<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019d485d-10ac-7da8-abc9-863df716d7b6,g:da05e22d-6622-44b5-adf3-9dd57366077a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="simple" xlink:href="bntx-20251231.xsd#ConsolidatedStatementsofProfitorLoss"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofProfitorLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-7ff4-9d87-be038c4aa03f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7195-a68d-0c07b91dbaea" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-7ff4-9d87-be038c4aa03f" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7195-a68d-0c07b91dbaea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_019d485d-14e3-792f-b124-8c3fb8fbf94a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-7ff4-9d87-be038c4aa03f" xlink:to="loc_ifrs-full_FinanceCosts_019d485d-14e3-792f-b124-8c3fb8fbf94a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_019d485d-14e3-7bbc-9289-31e4b27a6ba9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-7ff4-9d87-be038c4aa03f" xlink:to="loc_ifrs-full_FinanceIncome_019d485d-14e3-7bbc-9289-31e4b27a6ba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_019d485d-14e3-7fd1-87d4-067d235b76dc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-14e3-7e6e-876c-3677f337a3ed" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_019d485d-14e3-7fd1-87d4-067d235b76dc" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-14e3-7e6e-876c-3677f337a3ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-77f1-a255-6b26f9eadd82" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_019d485d-14e3-7fd1-87d4-067d235b76dc" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-77f1-a255-6b26f9eadd82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_019d485d-14e3-7f17-8db6-70b4dda0af75" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_019d485d-14e3-7f17-8db6-70b4dda0af75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_019d485d-14e3-73bc-b332-7e0546ea0cc6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_019d485d-14e3-73bc-b332-7e0546ea0cc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SalesAndMarketingExpense_019d485d-14e3-73a9-b399-5eec8e928b15" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SalesAndMarketingExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_SalesAndMarketingExpense_019d485d-14e3-73a9-b399-5eec8e928b15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_019d485d-14e3-7bec-b785-e787a4444047" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_019d485d-14e3-7bec-b785-e787a4444047" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_019d485d-14e3-7277-b922-c98ae9c850f4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_019d485d-14e3-7277-b922-c98ae9c850f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_019d485d-14e3-7da4-b676-55fcfaf1d884" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_CostOfSales_019d485d-14e3-7da4-b676-55fcfaf1d884" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019d485d-14e3-7fa5-bd66-a85d792f14ae" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019d485d-14e3-7af9-99bd-e639c0632457" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019d485d-14e3-7fa5-bd66-a85d792f14ae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="bntx-20251231.xsd#ConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_019d485d-14e3-7bb6-918b-6a6029fd4a67" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_019d485d-14e3-736f-9ec5-63b7255f875c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_019d485d-14e3-7bb6-918b-6a6029fd4a67" xlink:to="loc_ifrs-full_ProfitLoss_019d485d-14e3-736f-9ec5-63b7255f875c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_019d485d-14e3-727b-9ecf-aeffa0c62c03" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_019d485d-14e3-7bb6-918b-6a6029fd4a67" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_019d485d-14e3-727b-9ecf-aeffa0c62c03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7e47-accf-1e234cfd22e4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_019d485d-14e3-7bb2-8854-dd410b880107" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7e47-accf-1e234cfd22e4" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_019d485d-14e3-7bb2-8854-dd410b880107" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_019d485d-14e3-7fa8-b8bc-bca62da6a204" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7e47-accf-1e234cfd22e4" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_019d485d-14e3-7fa8-b8bc-bca62da6a204" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7f72-a805-c08ef97cfabf" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_019d485d-14e3-7104-b831-baccb8b31285" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7f72-a805-c08ef97cfabf" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_019d485d-14e3-7104-b831-baccb8b31285" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_019d485d-14e3-7efc-9871-555ec4622318" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7285-88a1-fdaac4e64039" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_019d485d-14e3-7efc-9871-555ec4622318" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7285-88a1-fdaac4e64039" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7d51-a3cf-1b5eb39cda06" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_019d485d-14e3-7efc-9871-555ec4622318" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019d485d-14e3-7d51-a3cf-1b5eb39cda06" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="simple" xlink:href="bntx-20251231.xsd#ConsolidatedStatementsofFinancialPosition"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofFinancialPosition" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_019d485d-14e3-7e3c-8c8d-72d38b278d0e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-7a82-96e6-0cdd8faaa155" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_019d485d-14e3-7e3c-8c8d-72d38b278d0e" xlink:to="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-7a82-96e6-0cdd8faaa155" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_019d485d-14e3-7a7c-aaed-392baa4ec301" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_019d485d-14e3-7e3c-8c8d-72d38b278d0e" xlink:to="loc_ifrs-full_CurrentAssets_019d485d-14e3-7a7c-aaed-392baa4ec301" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_019d485d-14e3-768b-8853-ed28ab7f745a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_019d485d-14e3-768b-8853-ed28ab7f745a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_019d485d-14e3-7803-8997-69552874d4cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialAssets_019d485d-14e3-7803-8997-69552874d4cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_019d485d-14e3-761b-8b7d-ec995ae05c0c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RightofuseAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_RightofuseAssets_019d485d-14e3-761b-8b7d-ec995ae05c0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_019d485d-14e3-73fa-9fd0-696d15ef1e25" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_019d485d-14e3-73fa-9fd0-696d15ef1e25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_019d485d-14e3-715b-a7f1-332e9a21655f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_DeferredTaxAssets_019d485d-14e3-715b-a7f1-332e9a21655f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsAndGoodwill_019d485d-14e3-7969-8792-0a7d49f87a8b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsAndGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_IntangibleAssetsAndGoodwill_019d485d-14e3-7969-8792-0a7d49f87a8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractAssets_019d485d-14e3-746b-97c4-ba1b7c5b4f3a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_NoncurrentContractAssets_019d485d-14e3-746b-97c4-ba1b7c5b4f3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_019d485d-14e3-7a0a-837e-56694fee2e8f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019d485d-14e3-77b4-a726-46bc96e4378c" xlink:to="loc_ifrs-full_Goodwill_019d485d-14e3-7a0a-837e-56694fee2e8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings_019d485d-14e3-708e-9191-d14736593e72" xlink:href="bntx-20251231.xsd#bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_bntx_NonCurrentLeaseLiabilitiesLoansAndBorrowings_019d485d-14e3-708e-9191-d14736593e72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_019d485d-14e3-719d-b6e3-4509d39f06a4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialLiabilities_019d485d-14e3-719d-b6e3-4509d39f06a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_019d485d-14e3-7fdb-85a1-d484b6c517d0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_019d485d-14e3-7fdb-85a1-d484b6c517d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_019d485d-14e3-707c-9862-c3e1765b1528" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_ifrs-full_NoncurrentProvisions_019d485d-14e3-707c-9862-c3e1765b1528" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_019d485d-14e3-751a-8210-e85ca3f0b6e9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_019d485d-14e3-751a-8210-e85ca3f0b6e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_019d485d-14e3-7935-bcab-1d5fde346b0a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-70b0-bdba-2ef1073e7363" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_019d485d-14e3-7935-bcab-1d5fde346b0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_019d485d-14e3-7121-8d3c-7d74ea70fee3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7902-ad46-07aeddbdf25d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_019d485d-14e3-7121-8d3c-7d74ea70fee3" xlink:to="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7902-ad46-07aeddbdf25d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-775a-a3ba-73fc32cfe538" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_019d485d-14e3-7121-8d3c-7d74ea70fee3" xlink:to="loc_ifrs-full_NoncurrentLiabilities_019d485d-14e3-775a-a3ba-73fc32cfe538" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentReceivables_019d485d-14e3-792a-b224-a648de837107" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentReceivables"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_019d485d-14e3-7dc3-948f-8beeb6512da7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:to="loc_ifrs-full_IssuedCapital_019d485d-14e3-7dc3-948f-8beeb6512da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CapitalReserve_019d485d-14e3-75de-8ca7-eb126f5312ea" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CapitalReserve"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:to="loc_ifrs-full_CapitalReserve_019d485d-14e3-75de-8ca7-eb126f5312ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_019d485d-14e3-7f22-a767-9e6686fdf045" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TreasuryShares"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:to="loc_ifrs-full_TreasuryShares_019d485d-14e3-7f22-a767-9e6686fdf045" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_019d485d-14e3-7849-8971-e915e1aa7527" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:to="loc_ifrs-full_RetainedEarnings_019d485d-14e3-7849-8971-e915e1aa7527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_019d485d-14e3-7ea0-b493-453145bdbbc4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019d485d-14e3-73b5-b699-3f50d909cd40" xlink:to="loc_ifrs-full_OtherReserves_019d485d-14e3-7ea0-b493-453145bdbbc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_019d485d-14e3-7960-8b2a-8f841683dbda" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_CurrentProvisions_019d485d-14e3-7960-8b2a-8f841683dbda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentLeaseLiabilitiesLoansAndBorrowings_019d485d-14e3-70f2-9e56-3f967584d74d" xlink:href="bntx-20251231.xsd#bntx_CurrentLeaseLiabilitiesLoansAndBorrowings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_bntx_CurrentLeaseLiabilitiesLoansAndBorrowings_019d485d-14e3-70f2-9e56-3f967584d74d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_019d485d-14e3-7ff3-bd84-f77beeeb09fb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_CurrentContractLiabilities_019d485d-14e3-7ff3-bd84-f77beeeb09fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_019d485d-14e3-7807-8203-4adbb94b0f75" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_019d485d-14e3-7807-8203-4adbb94b0f75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialLiabilities_019d485d-14e3-7c0a-b6da-2d4ce032547b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_OtherCurrentFinancialLiabilities_019d485d-14e3-7c0a-b6da-2d4ce032547b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_019d485d-14e3-7136-8874-67ebc20aecc1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_019d485d-14e3-7136-8874-67ebc20aecc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_019d485d-14e3-71a0-a5f7-d5dd57932784" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentNonfinancialLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019d485d-14e3-7d56-8718-ae3e654d3ec9" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_019d485d-14e3-71a0-a5f7-d5dd57932784" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentBiologicalAssets_019d485d-14e3-7b76-b7c2-de81a800b05f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentBiologicalAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_019d485d-14e3-7433-9f81-7515fe1dfdb1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Inventories"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_Inventories_019d485d-14e3-7433-9f81-7515fe1dfdb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_019d485d-14e3-7a07-937c-49efbe76ab6e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_019d485d-14e3-7a07-937c-49efbe76ab6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_019d485d-14e3-7fae-a298-df104f813f46" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_CashAndCashEquivalents_019d485d-14e3-7fae-a298-df104f813f46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractAssets_019d485d-14e3-732a-a965-da94610e8656" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_CurrentContractAssets_019d485d-14e3-732a-a965-da94610e8656" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_019d485d-14e3-7c95-9557-9418f3118e10" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_OtherCurrentFinancialAssets_019d485d-14e3-7c95-9557-9418f3118e10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialAssets_019d485d-14e3-7947-b2e4-508c5b015058" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentNonfinancialAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialAssets_019d485d-14e3-7947-b2e4-508c5b015058" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_019d485d-14e3-70da-9eae-0e51503ea269" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019d485d-14e3-7d4a-8911-746242504788" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_019d485d-14e3-70da-9eae-0e51503ea269" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_019d485d-14e3-78ec-b38d-0620ab6e790c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_019d485d-14e3-7a3b-b68a-45feae318b52" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_019d485d-14e3-78ec-b38d-0620ab6e790c" xlink:to="loc_ifrs-full_Liabilities_019d485d-14e3-7a3b-b68a-45feae318b52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_019d485d-14e3-77ca-bc98-646c0092a89a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_019d485d-14e3-78ec-b38d-0620ab6e790c" xlink:to="loc_ifrs-full_Equity_019d485d-14e3-77ca-bc98-646c0092a89a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="bntx-20251231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_019d485d-14e3-7bd4-9d51-34172ab3c9bd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_019d485d-14e3-7bd4-9d51-34172ab3c9bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_019d485d-14e3-7a92-af69-1b8ed94941bb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_019d485d-14e3-7a92-af69-1b8ed94941bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_019d485d-14e3-79d5-9ca3-57b372da1fa2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_019d485d-14e3-79d5-9ca3-57b372da1fa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities_019d485d-14e3-7e1d-9bdf-ebfc65443add" xlink:href="bntx-20251231.xsd#bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:to="loc_bntx_ShareRepurchaseProgramClassifiedAsFinancingActivities_019d485d-14e3-7e1d-9bdf-ebfc65443add" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsForShareIssueCosts_019d485d-14e3-7408-a0d8-db119e9b3963" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsForShareIssueCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-7fb1-9cda-ddc9146b3d26" xlink:to="loc_ifrs-full_PaymentsForShareIssueCosts_019d485d-14e3-7408-a0d8-db119e9b3963" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_019d485d-14e3-7593-ae45-12cc036e3a66" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_019d485d-14e3-7593-ae45-12cc036e3a66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_019d485d-14e3-739f-a022-c388928f17f5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_019d485d-14e3-739f-a022-c388928f17f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_019d485d-14e3-7f59-ba1c-af9ddbce4248" xlink:href="bntx-20251231.xsd#bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_bntx_AdjustmentsForIncreaseDecreaseInTradePayablesOtherLiabilitiesContractLiabilitiesAndProvisions_019d485d-14e3-7f59-ba1c-af9ddbce4248" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncome_019d485d-14e3-7c27-a97c-9f6c2805b074" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForFinanceIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncome_019d485d-14e3-7c27-a97c-9f6c2805b074" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_019d485d-14e3-7fa8-8730-009d465b6be0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_019d485d-14e3-7fa8-8730-009d465b6be0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-77a9-8dc4-75d658981983" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_019d485d-14e3-77a9-8dc4-75d658981983" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_019d485d-14e3-72b6-912c-e31d88f04b98" xlink:href="bntx-20251231.xsd#bntx_AdjustmentsForMovementsInGovernmentGrants"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_bntx_AdjustmentsForMovementsInGovernmentGrants_019d485d-14e3-72b6-912c-e31d88f04b98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_019d485d-14e3-7af5-88fe-cea7a77c43c2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_019d485d-14e3-7af5-88fe-cea7a77c43c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_019d485d-14e3-7fcf-a2c8-de04a13128d9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_019d485d-14e3-7fcf-a2c8-de04a13128d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_019d485d-14e3-7488-b96c-6631a603557b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_019d485d-14e3-7488-b96c-6631a603557b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_019d485d-14e3-73de-96f8-89382149cb96" xlink:href="bntx-20251231.xsd#bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_bntx_AdjustmentsForDecreaseIncreaseInTradeAccountsReceivableContractAssetsAndOtherAssets_019d485d-14e3-73de-96f8-89382149cb96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_019d485d-14e3-70e8-a9e7-ad684eb42b9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_019d485d-14e3-70e8-a9e7-ad684eb42b9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_019d485d-14e3-7597-b0d8-14bf746994e8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_019d485d-14e3-7597-b0d8-14bf746994e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_019d485d-14e3-7850-9d4f-914e7cd67ffc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_019d485d-14e3-7850-9d4f-914e7cd67ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_019d485d-14e3-7cb2-bf98-ab34843ce87e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_GainsLossesOnFinancialLiabilitiesAtFairValueThroughProfitOrLoss_019d485d-14e3-7cb2-bf98-ab34843ce87e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ShareBasedPaymentsClassifiedAsOperatingActivities_019d485d-14e3-7a04-bf43-fae0b6e3e9c6" xlink:href="bntx-20251231.xsd#bntx_ShareBasedPaymentsClassifiedAsOperatingActivities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_bntx_ShareBasedPaymentsClassifiedAsOperatingActivities_019d485d-14e3-7a04-bf43-fae0b6e3e9c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_GovernmentGrantsReceived_019d485d-14e3-70a5-8afa-e85b7de0ea7a" xlink:href="bntx-20251231.xsd#bntx_GovernmentGrantsReceived"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_bntx_GovernmentGrantsReceived_019d485d-14e3-70a5-8afa-e85b7de0ea7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_019d485d-14e3-746e-ac58-a7be29c967ec" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-79eb-af63-5b717d5dbf5a" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_019d485d-14e3-746e-ac58-a7be29c967ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities_019d485d-14e3-796d-8f2c-ec68aa8ee49c" xlink:href="bntx-20251231.xsd#bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_bntx_InvestmentProceedsFromMaturityOfOtherFinancialAssetsClassifiedAsInvestingActivities_019d485d-14e3-796d-8f2c-ec68aa8ee49c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019d485d-14e3-7758-974c-9f70ce535ddc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019d485d-14e3-7758-974c-9f70ce535ddc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities_019d485d-14e3-7935-afe0-eb1514c7861b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireInterestsInJointVenturesClassifiedAsInvestingActivities_019d485d-14e3-7935-afe0-eb1514c7861b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_019d485d-14e3-7144-b591-c789ef639d13" xlink:href="bntx-20251231.xsd#bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_bntx_PurchaseOfIntangibleAssetsAndRightOfUseAssetsClassifiedAsInvestingActivities_019d485d-14e3-7144-b591-c789ef639d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_019d485d-14e3-7031-8e42-55025b6d9649" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_019d485d-14e3-7031-8e42-55025b6d9649" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019d485d-14e3-70b9-a14a-7bc947283cdc" xlink:href="bntx-20251231.xsd#bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-7012-88e8-c24305b521e4" xlink:to="loc_bntx_ProceedsPaymentsFromSalesOrDestructionsOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019d485d-14e3-70b9-a14a-7bc947283cdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_019d485d-14e3-7179-915d-7a826233516f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-709a-86f0-c08d0009ebb8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_019d485d-14e3-7179-915d-7a826233516f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019d485d-14e3-709a-86f0-c08d0009ebb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-7bf0-b5c1-4a50d7ca495f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_019d485d-14e3-7179-915d-7a826233516f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019d485d-14e3-7bf0-b5c1-4a50d7ca495f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-790a-bf98-346ceb9025e5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_019d485d-14e3-7179-915d-7a826233516f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019d485d-14e3-790a-bf98-346ceb9025e5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7e4c-bba1-d2c130b788cd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_019d485d-15cb-7c24-ab59-6e3b37819991" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7e4c-bba1-d2c130b788cd" xlink:to="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_019d485d-15cb-7c24-ab59-6e3b37819991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GoodwillRecognisedAsOfAcquisitionDate_019d485d-15cb-739e-9223-b05c80a81b60" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GoodwillRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7e4c-bba1-d2c130b788cd" xlink:to="loc_ifrs-full_GoodwillRecognisedAsOfAcquisitionDate_019d485d-15cb-739e-9223-b05c80a81b60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_BargainFromTheAcquisitionAcquisitionDateFairValue_019d485d-15cb-7dbf-bec6-f969d164e00a" xlink:href="bntx-20251231.xsd#bntx_BargainFromTheAcquisitionAcquisitionDateFairValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7e4c-bba1-d2c130b788cd" xlink:to="loc_bntx_BargainFromTheAcquisitionAcquisitionDateFairValue_019d485d-15cb-7dbf-bec6-f969d164e00a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a60-9054-e3e10a63a2d7" xlink:href="bntx-20251231.xsd#bntx_AssetsRecognisedAsOfAcquisitionDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a9b-b123-59a8b1af42e4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a60-9054-e3e10a63a2d7" xlink:to="loc_ifrs-full_IdentifiableIntangibleAssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a9b-b123-59a8b1af42e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate_019d485d-15cb-79b9-8824-64298b7709ff" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a60-9054-e3e10a63a2d7" xlink:to="loc_ifrs-full_PropertyPlantAndEquipmentRecognisedAsOfAcquisitionDate_019d485d-15cb-79b9-8824-64298b7709ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate_019d485d-15cb-7f33-a52a-1dddf2b30167" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a60-9054-e3e10a63a2d7" xlink:to="loc_ifrs-full_CashAndCashEquivalentsRecognisedAsOfAcquisitionDate_019d485d-15cb-7f33-a52a-1dddf2b30167" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherAssetsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate_019d485d-15cb-7083-ba35-68e8a7ed9642" xlink:href="bntx-20251231.xsd#bntx_OtherAssetsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-7a60-9054-e3e10a63a2d7" xlink:to="loc_bntx_OtherAssetsNonCurrentAndCurrentRecognisedAsOfAcquisitionDate_019d485d-15cb-7083-ba35-68e8a7ed9642" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_019d485d-15cb-7d98-a3a3-6174b05620c0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7ec5-8de5-4e56462eed77" xlink:href="bntx-20251231.xsd#bntx_LiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_019d485d-15cb-7d98-a3a3-6174b05620c0" xlink:to="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7ec5-8de5-4e56462eed77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-73dd-ac0b-664c9143a9a3" xlink:href="bntx-20251231.xsd#bntx_AssetsRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IdentifiableAssetsAcquiredLiabilitiesAssumed_019d485d-15cb-7d98-a3a3-6174b05620c0" xlink:to="loc_bntx_AssetsRecognisedAsOfAcquisitionDate_019d485d-15cb-73dd-ac0b-664c9143a9a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-78b5-8616-82ae6d83674b" xlink:href="bntx-20251231.xsd#bntx_LiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7c51-8a4f-e955447d2542" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-78b5-8616-82ae6d83674b" xlink:to="loc_ifrs-full_NoncurrentLiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7c51-8a4f-e955447d2542" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7227-a662-e74b646759ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilitiesRecognisedAsOfAcquisitionDate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_LiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-78b5-8616-82ae6d83674b" xlink:to="loc_ifrs-full_CurrentLiabilitiesRecognisedAsOfAcquisitionDate_019d485d-15cb-7227-a662-e74b646759ca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails_1" xlink:type="simple" xlink:href="bntx-20251231.xsd#BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/BusinessCombinationsSummaryofFairValuesofIdentifiableNetAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7dec-b554-9c3a26a522c1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasePriceAcquisitionDateFairValue_019d485d-15cb-75f1-824b-da18a0e8604d" xlink:href="bntx-20251231.xsd#bntx_PurchasePriceAcquisitionDateFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7dec-b554-9c3a26a522c1" xlink:to="loc_bntx_PurchasePriceAcquisitionDateFairValue_019d485d-15cb-75f1-824b-da18a0e8604d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PreviouslyHeldNonListedEquityInvestment_019d485d-15cb-769e-8338-5f610c50357f" xlink:href="bntx-20251231.xsd#bntx_PreviouslyHeldNonListedEquityInvestment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AcquisitiondateFairValueOfTotalConsiderationTransferred_019d485d-15cb-7dec-b554-9c3a26a522c1" xlink:to="loc_bntx_PreviouslyHeldNonListedEquityInvestment_019d485d-15cb-769e-8338-5f610c50357f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractAssetsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#RevenuesfromContractswithCustomersContractAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContractAssets_019d485d-15cb-73b3-bc2b-8239da069dab" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractAssets_019d485d-15cb-7c6d-9175-7b4c038acef6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractAssets_019d485d-15cb-73b3-bc2b-8239da069dab" xlink:to="loc_ifrs-full_CurrentContractAssets_019d485d-15cb-7c6d-9175-7b4c038acef6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractAssets_019d485d-15cb-7b6d-87f0-17429c97211d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractAssets_019d485d-15cb-73b3-bc2b-8239da069dab" xlink:to="loc_ifrs-full_NoncurrentContractAssets_019d485d-15cb-7b6d-87f0-17429c97211d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_019d485d-15cb-77ca-823c-483ef18fd1a9" xlink:href="bntx-20251231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets_019d485d-15cb-7683-a3f5-0b0258bedb61" xlink:href="bntx-20251231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_019d485d-15cb-77ca-823c-483ef18fd1a9" xlink:to="loc_bntx_ReclassificationIoTradeAccountsReceivablesCurrentContractAssets_019d485d-15cb-7683-a3f5-0b0258bedb61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets_019d485d-15cb-75fb-b813-55f0a8bc0a44" xlink:href="bntx-20251231.xsd#bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationIoTradeAccountsReceivablesContractAssets_019d485d-15cb-77ca-823c-483ef18fd1a9" xlink:to="loc_bntx_ReclassificationIoTradeAccountsReceivablesNonCurrentContractAssets_019d485d-15cb-75fb-b813-55f0a8bc0a44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInContractAssets_019d485d-15cb-7500-a24d-a5867f10f94d" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInCurrentContractAssets_019d485d-15cb-7f3a-be19-44f8b23b786d" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractAssets_019d485d-15cb-7500-a24d-a5867f10f94d" xlink:to="loc_bntx_IncreaseDecreaseInCurrentContractAssets_019d485d-15cb-7f3a-be19-44f8b23b786d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInNonCurrentContractAssets_019d485d-15cb-77ea-b55c-9688d7213958" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractAssets_019d485d-15cb-7500-a24d-a5867f10f94d" xlink:to="loc_bntx_IncreaseDecreaseInNonCurrentContractAssets_019d485d-15cb-77ea-b55c-9688d7213958" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_019d485d-15cb-7520-a97a-4882c1597569" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentContractAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets_019d485d-15cb-7b60-b66c-ec0031cdf8f5" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_019d485d-15cb-7520-a97a-4882c1597569" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractAssets_019d485d-15cb-7b60-b66c-ec0031cdf8f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets_019d485d-15cb-7193-812a-cb2ad73c19c0" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractAssets_019d485d-15cb-7520-a97a-4882c1597569" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractAssets_019d485d-15cb-7193-812a-cb2ad73c19c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-74e0-aeb9-f500fc6b8655" xlink:href="bntx-20251231.xsd#bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-77b6-80ec-1726ef50fd45" xlink:href="bntx-20251231.xsd#bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-74e0-aeb9-f500fc6b8655" xlink:to="loc_bntx_CurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-77b6-80ec-1726ef50fd45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-7a7b-8025-4b51a4801893" xlink:href="bntx-20251231.xsd#bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-74e0-aeb9-f500fc6b8655" xlink:to="loc_bntx_NonCurrentContractAssetsAttibutableToPerformanceObligationsSatisfiedInPriorPeriods_019d485d-15cb-7a7b-8025-4b51a4801893" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#RevenuesfromContractswithCustomersContractLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RevenuesfromContractswithCustomersContractLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInContractLiabilities_019d485d-15cb-7b92-b451-8496e7d4a5d8" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilities_019d485d-15cb-7463-8a92-0872795f5d73" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInNonCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilities_019d485d-15cb-7b92-b451-8496e7d4a5d8" xlink:to="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilities_019d485d-15cb-7463-8a92-0872795f5d73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInCurrentContractLiabilities_019d485d-15cb-7395-8111-845ed00c4915" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilities_019d485d-15cb-7b92-b451-8496e7d4a5d8" xlink:to="loc_bntx_IncreaseDecreaseInCurrentContractLiabilities_019d485d-15cb-7395-8111-845ed00c4915" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_019d485d-15cb-7631-8fc0-8e5ad37eee24" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentContractLiabilitesRecognizedAsRevenue_019d485d-15cb-7417-8e7a-0129f1a91235" xlink:href="bntx-20251231.xsd#bntx_CurrentContractLiabilitesRecognizedAsRevenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_019d485d-15cb-7631-8fc0-8e5ad37eee24" xlink:to="loc_bntx_CurrentContractLiabilitesRecognizedAsRevenue_019d485d-15cb-7417-8e7a-0129f1a91235" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonCurrentContractLiabilitesRecognizedAsRevenue_019d485d-15cb-7589-9615-c4e6ecdc32d9" xlink:href="bntx-20251231.xsd#bntx_NonCurrentContractLiabilitesRecognizedAsRevenue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_DecreaseThroughPerformanceObligationBeingSatisfiedContractLiabilities_019d485d-15cb-7631-8fc0-8e5ad37eee24" xlink:to="loc_bntx_NonCurrentContractLiabilitesRecognizedAsRevenue_019d485d-15cb-7589-9615-c4e6ecdc32d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContractLiabilities_019d485d-15cb-7f8f-9b03-6d7b11ad2c22" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_019d485d-15cb-7179-9655-19dfb8459b0d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractLiabilities_019d485d-15cb-7f8f-9b03-6d7b11ad2c22" xlink:to="loc_ifrs-full_CurrentContractLiabilities_019d485d-15cb-7179-9655-19dfb8459b0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_019d485d-15cb-7472-9cd4-fbd0cc7db115" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ContractLiabilities_019d485d-15cb-7f8f-9b03-6d7b11ad2c22" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_019d485d-15cb-7472-9cd4-fbd0cc7db115" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_019d485d-15cb-7a42-a28d-550730a8d247" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities_019d485d-15cb-7431-8034-46af17686c1d" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_019d485d-15cb-7a42-a28d-550730a8d247" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentCurrentContractLiabilities_019d485d-15cb-7431-8034-46af17686c1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities_019d485d-15cb-716d-87e8-755b317b4f8d" xlink:href="bntx-20251231.xsd#bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_ReclassificationFromNonCurrentToCurrentContractLiabilities_019d485d-15cb-7a42-a28d-550730a8d247" xlink:to="loc_bntx_ReclassificationFromNonCurrentToCurrentNonCurrentContractLiabilities_019d485d-15cb-716d-87e8-755b317b4f8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfContractLiabilities_019d485d-15cb-71bd-adc4-f1cbd235e05e" xlink:href="bntx-20251231.xsd#bntx_CurrencyEffectsOfContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfCurrentContractLiabilities_019d485d-15cb-725c-9bc4-c2d52b0616dc" xlink:href="bntx-20251231.xsd#bntx_CurrencyEffectsOfCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_CurrencyEffectsOfContractLiabilities_019d485d-15cb-71bd-adc4-f1cbd235e05e" xlink:to="loc_bntx_CurrencyEffectsOfCurrentContractLiabilities_019d485d-15cb-725c-9bc4-c2d52b0616dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrencyEffectsOfNonCurrentContractLiabilities_019d485d-15cb-76b9-b2c3-b3a88ec80790" xlink:href="bntx-20251231.xsd#bntx_CurrencyEffectsOfNonCurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_CurrencyEffectsOfContractLiabilities_019d485d-15cb-71bd-adc4-f1cbd235e05e" xlink:to="loc_bntx_CurrencyEffectsOfNonCurrentContractLiabilities_019d485d-15cb-76b9-b2c3-b3a88ec80790" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInContractLiabilitiesFromBusinessCombinations_019d485d-15cb-7d02-b5be-42a177f772a9" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInContractLiabilitiesFromBusinessCombinations"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInCurrentContractLiabilitiesFromBusinessCombinations_019d485d-15cb-798c-9678-0c485680b8c9" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInCurrentContractLiabilitiesFromBusinessCombinations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilitiesFromBusinessCombinations_019d485d-15cb-7d02-b5be-42a177f772a9" xlink:to="loc_bntx_IncreaseDecreaseInCurrentContractLiabilitiesFromBusinessCombinations_019d485d-15cb-798c-9678-0c485680b8c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilitiesFromBusinessCombinations_019d485d-15cb-73d2-a0f4-df72a56fe6e7" xlink:href="bntx-20251231.xsd#bntx_IncreaseDecreaseInNonCurrentContractLiabilitiesFromBusinessCombinations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IncreaseDecreaseInContractLiabilitiesFromBusinessCombinations_019d485d-15cb-7d02-b5be-42a177f772a9" xlink:to="loc_bntx_IncreaseDecreaseInNonCurrentContractLiabilitiesFromBusinessCombinations_019d485d-15cb-73d2-a0f4-df72a56fe6e7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesOtherOperatingResultDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#IncomeandExpensesOtherOperatingResultDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesOtherOperatingResultDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_019d485d-15cc-7cd5-a6c9-4e29dbdba317" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_019d485d-15cc-780b-9b73-5510fd5989ee" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_019d485d-15cc-7cd5-a6c9-4e29dbdba317" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_019d485d-15cc-780b-9b73-5510fd5989ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019d485d-15cc-78d1-9c38-f9470e1c8f2a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_019d485d-15cc-7cd5-a6c9-4e29dbdba317" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019d485d-15cc-78d1-9c38-f9470e1c8f2a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#IncomeandExpensesFinanceIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesFinanceIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_019d485d-15cc-7246-b1b5-46be3cc9022d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeLoss_019d485d-15cc-7b26-91d7-be0c167fb3c2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NetForeignExchangeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019d485d-15cc-7246-b1b5-46be3cc9022d" xlink:to="loc_ifrs-full_NetForeignExchangeLoss_019d485d-15cc-7b26-91d7-be0c167fb3c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpense_019d485d-15cc-7de4-8ce2-b4ee5a661f18" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019d485d-15cc-7246-b1b5-46be3cc9022d" xlink:to="loc_ifrs-full_InterestExpense_019d485d-15cc-7de4-8ce2-b4ee5a661f18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinanceCost_019d485d-15cc-70b4-8532-1724f31fa3ab" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherFinanceCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019d485d-15cc-7246-b1b5-46be3cc9022d" xlink:to="loc_ifrs-full_OtherFinanceCost_019d485d-15cc-70b4-8532-1724f31fa3ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_019d485d-15cc-7a4f-ae78-f9c20d9f6c9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_019d485d-15cc-770e-9bc8-a2ec8c562323" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_019d485d-15cc-7a4f-ae78-f9c20d9f6c9f" xlink:to="loc_ifrs-full_FinanceIncome_019d485d-15cc-770e-9bc8-a2ec8c562323" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_019d485d-15cc-7308-bef9-d2d9f88aae3f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_019d485d-15cc-7a4f-ae78-f9c20d9f6c9f" xlink:to="loc_ifrs-full_FinanceCosts_019d485d-15cc-7308-bef9-d2d9f88aae3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_019d485d-15cc-7d85-a950-6026edc0b5fc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueCalculatedUsingEffectiveInterestMethod_019d485d-15cc-763c-bc71-0d872f13678e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestRevenueCalculatedUsingEffectiveInterestMethod"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_019d485d-15cc-7d85-a950-6026edc0b5fc" xlink:to="loc_ifrs-full_InterestRevenueCalculatedUsingEffectiveInterestMethod_019d485d-15cc-763c-bc71-0d872f13678e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinanceIncome_019d485d-15cc-78e4-90f2-a3a1e37215e9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherFinanceIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_019d485d-15cc-7d85-a950-6026edc0b5fc" xlink:to="loc_ifrs-full_OtherFinanceIncome_019d485d-15cc-78e4-90f2-a3a1e37215e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeGain_019d485d-15cc-7cf0-8f85-4def329f66ba" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NetForeignExchangeGain"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_019d485d-15cc-7d85-a950-6026edc0b5fc" xlink:to="loc_ifrs-full_NetForeignExchangeGain_019d485d-15cc-7cf0-8f85-4def329f66ba" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeandExpensesSummaryofEmployeeBenefitsExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EmployeeBenefitsExpense_019d485d-15cc-7b7a-9487-06fcddf84397" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SocialSecurityContributions_019d485d-15cc-75ff-9c87-54ff4c0cb5e0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SocialSecurityContributions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019d485d-15cc-7b7a-9487-06fcddf84397" xlink:to="loc_ifrs-full_SocialSecurityContributions_019d485d-15cc-75ff-9c87-54ff4c0cb5e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_019d485d-15cc-7e4a-8cd7-0550a41a0813" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019d485d-15cc-7b7a-9487-06fcddf84397" xlink:to="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_019d485d-15cc-7e4a-8cd7-0550a41a0813" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WagesAndSalaries_019d485d-15cc-7dba-8afc-6dceb4381882" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WagesAndSalaries"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019d485d-15cc-7b7a-9487-06fcddf84397" xlink:to="loc_ifrs-full_WagesAndSalaries_019d485d-15cc-7dba-8afc-6dceb4381882" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofCurrentandDeferredTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-7204-a435-38e4ea83e87d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxExpenseIncome_019d485d-15cc-7d7e-8d69-102f9ef6afe4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DeferredTaxExpenseIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-7204-a435-38e4ea83e87d" xlink:to="loc_ifrs-full_DeferredTaxExpenseIncome_019d485d-15cc-7d7e-8d69-102f9ef6afe4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxExpenseIncome_019d485d-15cc-7343-9bdb-6a160966e244" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxExpenseIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-7204-a435-38e4ea83e87d" xlink:to="loc_ifrs-full_CurrentTaxExpenseIncome_019d485d-15cc-7343-9bdb-6a160966e244" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/IncomeTaxSummaryofReconciliationofExpectedIncomeTaxBenefittoActualIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectFromChangeInTaxRate_019d485d-15cc-74b5-b7fc-70cb2b163042" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TaxEffectFromChangeInTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_TaxEffectFromChangeInTaxRate_019d485d-15cc-74b5-b7fc-70cb2b163042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_019d485d-15cc-7905-8840-dfc2ecc48ba8" xlink:href="bntx-20251231.xsd#bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_NonRecognitionOfTaxEffectOnShareBasedPaymentExpenses_019d485d-15cc-7905-8840-dfc2ecc48ba8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_019d485d-15cc-7f02-9f4e-434f1ac4fc9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TaxExpenseIncomeAtApplicableTaxRate"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_TaxExpenseIncomeAtApplicableTaxRate_019d485d-15cc-7f02-9f4e-434f1ac4fc9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectiveEquityTransactionCosts_019d485d-15cc-7674-8b6d-69b0603fac8e" xlink:href="bntx-20251231.xsd#bntx_TaxEffectiveEquityTransactionCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_TaxEffectiveEquityTransactionCosts_019d485d-15cc-7674-8b6d-69b0603fac8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_019d485d-15cc-7a5d-bc0a-39a1122b52dd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_OtherTaxEffectsForReconciliationBetweenAccountingProfitAndTaxExpenseIncome_019d485d-15cc-7a5d-bc0a-39a1122b52dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_019d485d-15cc-7993-bfe9-d6d5ad0df2c3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_AdjustmentsForCurrentTaxOfPriorPeriod_019d485d-15cc-7993-bfe9-d6d5ad0df2c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_NonTaxEffectiveBargainPurchase_019d485d-15cc-7fbd-94f5-6c10528fc619" xlink:href="bntx-20251231.xsd#bntx_NonTaxEffectiveBargainPurchase"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_NonTaxEffectiveBargainPurchase_019d485d-15cc-7fbd-94f5-6c10528fc619" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectNonTaxEffectiveIncome_019d485d-15cc-75d1-b569-0f4331d567bf" xlink:href="bntx-20251231.xsd#bntx_TaxEffectNonTaxEffectiveIncome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_TaxEffectNonTaxEffectiveIncome_019d485d-15cc-75d1-b569-0f4331d567bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfChangeInValuationAllowance_019d485d-15cc-7ce0-8d98-17067953ea82" xlink:href="bntx-20251231.xsd#bntx_TaxEffectOfChangeInValuationAllowance"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_TaxEffectOfChangeInValuationAllowance_019d485d-15cc-7ce0-8d98-17067953ea82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfForeignTaxRates_019d485d-15cc-77a8-83b9-c899f858b343" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TaxEffectOfForeignTaxRates"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_TaxEffectOfForeignTaxRates_019d485d-15cc-77a8-83b9-c899f858b343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions_019d485d-15cc-7287-aba8-20435b3446b8" xlink:href="bntx-20251231.xsd#bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_TaxEffectOfExpenseNotDeductibleInDeterminingTaxableProfitTaxLossNetOfAddiitonalDeductions_019d485d-15cc-7287-aba8-20435b3446b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_019d485d-15cc-7fe3-8ced-fa26c2f7b346" xlink:href="bntx-20251231.xsd#bntx_TaxEffectOfDeviationDueToLocalTaxBasis"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_bntx_TaxEffectOfDeviationDueToLocalTaxBasis_019d485d-15cc-7fe3-8ced-fa26c2f7b346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TaxEffectOfTaxLosses_019d485d-15cc-7041-8b8f-c5160479309c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TaxEffectOfTaxLosses"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019d485d-15cc-70c5-9d68-79700c5023f4" xlink:to="loc_ifrs-full_TaxEffectOfTaxLosses_019d485d-15cc-7041-8b8f-c5160479309c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/EarningsperShareSummaryofIncomeandShareDataUsedintheBasicanddilutedEPSCalculationsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#EarningsperShareSummaryofIncomeandShareDataUsedintheBasicanddilutedEPSCalculationsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/EarningsperShareSummaryofIncomeandShareDataUsedintheBasicanddilutedEPSCalculationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustedWeightedAverageShares_019fae9c-2d68-77c1-aa1a-5deb84b0b19b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustedWeightedAverageShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WeightedAverageShares_019fae9c-2d68-7b2c-983e-24cab9f99b3a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AdjustedWeightedAverageShares_019fae9c-2d68-77c1-aa1a-5deb84b0b19b" xlink:to="loc_ifrs-full_WeightedAverageShares_019fae9c-2d68-7b2c-983e-24cab9f99b3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutiveEffectOfShareOptionsOnNumberOfOrdinaryShares_019fae9c-2d68-795a-a483-33a7b491c471" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DilutiveEffectOfShareOptionsOnNumberOfOrdinaryShares"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_AdjustedWeightedAverageShares_019fae9c-2d68-77c1-aa1a-5deb84b0b19b" xlink:to="loc_ifrs-full_DilutiveEffectOfShareOptionsOnNumberOfOrdinaryShares_019fae9c-2d68-795a-a483-33a7b491c471" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherIntangibleAssetsandGoodwillSummaryofGoodwillRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_019d485d-15cc-7db8-87a4-9b1277bfc616" xlink:href="bntx-20251231.xsd#bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife_019d485d-15cc-76ad-a933-64bd5a86ebec" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_019d485d-15cc-7db8-87a4-9b1277bfc616" xlink:to="loc_ifrs-full_IntangibleAssetsWithIndefiniteUsefulLife_019d485d-15cc-76ad-a933-64bd5a86ebec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_019d485d-15cc-79db-b96b-ac63beaeaaed" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_IntangibleAssetsWithIndefiniteUsefulLifeAndGoodwill_019d485d-15cc-7db8-87a4-9b1277bfc616" xlink:to="loc_ifrs-full_Goodwill_019d485d-15cc-79db-b96b-ac63beaeaaed" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofFinancialAssetsandLiabilitiesatAmortizedCostandatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssets_019d485d-15cc-764e-84f0-d70bc7324570" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssets_019d485d-15cc-7bdd-8dc5-cb4fa0b6a3f0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_019d485d-15cc-764e-84f0-d70bc7324570" xlink:to="loc_ifrs-full_CurrentFinancialAssets_019d485d-15cc-7bdd-8dc5-cb4fa0b6a3f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_019d485d-15cc-73b9-a27d-ec5058e2cd79" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialAssets_019d485d-15cc-764e-84f0-d70bc7324570" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_019d485d-15cc-73b9-a27d-ec5058e2cd79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_019d485d-15cc-71a7-8944-f64e4beed9f0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_019d485d-15cc-70bb-8938-f1451d1dae20" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-15cc-71a7-8944-f64e4beed9f0" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_019d485d-15cc-70bb-8938-f1451d1dae20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_019d485d-15cc-76ed-9afd-56fcc8396d4a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-15cc-71a7-8944-f64e4beed9f0" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_019d485d-15cc-76ed-9afd-56fcc8396d4a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/FinancialAssetsandFinancialLiabilitiesSummaryofMaturityProfileofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_InterestBearingLoansAndBorrowings_019d485d-1689-77d2-a67a-fcc5b96d8379" xlink:href="bntx-20251231.xsd#bntx_InterestBearingLoansAndBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_bntx_InterestBearingLoansAndBorrowings_019d485d-1689-77d2-a67a-fcc5b96d8379" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinancialLiabilities_019d485d-1689-72c3-aa1b-0fb6f90983f0" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_ifrs-full_OtherFinancialLiabilities_019d485d-1689-72c3-aa1b-0fb6f90983f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherPayables_019d485d-1689-7933-860a-c648431a1026" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_ifrs-full_TradeAndOtherPayables_019d485d-1689-7933-860a-c648431a1026" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_019d485d-1689-7e23-9316-43b1439afe05" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination_019d485d-1689-7e23-9316-43b1439afe05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_019d485d-1689-7458-b4b9-1db4fae92705" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LeaseLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_ifrs-full_LeaseLiabilities_019d485d-1689-7458-b4b9-1db4fae92705" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_019d485d-1689-7d87-acfb-7a79b3d93863" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019d485d-1689-7395-a585-edbe9b1b652e" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_019d485d-1689-7d87-acfb-7a79b3d93863" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#InventoriesSummaryofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/InventoriesSummaryofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_019d485d-1689-7430-b64a-3c08978d8489" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Inventories"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_019d485d-1689-7171-8b84-271bf9c583d7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_019d485d-1689-7430-b64a-3c08978d8489" xlink:to="loc_ifrs-full_CurrentRawMaterialsAndCurrentProductionSupplies_019d485d-1689-7171-8b84-271bf9c583d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinishedGoods_019d485d-1689-738a-8e92-ffc9a4560fe7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinishedGoods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_019d485d-1689-7430-b64a-3c08978d8489" xlink:to="loc_ifrs-full_FinishedGoods_019d485d-1689-738a-8e92-ffc9a4560fe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WorkInProgress_019d485d-1689-7465-baaf-b0ec279a1025" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WorkInProgress"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Inventories_019d485d-1689-7430-b64a-3c08978d8489" xlink:to="loc_ifrs-full_WorkInProgress_019d485d-1689-7465-baaf-b0ec279a1025" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#OtherNonFinancialAssetsSummaryofOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-72d1-aba4-c3ae84a8496e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNonfinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialAssets_019d485d-1689-7b41-9840-4ed0d4ea345e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentNonfinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-72d1-aba4-c3ae84a8496e" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialAssets_019d485d-1689-7b41-9840-4ed0d4ea345e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_019d485d-1689-7e5a-afd8-5d3cfa02be34" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-72d1-aba4-c3ae84a8496e" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_019d485d-1689-7e5a-afd8-5d3cfa02be34" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1" xlink:type="simple" xlink:href="bntx-20251231.xsd#OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialAssetsSummaryofOtherAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-7f73-8f03-c1dd5a92d4fa" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNonfinancialAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherCurrentAssetsOther_019d485d-1689-7a45-881d-30ef9b95688b" xlink:href="bntx-20251231.xsd#bntx_OtherCurrentAssetsOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-7f73-8f03-c1dd5a92d4fa" xlink:to="loc_bntx_OtherCurrentAssetsOther_019d485d-1689-7a45-881d-30ef9b95688b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_DeferredExpense_019d485d-1689-7c4d-924a-e6c9f62bc093" xlink:href="bntx-20251231.xsd#bntx_DeferredExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-7f73-8f03-c1dd5a92d4fa" xlink:to="loc_bntx_DeferredExpense_019d485d-1689-7c4d-924a-e6c9f62bc093" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_019d485d-1689-71a7-a47e-2effa1b57256" xlink:href="bntx-20251231.xsd#bntx_CurrentPrepaymentsRelatedToServiceContracts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialAssets_019d485d-1689-7f73-8f03-c1dd5a92d4fa" xlink:to="loc_bntx_CurrentPrepaymentsRelatedToServiceContracts_019d485d-1689-71a7-a47e-2effa1b57256" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ShareBasedPaymentsSummaryofExpenseRecognizedforEmployeeServicesReceivedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_019d485d-1689-7cc9-ba8e-33b18c49bde3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_019d485d-1689-70b2-9b50-777973f0d0e7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_019d485d-1689-7cc9-ba8e-33b18c49bde3" xlink:to="loc_ifrs-full_ExpenseFromEquitysettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_019d485d-1689-70b2-9b50-777973f0d0e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_019d485d-1689-74bc-9a8b-b84cdb278397" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_019d485d-1689-7cc9-ba8e-33b18c49bde3" xlink:to="loc_ifrs-full_ExpenseFromCashsettledSharebasedPaymentTransactionsInWhichGoodsOrServicesReceivedDidNotQualifyForRecognitionAsAssets_019d485d-1689-74bc-9a8b-b84cdb278397" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ProvisionsProvisionsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#ProvisionsProvisionsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ProvisionsProvisionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_019d485d-1689-7059-b5c5-86e0857c912b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Provisions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_019d485d-1689-71c2-94ed-476b5b3ed292" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-7059-b5c5-86e0857c912b" xlink:to="loc_ifrs-full_CurrentProvisions_019d485d-1689-71c2-94ed-476b5b3ed292" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_019d485d-1689-78ae-a551-fcdf72f24417" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-7059-b5c5-86e0857c912b" xlink:to="loc_ifrs-full_NoncurrentProvisions_019d485d-1689-78ae-a551-fcdf72f24417" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/ProvisionsProvisionsDetails_1" xlink:type="simple" xlink:href="bntx-20251231.xsd#ProvisionsProvisionsDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/ProvisionsProvisionsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_019d485d-1689-718d-adb6-77a010d28702" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Provisions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalProceedingsProvision_019d485d-1689-7a75-aeec-6994a12c108f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LegalProceedingsProvision"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-718d-adb6-77a010d28702" xlink:to="loc_ifrs-full_LegalProceedingsProvision_019d485d-1689-7a75-aeec-6994a12c108f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermOnerousContractsProvision_019d485d-1689-7aad-9108-99a50381f784" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermOnerousContractsProvision"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-718d-adb6-77a010d28702" xlink:to="loc_ifrs-full_ShorttermOnerousContractsProvision_019d485d-1689-7aad-9108-99a50381f784" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermRestructuringProvision_019d485d-1689-7cc7-b4d5-ffea6fa29aa7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermRestructuringProvision"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-718d-adb6-77a010d28702" xlink:to="loc_ifrs-full_ShorttermRestructuringProvision_019d485d-1689-7cc7-b4d5-ffea6fa29aa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherProvisions_019d485d-1689-7a2d-9adf-8239429f8dd1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Provisions_019d485d-1689-718d-adb6-77a010d28702" xlink:to="loc_ifrs-full_OtherProvisions_019d485d-1689-7a2d-9adf-8239429f8dd1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-73a1-8184-92f2ad358d42" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNonfinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_019d485d-1689-7d7a-bfa9-d8335d29430b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentNonfinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-73a1-8184-92f2ad358d42" xlink:to="loc_ifrs-full_OtherCurrentNonfinancialLiabilities_019d485d-1689-7d7a-bfa9-d8335d29430b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_019d485d-1689-75e2-a720-664a1f738603" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNoncurrentNonfinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-73a1-8184-92f2ad358d42" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialLiabilities_019d485d-1689-75e2-a720-664a1f738603" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="simple" xlink:href="bntx-20251231.xsd#OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/OtherNonFinancialLiabilitiesSummaryofOtherLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherNonfinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GovernmentGrants_019d485d-1689-7255-83a3-ba1adb59e247" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GovernmentGrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:to="loc_ifrs-full_GovernmentGrants_019d485d-1689-7255-83a3-ba1adb59e247" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses_019d485d-1689-7997-87be-03baf5325961" xlink:href="bntx-20251231.xsd#bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:to="loc_bntx_LiabilitiesFromWageTaxesAndSocialSecuritiesExpenses_019d485d-1689-7997-87be-03baf5325961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_OtherLiabilitiesOther_019d485d-1689-7ce8-a72c-8f2c23013eb8" xlink:href="bntx-20251231.xsd#bntx_OtherLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:to="loc_bntx_OtherLiabilitiesOther_019d485d-1689-7ce8-a72c-8f2c23013eb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LiabilitiesForEmployeeBenefits_019d485d-1689-7f16-8429-b4d344f681e9" xlink:href="bntx-20251231.xsd#bntx_LiabilitiesForEmployeeBenefits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:to="loc_bntx_LiabilitiesForEmployeeBenefits_019d485d-1689-7f16-8429-b4d344f681e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_019d485d-1689-7e26-860d-25e54f41059f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherNonfinancialLiabilities_019d485d-1689-7702-9b4d-0c59775378e5" xlink:to="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_019d485d-1689-7e26-860d-25e54f41059f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasesSummaryofLeaseLiabilityIncludedinInterestBearingLoansandBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_019d485d-1689-74aa-8670-9abad5149907" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LeaseLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_019d485d-1689-7532-9433-409ee2a843de" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_019d485d-1689-74aa-8670-9abad5149907" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_019d485d-1689-7532-9433-409ee2a843de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_019d485d-1689-7eee-9109-00329b57cfdb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_LeaseLiabilities_019d485d-1689-74aa-8670-9abad5149907" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_019d485d-1689-7eee-9109-00329b57cfdb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/LeasessummaryofAmountsRecognizedinConsolidatedStatementofOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_019d485d-1689-7c7f-a8b1-85174125fde5" xlink:href="bntx-20251231.xsd#bntx_LeaseExpensesRecognizedInProfitOrLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_019d485d-1689-7053-81ab-fc7de1ef9481" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_019d485d-1689-7c7f-a8b1-85174125fde5" xlink:to="loc_ifrs-full_DepreciationAmortisationAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_019d485d-1689-7053-81ab-fc7de1ef9481" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_019d485d-1689-7227-af4a-7b36049bf354" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_019d485d-1689-7c7f-a8b1-85174125fde5" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_019d485d-1689-7227-af4a-7b36049bf354" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed_019d485d-1689-75d2-b85a-0bd641391061" xlink:href="bntx-20251231.xsd#bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_LeaseExpensesRecognizedInProfitOrLoss_019d485d-1689-7c7f-a8b1-85174125fde5" xlink:to="loc_bntx_ExpenseRelatingToShortTermLeasesAndLeasesOfLowValueAssetsForWhichRecognitionExemptionHasBeenUsed_019d485d-1689-75d2-b85a-0bd641391061" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofCompensationofKeyManagementPersonnelDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensation"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_019d485d-1689-79c5-820f-2344c848bb1d" xlink:href="bntx-20251231.xsd#bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:to="loc_bntx_KeyManagementPersonnelCompensationShortTermEmployeeBenefitsSecondInstallment_019d485d-1689-79c5-820f-2344c848bb1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_019d485d-1689-726c-b804-bdd09f1ac391" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_019d485d-1689-726c-b804-bdd09f1ac391" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_019d485d-1689-7ef8-8910-d1185495a83e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_019d485d-1689-7ef8-8910-d1185495a83e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_019d485d-1689-7164-9580-f540f0e1bc1e" xlink:href="bntx-20251231.xsd#bntx_KeyManagementPersonnelCompensationFixedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:to="loc_bntx_KeyManagementPersonnelCompensationFixedCompensation_019d485d-1689-7164-9580-f540f0e1bc1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_KeyManagementPersonnelCompensationOtherVariableCompensation_019d485d-1689-7862-8af9-409e48ce41c6" xlink:href="bntx-20251231.xsd#bntx_KeyManagementPersonnelCompensationOtherVariableCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019d485d-1689-71e3-a532-fe7907d7c139" xlink:to="loc_bntx_KeyManagementPersonnelCompensationOtherVariableCompensation_019d485d-1689-7862-8af9-409e48ce41c6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="simple" xlink:href="bntx-20251231.xsd#RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails"/>
  <link:calculationLink xlink:role="http://www.biontech.de/role/RelatedPartyDisclosuresSummaryofTransactionsBetweenRelatedPartiesAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesFromRelatedPartyTransactions_019d485d-1689-7a6d-90dd-f038d2aecfff" xlink:href="bntx-20251231.xsd#bntx_PurchasesFromRelatedPartyTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_019d485d-1689-7a0f-add6-fe2e395ddbb7" xlink:href="bntx-20251231.xsd#bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_019d485d-1689-7a6d-90dd-f038d2aecfff" xlink:to="loc_bntx_PurchasesOfGoodsAndServiceRelatedPartyTransactions_019d485d-1689-7a0f-add6-fe2e395ddbb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_019d485d-1689-71df-9279-58d537771e19" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_bntx_PurchasesFromRelatedPartyTransactions_019d485d-1689-7a6d-90dd-f038d2aecfff" xlink:to="loc_ifrs-full_PurchasesOfPropertyAndOtherAssetsRelatedPartyTransactions_019d485d-1689-71df-9279-58d537771e19" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
