Income (Loss) Attributable to Parent Long-term Debt, Type [Axis] Long-Term Debt, Type [Axis] Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Marketable debt securities, available-for-sale, unrealized gains, current Debt Securities Available For Sale, Unrealized Gain, Current Debt Securities Available For Sale, Unrealized Gain, Current Statement [Table] Statement [Table] Restatement Determination Date: Restatement Determination Date [Axis] Proceeds from exercise of stock options Proceeds from Stock Options Exercised Interest income Investment Income, Interest Exercisable (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Debt instrument, convertible, threshold consecutive trading days Debt Instrument, Convertible, Threshold Consecutive Trading Days Loss from continuing operations, net of tax Net loss from continuing operations Income (Loss) from Continuing Operations, Net of Tax, Attributable to Parent Sales discounts, rebates, and allowances Sales Discounts, Rebates, And Allowances, Current Sales Discounts, Rebates, And Allowances, Current Amortization of intangibles - royalties and milestones Royalties and Milestine Agreements [Member] Royalties and Milestine Agreements Gary Lyons [Member] Gary Lyons Long-term debt, term Long-Term Debt, Term Sandra Calvin [Member] Sandra Calvin Pension Benefits Adjustments, Footnote Pension Benefits Adjustments, Footnote [Text Block] Debt Conversion, Scenario Two Debt Conversion, Scenario Two [Member] Debt Conversion, Scenario Two