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  <xs:element id="sny_COVID19AndInfluenzaVaccinesMember" abstract="true" name="COVID19AndInfluenzaVaccinesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_LaunchesMember" abstract="true" name="LaunchesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_RevenueFromVaxServeSalesOfNonSanofiProducts" abstract="false" name="RevenueFromVaxServeSalesOfNonSanofiProducts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_RevenueFromIntragroupSalesFromContinuingToDiscontinuedOperations" abstract="false" name="RevenueFromIntragroupSalesFromContinuingToDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_MiscellaneousOtherRevenue" abstract="false" name="MiscellaneousOtherRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_NumberOfOperatingSegments" abstract="false" name="NumberOfOperatingSegments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sny_ProportionOfOwnershipInterestDisposedInSubsidiary" abstract="false" name="ProportionOfOwnershipInterestDisposedInSubsidiary" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInRevenueOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInRevenueOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInRevenueAtConstantExchangeRatesNonIFRSPercentage" abstract="false" name="IncreaseDecreaseInRevenueAtConstantExchangeRatesNonIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInOtherRevenueOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInOtherRevenueOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInOtherRevenueAtConstantExchangeRatesNonIFRSPercentage" abstract="false" name="IncreaseDecreaseInOtherRevenueAtConstantExchangeRatesNonIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInCostOfSalesOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInCostOfSalesOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInCostOfSalesAtConstantExchangeRatesPercentageNonIFRS" abstract="false" name="IncreaseDecreaseInCostOfSalesAtConstantExchangeRatesPercentageNonIFRS" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInResearchAndDevelopmentExpensesOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInResearchAndDevelopmentExpensesOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInResearchAndDevelopmentExpensesAtConstantExchangeRatesNonIFRSPercentage" abstract="false" name="IncreaseDecreaseInResearchAndDevelopmentExpensesAtConstantExchangeRatesNonIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInSellingAndGeneralExpensesOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInSellingAndGeneralExpensesOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInSellingAndGeneralExpensesAtConstantExchangeRatesNonIFRSPercentage" abstract="false" name="IncreaseDecreaseInSellingAndGeneralExpensesAtConstantExchangeRatesNonIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_MiscellaneousOtherOperatingIncomeExpenses" abstract="false" name="MiscellaneousOtherOperatingIncomeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_BusinessOperatingIncome" abstract="false" name="BusinessOperatingIncome" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_IncreaseDecreaseInBusinessOperatingIncomeOnAReportedBasisIFRSPercentage" abstract="false" name="IncreaseDecreaseInBusinessOperatingIncomeOnAReportedBasisIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_IncreaseDecreaseInBusinessOperatingIncomeAtConstantExchangeRatesNonIFRSPercentage" abstract="false" name="IncreaseDecreaseInBusinessOperatingIncomeAtConstantExchangeRatesNonIFRSPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="sny_BusinessOperatingIncomeAsPercentOfNetSales" abstract="false" name="BusinessOperatingIncomeAsPercentOfNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sny_ExpenseArisingFromTheImpactOfAcquisitionsOnInventories" abstract="false" name="ExpenseArisingFromTheImpactOfAcquisitionsOnInventories" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_OtherCountriesExcludingEuropeAndNorthAmericaMember" abstract="true" name="OtherCountriesExcludingEuropeAndNorthAmericaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_DisclosureOfInformationAboutMajorCustomersAndCreditRiskTable" abstract="true" name="DisclosureOfInformationAboutMajorCustomersAndCreditRiskTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="sny_CertainWholesalersInTheUnitedStatesMember" abstract="true" name="CertainWholesalersInTheUnitedStatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_CustomerOneMember" abstract="true" name="CustomerOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_CustomerTwoMember" abstract="true" name="CustomerTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_CustomerThreeMember" abstract="true" name="CustomerThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="sny_DisclosureOfInformationAboutMajorCustomersAndCreditRiskLineItems" abstract="true" name="DisclosureOfInformationAboutMajorCustomersAndCreditRiskLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="sny_NumberOfLargestCustomers" abstract="false" name="NumberOfLargestCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="sny_RevenueFromDisposalGroupIncludingDiscontinuedOperations" abstract="false" name="RevenueFromDisposalGroupIncludingDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_OperatingRevenueDisposalGroupIncludingDiscontinuedOperations" abstract="false" name="OperatingRevenueDisposalGroupIncludingDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_GainOnDisposalOfOpellaDisposalGroupIncludingDiscontinuedOperations" abstract="false" name="GainOnDisposalOfOpellaDisposalGroupIncludingDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_IncomeBeforeTaxAndInvestmentsAccountedForUsingTheEquityMethodDisposalGroupIncludingDiscontinuedOperations" abstract="false" name="IncomeBeforeTaxAndInvestmentsAccountedForUsingTheEquityMethodDisposalGroupIncludingDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="sny_IncomeTaxExpenseBenefitDisposalGroupIncludingDiscontinuedOperations" abstract="false" name="IncomeTaxExpenseBenefitDisposalGroupIncludingDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
