v3.26.1
Intangible assets and goodwill - Definite-lived Intangibles (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Dec. 31, 2025
Aug. 05, 2025
Definite-lived intangible assets            
Accrued royalties $ 13,580   $ 13,580   $ 9,574  
Total definite-lived intangibles, net 402,926   402,926      
Definite-lived intangibles            
Amortization $ (11,841) $ (4,061) $ (23,422) $ (7,859)    
Weighted Average            
Definite-lived intangible assets            
Remaining amortization period 10 years 8 months 12 days   10 years 8 months 12 days      
Censa Merger Agreement            
Definite-lived intangible assets            
Maximum Upfront Consideration Agreed To Be Paid $ 250,000   $ 250,000      
Rights Satisfaction Agreement            
Definite-lived intangible assets            
Maximum Upfront Consideration Agreed To Be Paid           $ 250,000
Akcea | Waylivra            
Definite-lived intangible assets            
Royalty payments     2,900      
Akcea | Waylivra | Accounts payable and accrued expenses            
Definite-lived intangible assets            
Accrued royalties 400   400      
Akcea | Tegsedi            
Definite-lived intangible assets            
Royalty payments     3,200      
Akcea | Tegsedi | Accounts payable and accrued expenses            
Definite-lived intangible assets            
Accrued royalties 2,000   2,000      
Censa | Waylivra            
Definite-lived intangible assets            
Royalty payments     2,900      
Censa | Tegsedi            
Definite-lived intangible assets            
Royalty payments     3,200      
Censa | Sephience            
Definite-lived intangible assets            
Royalty payments     2,200      
Censa | Sephience | Accounts payable and accrued expenses            
Definite-lived intangible assets            
Accrued royalties 2,200   2,200      
Censa | Censa Merger Agreement            
Definite-lived intangible assets            
Milestone obligation payments recorded     30,000      
Definite-lived intangible assets            
Definite-lived intangible assets            
Total definite-lived intangibles, net 402,926   402,926      
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     444,591      
Additions     38,309      
Foreign currency translation     (1,335)      
Ending balance - Definite-lived assets, Gross 481,565   481,565      
Beginning balance - Accumulated amortization     (55,838)      
Amortization (11,800) $ (4,100) (23,422) $ (7,900)    
Foreign currency translation - Accumulated amortization     621      
Ending balance - Accumulated amortization (78,639)   (78,639)      
Definite-lived intangible assets | Waylivra            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     18,598      
Additions     2,933      
Foreign currency translation     (578)      
Ending balance - Definite-lived assets, Gross 20,953   20,953      
Beginning balance - Accumulated amortization     (8,689)      
Amortization     (1,853)      
Foreign currency translation - Accumulated amortization     284      
Ending balance - Accumulated amortization (10,258)   (10,258)      
Definite-lived intangible assets | Tegsedi            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     24,825      
Additions     3,186      
Foreign currency translation     (757)      
Ending balance - Definite-lived assets, Gross 27,254   27,254      
Beginning balance - Accumulated amortization     (10,295)      
Amortization     (2,455)      
Foreign currency translation - Accumulated amortization     337      
Ending balance - Accumulated amortization (12,413)   (12,413)      
Definite-lived intangible assets | Kebilidi            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     10,731      
Ending balance - Definite-lived assets, Gross 10,731   10,731      
Beginning balance - Accumulated amortization     (1,006)      
Amortization     (972)      
Ending balance - Accumulated amortization (1,978)   (1,978)      
Definite-lived intangible assets | Upstaza            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     106,937      
Ending balance - Definite-lived assets, Gross 106,937   106,937      
Beginning balance - Accumulated amortization     (27,437)      
Amortization     (7,950)      
Ending balance - Accumulated amortization (35,387)   (35,387)      
Definite-lived intangible assets | Sephience            
Definite-lived intangibles            
Beginning balance - Definite-lived assets, Gross     283,500      
Additions     32,190      
Ending balance - Definite-lived assets, Gross 315,690   315,690      
Beginning balance - Accumulated amortization     (8,411)      
Amortization     (10,192)      
Ending balance - Accumulated amortization $ (18,603)   $ (18,603)