In 2017, the Company adopted the 2017 IPO Stock Incentive Plan (“Plan”), which governs the issuance of equity awards to employees, certain non-employee consultants, and directors. Initially, the Company reserved 900 thousand shares for issuance under the Plan with an initial sublimit for incentive stock options of 900 thousand shares. On an annual basis, the amount of shares available for issuance under the Plan increases by an amount equal to four percent of the total outstanding shares as of the last day of the preceding calendar year. The sublimit of incentive stock options is not subject to the increase. The Company has historically granted stock options, restricted stock awards (“RSAs”), restricted stock units (“RSUs”) and performance-based restricted stock units (“PSUs”) to certain employees.


	Stock Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value(1) (in thousands)
Outstanding as of December 31, 2025	2,030,417	$	99.45	6.8	$	298,662
Granted	323,080	$	280.66
Exercised	(302,747)	$	71.55
Cancelled or forfeited	(75,646)	$	162.08

Outstanding as of June 30, 2026	1,975,104	$	130.97	7.0	$	475,417
Exercisable as of June 30, 2026	1,193,485	$	82.51	5.8	$	345,113

(1)Aggregate intrinsic value represents the difference between the closing stock price of our common stock on December 31, 2025 and June 30, 2026 and the exercise price of outstanding in-the-money options on the respective date.


	Stock Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value(1) (in thousands)
Outstanding as of December 31, 2024	2,049,063	$	82.69	7.3	$	156,404
Granted	335,743	$	166.90
Exercised	(45,533)	$	71.56
Cancelled or forfeited	(63,985)	$	105.98

Outstanding as of June 30, 2025	2,275,288	$	94.68	7.1	$	117,142
Exercisable as of June 30, 2025	1,255,141	$	70.95	6.2	$	85,882

(1)Aggregate intrinsic value represents the difference between the closing stock price of our Common Stock on December 31, 2024 and June 30, 2025 and the exercise price of outstanding in-the-money options on the respective date.

The total intrinsic value (the amount by which the fair market value exceeds the exercise price) of stock options exercised was $30.4 million and $2.0 million during the three months ended June 30, 2026 and 2025, respectively, and $62.5 million and $3.4 million for the six months ended June 30, 2026 and 2025, respectively.

The weighted-average grant-date fair value per share of options granted to employees and directors was $196.07 and $87.69 during the three months ended June 30, 2026 and 2025, respectively, and $178.27 and $109.93 for the six months ended June 30, 2026 and 2025, respectively.

There was $90.6 million of unrecognized stock-based compensation expense related to employees’ and directors’ options that is expected to be recognized over a weighted-average period of 3.1 years as of June 30, 2026.


	Six Months Ended June 30,
	2026			2025
	Number of Shares	Weighted-Average Grant Date Fair Value		Number of Shares	Weighted-Average Grant Date Fair Value
Non-vested RSUs, beginning of period	331,574	$	152.97	308,096	$	135.22
Granted	96,522	$	275.69	133,756	$	178.66
Vested	(106,567)	$	143.58	(84,124)	$	129.58
Forfeited	(17,038)	$	167.39	(18,850)	$	148.92
Non-vested RSUs, end of period	304,491	$	194.35	338,878	$	153.01

There was $51.9 million of unrecognized stock-based compensation expense related to employees’ RSU awards that is expected to be recognized over a weighted-average period of 2.9 years as of June 30, 2026.


	Six Months Ended June 30,
	2026			2025
	Number of Shares	Weighted-Average Grant Date Fair Value		Number of Shares	Weighted-Average Grant Date Fair Value
Non-vested PSUs, beginning of period	56,250	$	159.47	137,500	$	145.37
Granted	43,536	$	275.64	—	$	—
Vested	(56,250)	$	159.47	(81,250)	$	135.61

Forfeited	—	$	—	—	$	—
Non-vested PSUs, end of period	43,536	$	275.64	56,250	$	159.47

PSUs granted during the period are subject to regulatory performance-based vesting conditions, as determined by the Compensation Committee of the Company’s Board of Directors, and vest on a three year cliff basis upon satisfaction of such conditions.

There was $10.7 million of unrecognized stock-based compensation expense related to employees’ PSU awards that is expected to be recognized over a weighted-average period of 2.7 years as of June 30, 2026.

The Company recorded stock-based compensation expense, net related to its stock options, RSUs and PSUs in the condensed consolidated statements of operations and comprehensive income for the three and six months ended June 30, 2026 and 2025 as follows:


	Three Months Ended June 30,			Six Months Ended June 30,
(in thousands)		2026		2025		2026		2025
Research and development		2,463		2,627		4,640		5,096
Selling, general and administrative		11,693		11,492		23,125		22,501
Total stock-based compensation		$	14,156	$	14,119	$	27,765	$	27,597

The Company capitalized into inventory stock-based compensation associated with the allocation of labor costs related to work performed to manufacture VYJUVEK of $1.1 million and $1.0 million for the three months ended June 30, 2026 and 2025, respectively, and $2.0 million and $1.9 million for the six months ended June 30, 2026 and 2025, respectively.