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markets based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 100 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0004 0.0004 0.0025 0 0.0015 0 0 0 0.0007 0.0005 0 0 0.0025 0 0.0036 0.0009 0.0019 0.0004 0.0029 0.0004 0 0 0 0 0 -0.0004 0.0036 0.0009 0.0019 0.0004 0.0029 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 610 9 19 4 30 0 684 29 61 13 93 0 765 51 107 23 163 0 1004 115 243 51 368 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 7% of the average value of its portfolio.</span></p> 0.07 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities of its benchmark index, the Russell 3000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The Russell 3000 Index measures the performance of the largest 3,000 U.S. companies representing approximately 96% of the investable U.S. equity market. The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various U.S. equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the Russell 3000 Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization or index weighting of one or more constituents of its benchmark index, the Russell 3000 Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x8x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Equity Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 21.98%, for the quarter ended June 30, 2020. Worst quarter: -20.87%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2198 2020-06-30 Worst quarter -0.2087 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.1707 0.1311 0.1425 0.1610 0.1252 0.1364 0.1025 0.1032 0.1178 0.1704 0.1301 0.1414 0.1688 0.1294 0.1407 0.1677 0.1282 0.1396 0.1003 0.1148 0.1326 0.1712 0.1316 0.1357 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 0.1357 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Large Cap Growth Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of equity securities of large domestic growth companies based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0008 0.0001 0.0025 0.0001 0.0012 0.0005 0.0029 0.0005 0 0 0 -0.0005 0.0012 0.0005 0.0029 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 12 5 30 0 39 16 93 0 68 28 163 0 154 64 368 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 27% of the average value of its portfolio.</span></p> 0.27 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in securities of its benchmark index, the Russell 1000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Growth Index. The Russell 1000 Growth Index is a subset of the Russell 1000 Index, which represents the performance of the large-cap growth segment of the U.S. equity universe. It includes those Russell 1000 Index companies with higher relative price-to-book ratios and higher forecasted growth values.</span><span style="font-size:9.0pt; font-family:Arial; font-style:normal; color:#5C5C5C; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various U.S. equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the Russell 1000 Growth Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">or index weighting of one or more constituents of its benchmark index, the Russell 1000 Growth Index, which the Fund seeks to track.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x21x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-8.65pt; font-weight:normal; margin-left:44.65pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:5.325pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Growth Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Due to their relatively high valuations, growth stocks are typically more volatile than value stocks and may experience a larger decline on a forecast of lower earnings, or a negative event or market development, than would a value stock.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I and the Retirement Class over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. Performance information is not included for Class W as it is not currently operational. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Large Cap Growth Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 27.79%, for the quarter ended June 30, 2020. Worst quarter: -20.95%, for the quarter ended June 30, 2022.</span></p> Best quarter 0.2779 2020-06-30 Worst quarter -0.2095 2022-06-30 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1850 0.1526 0.1806 0.1710 0.1360 0.1688 0.1160 0.1171 0.1501 0.1843 0.1514 0.1794 0.1821 0.1498 0.1777 Russell 1000® Index (reflects no deductions for fees, expenses or taxes) 0.1737 0.1359 0.1459 Russell 1000® Growth Index 0.1856 0.1532 0.1813 Current performance of the Fund’s shares may be higher or lower than that shown above. After-tax returns are shown for only one class, and after-tax returns for other classes will vary. After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Large Cap Value Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of equity securities of large domestic value companies based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0010 0.0001 0.0026 0.0001 0.0014 0.0005 0.0030 0.0005 0 0 0 -0.0005 0.0014 0.0005 0.0030 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 14 5 31 0 45 16 97 0 79 28 169 0 179 64 381 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 31% of the average value of its portfolio.</span></p> 0.31 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in securities of its benchmark index, the Russell 1000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Value Index. The Russell 1000 Value Index is a subset of the Russell 1000 Index, which represents the </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">performance of the large-cap value segment of the U.S. equity universe. It includes those Russell 1000 Index companies with lower relative price-to-book ratios and lower expected growth values. The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various U.S. equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the Russell 1000 Value Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization or index weighting of one or more constituents of its benchmark index, the Russell 1000 Value Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x34x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:39.6pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Value Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Securities believed to be undervalued are subject to the risks that the issuer’s potential business prospects are not realized, its potential value is never recognized by the market or the securities were appropriately priced when acquired. As a result, value stocks can be overpriced when acquired and may not perform as anticipated.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I and the Retirement Class over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. Performance information is not included for Class W as it is not currently operational. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Large Cap Value Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 16.25%, for the quarter ended December 31, 2020. Worst quarter: -26.61%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.1625 2020-12-31 Worst quarter -0.2661 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1584 0.1127 0.1048 0.1383 0.0988 0.0921 0.1002 0.0855 0.0820 0.1575 0.1115 0.1036 0.1555 0.1100 0.1021 Russell 1000® Index (reflects no deductions for fees, expenses or taxes) 0.1737 0.1359 0.1459 Russell 1000® Value Index 0.1591 0.1133 0.1053 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen S&P 500 Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of equity securities of large domestic companies selected to track U.S. equity markets based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0015 0.0001 0.0026 0.0001 0.0019 0.0005 0.0030 0.0005 0 0 0 -0.0005 0.0019 0.0005 0.0030 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 19 5 31 0 61 16 97 0 107 28 169 0 243 64 381 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 8% of the average value of its portfolio.</span></p> 0.08 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in securities of its benchmark index, the S&amp;P 500^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The S&amp;P 500 Index includes 500 leading companies and captures approximately 80% coverage of </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">available market capitalization of the U.S. equity market. The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various U.S. equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the S&amp;P 500 Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization or index weighting of one or more constituents of its benchmark index, the S&amp;P 500 Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x47x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I and the Retirement Class over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. Performance information is not included for Class W as it is not currently operational. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen S&P 500 Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 20.53%, for the quarter ended June 30, 2020. Worst quarter: -19.59%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2053 2020-06-30 Worst quarter -0.1959 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1782 0.1437 0.1476 0.1691 0.1382 0.1418 0.1075 0.1141 0.1227 0.1764 0.1422 0.1462 0.1753 0.1408 0.1447 S&P 500® Index (reflects no deductions for fees, expenses or taxes) 0.1788 0.1442 0.1482 Current performance of the Fund’s shares may be higher or lower than that shown above. After-tax returns are shown for only one class, and after-tax returns for other classes will vary. After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Small Cap Blend Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of equity securities in smaller domestic companies based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0013 0.0001 0.0026 0.0001 0.0017 0.0005 0.0030 0.0005 0 0 0 -0.0005 0.0017 0.0005 0.0030 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 17 5 31 0 55 16 97 0 96 28 169 0 217 64 381 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 13% of the average value of its portfolio.</span></p> 0.13 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities included in its benchmark index, the Russell 2000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The Russell 2000 Index measures the performance of the small-cap segment of the U.S. equity universe. The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various U.S. equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the Russell 2000 Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization or index weighting of one or more constituents of its benchmark index, the Russell 2000 Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x60x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I and the Retirement Class over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. Performance information is not included for Class W as it is not currently operational. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Small Cap Blend Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 31.32%, for the quarter ended December 31, 2020. Worst quarter: -30.55%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.3132 2020-12-31 Worst quarter -0.3055 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1279 0.0617 0.0974 0.1148 0.0480 0.0829 0.0807 0.0452 0.0754 0.1278 0.0602 0.0960 0.1250 0.0588 0.0946 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 Russell 2000® Index 0.1281 0.0609 0.0962 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Emerging Markets Equity Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of emerging market equity investments based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 100 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0025 0 0.0015 0 0 0 0.0016 0.0014 0.0005 0.0005 0.0030 0.0005 0.0051 0.0024 0.0030 0.0015 0.0040 0.0015 0 0 0 0 0 -0.0015 0.0051 0.0024 0.0030 0.0015 0.0040 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 624 25 31 15 41 0 729 77 97 48 128 0 844 135 169 85 224 0 1179 306 381 192 505 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 14% of the average value of its portfolio.</span></p> 0.14 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities that comprise its benchmark index, the MSCI Emerging Markets^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index (“MSCI EM Index”), or in instruments with economic characteristics similar to all or a portion of the MSCI EM Index. The MSCI EM Index is designed to measure equity market performance in the global emerging markets. The Fund buys most, but not necessarily all, of the stocks in its benchmark index, and will attempt to closely match the overall investment attributes of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various emerging market equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the MSCI EM Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization or index weighting of one or more constituents of its benchmark index, the MSCI EM Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x73x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials and information technology sectors, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in China, although this may change over time. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Emerging Markets Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks of foreign investment often increases in countries with emerging markets or those economically tied to emerging market countries. For example, these countries may have more unstable governments than developed countries, and their economies may be based on only a few industries. Emerging market countries may also have less stringent regulation of accounting, auditing, financial reporting and recordkeeping requirements. As a result, there could be less information available about issuers in emerging market countries, which could negatively affect Nuveen Asset Management’s ability to evaluate local companies or their potential impact on the Fund’s performance. Because their financial markets may be very small, share prices of financial instruments in emerging market countries may be volatile and difficult to determine. Financial instruments of issuers in these countries may have lower overall liquidity than those of issuers in more developed countries and may be more vulnerable to market manipulation. In addition, foreign investors such as the Fund are </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">subject to a variety of special restrictions in many emerging market countries. Moreover, legal remedies for investors in emerging markets may be more limited, and U.S. authorities may have less ability to enforce certain regulatory or legal obligations or otherwise bring actions against bad actors in emerging market countries.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Emerging Markets Equity Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 19.18%, for the quarter ended June 30, 2020. Worst quarter: -24.02%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.1918 2020-06-30 Worst quarter -0.2402 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.3413 0.0387 0.0820 0.3259 0.0305 0.0749 0.2018 0.0272 0.0646 0.3399 0.0372 0.0807 0.3395 0.0371 0.0804 0.3382 0.0361 0.0794 0.2593 0.0230 0.0718 0.3434 0.0405 0.0654 MSCI Emerging Markets Index 0.3357 0.0420 0.0842 0.0662 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen International Equity Index Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of foreign equity investments based on a market index. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0004 0.0004 0.0004 0.0004 0.0004 0 0.0015 0 0 0 0.0014 0.0001 0.0001 0.0026 0.0001 0.0018 0.0020 0.0005 0.0030 0.0005 0 0 0 0 -0.0005 0.0018 0.0020 0.0005 0.0030 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 18 20 5 31 0 58 64 16 97 0 101 113 28 169 0 230 255 64 381 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 9% of the average value of its portfolio.</span></p> 0.09 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in securities of its benchmark index, the MSCI EAFE^® (Europe, Australasia, Far East) Index (the “MSCI EAFE Index”). The MSCI EAFE Index is designed to measure equity market performance in developed markets around the world, excluding the U.S. and Canada. The Fund buys most, but not necessarily all, of the stocks included in its benchmark index, and will attempt to closely match the overall investment characteristics of its benchmark index. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is designed to track various foreign equity markets as a whole or a segment of these markets. The Fund primarily invests its assets in equity securities its sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), has selected to track a designated stock market index. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Because the return of an index is not reduced by investment and other operating expenses, the Fund’s ability to match the returns of the MSCI EAFE Index is negatively affected by the costs of buying and selling securities as well as the Fund’s fees and other expenses. The use of a particular index by the Fund is not a fundamental policy and may be changed without shareholder approval. The portfolio management team of Nuveen Asset Management will attempt to build a portfolio that generally matches the market weighted investment characteristics of the Fund’s benchmark index.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is classified as a diversified investment company, as defined under the Investment Company Act of 1940, as amended (the “1940 Act”). However, the Fund may become non-diversified under the 1940 Act without the approval of Fund shareholders solely as a result of a change in relative market capitalization </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">or index weighting of one or more constituents of its benchmark index, the MSCI EAFE Index, which the Fund seeks to track. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x86x1"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in Japan, although this may change over time. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">(including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Index Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the Fund</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;"> merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—While the Fund is considered to be a diversified investment company under the 1940 Act, the Fund may become non-diversified under the 1940 Act without Fund shareholder approval when necessary to continue to track its benchmark index. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen International Equity Index Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 18.12%, for the quarter ended December 31, 2022. Worst quarter: -23.01%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.1812 2022-12-31 Worst quarter -0.2301 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.3158 0.0902 0.0836 0.2955 0.0809 0.0754 0.1868 0.0686 0.0657 0.3142 0.0890 0.0824 0.3145 0.0886 0.0820 0.3127 0.0875 0.0809 0.3163 0.0908 0.0832 MSCI EAFE® Index 0.3122 0.0892 0.0818 0.0814 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Emerging Markets Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, by investing primarily in a portfolio of emerging markets equity investments. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 90 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0084 0.0084 0.0084 0.0084 0.0084 0.0084 0.0025 0 0.0015 0 0 0 0.0019 0.0019 0.0005 0.0005 0.0030 0.0005 0.0128 0.0103 0.0104 0.0089 0.0114 0.0089 0 0 0 0 0 -0.0089 0.0128 0.0103 0.0104 0.0089 0.0114 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 698 105 106 91 116 0 958 328 331 284 362 0 1237 569 574 493 628 0 2031 1259 1271 1096 1386 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 112% of the average value of its portfolio.</span></p> 1.12 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities of emerging market issuers or in instruments with economic characteristics similar to emerging market equity securities. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. The Fund considers an “emerging market security” to be a security that is principally traded on a securities exchange of an emerging market or that is issued by an issuer that has primary operations in an emerging market. The Fund generally defines an “emerging market” as any of the countries or markets represented in the Fund’s benchmark index, the MSCI Emerging Markets^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index (“MSCI EM Index”), or any other country or market with similar emerging characteristics. The stock selection decisions of the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), drive Nuveen Asset Management’s country and regional asset allocations for the Fund. However, Nuveen Asset Management regularly compares the Fund’s sector and country exposure against the MSCI EM Index to assess its comparative investment exposures. Nuveen Asset Management looks for companies of any size that it believes have sustainable earnings growth, focused management with successful track records, unique and easy-to-understand franchises (brands), stock prices that do not fully reflect the stock’s potential value (based on current earnings, assets, and long-term growth </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">prospects), and consistent generation of free cash flow. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund may purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x8x2"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology and financials sectors, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund invests a significant portion of its assets in the securities of companies</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in China, although this may change over time. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Emerging Markets Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks of foreign investment often increases in countries with emerging markets or those economically tied to emerging market countries. For example, these countries may have more unstable governments than developed countries, and their economies may be based on only a few industries. Emerging market countries may also have less stringent regulation of accounting, auditing, financial reporting and recordkeeping requirements. As a result, there could be less information available about issuers in emerging market countries, which could negatively affect Nuveen Asset Management’s ability to evaluate local companies or their potential impact on the Fund’s performance. Because their financial markets may be very small, share prices of financial instruments in emerging market countries may be volatile and difficult to determine. Financial instruments of issuers in these countries may have lower overall liquidity than those of issuers in more developed countries and may be more vulnerable to market manipulation. In addition, foreign investors such as the Fund are </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">subject to a variety of special restrictions in many emerging market countries. Moreover, legal remedies for investors in emerging markets may be more limited, and U.S. authorities may have less ability to enforce certain regulatory or legal obligations or otherwise bring actions against bad actors in emerging market countries.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> Frontier markets are those emerging markets that are considered to be among the smallest, least mature and least liquid, and as a result, the risks of investing in emerging markets are magnified in frontier markets.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Emerging Markets Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 23.74%, for the quarter ended June 30, 2020. Worst quarter: -28.45%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2374 2020-06-30 Worst quarter -0.2845 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.3605 0.0061 0.0706 0.3415 -0.0128 0.0564 0.2131 -0.0019 0.0535 0.3585 0.0053 0.0699 0.3580 0.0051 0.0693 0.3575 0.0045 0.0688 0.2777 -0.0094 0.0604 0.3732 0.0152 0.0668 MSCI Emerging Markets Index 0.3357 0.0420 0.0842 0.0662 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen International Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, primarily from equity securities of foreign issuers. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 90 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0044 0.0044 0.0044 0.0044 0.0044 0.0044 0.0025 0 0.0015 0 0 0 0.0013 0.0011 0.0001 0.0001 0.0026 0.0001 0.0082 0.0055 0.0060 0.0045 0.0070 0.0045 0 0 0 0 0 -0.0045 0.0082 0.0055 0.0060 0.0045 0.0070 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 654 56 61 46 72 0 822 176 192 144 224 0 1004 307 335 252 390 0 1530 689 750 567 871 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 25% of the average value of its portfolio.</span></p> 0.25 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities of foreign issuers. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. The Fund has a policy of maintaining investments of equity securities of foreign issuers in at least three countries other than the United States. The Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), selects individual stocks, and lets the Fund’s country and regional asset allocations evolve from their stock selection. The Fund may invest in emerging markets to varying degrees, depending on the prevalence of stock specific opportunities. The Fund may invest in companies of all sizes, including smaller, lesser-known companies where Nuveen Asset Management believes it has some unique insights into the company. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management typically invests in companies that can demonstrate an ability to generate free cash flow and strong market share. In addition, Nuveen Asset Management looks for companies with performance oriented management that focuses on growth through innovation, sustainable earnings growth and shareholder returns. Nuveen Asset Management will typically invest in these types of companies when Nuveen Asset Management believes that their stock prices do not fully reflect the stock’s potential value, based on current earnings, assets and long-term growth prospects. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund is actively managed; however, Nuveen Asset Management regularly reviews the Fund’s sector and country exposure against the Fund’s benchmark index, the MSCI EAFE^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(Europe, Australasia, Far East) Index (the “MSCI EAFE Index”), to seek to control risk.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund may purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x21x2"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in Japan, although this may change over time. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Emerging Markets Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks of foreign investment often increases in countries with emerging markets or those economically tied to emerging market countries. For example, these countries may have more unstable governments than developed countries, and their economies may be based on only a few industries. Emerging market countries may also have less stringent regulation of accounting, auditing, financial reporting and recordkeeping requirements. As a result, there could be less information available about issuers in emerging market countries, which could negatively affect Nuveen Asset Management’s ability to evaluate local companies or their potential impact on the Fund’s performance. Because their financial markets may be very small, share prices of financial instruments in emerging market countries may be volatile and difficult to determine. Financial instruments of issuers in these countries may have lower overall liquidity than those of issuers in more developed countries and may be more vulnerable to market manipulation. In addition, foreign investors such as the Fund are </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">subject to a variety of special restrictions in many emerging market countries. Moreover, legal remedies for investors in emerging markets may be more limited, and U.S. authorities may have less ability to enforce certain regulatory or legal obligations or otherwise bring actions against bad actors in emerging market countries.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen International Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 21.00%, for the quarter ended June 30, 2020. Worst quarter: -24.85%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2100 2020-06-30 Worst quarter -0.2485 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.3333 0.0823 0.0803 0.2930 0.0718 0.0722 0.2143 0.0637 0.0642 0.3326 0.0813 0.0792 0.3306 0.0807 0.0787 0.3299 0.0796 0.0776 0.2534 0.0662 0.0704 0.3393 0.0872 0.0852 MSCI EAFE® Index 0.3122 0.0892 0.0818 0.0814 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen International Opportunities Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, primarily from equity securities of foreign issuers. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 90 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0058 0.0058 0.0058 0.0058 0.0058 0.0058 0.0025 0 0.0015 0 0 0 0.0014 0.0010 0.0002 0.0002 0.0027 0.0002 0.0097 0.0068 0.0075 0.0060 0.0085 0.0060 0 0 0 0 0 -0.0060 0.0097 0.0068 0.0075 0.0060 0.0085 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 668 69 77 61 87 0 866 218 240 192 271 0 1080 379 417 335 471 0 1696 847 930 750 1049 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 58% of the average value of its portfolio.</span></p> 0.58 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund primarily invests in equity securities of issuers in developed and emerging markets located around the world but outside the United States. The Fund anticipates investing in a number of foreign markets, but at a minimum it will invest in at least three countries outside the United States. The Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), selects individual stocks, and lets the Fund’s country and regional asset allocations evolve from this stock selection. The Fund may invest in companies of all sizes.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management typically invests in companies that it believes can demonstrate positive and sustainable structural change. In addition, Nuveen Asset Management looks for companies in the early stages of a structural growth opportunity driven by differentiated products and/or services that maintain strong barriers to entry, continue to outgrow peers and demonstrate accelerating top-line growth with margin expansion. Nuveen Asset Management will typically invest in these types of companies when Nuveen Asset Management believes that their stock prices do not fully reflect the stock’s potential value, based on current earnings, assets and long-term growth prospects. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund is actively managed; however, Nuveen Asset Management regularly reviews the Fund’s sector and country exposure against the Fund’s benchmark index, the MSCI ACWI (All Country World Index) ex USA^®Growth </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index (the “MSCI ACWI ex USA Growth Index”), to seek to control risk.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund may purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x34x2"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Emerging Markets Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks of foreign investment often increases in countries with emerging markets or those economically tied to emerging </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">market countries. For example, these countries may have more unstable governments than developed countries, and their economies may be based on only a few industries. Emerging market countries may also have less stringent regulation of accounting, auditing, financial reporting and recordkeeping requirements. As a result, there could be less information available about issuers in emerging market countries, which could negatively affect Nuveen Asset Management’s ability to evaluate local companies or their potential impact on the Fund’s performance. Because their financial markets may be very small, share prices of financial instruments in emerging market countries may be volatile and difficult to determine. Financial instruments of issuers in these countries may have lower overall liquidity than those of issuers in more developed countries and may be more vulnerable to market manipulation. In addition, foreign investors such as the Fund are </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">subject to a variety of special restrictions in many emerging market countries. Moreover, legal remedies for investors in emerging markets may be more limited, and U.S. authorities may have less ability to enforce certain regulatory or legal obligations or otherwise bring actions against bad actors in emerging market countries.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> Frontier markets are those emerging markets that are considered to be among the smallest, least mature and least liquid, and as a result, the risks of investing in emerging markets are magnified in frontier markets.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen International Opportunities Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 33.30%, for the quarter ended June 30, 2020. Worst quarter: -22.53%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.3330 2020-06-30 Worst quarter -0.2253 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 2018-09-28 0.2039 0.0178 0.0768 0.1815 0.0087 0.0705 0.1294 0.0127 0.0619 0.2034 0.0170 0.0760 0.2024 0.0165 0.0754 0.2009 0.0159 0.0748 0.1300 0.0021 0.0662 0.2113 0.0239 0.0681 MSCI ACWI ex USA 0.3239 0.0791 0.0841 0.0794 MSCI ACWI ex USA Growth 0.2565 0.0401 0.0792 0.0726 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Quant International Small Cap Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 90 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0064 0.0064 0.0064 0.0064 0.0064 0.0064 0.0025 0 0.0015 0 0 0 0.0020 0.0018 0.0012 0.0007 0.0032 0.0007 0.0109 0.0082 0.0091 0.0071 0.0096 0.0071 0 0 -0.0001 0 0 -0.0071 0.0109 0.0082 0.0090 0.0071 0.0096 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be:</span></p> 680 84 92 73 98 0 902 262 289 227 306 0 1141 455 503 395 531 0 1827 1014 1119 883 1178 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 112% of the average value of its portfolio.</span></p> 1.12 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in small-cap equity securities of foreign issuers. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. In seeking a favorable long-term total return, the Fund will invest in securities that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes have favorable prospects for long-term capital appreciation. A “small-cap” equity security is a security within the capitalization range of the companies included in the Fund’s benchmark index, the MSCI ACWI ex USA Small Cap^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index (the “Index”). The market capitalization range is determined based on the companies in the Index as of the last business day of the month in which the Index was most recently rebalanced and may be updated to reflect any changes to the Index composition and the market capitalization of companies in the Index. The Fund may invest in equity securities of small companies across a wide range of sectors, growth rates and valuations. From time to time, Nuveen Asset Management reviews the Fund’s sector and country exposure against the Index to seek to control risk in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">relation to the Index. The Fund may invest in emerging markets to varying degrees, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">depending on stock-specific opportunities. The Fund considers investments of foreign issuers to generally include any one or more of the following: </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(1) companies whose securities are principally traded outside of the United States,</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> (2) companies having their principal business operations outside of the United States, (3) companies organized outside of the United States, and (4) foreign governments and agencies or instrumentalities of foreign governments. The Fund has a policy of maintaining investments of equity securities of foreign issuers in at least three countries other than the United States. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management uses proprietary quantitative models, or models utilizing econometric and mathematical techniques based on financial and </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment theories, to evaluate and score a broad universe of stocks in which the Fund invests. These models typically weigh many different variables, including the valuation of the individual stock versus the market or its peers, future earnings and sustainable growth prospects, and the price and volume trends of the stock. The score is </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">used to form the portfolio, and the following additional inputs may also be</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">considered: weightings of the stock and its corresponding sector in the benchmark, correlations</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> of the stocks in the universe and trading costs. The Fund may purchase foreign equity securities denominated in U.S. dollars or in non-U.S. dollar currencies, and equity securities issued in connection with reorganizations and other special situations. Although Nuveen Asset Management does not anticipate that the Fund will have significant exposure to equity securities issued in connection with reorganizations and other special situations, the Fund is not subject to any preset limit.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The overall goal is to build a portfolio of stocks that generate a favorable long-term total return, while also managing the relative risk of the Fund versus the Index. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies. The Fund’s strategy is based upon Nuveen Asset Management’s understanding of the interplay of market factors and does not assure the Fund will perform as intended. The markets or the prices of individual securities may be affected by factors not taken into account in Nuveen Asset Management’s analysis.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x47x2"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;"> </span><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the industrials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not adequately take into account certain factors, may contain design flaws or inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in Japan, although this may change over time. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Emerging Markets Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks of foreign investment often increases in countries with emerging markets or those economically tied to emerging market countries. For example, these countries may have more unstable governments than developed countries, and their economies may be based on only a few industries. Emerging market countries may also have less stringent regulation of accounting, auditing, financial reporting and recordkeeping requirements. As a result, there could be less information available about issuers in emerging market countries, which could negatively affect Nuveen Asset Management’s ability to evaluate local companies or their potential impact on the Fund’s performance. Because their financial markets may be very small, share prices of financial instruments in emerging market countries may be volatile and difficult to determine. Financial instruments of issuers in these countries may have lower overall liquidity than those of issuers in more developed countries and may be more vulnerable to market manipulation. In addition, foreign investors such as the Fund are </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">subject to a variety of special restrictions in many emerging market countries. Moreover, legal remedies for investors in emerging markets may be more limited, and U.S. authorities may have less ability to enforce certain regulatory or legal obligations or otherwise bring actions against bad actors in emerging market countries.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. Fund investments in securities of small-cap companies are often less liquid than Fund investments in securities of larger companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Special Situation Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Stocks of companies involved in acquisitions, consolidations, tender offers or exchanges, takeovers, reorganizations, mergers and other special situations can involve the risk that such situations may not materialize or may develop in unexpected ways. Consequently, those stocks can involve more risk than ordinary securities.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year since inception of Class R6. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Quant International Small Cap Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 23.57%, for the quarter ended June 30, 2020. Worst quarter: -32.23%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2357 2020-06-30 Worst quarter -0.3223 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2016-12-09 2018-09-28 2018-09-28 2018-09-28 0.3566 0.0872 0.0791 0.3204 0.0734 0.0657 0.2186 0.0651 0.0595 0.3565 0.0868 0.0785 0.3545 0.0852 0.0774 0.3538 0.0847 0.0767 0.2753 0.0703 0.0678 0.3675 0.0952 0.0784 MSCI ACWI ex USA 0.3239 0.0791 0.0878 0.0794 MSCI ACWI ex USA Small Cap Index 0.2926 0.0691 0.0862 0.0733 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen International Responsible Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return that reflects the investment performance of the overall foreign equity markets while giving special consideration to certain environmental, social and governance (“ESG”) criteria. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 90 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0030 0.0030 0.0030 0.0030 0.0030 0.0025 0 0.0015 0 0 0.0016 0.0007 0.0004 0.0003 0.0028 0.0071 0.0037 0.0049 0.0033 0.0058 -0.0013 -0.0013 -0.0013 -0.0013 -0.0013 0.0058 0.0024 0.0036 0.0020 0.0045 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be:</span></p> 631 25 37 20 46 760 88 127 75 155 919 177 244 155 294 1380 438 587 388 697 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 21% of the average value of its portfolio.</span></p> 0.21 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities of foreign issuers that meet the Fund’s ESG criteria. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. The Fund attempts to achieve the return of the foreign equity markets, as represented by its benchmark index, the MSCI EAFE^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(Europe, Australasia, Far East) Index (the “MSCI EAFE Index”), while taking into consideration certain ESG criteria, which include criteria relating to carbon intensity and fossil fuel reserves. See “Additional information about the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund’s benchmark index” in the non-summary portion of the Prospectus for more information about the Fund’s benchmark. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund holdings may be denominated in U.S. dollars or non-U.S. dollar currencies. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">When selecting investments for the Fund, Nuveen Asset Management, LLC (“Nuveen Asset Management”), the Fund’s sub-adviser, considers certain ESG criteria. The ESG criteria are generally implemented based on data provided by independent research vendor(s). The evaluation process favors companies with leadership in ESG performance relative to their peers. Typically, environmental assessment categories include climate change, natural resource use, waste management and environmental opportunities. Social evaluation categories </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">include human capital, product safety and social opportunities. Governance assessment categories include corporate governance, business ethics and government and public policy. How well companies adhere to international norms and principles and involvement in major ESG controversies (examples of which may relate to the environment, customers, human rights and community, labor rights and supply chain, and governance) are other considerations.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The ESG evaluation process is conducted on an industry-specific basis and involves the identification of key performance indicators, which are given more or less relative weight compared to the broader range of potential assessment categories. When ESG concerns exist, the evaluation process gives careful consideration to how companies address the risks and opportunities they face in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the context of their sector or industry and relative to their peers. The Fund will not</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> generally invest in companies significantly involved in certain business activities, including but not limited to the production of alcohol, tobacco, military weapons, firearms, thermal coal, adult entertainment, arctic oil and gas, oil sands extraction, for-profit prisons and gambling products and services.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">In addition to the overall ESG performance evaluation, the Fund favors companies that (1) demonstrate leadership in managing and mitigating their current carbon intensity and (2) do not have evidence of fossil fuel reserves ownership, regardless of industry. The determination of leadership criteria takes into consideration company carbon intensity in relative terms (e.g., tons of carbon emitted per unit of economic output such as sales). Reserves are fossil fuel deposits that have not yet been extracted. Evidence of fossil fuel reserves ownership includes company disclosure and statements regarding ownership. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">After the ESG evaluation process is conducted, Nuveen Asset Management then uses quantitative investment techniques to attempt to closely match, to the extent practicable, the overall risk characteristics of the benchmark index. Under these quantitative investment techniques, the Fund uses a risk model to evaluate the stocks in which the Fund may invest and to inform the construction of a broadly diversified group of stocks. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">While Nuveen Asset Management generally invests in companies that meet the ESG criteria, it is not required to invest in every company that meets these criteria. In addition, concerns with respect to one ESG assessment category may not automatically eliminate an issuer from being considered an eligible Fund investment. The ESG criteria the Fund takes into consideration are non-fundamental investment policies and may be changed without the approval of the Fund’s shareholders.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Investing on the basis of ESG criteria is qualitative and subjective by nature. There can be no assurance that every Fund investment will meet ESG criteria, or will do so at all times, or that the ESG criteria or any judgment exercised by Nuveen Asset Management will reflect the beliefs or values of any particular investor.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x60x2"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">ESG Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that because the Fund’s ESG criteria exclude securities of certain issuers for nonfinancial reasons, the Fund may forgo some market opportunities available to funds that do not use these criteria.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Low-Carbon Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that because the Fund’s investment strategy includes a special emphasis on companies with low current carbon intensity and an absence of fossil fuel reserves ownership, the Fund’s portfolio might exclude certain issuers for nonfinancial reasons and the Fund may forgo some market opportunities that otherwise would be available.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials and industrials sectors, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. To the extent the Fund invests a significant portion of its assets in the securities of companies in a single country or region, it may be more susceptible to adverse economic, market, political or regulatory events or conditions affecting that country or region. The Fund currently invests a significant portion of its assets in companies located in Japan, although this may change over time. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Benchmark Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Fund’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Fund merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not adequately take into account certain factors, may contain design flaws or inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class and Class A over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen International Responsible Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 18.24%, for the quarter ended December 31, 2022. Worst quarter: -22.29%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.1824 2022-12-31 Worst quarter -0.2229 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.2859 0.0858 0.0833 0.2587 0.0760 0.0762 0.1710 0.0654 0.0663 0.2863 0.0849 0.0824 0.2844 0.0841 0.0815 0.2831 0.0832 0.0806 0.2077 0.0698 0.0734 MSCI EAFE® Index 0.3122 0.0892 0.0818 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Core Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">appreciation, primarily from </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">equity securities. </span></p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0039 0.0039 0.0039 0.0039 0.0039 0.0039 0.0025 0 0.0015 0 0 0 0.0008 0.0008 0.0001 0.0001 0.0026 0.0001 0.0072 0.0047 0.0055 0.0040 0.0065 0.0040 0 0 0 0 0 -0.0040 0.0072 0.0047 0.0055 0.0040 0.0065 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 644 48 56 41 66 0 792 151 176 128 208 0 953 263 307 224 362 0 1418 591 689 505 810 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 117% of the average value of its portfolio.</span></p> 1.17 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in equity securities. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. In seeking a favorable long-term total return, the Fund will invest in securities which the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes have the potential for capital appreciation, dividend income, or both. The Fund focuses on large-cap securities that Nuveen Asset Management believes to be attractively valued, show the potential to appreciate faster than the rest of the market and return cash to shareholders in the form of dividends, stock buy-backs or both. Nuveen Asset Management seeks to construct a portfolio whose weighted average market capitalization is similar to the Fund’s benchmark index, the Standard &amp; Poor’s 500^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index (the “S&amp;P 500 Index”). For purposes of the 80% investment policy, the term "assets" means net assets, plus the amount of any borrowings for investment purposes. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management generally looks for companies that it believes are leaders in their respective industries, with sustainable competitive advantages. Nuveen Asset Management also looks for companies that it believes have management teams that are dedicated to creating shareholder value. The Fund is classified as a non-diversified investment company under the Investment Company Act of 1940, as amended (the “1940 Act”), which means it may invest a significant portion of its assets in a relatively small number of issuers, which may increase risk as compared to a fund that is classified as a diversified investment company. The Fund may invest up to 20% of its assets in foreign issuers when Nuveen Asset Management believes these issuers offer more attractive investment opportunities. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x8x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:39.6pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Growth Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Due to their relatively high valuations, growth stocks are typically more volatile than value stocks and may experience a larger decline on a forecast of lower earnings, or a negative event or market development, than would a value stock.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The Fund is considered to be non-diversified under the 1940 Act. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Core Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 22.22%, for the quarter ended June 30, 2020. Worst quarter: -21.52%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2222 2020-06-30 Worst quarter -0.2152 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 0.1411 0.1380 0.1412 0.1055 0.0981 0.1126 0.1058 0.1001 0.1091 0.1404 0.1370 0.1402 0.1388 0.1362 0.1395 0.1380 0.1352 0.1383 0.0722 0.1216 0.1313 0.1451 0.1425 0.1376 S&P 500® Index (reflects no deductions for fees, expenses or taxes) 0.1788 0.1442 0.1482 0.1432 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Large Cap Growth Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term return, mainly through capital appreciation, primarily from equity securities. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0039 0.0039 0.0039 0.0039 0.0039 0.0039 0.0025 0 0.0015 0 0 0 0.0010 0.0004 0.0001 0.0001 0.0026 0.0001 0.0074 0.0043 0.0055 0.0040 0.0065 0.0040 0 0 0 0 0 -0.0040 0.0074 0.0043 0.0055 0.0040 0.0065 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 646 44 56 41 66 0 798 138 176 128 208 0 963 241 307 224 362 0 1441 542 689 505 810 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 41% of the average value of its portfolio.</span></p> 0.41 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of the sum of its net assets and the amount of any borrowings for investment purposes in equity securities of large-capitalization growth companies. The Fund invests primarily in equity securities of large domestic companies, as defined by the Fund’s benchmark index, the Russell 1000^®Growth </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index, that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes present the opportunity for growth. Large-capitalization companies are those that have market capitalizations within the range of the companies in the Russell 1000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. Growth companies are those that are constituents of at least one of the following indexes on the last business day of the month in which its most recent reconstitution was completed (as adjusted by changes to an index between reconstitutions): Russell 3000 Growth Index, S&amp;P Composite 1500^®Growth Index, MSCI World IMI Growth Index. Generally, these equity securities will be those of large capitalized companies in new and emerging areas of the economy and companies with distinctive products or promising markets. Nuveen Asset Management looks for companies that it believes have the potential for strong earnings and/or sales growth, or that appear to be mispriced based on current earnings, assets or growth prospects. The Fund may invest in large, well-known, established companies, particularly when Nuveen Asset Management believes that the companies offer new or innovative products, services or processes that may enhance their future earnings. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund is classified as a non-diversified investment company under the Investment Company Act of 1940, as amended (the “1940 Act”), which means it may invest a significant portion of its assets in a relatively small number of issuers, which may increase risk as compared to a fund that is classified as a diversified investment company. </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund also seeks to invest in companies expected to benefit from prospective acquisitions, reorganizations, corporate restructurings or other special situations. The Fund may invest up to 20% of its assets in foreign </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">investments. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x21x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-8.65pt; font-weight:normal; margin-left:44.65pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:5.325pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Growth Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Due to their relatively high valuations, growth stocks are typically more volatile than value stocks and may experience a larger decline on a forecast of lower earnings, or a negative event or market development, than would a value stock.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Non-Diversification Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The Fund is considered to be non-diversified under the 1940 Act. Non-diversified status means that the Fund can invest a greater percentage of its assets in the securities of a single issuer than a diversified fund. Investing in a non-diversified fund involves </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">greater risk than </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing in a diversified fund because a loss in value of a particular </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may have a greater effect on the fund’s return since that </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investment may represent a larger portion of the fund’s total portfolio assets.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Special Situation Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Stocks of companies involved in acquisitions, consolidations, tender offers or exchanges, takeovers, reorganizations, mergers and other special situations can involve the risk that such situations may not materialize or may develop in unexpected ways. Consequently, those stocks can involve more risk than ordinary securities.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Large Cap Growth Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 27.99%, for the quarter ended June 30, 2020. Worst quarter: -23.09%, for the quarter ended June 30, 2022.</span></p> Best quarter 0.2799 2020-06-30 Worst quarter -0.2309 2022-06-30 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 2018-09-28 0.1559 0.1151 0.1580 0.1220 0.0984 0.1333 0.1159 0.0884 0.1240 0.1560 0.1143 0.1573 0.1541 0.1133 0.1562 0.1530 0.1123 0.1550 0.0862 0.0989 0.1479 0.1605 0.1195 0.1521 Russell 1000® Index (reflects no deductions for fees, expenses or taxes) 0.1737 0.1359 0.1459 0.1402 Russell 1000® Growth Index 0.1856 0.1532 0.1813 0.1759 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Large Cap Value Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, primarily from equity securities of large domestic companies. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0039 0.0039 0.0039 0.0039 0.0039 0.0039 0.0025 0 0.0015 0 0 0 0.0010 0.0004 0.0001 0.0001 0.0026 0.0001 0.0074 0.0043 0.0055 0.0040 0.0065 0.0040 0 0 0 0 0 -0.0040 0.0074 0.0043 0.0055 0.0040 0.0065 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 646 44 56 41 66 0 798 138 176 128 208 0 963 241 307 224 362 0 1441 542 689 505 810 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 17% of the average value of its portfolio.</span></p> 0.17 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of the sum of its net assets and the amount of any borrowings for investment purposes in equity securities of large-capitalization value companies. The Fund invests primarily in equity securities of large domestic companies, as defined by the Fund’s benchmark index, the Russell 1000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Value Index, that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes appear undervalued by the market based on an evaluation of their potential worth. Large-capitalization companies are those that have market capitalizations within the range of the companies in the Russell 1000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. Value companies are those that are constituents of at least one of the following indexes on the last business day of the month in which its most recent reconstitution was completed (as adjusted by changes to an index between reconstitutions): Russell 3000^®Value Index, S&amp;P Composite 1500^®Value Index, MSCI World IMI Value Index.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management uses a variety of comparative valuation criteria to determine whether shares of a particular company might be undervalued, including analyses of historical valuations of the same security; valuations of comparable securities in the same sector or the overall market; various financial ratios such as stock price-to-book value, stock price-to-earnings, and dividend yield; and free cash flow generated by the company. Nuveen Asset Management generally focuses on companies with normalized earnings and high operating leverage, which may cause the Fund to be more volatile in down markets than other large-cap value funds that have more defensive investment strategies.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund may invest up to 20% of its assets in foreign investments. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x34x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the financials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:39.6pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Value Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Securities believed to be undervalued are subject to the risks that the issuer’s potential business prospects are not realized, its potential value is never recognized by the market or the securities were appropriately priced when acquired. As a result, value stocks can be overpriced when acquired and may not perform as anticipated.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Large Cap Value Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 17.59%, for the quarter ended December 31, 2020. Worst quarter: -26.68%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.1759 2020-12-31 Worst quarter -0.2668 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 2018-09-28 0.1749 0.1274 0.1079 0.1489 0.1078 0.0912 0.1164 0.0976 0.0839 0.1751 0.1267 0.1073 0.1738 0.1257 0.1063 0.1721 0.1246 0.1051 0.1044 0.1109 0.0981 0.1799 0.1321 0.1073 Russell 1000® Index (reflects no deductions for fees, expenses or taxes) 0.1737 0.1359 0.1459 0.1402 Russell 1000® Value Index 0.1591 0.1133 0.1053 0.0974 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Quant Mid Cap Growth Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">appreciation, primarily from equity securities of medium-sized domestic companies</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">. </span></p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0047 0.0047 0.0047 0.0047 0.0047 0.0025 0 0.0015 0 0 0.0013 0.0019 0.0003 0.0003 0.0028 0.0085 0.0066 0.0065 0.0050 0.0075 0 0 0 0 0 0.0085 0.0066 0.0065 0.0050 0.0075 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the duration noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 657 67 66 51 77 831 211 208 160 240 1019 368 362 280 417 1564 822 810 628 930 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 171% of the average value of its portfolio.</span></p> 1.71 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of the sum of its net assets and the amount of any borrowings for investment purposes in equity securities of mid-capitalization growth companies. In seeking a favorable long-term total return, the Fund will invest in securities that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes have favorable prospects for significant long-term capital appreciation potential. Mid-capitalization companies are those that have market capitalizations within the range of the companies in the Russell Midcap^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. Growth companies are those that are constituents of at least one of the following indexes on the last business day of the month in which its most recent reconstitution was completed (as adjusted by changes to an index between reconstitutions): Russell 3000 Growth Index, S&amp;P Composite 1500^®Growth Index, MSCI World IMI Growth Index.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks to add incremental return over the Russell Midcap</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Growth Index, its benchmark index, while also managing the relative risk of the Fund versus its benchmark index. Nuveen Asset Management uses proprietary quantitative models, or models utilizing econometric and mathematical techniques, based on financial and investment theories to evaluate and score a broad universe of stocks in which the Fund invests. These models typically weigh many different variables, including the valuation of the individual stock versus the market or its peers, future earnings and sustainable growth prospects, and the price and volume trends of the stock. The score is used to form the portfolio, and the following additional inputs may also be considered: weightings of the stock and its corresponding sector in the benchmark, correlations of the stocks in the universe and trading costs. The Fund may purchase foreign equity securities, denominated in U.S. dollars or in non-U.S. dollar currencies, and equity securities issued in connection with reorganizations and other special situations.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The overall goal is to build a portfolio of stocks that generate a favorable long-term total return, while also managing the relative risk of the Fund versus its benchmark index. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies. The Fund’s strategy is based upon Nuveen Asset Management’s understanding of the interplay of market factors and does not assure the Fund will perform as intended. The markets or the prices of individual securities may be affected by factors not taken into account in Nuveen Asset Management’s analysis.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x47x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the industrials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not adequately take into account certain factors, may contain design flaws or </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-8.65pt; font-weight:normal; margin-left:44.65pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:5.325pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Growth Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Due to their relatively high valuations, growth stocks are typically more volatile than value stocks and may experience a larger decline on a forecast of lower earnings, or a negative event or market development, than would a value stock.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Special Situation Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Stocks of companies involved in acquisitions, consolidations, tender offers or exchanges, takeovers, reorganizations, mergers and other special situations can involve the risk that such situations may not materialize or may develop in unexpected ways. Consequently, those stocks can involve more risk than ordinary securities.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class and Class A over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. As of March 1, 2025, certain changes were made to the Fund’s investment strategies. Performance information prior to this date reflects the Fund’s investment strategies before this date. As a result, the Fund’s performance after March 1, 2025 may differ materially from the performance information shown below for the period prior to March 1, 2025. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Quant Mid Cap Growth Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 32.24%, for the quarter ended June 30, 2020. Worst quarter: -25.60%, for the quarter ended June 30, 2022.</span></p> Best quarter 0.3224 2020-06-30 Worst quarter -0.2560 2022-06-30 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.0448 -0.0105 0.0807 0.0204 -0.0227 0.0601 0.0442 -0.0085 0.0603 0.0444 -0.0115 0.0799 0.0438 -0.0119 0.0791 0.0422 -0.0130 0.0780 -0.0185 -0.0250 0.0711 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 Russell Midcap® Growth Index 0.0866 0.0665 0.1249 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Mid Cap Value Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">appreciation, primarily from equity securities of medium-sized domestic companies</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">. </span></p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0044 0.0044 0.0044 0.0044 0.0044 0.0025 0 0.0015 0 0 0.0011 0.0011 0.0002 0.0002 0.0027 0.0080 0.0055 0.0061 0.0046 0.0071 0 0 0 0 0 0.0080 0.0055 0.0061 0.0046 0.0071 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the duration noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 652 56 62 47 73 816 176 195 148 227 994 307 340 258 395 1508 689 762 579 883 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 28% of the average value of its portfolio.</span></p> 0.28 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of the sum of its net assets and the amount of any borrowings for investment purposes in equity securities of mid-capitalization value companies. The Fund will invest primarily in equity securities of medium-sized domestic companies, as defined by the Fund’s benchmark index, the Russell Midcap^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Value Index, that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes appear undervalued by the market based on an evaluation of their potential worth. Mid-capitalization companies are those that have market capitalizations within the range of the companies in the Russell Midcap^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. Value companies are those that are constituents of at least one of the following indexes on the last business day of the month in which its most recent reconstitution was completed (as adjusted by changes to an index between reconstitutions): Russell 3000 Value Index, S&amp;P Composite 1500^®Value Index, MSCI World IMI Value Index.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Nuveen Asset Management uses a variety of comparative valuation criteria to determine whether shares of a particular company might be undervalued, including analyses of historical valuations of the same security; valuations of comparable securities in the same sector or the overall market; various financial ratios such as stock price-to-earnings, stock price-to-book value, free cash flow, debt-to-capital and, to a lesser extent, dividend yield.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund may invest up to 20% of its assets in foreign investments. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x60x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. </p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Style Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that use of a particular investing style (such as growth or value</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investing) may fall out of favor in the marketplace for various periods of time and result in underperformance relative to the broader market sector or significant declines in the value of the Fund’s portfolio investments. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:39.6pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Risks of Value Investing</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Securities believed to be undervalued are subject to the risks that the issuer’s potential business prospects are not realized, its potential value is never recognized by the market or the securities were appropriately priced when acquired. As a result, value stocks can be overpriced when acquired and may not perform as anticipated.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class and Class A over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive, reimburse and/or compensate the Fund for certain fees, expenses and/or costs. Without these reductions and/or compensation, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Mid Cap Value Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 21.51%, for the quarter ended December 31, 2020. Worst quarter: -34.38%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2151 2020-12-31 Worst quarter -0.3438 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1022 0.1075 0.0855 0.0791 0.0826 0.0609 0.0716 0.0797 0.0626 0.1011 0.1064 0.0845 0.1011 0.1058 0.0838 0.0998 0.1048 0.0828 0.0353 0.0912 0.0758 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 Russell Midcap® Value Index 0.1105 0.0983 0.0978 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Quant Small Cap Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation, primarily from equity securities of smaller domestic companies. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0039 0.0039 0.0039 0.0039 0.0039 0.0039 0.0025 0 0.0015 0 0 0 0.0010 0.0007 0.0001 0.0001 0.0026 0.0001 0.0074 0.0046 0.0055 0.0040 0.0065 0.0040 0 0 0 0 0 -0.0040 0.0074 0.0046 0.0055 0.0040 0.0065 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 646 47 56 41 66 0 798 148 176 128 208 0 963 258 307 224 362 0 1441 579 689 505 810 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 76% of the average value of its portfolio.</span></p> 0.76 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in small-cap equity securities. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. In seeking a favorable long-term total return, the Fund will invest in securities that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes have favorable prospects for significant long-term capital appreciation potential. A “small-cap” equity security is a security within the capitalization range of the companies included in the Fund’s benchmark index, the Russell 2000^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. The Fund invests primarily in equity securities of smaller domestic companies across a wide range of sectors, growth rates and valuations. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks to add incremental return over its stated benchmark index, while also managing the relative risk of the Fund versus its benchmark index. Nuveen Asset Management uses proprietary quantitative models, or models utilizing econometric and mathematical techniques, based on financial and investment theories to evaluate and score a broad universe of stocks in which the Fund invests. These models typically weigh many different variables, including the valuation of the individual stock versus the market or its peers, future earnings and sustainable growth prospects, and the price and volume trends of the stock. The score is used to form the portfolio and the following additional inputs may also be considered: </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">weightings of the stock and its corresponding sector in the benchmark, correlations</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> between the performance of the stocks in the universe, and trading costs. The Fund may purchase foreign securities and securities issued in connection with reorganizations and other special situations.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The overall goal is to build a portfolio of stocks that generate a favorable long-term total return, while also managing the relative risk of the Fund versus its benchmark index. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies. The Fund’s strategy is based upon Nuveen Asset Management’s understanding of the interplay of market factors and does not assure the Fund will perform as intended. The markets or the prices of individual securities may be affected by factors not taken into account in Nuveen Asset Management’s analysis.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x73x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the health care sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not adequately take into account certain factors, may contain design flaws or inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Special Situation Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Stocks of companies involved in acquisitions, consolidations, tender offers or exchanges, takeovers, reorganizations, mergers and other special situations can involve the risk that such situations may not materialize or may develop in unexpected ways. Consequently, those stocks can involve more risk than ordinary securities.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Quant Small Cap Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 32.14%, for the quarter ended December 31, 2020. Worst quarter: -33.90%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.3214 2020-12-31 Worst quarter -0.3390 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2018-09-28 2018-09-28 2018-09-28 0.1648 0.1120 0.1118 0.1402 0.0851 0.0874 0.1125 0.0823 0.0837 0.1653 0.1115 0.1112 0.1637 0.1103 0.1102 0.1625 0.1092 0.1091 0.0941 0.0956 0.1020 0.1697 0.1166 0.0981 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 0.1357 Russell 2000® Index 0.1281 0.0609 0.0962 0.0683 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Quant Small/Mid Cap Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return, mainly through capital appreciation. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0042 0.0042 0.0042 0.0042 0.0042 0.0042 0.0025 0 0.0015 0 0 0 0.0011 0.0011 0.0005 0.0004 0.0027 0.0002 0.0078 0.0053 0.0062 0.0046 0.0069 0.0044 0 0 0 0 0 -0.0044 0.0078 0.0053 0.0062 0.0046 0.0069 0.0000 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the durations noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 650 54 63 47 70 0 810 170 199 148 221 0 983 296 346 258 384 0 1485 665 774 579 859 0 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 89% of the average value of its portfolio.</span></p> 0.89 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in small-cap and mid-cap equity securities. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. In seeking a favorable long-term total return, the Fund will invest in securities that the Fund’s sub-adviser, Nuveen Asset Management, LLC (“Nuveen Asset Management”), believes have favorable prospects for significant long-term capital appreciation potential. A “small-cap” or “mid-cap” equity security is a security within the capitalization range of the companies included in the Fund’s benchmark index, the Russell 2500</span><span style="font-size:9.0pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">^™</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently reconstituted and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index. The Fund invests primarily in equity securities of small- to mid-sized companies across a wide range of sectors, growth rates and valuations. For purposes of the 80% investment policy, the term “assets” means net assets, plus the amount of any borrowings for investment purposes.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund seeks to add incremental return over its stated benchmark index, while also managing the relative risk of the Fund versus its benchmark index. Nuveen Asset Management uses proprietary quantitative models, or models utilizing econometric and mathematical techniques, based on financial and investment theories to evaluate and score a broad universe of stocks in which the Fund invests. These models typically weigh many different variables, including the valuation of the individual stock versus the market or its peers, future earnings and sustainable growth prospects, and the price and volume trends of the stock. The score is used to form the portfolio, and the following additional inputs may also be considered: </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">weightings of the stock and its corresponding sector in the benchmark, correlations</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> of the stocks in the universe and trading </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">costs. The Fund may purchase foreign equity securities, denominated in U.S. dollars or in non-U.S. dollar currencies, and equity securities issued in connection with reorganizations and other special situations.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The overall goal is to build a portfolio of stocks that generate a favorable long-term total return, while also managing the relative risk of the Fund versus its benchmark index. The Fund may also purchase and sell futures, options, swaps and other equity derivatives to carry out the Fund’s investment strategies. The Fund’s strategy is based upon Nuveen Asset Management’s understanding of the interplay of market factors and does not assure the Fund will perform as intended. The markets or the prices of individual securities may be affected by factors not taken into account in Nuveen Asset Management’s analysis.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x86x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;"> </span><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the industrials sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not adequately take into account certain factors, may contain design flaws or inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Illiquid Investments Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">The risk that illiquid investments may be difficult to sell for the value at which they are carried, if at all, or at any price within the desired time frame. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Special Situation Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Stocks of companies involved in acquisitions, consolidations, tender offers or exchanges, takeovers, reorganizations, mergers and other special situations can involve the risk that such situations may not materialize or may develop in unexpected ways. Consequently, those stocks can involve more risk than ordinary securities.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Currency Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that foreign (non-U.S.) currencies may decline in value relative to the U.S. dollar and adversely affect the value of the Fund’s </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">investments in foreign currencies, securities denominated in foreign currencies </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">or derivative instruments that provide exposure to foreign currencies. Currency rates in foreign countries may fluctuate significantly over short periods of time for a number of reasons, including changes in interest rates and the imposition of currency controls or other political, economic and tax developments in the U.S. or abroad.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Derivatives Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risks associated with investing in derivatives, including futures, options, swaps, and other equity derivative instruments, and other similar instruments (referred to collectively as “derivatives”) may be different and greater than the risks associated with directly investing in the underlying securities and other instruments, and include leverage risk, market risk, counterparty risk, liquidity risk, operational risk and legal risk. The Fund may use more complex derivatives that might be particularly susceptible to liquidity, credit and counterparty risk. When investing in derivatives, the Fund may lose more than the principal amount invested. Derivatives used for hedging or risk management may not operate as intended, may expose the Fund to other risks, and may be insufficient to protect the Fund from the risks they were intended to hedge.</span></p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year since inception of Class R6. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class, Class A and Class W over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market index and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market index and benchmark index listed below are unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market index and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Quant Small/Mid Cap Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 27.30%, for the quarter ended June 30, 2020. Worst quarter: -31.11%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2730 2020-06-30 Worst quarter -0.3111 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2016-08-05 2018-09-28 2018-09-28 2018-09-28 0.1620 0.1292 0.1352 0.1379 0.1000 0.1110 0.1106 0.0950 0.1034 0.1611 0.1279 0.1345 0.1596 0.1272 0.1334 0.1591 0.1266 0.1324 0.0908 0.1121 0.1240 0.1670 0.1346 0.1239 Russell 3000® Index (reflects no deductions for fees, expenses or taxes) 0.1715 0.1315 0.1429 0.1357 Russell 2500™ Index 0.1191 0.0726 0.1000 0.0822 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary. Nuveen Large Cap Responsible Equity Fund Investment objective <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund seeks a favorable long-term total return that reflects the investment performance of the U.S. equity markets, as represented by the benchmark index, while giving special consideration to certain environmental, social and governance (“ESG”) criteria. </p> Fees and expenses <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The following tables describe the fees and expenses that you may pay if you buy, hold and sell shares of the Fund.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> You may pay other fees, such as brokerage commissions and other fees to financial intermediaries, when buying or selling shares of the Fund, which are not reflected in the tables and examples below.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> You may qualify for sales charge discounts if you and your family invest, or agree to invest in the future, at least $50,000 in the Fund or in other Nuveen mutual funds. More information about these and other discounts, as well as eligibility requirements for each share class, is available from your financial advisor and in “How You Can Buy and Sell Shares” on page 119 of the Fund’s Prospectus and “Purchase and Redemption of Fund Shares” on page 106 of the Fund’s Statement of Additional Information. In addition, more information about sales charge discounts and waivers for purchases of shares through specific financial intermediaries is set forth in the appendix to the Fund’s Prospectus entitled “Variations in Sales Charge Reductions and Waivers Available Through Certain Intermediaries.”</span></p> SHAREHOLDER FEES (fees paid directly from your investment) 0.0575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.00 0 0 0 0 ANNUAL FUND OPERATING EXPENSES (expenses that you pay each year as a percentage of the value of your investment) 0.0015 0.0015 0.0015 0.0015 0.0015 0.0025 0 0.0015 0 0 0.0009 0.0009 0.0002 0.0002 0.0027 0.0049 0.0024 0.0032 0.0017 0.0042 0 0 0 0 0 0.0049 0.0024 0.0032 0.0017 0.0042 Example <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">This example is intended to help you compare the cost of investing in shares of the Fund with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund for the time periods indicated and then redeem all your shares at the end of those periods. The example also assumes that your investment has a 5% return each year and that the Fund’s operating expenses, before fee waivers and/or expense reimbursements, remain the same. The example assumes that the Fund’s fee waiver and/or expense reimbursement arrangements will each remain in place for the duration noted in the table above. Although your actual costs may be higher or lower, based on these assumptions your costs would be: </span></p> 622 25 33 17 43 723 77 103 55 135 833 135 180 96 235 1156 306 406 217 530 Portfolio turnover <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The Fund pays transaction costs, such as commissions, as applicable, when it buys and sells securities (or “turns over” its portfolio). A higher portfolio turnover rate may indicate higher transaction costs and may result in higher taxes when Fund shares are held in a taxable account. These costs, which are not reflected in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">annual fund operating expenses or in the example, affect the Fund’s performance.</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> During the fiscal year ended October 31, 2025, the Fund’s portfolio turnover rate was 25% of the average value of its portfolio.</span></p> 0.25 Principal investment strategies <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Under normal circumstances, the Fund invests at least 80% of its assets in large-cap equity securities that meet the Fund’s ESG criteria. For these purposes, “equity securities” include equity securities of any type, including common stocks; preferred securities; warrants to purchase common stocks and preferred securities; convertible debt securities that are either in the money or immediately convertible into common stocks or preferred securities; common and preferred securities issued by master limited partnerships and real estate investment trusts; depositary receipts; and other securities with equity characteristics. The Fund attempts to achieve the return of the U.S. stock </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">market as represented by its benchmark, the S&amp;P 500^®</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Index, while taking into consideration certain</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> ESG criteria, which include criteria relating to carbon intensity and fossil fuel reserves. See “Additional information about the Fund’s benchmark index” in the non-summary portion of the Prospectus for more information about the Fund’s benchmark. For purposes of the 80% investment policy, “large-cap” securities are equity securities that have a market capitalization within the range of companies included in the S&amp;P 500 Index and “assets” means net assets, plus the amount of any borrowings for investment purposes. The market capitalization range is determined based on the companies in the index as of the last business day of the month in which the index was most recently rebalanced and may be updated to reflect any changes to the index composition and the market capitalization of companies in the index.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">When selecting investments for the Fund, Nuveen Asset Management, LLC (“Nuveen Asset Management”), the Fund’s sub-adviser, considers certain ESG criteria. The ESG criteria are generally implemented based on data provided by independent research vendor(s). The evaluation process favors companies with leadership in ESG performance relative to their peers. Typically, environmental assessment categories include climate change, natural resource use, waste management and environmental opportunities. Social evaluation categories </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">include human capital, product safety and social opportunities. Governance assessment categories include corporate governance, business ethics and government and public policy. How well companies adhere to international norms and principles and involvement in major ESG controversies (examples of which may relate to the environment, customers, human rights and community, labor rights and supply chain, and governance) are other considerations.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The ESG evaluation process is conducted on an industry-specific basis and involves the identification of key performance indicators, which are given more or less relative weight compared to the broader range of potential assessment categories. When ESG concerns exist, the evaluation process gives careful consideration to how companies address the risks and opportunities they face in </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the context of their sector or industry and relative to their peers. The Fund will not</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> generally invest in companies significantly involved in certain business activities, including but not limited to the production of alcohol, tobacco, military weapons, firearms, thermal coal, adult entertainment, arctic oil and gas, oil sands extraction, for-profit prisons and gambling products and services.</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">In addition to the overall ESG performance evaluation, the Fund favors companies that (1) demonstrate leadership in managing and mitigating their current carbon intensity and (2) do not have evidence of fossil fuel reserves ownership, regardless of industry. The determination of leadership criteria takes into consideration company carbon intensity in relative terms (e.g., tons of carbon emitted per unit of economic output such as sales). Reserves are fossil fuel deposits that have not yet been extracted. Evidence of fossil fuel reserves ownership includes company disclosure and statements regarding ownership.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">After the ESG evaluation process is conducted, Nuveen Asset Management then uses quantitative investment techniques to attempt to closely match, to the extent practicable, the overall risk characteristics of the benchmark index. Under these quantitative investment techniques, the Fund uses a risk model to evaluate the stocks in which the Fund may invest and to inform the construction of a broadly diversified group of stocks.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">While Nuveen Asset Management generally invests in companies that meet the ESG criteria, it is not required to invest in every company that meets these criteria. In addition, concerns with respect to one ESG assessment category may not automatically eliminate an issuer from being considered an eligible Fund investment. The ESG criteria the Fund takes into consideration are non-fundamental investment policies and may be changed without the approval of the Fund’s shareholders.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">Investing on the basis of ESG criteria is qualitative and subjective by nature. There can be no assurance that every Fund investment will meet ESG criteria, or will do so at all times, or that the ESG criteria or any judgment exercised by Nuveen Asset Management will reflect the beliefs or values of any particular investor. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The Fund is not restricted from investing in any securities issued or guaranteed by the U.S. government or its agencies or instrumentalities. The Fund may also invest in securities issued by other countries or their agencies or instrumentalities as approved by the Board of Trustees. The Fund may invest up to 15% of its assets in foreign investments.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:13.0pt; font-family:Sans-Serif; text-align:left; color:#595959; font-weight:bold; font-style:normal;"><span style="font-size:4.0pt; font-family:Arial; font-style:normal; color:#595959; font-weight:normal; text-decoration:none;"> </span><a href="" id="x99x3"></a><span style="font-size:13.0pt; font-family:Sans-Serif; font-style:normal; color:#595959; font-weight:bold; text-decoration:none;">Principal investment risks</span></p><p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:normal;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">You could lose money over short or long periods by investing in this Fund. An investment in the Fund, due to the nature of the Fund’s portfolio holdings, typically is subject to the following principal investment risks:</span></p> You could lose money over short or long periods by investing in this Fund. <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">ESG Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that because the Fund’s ESG criteria exclude securities of certain issuers for nonfinancial reasons, the Fund may forgo some market opportunities available to funds that do not use these criteria.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Low-Carbon Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that because the Fund’s investment strategy includes a special emphasis on companies with low current carbon intensity and an absence of fossil fuel reserves ownership, the Fund’s portfolio might exclude certain issuers for nonfinancial reasons and the Fund may forgo some market opportunities that otherwise would be available.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Market Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that market prices of portfolio investments held by the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Fund may fluctuate rapidly or unpredictably due to a variety of factors, including</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;"> responses to government actions or interventions, or changing economic, political or market conditions. Market risk may affect a single issuer, industry or sector of the economy, or it may affect the market as a whole. Such conditions may add significantly to the risk of volatility in the net asset value (“NAV”) of the Fund’s shares and adversely affect the Fund and its investments. From time to time, the Fund may invest a significant portion of its assets in companies in one or more related sectors or industries, which would make the Fund more vulnerable to adverse developments affecting such sectors or industries. The Fund currently invests a significant portion of its assets in companies in the information technology sector, although this may change over time.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Issuer Risk </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">(often called</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;"> Financial Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">)—The risk that an issuer’s earnings prospects, credit rating and overall financial position will deteriorate, causing a decline in the value of the issuer’s financial instruments over short or extended periods of time. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Foreign Investment Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—Foreign markets can be more volatile than the U.S. market due to increased risks of adverse issuer, political, regulatory, currency, market or economic developments as well as armed conflicts and can result in greater price volatility and perform differently from financial instruments of U.S. issuers. This risk may be heightened in emerging or developing markets. Foreign investments may also have lower liquidity and be more difficult to value than investments in U.S. issuers. Foreign investments may also be subject to risk of loss because of more or less foreign government regulation, less public information, less stringent </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">investor protections and less stringent accounting, corporate governance, financial reporting and disclosure standards. Changes in the value of foreign currencies may make the return on an investment increase or decrease, unrelated to the quality or performance of the investment itself. The imposition of sanctions, exchange controls (including repatriation restrictions), confiscations, trade restrictions (including tariffs) and other restrictions by the United States or other governments may also negatively impact the Fund’s investments. Economic sanctions and other similar governmental actions or developments could, among other things, effectively restrict or eliminate the Fund’s ability to purchase or sell certain foreign securities or groups of foreign securities, and/or thus may make the Fund’s investments in such securities less liquid (or illiquid) or more difficult to value. The type and severity of sanctions and other measures that may be imposed could vary broadly in scope, and their impact is impossible to predict.</p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Large-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that large-capitalization companies are more mature and may grow more slowly than the economy as a whole and tend to go in and out of favor based on market and economic conditions. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Mid-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the stocks of mid-capitalization companies often experience greater price volatility, lower trading volume and lower overall liquidity than the stocks of larger, more established companies.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Small-Cap Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">The risk that the stocks of small-capitalization </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">companies often experience greater price volatility than large- or mid-sized companies because small-cap companies are often newer or less established than larger companies and are likely to have more limited resources, products and markets. Securities of small-cap companies often have lower overall liquidity than securities of larger companies as a result of there being a smaller market for their securities, which can have an adverse effect on the pricing of these securities and on the ability to sell these securities when Nuveen Asset Management deems it appropriate. </span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Active Management Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that Nuveen Asset Management’s strategy, investment selection or trading execution may cause the Fund to underperform relative to the benchmark index or mutual funds with similar investment objectives and/or strategies and may not produce the desired results or expected returns.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Benchmark Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that the Fund’s performance may not correspond to its benchmark index for any period of time and may underperform such index or the overall financial market. </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Additionally, to the extent that the Fund’s investments vary from the composition of its benchmark index, </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Fund’s performance could potentially vary from the index’s performance to a greater extent than if </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">the </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; color:#000000; font-weight:normal; text-decoration:none;">Fund merely attempted to replicate the index.</span></p> <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:-6.5pt; font-weight:normal; margin-left:18.75pt; font-style:normal;"><span style="font-size:7.0pt; font-family:Symbol; font-style:normal; font-weight:normal; text-decoration:none;">·</span><span style="word-spacing:4.25pt;"> </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:bold; text-decoration:none;">Quantitative Analysis Risk</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">—The risk that stocks selected using quantitative modeling and analysis could perform differently from the market as a whole and the risk that such quantitative analysis and modeling may not </span></p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; margin-left:18.75pt; text-decoration:none;">adequately take into account certain factors, may contain design flaws or inaccurate assumptions and may rely on inaccurate data inputs, which may result in losses to the Fund.</p> Past performance <p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. The bar chart shows the annual total returns of Class R6 of the Fund, before taxes, in each full calendar year for the last ten years. Because the expenses vary across share classes, the performance of Class R6 may vary from the other share classes. Below the bar chart are the best and worst returns of Class R6 for a calendar quarter during the full calendar-year periods covered by the bar chart. The performance table following the bar chart shows the Fund’s average annual total returns for Class R6, Class I, Premier Class, Retirement Class and Class A over the applicable one-year, five-year, ten-year and since-inception periods ended December 31, 2025, and how those returns compare to those of the Fund’s broad-based securities market and benchmark index. For periods prior to August 1, 2026, Teachers Advisors, LLC (“Advisors”) served as investment adviser to the Fund. After-tax performance is shown only for Class R6 shares, and after-tax returns for the other classes of shares will vary from the after-tax returns presented for Class R6 shares.</p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; text-decoration:none;">The returns shown below reflect previous agreements by Advisors, the Fund’s prior investment adviser, to waive or reimburse the Fund for certain fees and expenses. Without these waivers and reimbursements, the returns of the Fund would have been lower. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. The broad-based securities market and benchmark index listed below is unmanaged, and you cannot invest directly in an index. The returns for the broad-based securities market and benchmark index reflect no deduction for fees, expenses or taxes. </p><p style="margin-top:revert; margin-bottom:revert; font-size:9.5pt; font-family:Sans-Serif; text-align:left; text-indent:12.25pt; font-weight:normal; font-style:italic;"><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">For current performance information of each share class, including performance to the most recent month-end, please visit </span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;">www.nuveen.com/performance</span><span style="font-size:9.5pt; font-family:Sans-Serif; font-style:italic; font-weight:normal; text-decoration:none;"> or call 800-257-8787.</span></p> The following chart and table help illustrate some of the risks of investing in the Fund by showing changes in the Fund’s performance from year to year. Past performance of the Fund (before and after taxes) is not necessarily an indication of how it will perform in the future. www.nuveen.com/performance ANNUAL TOTAL RETURNS FOR CLASS R6 SHARES (%)Nuveen Large Cap Responsible Equity Fund <p style="margin-top:revert; margin-bottom:revert; font-size:1.0pt; font-family:Sans-Serif; text-align:left; font-weight:normal; font-style:normal;"><span style="font-size:8.5pt; font-family:Sans-Serif; font-style:normal; font-weight:normal; text-decoration:none;">Best quarter: 22.26%, for the quarter ended June 30, 2020. Worst quarter: -20.49%, for the quarter ended March 31, 2020.</span></p> Best quarter 0.2226 2020-06-30 Worst quarter -0.2049 2020-03-31 AVERAGE ANNUAL TOTAL RETURNS For the Periods Ended December 31, 2025 † 0.1661 0.1193 0.1368 0.1422 0.0957 0.1179 0.1086 0.0898 0.1087 0.1660 0.1184 0.1361 0.1647 0.1174 0.1350 0.1636 0.1165 0.1340 0.0963 0.1032 0.1271 S&P 500® Index (reflects no deductions for fees, expenses or taxes) 0.1788 0.1442 0.1482 Current performance of the Fund’s shares may be higher or lower than that shown above. <p style="font-size:8.5pt; font-family:Sans-Serif; text-align:left; font-weight:normal; text-decoration:none;">After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. Actual after-tax returns depend on the investor’s tax situation and may differ from those shown. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). After-tax returns are shown for only one class, and after-tax returns for other classes will vary.</p> After-tax returns are calculated using the historical highest individual federal marginal income tax rates in effect during the periods shown and do not reflect the impact of state and local taxes. The after-tax returns shown are not relevant to investors who hold their Fund shares through tax-deferred arrangements such as 401(a), 401(k) or 403(b) plans or Individual Retirement Accounts (IRAs). 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dei_LegalEntityAxis compact cik0001084380_S000005371Member ~ ~ http://xbrl.sec.gov/rr/role/PerformanceTableData column period compact * row dei_DocumentInformationDocumentAxis compact cik0001084380_S000005371Summary20Member row dei_LegalEntityAxis compact cik0001084380_S000005371Member row oef_ClassAxis compact * row oef_PerformanceMeasureAxis compact * ~ TIAA-CREF FUNDS 0.1276 0.2109 -0.0522 0.3087 0.2082 0.2563 -0.1917 0.2591 0.2371 0.1707 0.0705 0.3007 -0.0155 0.3627 0.3843 0.2752 -0.2917 0.4263 0.3328 0.185 0.1723 0.1362 -0.0831 0.2639 0.029 0.2502 -0.0754 0.1147 0.1427 0.1584 0.1187 0.2177 -0.0445 0.3142 0.1834 0.2864 -0.1812 0.2622 0.2494 0.1782 0.2158 0.1483 -0.1084 0.2553 0.2015 0.1489 -0.2029 0.1704 0.1157 0.1279 0.1106 0.3745 -0.1457 0.1857 0.1768 -0.0306 -0.2022 0.0923 0.0671 0.3413 0.0122 0.2532 -0.1325 0.2179 0.0814 0.113 -0.142 0.182 0.037 0.3158 0.0596 0.4545 -0.1811 0.2862 0.1823 -0.1662 -0.2002 0.1397 -0.0029 0.3605 0.0041 0.3294 -0.2343 0.2319 0.1582 0.1081 -0.1733 0.1689 0.04 0.3333 -0.0069 0.352 -0.173 0.3032 0.3266 0.0333 -0.2447 0.1542 0.0072 0.2039 0.3494 -0.2321 0.2078 0.0586 0.1164 -0.1834 0.1693 0.0506 0.3566 0.0112 0.2452 -0.1358 0.2331 0.0987 0.1194 -0.1478 0.1925 0.0318 0.2859 0.086 0.2396 -0.0711 0.3023 0.2053 0.2538 -0.2211 0.3279 0.2898 0.1411 -0.0085 0.3451 0.0004 0.3071 0.4424 0.1677 -0.3276 0.4704 0.2917 0.1559 0.186 0.1252 -0.141 0.2881 0.0359 0.2701 -0.0699 0.1431 0.148 0.1749 0.0195 0.2621 -0.0817 0.3339 0.4533 0.0295 -0.3308 0.2145 0.085 0.0448 0.174 0.1113 -0.1415 0.2705 -0.0419 0.3218 -0.1034 0.1139 0.1449 0.1022 0.1997 0.1501 -0.1197 0.2386 0.1282 0.2506 -0.1544 0.187 0.1626 0.1648 0.1963 -0.0757 0.2995 0.1599 0.3204 -0.1641 0.2095 0.1833 0.162 0.1351 0.2093 -0.0553 0.3149 0.2034 0.2646 -0.1777 0.2249 0.1824 0.1661 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Estimate is for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Estimate is for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Estimate is for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Estimate is for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. July 31, 2028 July 31, 2028 July 31, 2028 July 31, 2028 July 31, 2028 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 Restated to reflect estimate for the current fiscal year. Restated to reflect estimate for the current fiscal year. February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 February 28, 2027 ~ http://TIAA.com/20251031/role/RRRiskTable3 ~ ~ http://TIAA.com/20251031/role/RRRiskTable5 ~ ~ http://TIAA.com/20251031/role/RRRiskTable7 ~ ~ http://TIAA.com/20251031/role/RRRiskTable9 ~ ~ http://TIAA.com/20251031/role/RRRiskTable11 ~ ~ http://TIAA.com/20251031/role/RRRiskTable13 ~ ~ http://TIAA.com/20251031/role/RRRiskTable15 ~ ~ http://TIAA.com/20251031/role/RRRiskTable17 ~ ~ http://TIAA.com/20251031/role/RRRiskTable19 ~ ~ http://TIAA.com/20251031/role/RRRiskTable21 ~ ~ http://TIAA.com/20251031/role/RRRiskTable23 ~ ~ http://TIAA.com/20251031/role/RRRiskTable25 ~ ~ http://TIAA.com/20251031/role/RRRiskTable27 ~ ~ http://TIAA.com/20251031/role/RRRiskTable29 ~ ~ http://TIAA.com/20251031/role/RRRiskTable31 ~ ~ http://TIAA.com/20251031/role/RRRiskTable33 ~ ~ http://TIAA.com/20251031/role/RRRiskTable35 ~ ~ http://TIAA.com/20251031/role/RRRiskTable37 ~ ~ http://TIAA.com/20251031/role/RRRiskTable39 ~ ~ http://TIAA.com/20251031/role/RRRiskTable41 ~ Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.44% of average daily net assets for Class A shares; (ii) 0.24% of average daily net assets for Class I shares; (iii) 0.24% of average daily net assets for Premier Class shares; (iv) 0.09% of average daily net assets for Class R6 shares; (v) 0.34% of average daily net assets for Retirement Class shares; and (vi) 0.09% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Estimate is for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.24% of average daily net assets for Class I shares; (ii) 0.09% of average daily net assets for Class R6 shares; (iii) 0.34% of average daily net assets for Retirement Class shares; and (iv) 0.09% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. Restated to reflect estimate for the current fiscal year. Estimate is for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.24% of average daily net assets for Class I shares; (ii) 0.09% of average daily net assets for Class R6 shares; (iii) 0.34% of average daily net assets for Retirement Class shares; and (iv) 0.09% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. Restated to reflect estimate for the current fiscal year. Estimate is for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.24% of average daily net assets for Class I shares; (ii) 0.09% of average daily net assets for Class R6 shares; (iii) 0.34% of average daily net assets for Retirement Class shares; and (iv) 0.09% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. Restated to reflect estimate for the current fiscal year. Estimate is for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.24% of average daily net assets for Class I shares; (ii) 0.09% of average daily net assets for Class R6 shares; (iii) 0.34% of average daily net assets for Retirement Class shares; and (iv) 0.09% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Additionally, pursuant to a Shareholder Servicing Plan with respect to Class I shares, payments to financial intermediaries under the Shareholder Servicing Plan are subject to maximum rates and Teachers Advisors, LLC has agreed to reimburse the Fund if total Class I expenses (subject to certain exclusions) exceed certain specified amounts. Because of the Shareholder Servicing Plan, Total annual Fund operating expenses after fee waiver and/or expense reimbursement for Class I shares will be less than the expense limitation. The Board of Trustees must annually approve the continuance of, as well as any material changes to, the Shareholder Servicing Plan. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.56% of average daily net assets for Class A shares; (ii) 0.36% of average daily net assets for Class I shares; (iii) 0.36% of average daily net assets for Premier Class shares; (iv) 0.21% of average daily net assets for Class R6 shares; (v) 0.46% of average daily net assets for Retirement Class shares; and (vi) 0.21% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.30% of average daily net assets for Class I shares; (ii) 0.30% of average daily net assets for Premier Class shares; (iii) 0.15% of average daily net assets for Class R6 shares; (iv) 0.40% of average daily net assets for Retirement Class shares; and (v) 0.15% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 1.30% of average daily net assets for Class A shares; (ii) 1.10% of average daily net assets for Class I shares; (iii) 1.10% of average daily net assets for Premier Class shares; (iv) 0.95% of average daily net assets for Class R6 shares; (v) 1.20% of average daily net assets for Retirement Class shares; and (vi) 0.95% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.95% of average daily net assets for Class A shares; (ii) 0.75% of average daily net assets for Class I shares; (iii) 0.75% of average daily net assets for Premier Class shares; (iv) 0.60% of average daily net assets for Class R6 shares; (v) 0.85% of average daily net assets for Retirement Class shares; and (vi) 0.60% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 1.05% of average daily net assets for Class A shares; (ii) 0.85% of average daily net assets for Class I shares; (iii) 0.85% of average daily net assets for Premier Class shares; (iv) 0.70% of average daily net assets for Class R6 shares; (v) 0.95% of average daily net assets for Retirement Class shares; and (vi) 0.70% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 1.10% of average daily net assets for Class A shares; (ii) 0.90% of average daily net assets for Class I shares; (iii) 0.90% of average daily net assets for Premier Class shares; (iv) 0.75% of average daily net assets for Class R6 shares; (v) 1.00% of average daily net assets for Retirement Class shares; and (vi) 0.75% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.75% of average daily net assets for Class A shares; (ii) 0.55% of average daily net assets for Class I shares; (iii) 0.55% of average daily net assets for Premier Class shares; (iv) 0.40% of average daily net assets for Class R6 shares; and (v) 0.65% of average daily net assets for Retirement Class shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has also agreed to waive fees and/or reimburse expenses to reduce the maximum Total annual operating expenses detailed above for each class of the Fund by 0.13%. This waiver and/or reimbursement arrangement may be terminated or modified prior to July 31, 2028 only with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.87% of average daily net assets for Class A shares; (ii) 0.67% of average daily net assets for Class I shares; (iii) 0.67% of average daily net assets for Premier Class shares; (iv) 0.52% of average daily net assets for Class R6 shares; (v) 0.77% of average daily net assets for Retirement Class shares; and (vi) 0.52% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.87% of average daily net assets for Class A shares; (ii) 0.67% of average daily net assets for Class I shares; (iii) 0.67% of average daily net assets for Premier Class shares; (iv) 0.52% of average daily net assets for Class R6 shares; (v) 0.77% of average daily net assets for Retirement Class shares; and (vi) 0.52% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.87% of average daily net assets for Class A shares; (ii) 0.67% of average daily net assets for Class I shares; (iii) 0.67% of average daily net assets for Premier Class shares; (iv) 0.52% of average daily net assets for Class R6 shares; (v) 0.77% of average daily net assets for Retirement Class shares; and (vi) 0.52% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.90% of average daily net assets for Class A shares; (ii) 0.70% of average daily net assets for Class I shares; (iii) 0.70% of average daily net assets for Premier Class shares; (iv) 0.55% of average daily net assets for Class R6 shares; and (v) 0.80% of average daily net assets for Retirement Class shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.90% of average daily net assets for Class A shares; (ii) 0.70% of average daily net assets for Class I shares; (iii) 0.70% of average daily net assets for Premier Class shares; (iv) 0.55% of average daily net assets for Class R6 shares; and (v) 0.80% of average daily net assets for Retirement Class shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.88% of average daily net assets for Class A shares; (ii) 0.68% of average daily net assets for Class I shares; (iii) 0.68% of average daily net assets for Premier Class shares; (iv) 0.53% of average daily net assets for Class R6 shares; (v) 0.78% of average daily net assets for Retirement Class shares; and (vi) 0.53% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.88% of average daily net assets for Class A shares; (ii) 0.68% of average daily net assets for Class I shares; (iii) 0.68% of average daily net assets for Premier Class shares; (iv) 0.53% of average daily net assets for Class R6 shares; (v) 0.78% of average daily net assets for Retirement Class shares; and (vi) 0.53% of average daily net assets for Class W shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. Nuveen Fund Advisors has contractually agreed to waive and/or reimburse Class W’s Management fees and Other expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses, Trustee expenses and extraordinary expenses) in their entirety. Nuveen Fund Advisors expects these waiver and/or reimbursement arrangements to remain in effect indefinitely, unless changed or terminated with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024. Restated to reflect estimate for the current fiscal year. Under the Fund’s expense reimbursement arrangements, the Fund’s investment adviser, Nuveen Fund Advisors, LLC (“Nuveen Fund Advisors”), has contractually agreed to reimburse the Fund for any Total annual Fund operating expenses (excluding interest, taxes, brokerage commissions or other transactional expenses, Acquired fund fees and expenses and extraordinary expenses) that exceed: (i) 0.57% of average daily net assets for Class A shares; (ii) 0.37% of average daily net assets for Class I shares; (iii) 0.37% of average daily net assets for Premier Class shares; (iv) 0.22% of average daily net assets for Class R6 shares; and (v) 0.47% of average daily net assets for Retirement Class shares of the Fund. These expense reimbursement arrangements will continue through at least February 28, 2027, unless changed with approval of the Board of Trustees. The Class A average annual total returns have been restated to reflect a maximum up-front sales charge of 5.75% applicable to the purchase of Class A shares, which was effective as of May 6, 2024.