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  <xs:element id="iipr_TermLoan4Member" abstract="true" name="TermLoan4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_TermLoan5Member" abstract="true" name="TermLoan5Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DebtInstrumentNumberOfExtensionOptions" abstract="false" name="DebtInstrumentNumberOfExtensionOptions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iipr_DebtInstrumentExtensionTerm" abstract="false" name="DebtInstrumentExtensionTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iipr_DebtInstrumentRestrictiveCovenantsMinimumNetWorth" abstract="false" name="DebtInstrumentRestrictiveCovenantsMinimumNetWorth" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_DebtInstrumentRestrictiveCovenantsMinimumLiquidAssets" abstract="false" name="DebtInstrumentRestrictiveCovenantsMinimumLiquidAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_LoanAndSecurityAgreementMember" abstract="true" name="LoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_IIPLifeScienceCreditFacilityMember" abstract="true" name="IIPLifeScienceCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_LineofCreditFacilityAccordionFeatureIncreaseLimit" abstract="false" name="LineofCreditFacilityAccordionFeatureIncreaseLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_DebtInstrumentCovenantDebtServiceCoverageRatioMinimum" abstract="false" name="DebtInstrumentCovenantDebtServiceCoverageRatioMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iipr_LongTermDebtMaturityAfterYearFour" abstract="false" name="LongTermDebtMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_MeasurementInputExpectedMarketYieldMember" abstract="true" name="MeasurementInputExpectedMarketYieldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_MeasurementInputWeightedAverageExpectedMarketYieldMember" abstract="true" name="MeasurementInputWeightedAverageExpectedMarketYieldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_SellerFinancedNoteMember" abstract="true" name="SellerFinancedNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_NotesDue2026Member" abstract="true" name="NotesDue2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_FinancialInstrumentsAtCarryingValueAbstract" abstract="true" name="FinancialInstrumentsAtCarryingValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iipr_FinancialInstrumentsAtFairValueAbstract" abstract="true" name="FinancialInstrumentsAtFairValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iipr_CashEquivalentsFairValueDisclosure" abstract="false" name="CashEquivalentsFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iipr_FinancingReceivableMeasurementInput" abstract="false" name="FinancingReceivableMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="iipr_PercentageOfMoneyMarketInvestmentsInUSGovernmentDebtSecurities" abstract="false" name="PercentageOfMoneyMarketInvestmentsInUSGovernmentDebtSecurities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iipr_FairValueInputsWeightedAverageDiscountRate" abstract="false" name="FairValueInputsWeightedAverageDiscountRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iipr_A2026PlanMember" abstract="true" name="A2026PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_CommitmentsRelatedToImprovementAllowancesMember" abstract="true" name="CommitmentsRelatedToImprovementAllowancesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_AmendedClassActionLawsuitMember" abstract="true" name="AmendedClassActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DerivativeActionLawsuitsMember" abstract="true" name="DerivativeActionLawsuitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_DerivativeActionLawsuitMember" abstract="true" name="DerivativeActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_CannabisPortfolioMember" abstract="true" name="CannabisPortfolioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iipr_LifeSciencePortfolioMember" abstract="true" name="LifeSciencePortfolioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
