<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e4705-ccf0-748e-89f6-4f46cae3c0aa,g:73d9f812-441f-490d-84fd-62e1327f277e-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:tvtx="http://www.travere.com/20260630" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.travere.com/20260630">
  <xs:import namespace="http://fasb.org/srt/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2026" schemaLocation="https://xbrl.sec.gov/country/2026/country-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tvtx-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tvtx-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tvtx-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tvtx-20260630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.travere.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETS" roleURI="http://www.travere.com/role/CONSOLIDATEDBALANCESHEETS">
        <link:definition>9952151 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETSParenthetical" roleURI="http://www.travere.com/role/CONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>9952152 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" roleURI="http://www.travere.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS">
        <link:definition>9952153 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" roleURI="http://www.travere.com/role/CONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY">
        <link:definition>9952154 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCASHFLOWS" roleURI="http://www.travere.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS">
        <link:definition>9952155 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESS" roleURI="http://www.travere.com/role/DESCRIPTIONOFBUSINESS">
        <link:definition>9952156 - Disclosure - DESCRIPTION OF BUSINESS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIES">
        <link:definition>9952157 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUERECOGNITION" roleURI="http://www.travere.com/role/REVENUERECOGNITION">
        <link:definition>9952158 - Disclosure - REVENUE RECOGNITION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COLLABORATIONANDLICENSEAGREEMENTS" roleURI="http://www.travere.com/role/COLLABORATIONANDLICENSEAGREEMENTS">
        <link:definition>9952159 - Disclosure - COLLABORATION AND LICENSE AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIES" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIES">
        <link:definition>9952160 - Disclosure - MARKETABLE DEBT SECURITIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="VARIABLEINTERESTENTITIES" roleURI="http://www.travere.com/role/VARIABLEINTERESTENTITIES">
        <link:definition>9952161 - Disclosure - VARIABLE INTEREST ENTITIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASES" roleURI="http://www.travere.com/role/LEASES">
        <link:definition>9952162 - Disclosure - LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTS" roleURI="http://www.travere.com/role/FAIRVALUEMEASUREMENTS">
        <link:definition>9952163 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETS" roleURI="http://www.travere.com/role/INTANGIBLEASSETS">
        <link:definition>9952164 - Disclosure - INTANGIBLE ASSETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONVERTIBLEDEBT" roleURI="http://www.travere.com/role/CONVERTIBLEDEBT">
        <link:definition>9952165 - Disclosure - CONVERTIBLE DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCRUEDEXPENSES" roleURI="http://www.travere.com/role/ACCRUEDEXPENSES">
        <link:definition>9952166 - Disclosure - ACCRUED EXPENSES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMELOSSPERCOMMONSHARE" roleURI="http://www.travere.com/role/NETINCOMELOSSPERCOMMONSHARE">
        <link:definition>9952167 - Disclosure - NET INCOME (LOSS) PER COMMON SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIES" roleURI="http://www.travere.com/role/COMMITMENTSANDCONTINGENCIES">
        <link:definition>9952168 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATION" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATION">
        <link:definition>9952169 - Disclosure - SHARE-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORY" roleURI="http://www.travere.com/role/INVENTORY">
        <link:definition>9952170 - Disclosure - INVENTORY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCOUNTSRECEIVABLE" roleURI="http://www.travere.com/role/ACCOUNTSRECEIVABLE">
        <link:definition>9952171 - Disclosure - ACCOUNTS RECEIVABLE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EQUITYOFFERINGS" roleURI="http://www.travere.com/role/EQUITYOFFERINGS">
        <link:definition>9952172 - Disclosure - EQUITY OFFERINGS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DIVESTITURES" roleURI="http://www.travere.com/role/DIVESTITURES">
        <link:definition>9952173 - Disclosure - DIVESTITURES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTINFORMATION" roleURI="http://www.travere.com/role/SEGMENTINFORMATION">
        <link:definition>9952174 - Disclosure - SEGMENT INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENTS" roleURI="http://www.travere.com/role/SUBSEQUENTEVENTS">
        <link:definition>9952175 - Disclosure - SUBSEQUENT EVENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESPolicies">
        <link:definition>9955511 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESTables" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESTables">
        <link:definition>9955512 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUERECOGNITIONTables" roleURI="http://www.travere.com/role/REVENUERECOGNITIONTables">
        <link:definition>9955513 - Disclosure - REVENUE RECOGNITION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESTables" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESTables">
        <link:definition>9955514 - Disclosure - MARKETABLE DEBT SECURITIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESTables" roleURI="http://www.travere.com/role/LEASESTables">
        <link:definition>9955515 - Disclosure - LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSTables" roleURI="http://www.travere.com/role/FAIRVALUEMEASUREMENTSTables">
        <link:definition>9955516 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSTables" roleURI="http://www.travere.com/role/INTANGIBLEASSETSTables">
        <link:definition>9955517 - Disclosure - INTANGIBLE ASSETS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONVERTIBLEDEBTTables" roleURI="http://www.travere.com/role/CONVERTIBLEDEBTTables">
        <link:definition>9955518 - Disclosure - CONVERTIBLE DEBT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCRUEDEXPENSESTables" roleURI="http://www.travere.com/role/ACCRUEDEXPENSESTables">
        <link:definition>9955519 - Disclosure - ACCRUED EXPENSES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMELOSSPERCOMMONSHARETables" roleURI="http://www.travere.com/role/NETINCOMELOSSPERCOMMONSHARETables">
        <link:definition>9955520 - Disclosure - NET INCOME (LOSS) PER COMMON SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONTables" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONTables">
        <link:definition>9955521 - Disclosure - SHARE-BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORYTables" roleURI="http://www.travere.com/role/INVENTORYTables">
        <link:definition>9955522 - Disclosure - INVENTORY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTINFORMATIONTables" roleURI="http://www.travere.com/role/SEGMENTINFORMATIONTables">
        <link:definition>9955523 - Disclosure - SEGMENT INFORMATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSDetails" roleURI="http://www.travere.com/role/DESCRIPTIONOFBUSINESSDetails">
        <link:definition>9955524 - Disclosure - DESCRIPTION OF BUSINESS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESNarrativeDetails" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESNarrativeDetails">
        <link:definition>9955525 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESScheduleofCostofGoodsSoldDetails" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESScheduleofCostofGoodsSoldDetails">
        <link:definition>9955526 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES - Schedule of Cost of Goods Sold (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESScheduleofRoyaltyExpenseDetails" roleURI="http://www.travere.com/role/BASISOFPRESENTATIONANDSIGNIFICANTACCOUNTINGPOLICIESScheduleofRoyaltyExpenseDetails">
        <link:definition>9955527 - Disclosure - BASIS OF PRESENTATION AND SIGNIFICANT ACCOUNTING POLICIES - Schedule of Royalty Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUERECOGNITIONNarrativeDetails" roleURI="http://www.travere.com/role/REVENUERECOGNITIONNarrativeDetails">
        <link:definition>9955528 - Disclosure - REVENUE RECOGNITION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="REVENUERECOGNITIONScheduleofNetProductRevenueDetails" roleURI="http://www.travere.com/role/REVENUERECOGNITIONScheduleofNetProductRevenueDetails">
        <link:definition>9955529 - Disclosure - REVENUE RECOGNITION - Schedule of Net Product Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COLLABORATIONANDLICENSEAGREEMENTSDetails" roleURI="http://www.travere.com/role/COLLABORATIONANDLICENSEAGREEMENTSDetails">
        <link:definition>9955530 - Disclosure - COLLABORATION AND LICENSE AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESScheduleofMarketableDebtSecuritiesDetails" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESScheduleofMarketableDebtSecuritiesDetails">
        <link:definition>9955531 - Disclosure - MARKETABLE DEBT SECURITIES - Schedule of Marketable Debt Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESScheduleofShorttermMarketableDebtSecuritiesDetails" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESScheduleofShorttermMarketableDebtSecuritiesDetails">
        <link:definition>9955532 - Disclosure - MARKETABLE DEBT SECURITIES - Schedule of Short-term&#160;Marketable Debt Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESScheduleofShorttermMarketableDebtSecuritiesDetails_1" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESScheduleofShorttermMarketableDebtSecuritiesDetails_1">
        <link:definition>9955532 - Disclosure - MARKETABLE DEBT SECURITIES - Schedule of Short-term&#160;Marketable Debt Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESNarrativeDetails" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESNarrativeDetails">
        <link:definition>9955533 - Disclosure - MARKETABLE DEBT SECURITIES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MARKETABLEDEBTSECURITIESScheduleofAvailableforSaleMarketableDebtSecuritiesinanUnrealizedLossPositionDetails" roleURI="http://www.travere.com/role/MARKETABLEDEBTSECURITIESScheduleofAvailableforSaleMarketableDebtSecuritiesinanUnrealizedLossPositionDetails">
        <link:definition>9955534 - Disclosure - MARKETABLE DEBT SECURITIES - Schedule of Available-for-Sale Marketable Debt Securities in an Unrealized Loss Position (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="VARIABLEINTERESTENTITIESDetails" roleURI="http://www.travere.com/role/VARIABLEINTERESTENTITIESDetails">
        <link:definition>9955535 - Disclosure - VARIABLE INTEREST ENTITIES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESNarrativeDetails" roleURI="http://www.travere.com/role/LEASESNarrativeDetails">
        <link:definition>9955536 - Disclosure - LEASES - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESScheduleofFutureMinimumRentalCommitmentsDetails" roleURI="http://www.travere.com/role/LEASESScheduleofFutureMinimumRentalCommitmentsDetails">
        <link:definition>9955537 - Disclosure - LEASES - Schedule of Future Minimum Rental Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESScheduleofFutureMinimumRentalCommitmentsDetails_1" roleURI="http://www.travere.com/role/LEASESScheduleofFutureMinimumRentalCommitmentsDetails_1">
        <link:definition>9955537 - Disclosure - LEASES - Schedule of Future Minimum Rental Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LEASESScheduleofWeightedaverageRemainingLeaseTermandDiscountRateDetails" roleURI="http://www.travere.com/role/LEASESScheduleofWeightedaverageRemainingLeaseTermandDiscountRateDetails">
        <link:definition>9955538 - Disclosure - LEASES - Schedule of Weighted-average Remaining Lease Term and Discount Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSNarrativeDetails" roleURI="http://www.travere.com/role/FAIRVALUEMEASUREMENTSNarrativeDetails">
        <link:definition>9955539 - Disclosure - FAIR VALUE MEASUREMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofFairValueonaRecurringBasisDetails" roleURI="http://www.travere.com/role/FAIRVALUEMEASUREMENTSScheduleofFairValueonaRecurringBasisDetails">
        <link:definition>9955540 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Fair Value on a Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSNarrativeDetails" roleURI="http://www.travere.com/role/INTANGIBLEASSETSNarrativeDetails">
        <link:definition>9955541 - Disclosure - INTANGIBLE ASSETS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSScheduleofFinitelivedAmortizableIntangibleAssetsDetails" roleURI="http://www.travere.com/role/INTANGIBLEASSETSScheduleofFinitelivedAmortizableIntangibleAssetsDetails">
        <link:definition>9955542 - Disclosure - INTANGIBLE ASSETS - Schedule of Finite-lived Amortizable Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONVERTIBLEDEBTScheduleofLongtermDebtInstrumentsDetails" roleURI="http://www.travere.com/role/CONVERTIBLEDEBTScheduleofLongtermDebtInstrumentsDetails">
        <link:definition>9955543 - Disclosure - CONVERTIBLE DEBT - Schedule of Long-term Debt Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONVERTIBLEDEBTNarrativeDetails" roleURI="http://www.travere.com/role/CONVERTIBLEDEBTNarrativeDetails">
        <link:definition>9955544 - Disclosure - CONVERTIBLE DEBT - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONVERTIBLEDEBTScheduleofInterestExpenseDetails" roleURI="http://www.travere.com/role/CONVERTIBLEDEBTScheduleofInterestExpenseDetails">
        <link:definition>9955545 - Disclosure - CONVERTIBLE DEBT - Schedule of Interest Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCRUEDEXPENSESDetails" roleURI="http://www.travere.com/role/ACCRUEDEXPENSESDetails">
        <link:definition>9955546 - Disclosure - ACCRUED EXPENSES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMELOSSPERCOMMONSHAREScheduleofBasicandDilutedNetLossPerShareDetails" roleURI="http://www.travere.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofBasicandDilutedNetLossPerShareDetails">
        <link:definition>9955547 - Disclosure - NET INCOME (LOSS) PER COMMON SHARE - Schedule of Basic and Diluted Net Loss Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETINCOMELOSSPERCOMMONSHAREScheduleofAntidilutiveSecuritiesDetails" roleURI="http://www.travere.com/role/NETINCOMELOSSPERCOMMONSHAREScheduleofAntidilutiveSecuritiesDetails">
        <link:definition>9955548 - Disclosure - NET INCOME (LOSS) PER COMMON SHARE - Schedule of Anti-dilutive Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESDetails" roleURI="http://www.travere.com/role/COMMITMENTSANDCONTINGENCIESDetails">
        <link:definition>9955549 - Disclosure - COMMITMENTS AND CONTINGENCIES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofStockOptionActivityDetails" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONScheduleofStockOptionActivityDetails">
        <link:definition>9955550 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Stock Option Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofServiceBasedRestrictedStockActivityDetails" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONScheduleofServiceBasedRestrictedStockActivityDetails">
        <link:definition>9955551 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Service Based Restricted Stock Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofPerformanceBasedRestrictedStockActivityDetails" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONScheduleofPerformanceBasedRestrictedStockActivityDetails">
        <link:definition>9955552 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Performance Based Restricted Stock Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesDetails" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesDetails">
        <link:definition>9955553 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Share Based Compensation Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesDetails_1" roleURI="http://www.travere.com/role/SHAREBASEDCOMPENSATIONScheduleofShareBasedCompensationExpensesDetails_1">
        <link:definition>9955553 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Share Based Compensation Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORYDetails" roleURI="http://www.travere.com/role/INVENTORYDetails">
        <link:definition>9955554 - Disclosure - INVENTORY (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INVENTORYDetails_1" roleURI="http://www.travere.com/role/INVENTORYDetails_1">
        <link:definition>9955554 - Disclosure - INVENTORY (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ACCOUNTSRECEIVABLEDetails" roleURI="http://www.travere.com/role/ACCOUNTSRECEIVABLEDetails">
        <link:definition>9955555 - Disclosure - ACCOUNTS RECEIVABLE (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EQUITYOFFERINGSDetails" roleURI="http://www.travere.com/role/EQUITYOFFERINGSDetails">
        <link:definition>9955556 - Disclosure - EQUITY OFFERINGS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DIVESTITURESDetails" roleURI="http://www.travere.com/role/DIVESTITURESDetails">
        <link:definition>9955557 - Disclosure - DIVESTITURES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTINFORMATIONNarrativeDetails" roleURI="http://www.travere.com/role/SEGMENTINFORMATIONNarrativeDetails">
        <link:definition>9955558 - Disclosure - SEGMENT INFORMATION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTINFORMATIONScheduleofReportableSegmentLossIncludingSignificantExpensesDetails" roleURI="http://www.travere.com/role/SEGMENTINFORMATIONScheduleofReportableSegmentLossIncludingSignificantExpensesDetails">
        <link:definition>9955559 - Disclosure - SEGMENT INFORMATION - Schedule of Reportable Segment Loss, Including Significant Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENTSDetails" roleURI="http://www.travere.com/role/SUBSEQUENTEVENTSDetails">
        <link:definition>9955560 - Disclosure - SUBSEQUENT EVENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="tvtx_EarningsPerShareBasicAndDilutedAbstract" abstract="true" name="EarningsPerShareBasicAndDilutedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tvtx_PaymentOfGuaranteedMinimumRoyalty" abstract="false" name="PaymentOfGuaranteedMinimumRoyalty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_ClinicalTrialExpensePolicyTextBlock" abstract="false" name="ClinicalTrialExpensePolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tvtx_ScheduleOfCostOfGoodsSoldTableTextBlock" abstract="false" name="ScheduleOfCostOfGoodsSoldTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tvtx_ScheduleOfRoyaltyExpenseTableTextBlock" abstract="false" name="ScheduleOfRoyaltyExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="tvtx_ChugaiMember" abstract="true" name="ChugaiMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_VariableInterestEntityGainFromSale" abstract="false" name="VariableInterestEntityGainFromSale" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_NumberOfPhaseThreeClinicalTrialsInProcess" abstract="false" name="NumberOfPhaseThreeClinicalTrialsInProcess" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tvtx_RoyaltiesAndMilestineAgreementsMember" abstract="true" name="RoyaltiesAndMilestineAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_RoyaltyExpenseAndAmortizationOfFiniteLivedIntangibleAssets" abstract="false" name="RoyaltyExpenseAndAmortizationOfFiniteLivedIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_RoyaltyCostsAndMilestonesCapitalized" abstract="false" name="RoyaltyCostsAndMilestonesCapitalized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_NumberOfDirectToPatientPharmaciesSoldTo" abstract="false" name="NumberOfDirectToPatientPharmaciesSoldTo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tvtx_FILSPARIMember" abstract="true" name="FILSPARIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_TioproninProductsMember" abstract="true" name="TioproninProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_ViforLtdMember" abstract="true" name="ViforLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_RegulatoryAndMarketAccessMilestoneMember" abstract="true" name="RegulatoryAndMarketAccessMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SalesBasedMilestonePaymentsMember" abstract="true" name="SalesBasedMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_RegulatoryDevelopmentAndSalesBasedMilestoneMember" abstract="true" name="RegulatoryDevelopmentAndSalesBasedMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_RegulatoryAndMinistryOfHealthLabourAndWelfareMilestoneMember" abstract="true" name="RegulatoryAndMinistryOfHealthLabourAndWelfareMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_CollaborativeArrangementUpfrontPayment" abstract="false" name="CollaborativeArrangementUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_CollaborativeArrangementContingentMilestonePaymentsFromCollaborator" abstract="false" name="CollaborativeArrangementContingentMilestonePaymentsFromCollaborator" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_CollaborativeArrangementRoyaltyPercentageOnNetSales" abstract="false" name="CollaborativeArrangementRoyaltyPercentageOnNetSales" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tvtx_LicenseAgreementForceMajeureEventPeriodThreshold" abstract="false" name="LicenseAgreementForceMajeureEventPeriodThreshold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tvtx_CollaborativeArrangementNumberOfPerformanceObligations" abstract="false" name="CollaborativeArrangementNumberOfPerformanceObligations" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tvtx_CollaborativeArrangementMilestonePaymentFromCollaboratorRecognized" abstract="false" name="CollaborativeArrangementMilestonePaymentFromCollaboratorRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleAmortizedCostBasisCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAmortizedCostBasisCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleUnrealizedGainCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedGainCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleUnrealizedLossCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedLossCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleAmortizedCostBasisNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAmortizedCostBasisNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleUnrealizedGainNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedGainNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleUnrealizedLossNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedLossNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAmortizedCost" abstract="false" name="DebtSecuritiesAvailableForSaleUnrealizedLossPositionAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_OfficeLease2020Member" abstract="true" name="OfficeLease2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_LesseeOperatingLeaseLiabilityToBePaidYearThreeAndAfterYearThree" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidYearThreeAndAfterYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_OperatingLeaseIncentiveTenantImprovements" abstract="false" name="OperatingLeaseIncentiveTenantImprovements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_StraightLineLeaseExpenseInExcessOfCashPayments" abstract="false" name="StraightLineLeaseExpenseInExcessOfCashPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2029Member" abstract="true" name="SeniorNotesDue2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2032Member" abstract="true" name="SeniorNotesDue2032Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_LigandLicenseAgreementMember" abstract="true" name="LigandLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_MissionLicenseAgreementMember" abstract="true" name="MissionLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_PaymentsPayableUponAchievementOfMilestones" abstract="false" name="PaymentsPayableUponAchievementOfMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_AnnualRoyaltyPercentage" abstract="false" name="AnnualRoyaltyPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2032IssuedPursuantToUnderwritersOptionMember" abstract="true" name="SeniorNotesDue2032IssuedPursuantToUnderwritersOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2029IssuedPursuantToUnderwritersOptionMember" abstract="true" name="SeniorNotesDue2029IssuedPursuantToUnderwritersOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2025Member" abstract="true" name="SeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_DebtConversionScenarioOneMember" abstract="true" name="DebtConversionScenarioOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_DebtConversionScenarioTwoMember" abstract="true" name="DebtConversionScenarioTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_DebtInstrumentConvertibleRedemptionOptionScheduledTradingDaysPriorToMaturityDate" abstract="false" name="DebtInstrumentConvertibleRedemptionOptionScheduledTradingDaysPriorToMaturityDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tvtx_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtInstrumentUnamortizedDebtIssuanceCosts" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalConvertibleDebtInstrumentUnamortizedDebtIssuanceCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DebtInstrumentRepurchaseAmountIncludingAccruedAndUnpaidInterest" abstract="false" name="DebtInstrumentRepurchaseAmountIncludingAccruedAndUnpaidInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_LongTermDebtExcludingCurrentMaturitiesRepaymentAmountUponConversion" abstract="false" name="LongTermDebtExcludingCurrentMaturitiesRepaymentAmountUponConversion" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_SeniorNotesDue2025SeniorNotesDue2029AndSeniorNotesDue2032Member" abstract="true" name="SeniorNotesDue2025SeniorNotesDue2029AndSeniorNotesDue2032Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SalesDiscountsRebatesAndAllowancesCurrent" abstract="false" name="SalesDiscountsRebatesAndAllowancesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_AccruedLiabilitiesResearchandDevelopmentCurrent" abstract="false" name="AccruedLiabilitiesResearchandDevelopmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_AccruedLiabilitiesSellingGeneralandAdministrativeCurrent" abstract="false" name="AccruedLiabilitiesSellingGeneralandAdministrativeCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_AccruedLiabilitiesMiscellaneousCurrent" abstract="false" name="AccruedLiabilitiesMiscellaneousCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_WeightedAverageNumberOfSharesOutstandingBasicContinuingOperations" abstract="false" name="WeightedAverageNumberOfSharesOutstandingBasicContinuingOperations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tvtx_WeightedAverageNumberOfSharesOutstandingDilutedContinuingOperations" abstract="false" name="WeightedAverageNumberOfSharesOutstandingDilutedContinuingOperations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tvtx_WeightedAverageNumberOfSharesOutstandingBasicDiscontinuedOperations" abstract="false" name="WeightedAverageNumberOfSharesOutstandingBasicDiscontinuedOperations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tvtx_WeightedAverageNumberOfSharesOutstandingDilutedDiscontinuedOperations" abstract="false" name="WeightedAverageNumberOfSharesOutstandingDilutedDiscontinuedOperations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tvtx_OrphanTechnologiesLimitedMember" abstract="true" name="OrphanTechnologiesLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_BusinessCombinationCumulativeMilestonePaymentsPaidUnderStockPurchaseAgreement" abstract="false" name="BusinessCombinationCumulativeMilestonePaymentsPaidUnderStockPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueRollForward" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tvtx_BileAcidProductPortfolioMember" abstract="true" name="BileAcidProductPortfolioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_DisposalGroupIncludingDiscontinuedOperationProceedsFromMilestonePayment" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationProceedsFromMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_AtTheMarketOfferingMember" abstract="true" name="AtTheMarketOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SaleOfStockAggregateOfferingAmountAuthorized" abstract="false" name="SaleOfStockAggregateOfferingAmountAuthorized" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DisposalGroupIncludingDiscontinuedOperationContingentConsiderationReceivable" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationContingentConsiderationReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_DisposalGroupIncludingDiscontinuedOperationMilestoneThresholds" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationMilestoneThresholds" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_ExternalResearchAndDevelopment" abstract="false" name="ExternalResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_InternalPersonnelCostsForResearchAndDevelopment" abstract="false" name="InternalPersonnelCostsForResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tvtx_PTE.Ltd.Member" abstract="true" name="PTE.Ltd.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_EricDubePh.D.Member" abstract="true" name="EricDubePh.D.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_ChristopherClineMember" abstract="true" name="ChristopherClineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_PeterHeermaMember" abstract="true" name="PeterHeermaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_JulaInrigM.D.Member" abstract="true" name="JulaInrigM.D.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_WilliamE.RotePh.D.Member" abstract="true" name="WilliamE.RotePh.D.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_ElizabethE.ReedMember" abstract="true" name="ElizabethE.ReedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_SandraCalvinMember" abstract="true" name="SandraCalvinMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_GaryLyonsMember" abstract="true" name="GaryLyonsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tvtx_JeffreyMecklerMember" abstract="true" name="JeffreyMecklerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
