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  <xs:element id="twst_CommonStockNumberOfVotesPerShare" abstract="false" name="CommonStockNumberOfVotesPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="twst_SaleOfStockAggregateOfferingPrice" abstract="false" name="SaleOfStockAggregateOfferingPrice" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_SaleOfStockSalesAgentCommissionRate" abstract="false" name="SaleOfStockSalesAgentCommissionRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="twst_SaleOfStockAvailableRemainingCapacityAmount" abstract="false" name="SaleOfStockAvailableRemainingCapacityAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_PerformanceStockUnitMember" abstract="true" name="PerformanceStockUnitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_EmployeeMember" abstract="true" name="EmployeeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_TwoThousandAndTwentyFourStockPurchasePlanMember" abstract="true" name="TwoThousandAndTwentyFourStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingRollForward" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="twst_UnvestedRestrictedStockUnitsAndPerformanceStockUnitsMember" abstract="true" name="UnvestedRestrictedStockUnitsAndPerformanceStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_SharesSubjectToEmployeeStockPurchasePlanMember" abstract="true" name="SharesSubjectToEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_CostOfRevenueExcludingDepreciationAmortizationAndShareBasedCompensationExpense" abstract="false" name="CostOfRevenueExcludingDepreciationAmortizationAndShareBasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_ResearchAndDevelopmentExpenseExcludingDepreciationAmortizationAndShareBasedCompensationExpense" abstract="false" name="ResearchAndDevelopmentExpenseExcludingDepreciationAmortizationAndShareBasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_SellingGeneralAndAdministrativeExpenseExcludingDepreciationAmortizationAndShareBasedCompensationExpense" abstract="false" name="SellingGeneralAndAdministrativeExpenseExcludingDepreciationAmortizationAndShareBasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="twst_RobertChessMember" abstract="true" name="RobertChessMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_PatrickFinnMember" abstract="true" name="PatrickFinnMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="twst_EmilyLeproustMember" abstract="true" name="EmilyLeproustMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
