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general and administrative expenses related to accelerated vesting options.

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Share ased compensation arrangement by share based payment exercise price per share.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Gross number of share options (or share units) granted during the period.

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Stock-Based Compensation - Additional Information (Details)						3 Months Ended			6 Months Ended
	Jun. 10, 2026 shares	Mar. 11, 2026 $ / shares shares	Feb. 19, 2026 $ / shares shares	Feb. 17, 2026 USD ($) $ / shares shares	Jun. 16, 2025	Jun. 30, 2026 USD ($) shares	Mar. 31, 2026 USD ($) shares	Jun. 30, 2025 shares	Jun. 30, 2026 USD ($) $ / shares shares	Jun. 30, 2025 USD ($)	Jan. 01, 2027 shares	Apr. 10, 2026 shares	Jun. 15, 2025 shares	Feb. 28, 2021 shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock options exercised \| $						$ 98,000	$ 1,033,000			$ 0
Weighted average fair value per share of options granted \| $ / shares									$ 21.04
Aggregate intrinsic value of stock options exercised \| $									$ 2,200,000
Grant date fair value of options vested \| $									1,100,000	$ 700,000
Unrecognized stock-based compensation expense \| $						62,200,000			$ 62,200,000
Weighted-average period									3 years 6 months 29 days
Options available for grant									3,107,976
Weighted-Average Exercise Price, Granted \| $ / shares									$ 27.06
Exercise of options into common stock, shares									134,185
Fair value of assumed options \| $				$ 500,000
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation expense remaining service period				3 years 6 months
Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Exercise price per share \| $ / shares				$ 1.16
Unrecognized compensation expense remaining service period				1 month 6 days
Common Stock Warrants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized stock-based compensation expense \| $						$ 0			$ 0
Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares issued								1,004
Exercise of options into common stock, shares						57,042	77,143
Exchange ratio				0.1993%
Common Stock \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Exercise price per share \| $ / shares				$ 5.22
Faeth Therapeutics LLC
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Exercise of options into common stock, shares				6,338,670
Employees vesting options				4,273,182
Research and development expenses related to accelerated vesting options \| $				$ 4,800,000					4,800,000
General and administrative expenses related to accelerated vesting options \| $				$ 6,200,000					$ 6,200,000
Faeth Therapeutics LLC \| Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common Stock, Converted in to Options to Purchase Common Stock				252,210
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average period									7 months 17 days
Employees vesting options									1,505
2021 Equity Incentive Plan \| Restricted Stock Units \| Vesting Period One
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									1 year
2021 Equity Incentive Plan \| Restricted Stock Units \| Vesting Period Two
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									2 years
2021 Equity Incentive Plan \| Restricted Stock Units \| Vesting Period Three
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									3 years
2021 Equity Incentive Plan \| Restricted Stock Units \| Vesting Period Four
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									4 years
2026 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance						2,376,981			2,376,981
Number of capital stock outstanding percentage									5.00%
2026 Equity Incentive Plan \| Forecast
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance											2,671,981
2021 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance													333,333	16,666
Shares issued under plan									12,220
Number of shares issued									0
Reverse stock split ratio					0.05
2026 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance	267,198
Percentage of number of shares of capital stock outstanding on last day of preceding year	1.00%
Purchase price of fair value common stock, percent	85.00%
Shares issued under plan	534,396								0
2026 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for issuance						250,350			250,350			450,000
Options available for grant									199,650
Inducement Grants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Options available for grant		166,435	2,319,891
Weighted-Average Exercise Price, Granted \| $ / shares		$ 29.37	$ 27.22
Vesting period									4 years
Inducement Grants \| Vesting Period One
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									1 year
Vesting (as a percent)									25.00%
Inducement Grants \| Vesting Period Two
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									3 years
Vesting (as a percent)									75.00%