0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Description of the Business link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Basis of Presentation and Recent Accounting Standards link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Net Product Sales link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Other Revenue link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Collaboration Agreements and Research and Development Funding Arrangement link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Financial Instruments link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Property, Plant and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Other Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Credit Agreement link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Stock-Based Compensation and Share Repurchase Programs link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Net loss per Share link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Basis of Presentation and Recent Accounting Standards (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Basis of Presentation and Recent Accounting Standards (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Net Product Sales (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Other Revenue (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Property, Plant and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Other Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Stock-Based Compensation and Share Repurchase Programs (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Net loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Description of the Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Basis of Presentation and Recent Accounting Standards - Schedule of Components of Accumulated Other Comprehensive Income (Loss) (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Basis of Presentation and Recent Accounting Standards - Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Net Product Sales - Schedule of Revenue from External Customers by Geographic Areas (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Net Product Sales - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Net Product Sales - Schedule of Disaggregation of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Net Product Sales - Schedule of Changes in Balances of Receivables and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Other Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaboration Agreements and Research and Development Funding Arrangement (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Financial Instruments - Schedule of Cash and Available-for-Sale Securities by Significant Investment Category (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Financial Instruments - Schedule of Cash and Available-for-Sale Securities by Significant Investment Category (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Financial Instruments - Schedule of Amortized Cost and Estimated Fair Value of Marketable Securities, by Contractual Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Financial Instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Financial Instruments - Schedule of Unrealized Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Financial Instruments - Schedule of Financial Assets Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Inventory - Schedule of Inventory, Current (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Inventory - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Property, Plant and Equipment, Net - Schedule of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Property, Plant, and Equipment, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Other Balance Sheet Components -Schedule of Accounts, Notes, Loans and Financing Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Other Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Other Balance Sheet Components - Schedule of Other Non-Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Other Balance Sheet Components - Schedule of Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Other Balance Sheet Components - Schedule of Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Other Balance Sheet Components - Schedule of Other Non-Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Other Balance Sheet Components - Schedule of Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Leases - Schedule of Assets and Liabilities, Lessee (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Leases - Schedule of Minimum Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Leases - Schedule of Minimum Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Credit Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Commitments and Contingencies - Legal Proceedings (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Commitments and Contingencies - Indemnification Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Commitments and Contingencies - Licenses to Patented Technology (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Stock-Based Compensation and Share Repurchase Programs - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Stock-Based Compensation and Share Repurchase Programs - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Stock-Based Compensation and Share Repurchase Programs - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Net loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink