v3.26.1
Commitments and Contingencies (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Mar. 01, 2026
USD ($)
Jun. 30, 2026
USD ($)
Feb. 28, 2026
USD ($)
candidate
Dec. 31, 2025
USD ($)
asset
Oct. 31, 2025
USD ($)
May 31, 2025
USD ($)
Mar. 31, 2024
USD ($)
Jun. 30, 2026
USD ($)
Jun. 30, 2025
USD ($)
Jun. 30, 2026
USD ($)
Jun. 30, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
May 06, 2026
USD ($)
Aug. 31, 2025
USD ($)
Jul. 31, 2025
USD ($)
May 31, 2023
amendment
Commitments and Contingencies                                  
Purchase obligation   $ 239,400           $ 239,400   $ 239,400              
Research and development               91,178 $ 54,081 199,870 $ 98,253            
Prepaid expenses and other current assets   68,570   $ 47,804       68,570   68,570              
Number of office lease amendment | amendment                                 4
Obtaining an operating lease right-of-use asset in exchange for an operating lease liability $ 1,400         $ 4,000       1,692 $ 3,982 $ 1,300 $ 1,600        
Operating lease right-of-use assets   5,578   4,939       5,578   5,578              
Unrecorded unconditional purchase obligation, including lease not yet commenced, total   $ 9,900           $ 9,900   $ 9,900              
Lessee, operating lease, lease not yet commenced, term of contract   84 months           84 months   84 months              
Operating lease prepayment amount                   $ 1,300              
Lessee, operating lease, term of contract (in days) 24 months                                
West Conshohocken, Pennsylvania                                  
Commitments and Contingencies                                  
Operating lease right-of-use assets   $ 4,000           $ 4,000   4,000              
Operating lease, liability   4,600           4,600   4,600              
Faroe License                                  
Commitments and Contingencies                                  
Upfront payment   25,000                              
Arrowhead License                                  
Commitments and Contingencies                                  
Collaborative arrangement, milestone payment, eligible to receive                           $ 975,000      
Hoffmann-La Roche ("Roche") | Research, Development and Commercialization Agreement                                  
Commitments and Contingencies                                  
Milestone payment due             $ 5,000                    
Remainder of future milestone payments                             $ 3,000    
CSPC                                  
Commitments and Contingencies                                  
Upfront payment         $ 120,000                        
Maximum of eligible milestone payments                               $ 2,000,000  
Pfizer                                  
Commitments and Contingencies                                  
Upfront payment       50,000                          
Maximum of eligible milestone payments       $ 70,000                          
Number of additional early stage MASH assets | asset       2                          
Suzhou Ribo Life Science Co. Ltd. And Ribocure Pharmaceuticals AB                                  
Commitments and Contingencies                                  
Upfront payment     $ 60,000                            
Maximum of eligible milestone payments     $ 4,400,000                            
Number of siRNA candidates | candidate     6                            
Research and development                   49,300              
Prepaid expenses and other current assets   $ 10,700           $ 10,700   $ 10,700