v3.26.1
Insider Trading Arrangements
 3 Months Ended
Jun. 30, 2026
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
During the fiscal quarter ended June 30, 2026, certain of our directors and officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as those terms are defined in Regulation S-K, Item 408, as set forth below. Each 10b5-1 plan listed below is part of such individual’s long-term asset diversification, tax and/or financial planning strategy, and has been entered into in accordance with the terms of our Insider Trading Policy. Under the terms of the plans, once the plans are in effect, the individuals listed below have no discretion or control over the timing or effectuation of any transactions in our securities pursuant to the plans, and sales will be made only if the stock meets the minimum price thresholds and/or other requirements specified in the applicable plan. Some of the planned sales relate to shares required to be sold by such individual to cover the tax withholding obligation in connection with the settlement of vested restricted stock units and/or performance restricted stock units. Each such director and/or officer continues to be subject to our stock ownership guidelines, and the execution of all potential sales under the plan would not by themselves cause any such individual to be out of compliance with the requirements of our stock ownership guidelines.
Trading Arrangements Adopted:
Name & TitleDate AdoptedCharacter of Trading Arrangement (1)Aggregate Number of Shares of Common Stock to be Sold Pursuant to Trading ArrangementExpiration Date (2)
Eric Dube, Ph.D.
   President and Chief Executive Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 1,071,749 shares
June 16, 2027
Christopher Cline
   Chief Financial Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 65,135 shares (3)
June 16, 2027
Peter Heerma
EVP, Chief Commercial Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 367,070 shares
June 16, 2027
Jula Inrig, M.D.
EVP, Head of R&D and Chief Medical Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 72,644 shares
June 16, 2027
William E. Rote, Ph.D.
   Chief Research Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 238,410 shares (4)
March 15, 2027
Elizabeth E. Reed
Chief Legal Officer, General Counsel and Corporate Secretary
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 200,121 shares (4)
June 16, 2027
Sandra Calvin
SVP and Chief Accounting Officer
June 16, 2026Rule 10b5-1 Trading Arrangement
Up to 22,740 shares
June 16, 2027
Gary Lyons
chair of our Board of Directors
May 18, 2026Rule 10b5-1 Trading Arrangement
Up to 10,000 shares (5)
May 17, 2027
Jeffrey Meckler
member of our Board of Directors
June 11, 2026Rule 10b5-1 Trading Arrangement
Up to 20,000 shares (6)
May 22, 2027
1Each trading arrangement marked as a “Rule 10b5-1 Trading Arrangement” is intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act (the “Rule”).
2Each trading arrangement permits transactions through and including the earlier to occur of (a) the completion of all sales and (b) the date listed in the table. Each trading arrangement marked as a “Rule 10b5-1 Trading Arrangement” only permits transactions upon expiration of the applicable mandatory cooling-off period under the Rule.
3Includes shares underlying stock options expiring in May 2027.
4Includes shares underlying stock options expiring in May 2028.
5Consists of shares underlying stock options expiring in May 2027.
6Consists of shares underlying stock options expiring in May 2027 and May 2028.
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Eric Dube, Ph.D. [Member]  
Trading Arrangements, by Individual  
Name Eric Dube, Ph.D.
Title President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 1,071,749
Christopher Cline [Member]  
Trading Arrangements, by Individual  
Name Christopher Cline
Title Chief Financial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 65,135
Peter Heerma [Member]  
Trading Arrangements, by Individual  
Name Peter Heerma
Title EVP, Chief Commercial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 367,070
Jula Inrig, M.D. [Member]  
Trading Arrangements, by Individual  
Name Jula Inrig, M.D.
Title EVP, Head of R&D and Chief Medical Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 72,644
William E. Rote, Ph.D. [Member]  
Trading Arrangements, by Individual  
Name William E. Rote, Ph.D.
Title Chief Research Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date March 15, 2027
Arrangement Duration 272 days
Aggregate Available 238,410
Elizabeth E. Reed [Member]  
Trading Arrangements, by Individual  
Name Elizabeth E. Reed
Title Chief Legal Officer, General Counsel and Corporate Secretary
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 200,121
Sandra Calvin [Member]  
Trading Arrangements, by Individual  
Name Sandra Calvin
Title SVP and Chief Accounting Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2026
Expiration Date June 16, 2027
Arrangement Duration 365 days
Aggregate Available 22,740
Gary Lyons [Member]  
Trading Arrangements, by Individual  
Name Gary Lyons
Title chair of our Board of Directors
Rule 10b5-1 Arrangement Adopted true
Adoption Date May 18, 2026
Expiration Date May 17, 2027
Arrangement Duration 364 days
Aggregate Available 10,000
Jeffrey Meckler [Member]  
Trading Arrangements, by Individual  
Name Jeffrey Meckler
Title member of our Board of Directors
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 11, 2026
Expiration Date May 22, 2027
Arrangement Duration 345 days
Aggregate Available 20,000