v3.26.1
NET PRODUCT REVENUES (Tables)
 6 Months Ended
Jun. 30, 2026
Revenue from Contract with Customer [Abstract]  
Schedule of Deferred Revenue Activity
Net product revenues, classified based on the geographic region in which the product is sold and by franchise (“TTR,” which includes AMVUTTRA and ONPATTRO, and “Rare,” which includes GIVLAARI and OXLUMO) consisted of the following:
Three Months Ended June 30,Six Months Ended June 30,
(In thousands)2026202520262025
AMVUTTRA
United States$809,079 $361,346 $1,511,633 $559,310 
Europe119,010 92,868 232,323 172,956 
Rest of World83,673 37,739 157,737 69,679 
Total1,011,762 491,953 1,901,693 801,945 
ONPATTRO
United States9,863 22,053 20,029 37,625 
Europe5,508 21,246 13,073 47,787 
Rest of World3,090 9,239 5,840 16,615 
Total18,461 52,538 38,942 102,027 
Total TTR
1,030,223 544,491 1,940,635 903,972 
GIVLAARI
United States58,000 55,151 107,091 98,945 
Europe24,323 20,966 44,613 39,510 
Rest of World7,441 4,732 12,454 9,362 
Total89,764 80,849 164,158 147,817 
OXLUMO
United States18,545 16,019 35,510 30,128 
Europe22,678 21,929 47,068 42,913 
Rest of World10,899 8,924 20,865 15,920 
Total52,122 46,872 103,443 88,961 
Total Rare
141,886 127,721 267,601 236,778 
Total net product revenues$1,172,109 $672,212 $2,208,236 $1,140,750 
Schedule of Balances and Activity in Each Product Revenue Allowance and Reserve Category
The following table summarizes balances and activity in each product revenue allowance and reserve category:
(In thousands)Chargebacks and Rebates
Other Incentives and Allowances
Total
Beginning balance as of December 31, 2025
$399,853 $25,797 $425,650 
Provision related to current year sales
602,876 62,545 665,421 
Provision related to prior years’ sales
(2,166)(992)(3,158)
Credit or payments made during the period for current year sales
(337,561)(42,398)(379,959)
Credit or payments made during the period for prior years’ sales
(189,730)(15,385)(205,115)
Total as of June 30, 2026
$473,272 $29,567 $502,839