v3.26.1
Segments and geographic information - Significant segment expenses (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Mar. 31, 2026
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2026
Jun. 30, 2025
Segments and geographic information            
Collaboration revenue $ 629   $ 2,920   $ 1,516 $ 12,897
Research and development:            
Total research and development 41,160   71,029   90,061 130,087
General and administrative:            
Total general and administrative 14,028   18,493   31,496 39,616
Total operating expenses 55,188   89,522   121,557 169,703
Net loss (50,333) $ (60,825) (78,952) $ (60,754) (111,158) (139,706)
Single reportable segment            
Segments and geographic information            
Collaboration revenue 629   2,920   1,516 12,897
Research and development:            
Discovery, platform and other expense 8,953   12,496   16,865 21,144
Employee and contractor related expenses 12,355   17,958   30,145 35,544
Share-based compensation 2,624   4,153   5,573 8,505
Facility expenses 1,317   1,744   3,262 3,531
Research and development incentives and government grants (6,513)   (11,531)   (12,548) (20,838)
Total research and development 41,160   71,029   90,061 130,087
General and administrative:            
Personnel-related costs 5,610   7,056   13,272 14,106
Professional and consulting fees 2,734   4,573   6,129 11,001
Other general and administrative costs 1,973   2,327   4,510 4,520
Share-based compensation 3,780   5,282   7,761 10,535
Effect of foreign exchange rates (69)   (745)   (176) (546)
Total general and administrative 14,028   18,493   31,496 39,616
Total operating expenses 55,188   89,522   121,557 169,703
Other segment items 4,226   7,650   8,883 17,100
Net loss $ (50,333)   $ (78,952)   $ (111,158) $ (139,706)
Segment Reporting, Other Segment Item, Composition, Description Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.   Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.   Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes. Other segment items include interest and other income, interest expense, and provision for (benefit from) income taxes.
Single reportable segment | Zelenectide pevedotin (Nectin-4 BDC)            
Research and development:            
Project specific costs $ 19,565   $ 44,396   $ 40,629 $ 76,743
Single reportable segment | Nuzefatide pevedotin (EphA2 BDC)            
Research and development:            
Project specific costs 2,165   1,828   4,686 4,346
Single reportable segment | BT1702 (MT1-MMP BRC)            
Research and development:            
Project specific costs 338       558  
Single reportable segment | Bicycle tumor-targeted immune cell agonists            
Research and development:            
Project specific costs $ 356   $ (15)   $ 891 $ 1,112