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Amount of refund of consideration received under prior collaboration arrangements.

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The entity's share of the income (loss) generated on U.S. sales.

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The number of products of the company.

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Remaining potential milestones that can be achieved.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Revenue recognition - Collaboration and License Revenue (Details) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Jan. 31, 2025 USD ($)	Jun. 30, 2026 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2026 USD ($) product	Jun. 30, 2025 USD ($)	Nov. 30, 2011 USD ($)
Revenue recognition
Number of approved products \| product				2
Revenue		$ 360,519	$ 178,875	$ 633,070	$ 1,354,971
Collaboration and license revenue
Revenue recognition
Revenue		50,595	2,941	50,738	989,172
Royalty revenue
Revenue recognition
Revenue		71,105	57,605	117,940	94,044
Novartis
Revenue recognition
Development milestone obligation revenue received				$ 50,000
SMA License Agreement
Revenue recognition
Number of approved products \| product				1
SMA License Agreement \| Collaboration and license revenue
Revenue recognition
Revenue		0	0	$ 0	0
SMA License Agreement \| Royalty revenue
Revenue recognition
Revenue		71,100	57,600	117,900	94,000
License and Collaboration Agreement
Revenue recognition
Refund of revenue related to prior collaboration arrangements					3,500
License and Collaboration Agreement \| Novartis
Revenue recognition
Cash proceeds from upfront payment on collaboration agreement	$ 1,000,000
Percentage share of the income (loss) generated on U.S. sales	40.00%
License and Collaboration Agreement \| Novartis \| Collaboration and license revenue
Revenue recognition
Revenue		50,600	$ 2,900	50,700	$ 992,700
Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		0		0
Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		$ 150,000		$ 150,000
Maximum \| License and Collaboration Agreement \| Novartis
Revenue recognition
Potential future proceeds contingent on achievement of developmental, regulatory and sales milestones and tiered royalties	$ 1,900,000
Maximum \| Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved						$ 135,000
Maximum \| Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved						$ 325,000