Significant agreements - Summary of Contract Assets and Liabilities (Details) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2026	Dec. 31, 2025
Contract liabilities:
Beginning Balance	$ 38,469	$ 101,658
Additions	567	960
Deductions	(1,516)	(70,586)
Impact of Exchange Rates	(564)	6,437
Ending Balance	36,956	38,469
Contract assets
Contract assets	0	0
Bayer collaboration deferred revenue
Contract liabilities:
Beginning Balance	34,629	39,960
Additions	567	960
Deductions	(1,516)	(8,920)
Impact of Exchange Rates	(506)	2,629
Ending Balance	33,174	34,629
Bayer collaboration deferred revenue \| Deferred revenue material rights option
Contract liabilities:
Ending Balance	31,100
Novartis collaboration deferred revenue
Contract liabilities:
Beginning Balance	0	44,073
Additions		0
Deductions		(46,985)
Impact of Exchange Rates		2,912
Ending Balance	0	0
Ionis collaboration deferred revenue
Contract liabilities:
Beginning Balance	3,840	3,587
Additions	0	0
Deductions	0	0
Impact of Exchange Rates	(58)	253
Ending Balance	3,782	3,840
Ionis collaboration deferred revenue \| Deferred revenue material rights option
Contract liabilities:
Ending Balance	3,800
Genentech collaboration deferred revenue
Contract liabilities:
Beginning Balance	0	14,038
Additions		0
Deductions		(14,681)
Impact of Exchange Rates		643
Ending Balance	$ 0	$ 0