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  <xs:element id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFees" abstract="false" name="OffBalanceSheetContractualObligationsSubjectToCancellationFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueWithinOneYear" abstract="false" name="OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueWithinOneYear" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueInSecondAndThirdYear" abstract="false" name="OffBalanceSheetContractualObligationsSubjectToCancellationFeesDueInSecondAndThirdYear" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_CancellationFeesUnderAgreementsWithContractManufacturers" abstract="false" name="CancellationFeesUnderAgreementsWithContractManufacturers" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_OneOperatingSegmentMember" abstract="true" name="OneOperatingSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="rigl_CommercialRelatedExpenses" abstract="false" name="CommercialRelatedExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_OutsideClinicalTrialRelatedExpenses" abstract="false" name="OutsideClinicalTrialRelatedExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="rigl_ConsultantsAndThirdPartyServicesExpense" abstract="false" name="ConsultantsAndThirdPartyServicesExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
