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Commitments and Contingencies - Censa agreement (Details) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Aug. 05, 2025	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025	Dec. 31, 2025	Jul. 31, 2025	May 05, 2020
Commitments and contingencies
Revenue		$ 360,519	$ 178,875	$ 633,070	$ 1,354,971
Milestone Payable		30,000	25,150	30,000	25,150	$ 416
Product
Commitments and contingencies
Revenue		238,819	118,329	464,392	271,755
Censa Merger Agreement
Commitments and contingencies
Maximum amount of upfront consideration		250,000		250,000
Rights Satisfaction Agreement
Commitments and contingencies
Maximum amount of upfront consideration	$ 250,000
Maximum amount of additional milestone payable	100,000
Additional milestone payable for right holders	500,000
Payment of upfront consideration	225,100
Additional milestone obligated to be paid	$ 90,000
Rights Satisfaction Agreement \| Annual net sales less than or equal to $250 million
Commitments and contingencies
Percentage on annual net sales	8.00%
Rights Satisfaction Agreement \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Percentage on annual net sales	10.00%
Rights Satisfaction Agreement \| Annual net sales greater than $500 million
Commitments and contingencies
Percentage on annual net sales	12.00%
Rights Satisfaction Agreement \| First occurrence of a three or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period	3 years
Amount of net sales of product	$ 3,000,000
Rights Satisfaction Agreement \| First occurrence of a five or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period	5 years
Amount of net sales of product	$ 5,000,000
Rights Satisfaction Agreement \| First occurrence of a seven or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period	7 years
Amount of net sales of product	$ 7,000,000
Rights Satisfaction Agreement \| First occurrence of a nine or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period	9 years
Amount of net sales of product	$ 9,000,000
Rights Satisfaction Agreement \| First occurrence of a eleven or fewer consecutive calendar year period
Commitments and contingencies
Threshold consecutive calendar period	11 years
Amount of net sales of product	$ 11,000,000
Minimum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Revenue	250,000
Minimum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $500 million
Commitments and contingencies
Revenue	500,000
Maximum \| Rights Satisfaction Agreement \| Product \| Annual net sales less than or equal to $250 million
Commitments and contingencies
Revenue	250,000
Maximum \| Rights Satisfaction Agreement \| Product \| Annual net sales greater than $250 million but less than $500 million
Commitments and contingencies
Revenue	$ 500,000
Censa
Commitments and contingencies
Asset acquisition, development and regulatory milestones								$ 109,000
Censa \| Censa Merger Agreement
Commitments and contingencies
Milestone payments triggered		$ 30,000	$ 25,000	30,000	$ 25,000
Milestone Payable							$ 32,500
Threshold revenue to milestone payment				250,000
Censa \| Maximum
Commitments and contingencies
Asset acquisition, milestone, amount								217,500
Asset acquisition, net sales milestone								$ 160,000
Former Censa Securityholders \| Development and Regulatory Milestones
Commitments and contingencies
Milestone obligation payments made				152,500
Potential milestone payments due				217,500
Former Censa Securityholders \| Rights Satisfaction Agreement
Commitments and contingencies
Ownership percentage prior to merger	90.00%
Sephience \| Censa
Commitments and contingencies
Royalty payments				2,200
Tegsedi \| Censa
Commitments and contingencies
Royalty payments				3,200
Waylivra \| Censa
Commitments and contingencies
Royalty payments				$ 2,900