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  <xs:element id="soph_TransactionsWithOwnersAbstract" abstract="true" name="TransactionsWithOwnersAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_IncreaseDecreaseThroughExerciseOfOptionsAndVestingOfOtherEquityInstrumentsEquity" abstract="false" name="IncreaseDecreaseThroughExerciseOfOptionsAndVestingOfOtherEquityInstrumentsEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_IncreaseDecreaseThroughVestingOfOtherEquityInstrumentsEquity" abstract="false" name="IncreaseDecreaseThroughVestingOfOtherEquityInstrumentsEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_AdjustmentsForFinanceExpenseIncomeNet" abstract="false" name="AdjustmentsForFinanceExpenseIncomeNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_AdjustmentsForCreditLossAllowance" abstract="false" name="AdjustmentsForCreditLossAllowance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_AdjustmentsForResearchTaxCredit" abstract="false" name="AdjustmentsForResearchTaxCredit" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_WorkingCapitalChangesAbstract" abstract="true" name="WorkingCapitalChangesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_CapitalizedSoftwareDevelopmentCosts" abstract="false" name="CapitalizedSoftwareDevelopmentCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_DisclosureOfCompanyInformationAbstract" abstract="true" name="DisclosureOfCompanyInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_DisclosureOfCompanyInformationAndOperationsTextBlock" abstract="false" name="DisclosureOfCompanyInformationAndOperationsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DisclosureOfEventsAfterReportingPeriodAbstract" abstract="true" name="DisclosureOfEventsAfterReportingPeriodAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_DescriptionOfAccountingPolicyForBasisOfPreparationTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForBasisOfPreparationTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DescriptionOfAccountingPolicyForAccountingPoliciesTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForAccountingPoliciesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DescriptionOfAccountingPolicyForNewStandardsTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForNewStandardsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DescriptionOfAccountingPolicyForUseOfEstimatesTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForUseOfEstimatesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DescriptionOfAccountingPolicyForGoingConcernBasisTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForGoingConcernBasisTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DisclosureOfDetailedInformationAboutSubsidiariesTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutSubsidiariesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DisclosureOfDetailedInformationAboutAccountsReceivableAndLeaseReceivableTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutAccountsReceivableAndLeaseReceivableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DisclosureOfDetailedInformationAboutAllowanceForCreditLossesInAccountsReceivableTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutAllowanceForCreditLossesInAccountsReceivableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_DisclosureOfDetailedInformationAboutWarrantLiabilityTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutWarrantLiabilityTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="soph_SophiaGeneticsSASMember" abstract="true" name="SophiaGeneticsSASMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SophiaGeneticLimitedMember" abstract="true" name="SophiaGeneticLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SophiaGeneticsIncMember" abstract="true" name="SophiaGeneticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SophiaGeneticsIntermediacaoDeNegociosLTDAMember" abstract="true" name="SophiaGeneticsIntermediacaoDeNegociosLTDAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SophiaGeneticsPtyLtdMember" abstract="true" name="SophiaGeneticsPtyLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SophiaGeneticsSRLMember" abstract="true" name="SophiaGeneticsSRLMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SOPHiAGENETICSGmbHMember" abstract="true" name="SOPHiAGENETICSGmbHMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_DisclosureOfCompanyInformationAndOperationsTable" abstract="true" name="DisclosureOfCompanyInformationAndOperationsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_DisclosureOfCompanyInformationAndOperationsLineItems" abstract="true" name="DisclosureOfCompanyInformationAndOperationsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_NumberOfTreasurySharesIssued" abstract="false" name="NumberOfTreasurySharesIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_NumberOfEquitySharesIssued" abstract="false" name="NumberOfEquitySharesIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_SaleOfSharesPricePerShare" abstract="false" name="SaleOfSharesPricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="soph_NumberOfOrdinarySharesIssuedUponExercise" abstract="false" name="NumberOfOrdinarySharesIssuedUponExercise" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_DisclosureOfFairValueMeasurementOfAssetsAndLiabilitiesTable" abstract="true" name="DisclosureOfFairValueMeasurementOfAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_CashAndCashEquivalentsMember" abstract="true" name="CashAndCashEquivalentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantLiabilityMember" abstract="true" name="WarrantLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_DisclosureOfFairValueMeasurementOfAssetsAndLiabilitiesLineItems" abstract="true" name="DisclosureOfFairValueMeasurementOfAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_DisclosureOfOperatingSegmentsNumberOfSegments" abstract="false" name="DisclosureOfOperatingSegmentsNumberOfSegments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="soph_EuropeMiddleEastAndAfricaMember" abstract="true" name="EuropeMiddleEastAndAfricaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_OtherCountriesInEuropeMiddleEastAndAfricaMember" abstract="true" name="OtherCountriesInEuropeMiddleEastAndAfricaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_OtherCountriesInNorthAmericaMember" abstract="true" name="OtherCountriesInNorthAmericaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SOPHiADDMPlatformMember" abstract="true" name="SOPHiADDMPlatformMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WorkflowEquipmentAndServicesMember" abstract="true" name="WorkflowEquipmentAndServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_FinancialAssetsAccountsReceivableMember" abstract="true" name="FinancialAssetsAccountsReceivableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WriteOffAndAdditionalAdjustmentsFinancialAssets" abstract="false" name="WriteOffAndAdditionalAdjustmentsFinancialAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_PercentageOfCustomerBalanceAccountReceivable" abstract="false" name="PercentageOfCustomerBalanceAccountReceivable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="soph_AccountsReceivableInAggregateAmount" abstract="false" name="AccountsReceivableInAggregateAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_DisclosureOfLeaseTable" abstract="true" name="DisclosureOfLeaseTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_OfficeSpaceMember" abstract="true" name="OfficeSpaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_BostonMassachusettsMember" abstract="true" name="BostonMassachusettsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_DisclosureOfLeaseLineItems" abstract="true" name="DisclosureOfLeaseLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_LeaseNotYetCommencedTerm" abstract="false" name="LeaseNotYetCommencedTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="soph_AreaOfOfficeSpaceLeaseNotYetCommenced" abstract="false" name="AreaOfOfficeSpaceLeaseNotYetCommenced" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:areaItemType"/>
  <xs:element id="soph_LeaseDirectCosts" abstract="false" name="LeaseDirectCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_PerceptiveCreditAgreementMember" abstract="true" name="PerceptiveCreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditAgreementTrancheAMember" abstract="true" name="PerceptiveCreditAgreementTrancheAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditAgreementTrancheBMember" abstract="true" name="PerceptiveCreditAgreementTrancheBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditAgreementTrancheCMember" abstract="true" name="PerceptiveCreditAgreementTrancheCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditAgreementTrancheDMember" abstract="true" name="PerceptiveCreditAgreementTrancheDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_BorrowingTermsAxis" abstract="true" name="BorrowingTermsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_BorrowingTermsDomain" abstract="true" name="BorrowingTermsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_TermSecuredOvernightFinancingRateSOFRFloorMember" abstract="true" name="TermSecuredOvernightFinancingRateSOFRFloorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_TermSecuredOvernightFinancingRateSOFRMember" abstract="true" name="TermSecuredOvernightFinancingRateSOFRMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditHoldingsIVLPMember" abstract="true" name="PerceptiveCreditHoldingsIVLPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantTermsAxis" abstract="true" name="WarrantTermsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_WarrantTermsDomain" abstract="true" name="WarrantTermsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantRightsTrancheAMember" abstract="true" name="WarrantRightsTrancheAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantRightsTrancheBMember" abstract="true" name="WarrantRightsTrancheBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantRightsTrancheCMember" abstract="true" name="WarrantRightsTrancheCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_WarrantRightsTrancheDMember" abstract="true" name="WarrantRightsTrancheDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_BorrowingFacilitiesMaximumBorrowingCapacity" abstract="false" name="BorrowingFacilitiesMaximumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_WarrantsOrRightsNumberOfSharesCalledByWarrantsOrRights" abstract="false" name="WarrantsOrRightsNumberOfSharesCalledByWarrantsOrRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_ExercisePriceOfWarrantRights" abstract="false" name="ExercisePriceOfWarrantRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="soph_ProceedsFromBorrowings" abstract="false" name="ProceedsFromBorrowings" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_BorrowingFacilitiesIncreaseDecreaseInMaximumBorrowingCapacity" abstract="false" name="BorrowingFacilitiesIncreaseDecreaseInMaximumBorrowingCapacity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_BorrowingFacilitiesThresholdTrailingTwelveMonthsRevenueThresholdAllowableProceedsFromBorrowingsTrigger" abstract="false" name="BorrowingFacilitiesThresholdTrailingTwelveMonthsRevenueThresholdAllowableProceedsFromBorrowingsTrigger" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_WarrantsOrRightsIncreaseDecreaseInNumberOfSharesCalledByWarrantsOrRights" abstract="false" name="WarrantsOrRightsIncreaseDecreaseInNumberOfSharesCalledByWarrantsOrRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_BorrowingMaturityTerm" abstract="false" name="BorrowingMaturityTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="soph_RedemptionPeriodOfWarrantRights" abstract="false" name="RedemptionPeriodOfWarrantRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="soph_ExercisePriceMeasurementInputMember" abstract="true" name="ExercisePriceMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SharePriceMeasurementInputMember" abstract="true" name="SharePriceMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_ExpectedTermMeasurementInputMember" abstract="true" name="ExpectedTermMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_DividendYieldMeasurementInputMember" abstract="true" name="DividendYieldMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_BlackScholesPricingModelValueMeasurementInputMember" abstract="true" name="BlackScholesPricingModelValueMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_ExpectedVolatilityMeasurementInputMember" abstract="true" name="ExpectedVolatilityMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_PerceptiveCreditHoldingsWarrantsMember" abstract="true" name="PerceptiveCreditHoldingsWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_ChangesInBorrowingsAbstract" abstract="true" name="ChangesInBorrowingsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_ProceedsFromBorrowingsNetOfCostsIncurred" abstract="false" name="ProceedsFromBorrowingsNetOfCostsIncurred" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_BorrowingsForeignCurrencyTranslationGainLoss" abstract="false" name="BorrowingsForeignCurrencyTranslationGainLoss" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_ChangesInWarrantLiabilityAbstract" abstract="true" name="ChangesInWarrantLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="soph_ProceedsFromWarrantLiability" abstract="false" name="ProceedsFromWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_WarrantLiabilityForeignExchangeGainLoss" abstract="false" name="WarrantLiabilityForeignExchangeGainLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_WarrantsOrRightsNumberOfWarrantsIssued" abstract="false" name="WarrantsOrRightsNumberOfWarrantsIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="soph_IncomeStatementLocationAxis" abstract="true" name="IncomeStatementLocationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="soph_IncomeStatementLocationDomain" abstract="true" name="IncomeStatementLocationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_ResearchAndDevelopmentExpenseMember" abstract="true" name="ResearchAndDevelopmentExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_SalesAndMarketingExpenseMember" abstract="true" name="SalesAndMarketingExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_GeneralAndAdministrativeExpenseMember" abstract="true" name="GeneralAndAdministrativeExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_NumberOfExecutiveOfficers" abstract="false" name="NumberOfExecutiveOfficers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="soph_NumberOfNonExecutiveOfficers" abstract="false" name="NumberOfNonExecutiveOfficers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="soph_A2025GuardantHealthSuitMember" abstract="true" name="A2025GuardantHealthSuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="soph_FutureLeasePaymentsUnderShortTermLeasesNotRecognized" abstract="false" name="FutureLeasePaymentsUnderShortTermLeasesNotRecognized" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_LitigationSettlementAmountAwardedFromOtherParty" abstract="false" name="LitigationSettlementAmountAwardedFromOtherParty" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_ProceedsFromLegalSettlements" abstract="false" name="ProceedsFromLegalSettlements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_LitigationSettlementInterimAmountAwardedFromOtherParty" abstract="false" name="LitigationSettlementInterimAmountAwardedFromOtherParty" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="soph_LitigationSettlementCourtFeesRefund" abstract="false" name="LitigationSettlementCourtFeesRefund" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
