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  <xs:element id="nly_ReceivableForInvestmentSecuritiesSold" abstract="false" name="ReceivableForInvestmentSecuritiesSold" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_FinancingAndAccruedInvestmentIncomeReceivable" abstract="false" name="FinancingAndAccruedInvestmentIncomeReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_SecuritizedDebtOfConsolidatedVie" abstract="false" name="SecuritizedDebtOfConsolidatedVie" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PayableForInvestmentSecuritiesPurchased" abstract="false" name="PayableForInvestmentSecuritiesPurchased" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ServicingAndRelatedExpense" abstract="false" name="ServicingAndRelatedExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_NetServicingIncome" abstract="false" name="NetServicingIncome" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_DerivativeGainLossonDerivativeNetIncludingUSTreasuries" abstract="false" name="DerivativeGainLossonDerivativeNetIncludingUSTreasuries" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ComprehensiveIncomeLossAttributableToCommonStockHolders" abstract="false" name="ComprehensiveIncomeLossAttributableToCommonStockHolders" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AmortizationOfSecuritizedDebtPremiumsAndDiscountsNet" abstract="false" name="AmortizationOfSecuritizedDebtPremiumsAndDiscountsNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtPremiumsAndDiscountsDeferredFinancingCostsAndDiscountsOfInvestments" abstract="false" name="DepreciationDepletionAndAmortizationExcludingAmortizationOfDebtPremiumsAndDiscountsDeferredFinancingCostsAndDiscountsOfInvestments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_GainLossOnInvestmentsDebtAndDerivatives" abstract="false" name="GainLossOnInvestmentsDebtAndDerivatives" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsForPurchaseOfLoansOperatingActivities" abstract="false" name="PaymentsForPurchaseOfLoansOperatingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsFromUSTreasurySecurities" abstract="false" name="ProceedsFromUSTreasurySecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsOnU.S.TreasurySecurities" abstract="false" name="PaymentsOnU.S.TreasurySecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsForProceedsFromDerivativeInstrumentOperatingActivities" abstract="false" name="PaymentsForProceedsFromDerivativeInstrumentOperatingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsToAcquireInterestInMortgageServicingRights" abstract="false" name="PaymentsToAcquireInterestInMortgageServicingRights" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsFromUnconsolidatedJointVentureExcessOfCumulativeEarnings" abstract="false" name="ProceedsFromUnconsolidatedJointVentureExcessOfCumulativeEarnings" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsFromRepurchaseAgreements" abstract="false" name="ProceedsFromRepurchaseAgreements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PrincipalPaymentsOnRepurchaseAgreements" abstract="false" name="PrincipalPaymentsOnRepurchaseAgreements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsFromReliefOfSecuritizedDebt" abstract="false" name="PaymentsFromReliefOfSecuritizedDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsFromParticipatingMortgageLoans" abstract="false" name="ProceedsFromParticipatingMortgageLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PaymentsOnRepurchaseOfParticipatingMortgageLoans" abstract="false" name="PaymentsOnRepurchaseOfParticipatingMortgageLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_PrincipalPaymentsOnParticipationMortgageLoansIssued" abstract="false" name="PrincipalPaymentsOnParticipationMortgageLoansIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestPaidExcludingInterestPaidOnInterestRateSwaps" abstract="false" name="InterestPaidExcludingInterestPaidOnInterestRateSwaps" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestPaidNetInterestRateDerivative" abstract="false" name="InterestPaidNetInterestRateDerivative" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsFromPaymentsForTaxes" abstract="false" name="ProceedsFromPaymentsForTaxes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_NetChangeInUnrealizedGainLossOnAvailableforsaleSecuritiesAndInterestRateSwapsNetOfReclassificationAdjustment" abstract="false" name="NetChangeInUnrealizedGainLossOnAvailableforsaleSecuritiesAndInterestRateSwapsNetOfReclassificationAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_RiskManagementAbstract" abstract="true" name="RiskManagementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_RiskAssociatedWithInvestmentsInMortgageLoansAndMortgageBackedSecuritiesDisclosureTextBlock" abstract="false" name="RiskAssociatedWithInvestmentsInMortgageLoansAndMortgageBackedSecuritiesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ConsolidationVotingInterestEntityPolicyPolicyTextBlock" abstract="false" name="ConsolidationVotingInterestEntityPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_RepurchaseAgreementsPolicyTextBlock" abstract="false" name="RepurchaseAgreementsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfInvestmentGroupsTableTextBlock" abstract="false" name="ScheduleOfInvestmentGroupsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfMortgageBackedSecuritiesAgencyConcentrationTableTextBlock" abstract="false" name="ScheduleOfMortgageBackedSecuritiesAgencyConcentrationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfMortgageBackedSecuritiesByEstimatedWeightedAverageLifeClassificationTableTextBlock" abstract="false" name="ScheduleOfMortgageBackedSecuritiesByEstimatedWeightedAverageLifeClassificationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfUnrealizedLossesOnInvestmentsTableTextBlock" abstract="false" name="ScheduleOfUnrealizedLossesOnInvestmentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_SummaryOfLoansInvestmentActivityTableTextBlock" abstract="false" name="SummaryOfLoansInvestmentActivityTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfFairValueAndUnpaidPrincipalBalancesOfMortgageLoansTableTextBlock" abstract="false" name="ScheduleOfFairValueAndUnpaidPrincipalBalancesOfMortgageLoansTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_MortgageLoansHeldForPortfolioTableTextBlock" abstract="false" name="MortgageLoansHeldForPortfolioTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_DerivativeAssetsAndLiabilitiesOffsettingTableTextBlock" abstract="false" name="DerivativeAssetsAndLiabilitiesOffsettingTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfDerivativeInstrumentsInStatementOfOperationsAndComprehensiveIncomeTableTextBlock" abstract="false" name="ScheduleOfDerivativeInstrumentsInStatementOfOperationsAndComprehensiveIncomeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_ScheduleOfRepurchaseAgreementsRemainingMaturityTableTextBlock" abstract="false" name="ScheduleOfRepurchaseAgreementsRemainingMaturityTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_SummaryOfInterestIncomeRecognitionMethodologyForResidentialInvestmentSecuritiesTableTextBlock" abstract="false" name="SummaryOfInterestIncomeRecognitionMethodologyForResidentialInvestmentSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_LesseeOperatingLeasesSupplementalInformationTableTextBlock" abstract="false" name="LesseeOperatingLeasesSupplementalInformationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nly_NumberOfInvestmentGroups" abstract="false" name="NumberOfInvestmentGroups" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="nly_AvailableForSaleSecurities1Member" abstract="true" name="AvailableForSaleSecurities1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_AgencyMortgageBackedSecuritiesRecognizedThroughComprehensiveIncomeMember" abstract="true" name="AgencyMortgageBackedSecuritiesRecognizedThroughComprehensiveIncomeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_AgencyMortgageBackedSecuritiesRecognizedThroughEarningsMember" abstract="true" name="AgencyMortgageBackedSecuritiesRecognizedThroughEarningsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_CreditRiskTransferSecuritiesMember" abstract="true" name="CreditRiskTransferSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_NonAgencyMortgageBackedSecuritiesMember" abstract="true" name="NonAgencyMortgageBackedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_CommercialRealEstateDebtInvestmentSecuritiesRecognizedThroughEarningsMember" abstract="true" name="CommercialRealEstateDebtInvestmentSecuritiesRecognizedThroughEarningsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_ResidentialMortgageLoansMember" abstract="true" name="ResidentialMortgageLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_InterestsInMortgageServicingRightsMember" abstract="true" name="InterestsInMortgageServicingRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_ResidentialMortgageLoansAssetTransferredOrPledgedToSecuritizationRecognizedThroughEarningsMember" abstract="true" name="ResidentialMortgageLoansAssetTransferredOrPledgedToSecuritizationRecognizedThroughEarningsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_ReverseRepurchaseAgreementMember" abstract="true" name="ReverseRepurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_SecuritizedDebtOfConsolidatedVIEsMember" abstract="true" name="SecuritizedDebtOfConsolidatedVIEsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MortgageBackedSecuritiesSoldCarryingValue" abstract="false" name="MortgageBackedSecuritiesSoldCarryingValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_DebtSecuritiesAvailableForSaleLineItems" abstract="true" name="DebtSecuritiesAvailableForSaleLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_DebtSecuritiesAvailableForSaleRollForward" abstract="true" name="DebtSecuritiesAvailableForSaleRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_PaymentstoAcquireDebtSecuritiesAvailableforsaleExcludingVariableInterestEntity" abstract="false" name="PaymentstoAcquireDebtSecuritiesAvailableforsaleExcludingVariableInterestEntity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_ProceedsfromSaleofDebtSecuritiesAvailableforsaleExcludingVariableInterestEntity" abstract="false" name="ProceedsfromSaleofDebtSecuritiesAvailableforsaleExcludingVariableInterestEntity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AccretionAmortizationOfDebtSecuritiesAvailableForSale" abstract="false" name="AccretionAmortizationOfDebtSecuritiesAvailableForSale" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_MortgageBackedSecuritiesPortfolioTable" abstract="true" name="MortgageBackedSecuritiesPortfolioTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="nly_ResidentialInvestmentsMember" abstract="true" name="ResidentialInvestmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_ResidentialCreditSecuritiesMortgageBackedSecuritiesMember" abstract="true" name="ResidentialCreditSecuritiesMortgageBackedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_FixedRatePassThroughMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="FixedRatePassThroughMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_AdjustableRatePassThroughMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="AdjustableRatePassThroughMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_InterestOnlyMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="InterestOnlyMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MultifamilyMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="MultifamilyMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_CreditRiskTransferMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="CreditRiskTransferMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_NonQualifiedMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="NonQualifiedMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_PrimeMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="PrimeMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_SBCMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="SBCMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_NplRplMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="NplRplMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_RTLMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="RTLMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_PrimeJumboGreaterThanOrEqualToTwoThousandTenVintageMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="PrimeJumboGreaterThanOrEqualToTwoThousandTenVintageMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MultifamilyInterestOnlySecurityMember" abstract="true" name="MultifamilyInterestOnlySecurityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_PrimeInterestonlyMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="PrimeInterestonlyMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_PrimeJumboGreaterThanOrEqualToTwoThousandTenVintageInterestOnlyMortgageBackedSecuritiesAvailableForSaleMember" abstract="true" name="PrimeJumboGreaterThanOrEqualToTwoThousandTenVintageInterestOnlyMortgageBackedSecuritiesAvailableForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MortgageBackedSecuritiesPortfolioLineItems" abstract="true" name="MortgageBackedSecuritiesPortfolioLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_DebtSecuritiesAvailableforsaleRemainingPremium" abstract="false" name="DebtSecuritiesAvailableforsaleRemainingPremium" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_DebtSecuritiesAvailableforsaleRemainingDiscount" abstract="false" name="DebtSecuritiesAvailableforsaleRemainingDiscount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AgencyMortgageBackedSecuritiesMember" abstract="true" name="AgencyMortgageBackedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MortgageBackedSecuritiesEstimatedWeightedAverageLifeFairValueAbstract" abstract="true" name="MortgageBackedSecuritiesEstimatedWeightedAverageLifeFairValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeOfLessThanOneYearFairValue" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeOfLessThanOneYearFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanOneAndLessThanFiveYearsFairValue" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanOneAndLessThanFiveYearsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanFiveAndLessThanTenYearsFairValue" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanFiveAndLessThanTenYearsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeAfterTenYearsFairValue" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeAfterTenYearsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_MortgageBackedSecuritiesEstimatedWeightedAverageLifeAmortizedCostAbstract" abstract="true" name="MortgageBackedSecuritiesEstimatedWeightedAverageLifeAmortizedCostAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeOfLessThanOneYearAmortizedCost" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeOfLessThanOneYearAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanOneAndLessThanFiveYearsAmortizedCost" abstract="false" name="AvailableForSaleSecuritiesDebtExpectedLifeGreaterThanOneAndLessThanFiveYearsAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="nly_InterestIncomeSecuritiesMortgageBackedAndAgencyDebentures" abstract="false" name="InterestIncomeSecuritiesMortgageBackedAndAgencyDebentures" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestIncomeResidentialMortgageLoans" abstract="false" name="InterestIncomeResidentialMortgageLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestIncomeCommercialRealEstateDebtAndPreferredEquity" abstract="false" name="InterestIncomeCommercialRealEstateDebtAndPreferredEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestPaidOnRepurchaseAgreements" abstract="false" name="InterestPaidOnRepurchaseAgreements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestExpenseSecuritizedDebtOfConsolidatedVie" abstract="false" name="InterestExpenseSecuritizedDebtOfConsolidatedVie" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_InterestExpenseParticipationSold" abstract="false" name="InterestExpenseParticipationSold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_EarningsPerShareBasicAndDiluted1Abstract" abstract="true" name="EarningsPerShareBasicAndDiluted1Abstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_IncomeTaxesTable" abstract="true" name="IncomeTaxesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="nly_TaxableREITSubsidiaryMember" abstract="true" name="TaxableREITSubsidiaryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_IncomeTaxesLineItems" abstract="true" name="IncomeTaxesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nly_PercentageOfTaxableIncomeRequiredToBeDistributedWhileOperatingAsReit" abstract="false" name="PercentageOfTaxableIncomeRequiredToBeDistributedWhileOperatingAsReit" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="nly_CorporateAndReconcilingItemsMember" abstract="true" name="CorporateAndReconcilingItemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_AgencySegmentMember" abstract="true" name="AgencySegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_ResidentialCreditSegmentMember" abstract="true" name="ResidentialCreditSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_MortgageServicingRightsSegmentMember" abstract="true" name="MortgageServicingRightsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nly_OBX2026NQM9Member" abstract="true" name="OBX2026NQM9Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_OBX2026NQM10Member" abstract="true" name="OBX2026NQM10Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nly_NumberOfClosedSecuritizations" abstract="false" name="NumberOfClosedSecuritizations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
