v3.26.1
CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Cash flows from operating activities    
Net loss $ (134,594) $ (81,356)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 7,863 8,157
Amortization of discount on investment securities (7,907) (4,163)
Share-based compensation expense 10,106 9,494
Royalty financing agreement interest expense, net of interest paid 17,384 20,626
Deferred tax expense 2,329 921
Changes in fair value of contingent consideration (82) 3,470
Changes in fair value of liability related to pre-funded warrants 12,201  
Unrealized foreign exchange losses / (gains), net 8,329 (25,163)
Other items, net (2,426) (3,651)
Changes in operating assets and liabilities:    
Accounts receivable, prepaid expenses, and other current assets and receivables 8,846 (6,761)
Accounts payable 68 (2,297)
Accrued expenses, other liabilities, and operating leases 11,064 (3,272)
Net cash used in operating activities (66,819) (83,995)
Cash flows from investing activities    
Proceeds on maturity of debt securities 384,981 213,763
Investments in debt securities (232,550) (120,205)
Purchases of property, plant, and equipment (612) (386)
Net cash generated from investing activities 151,819 93,172
Cash flows from financing activities    
Proceeds from follow-on public offering of ordinary shares, net of issuance costs 242,681 80,511
Proceeds from issuance of ordinary shares related to employee stock options and purchase plans 6,985 203
Net cash generated from financing activities 249,666 80,714
Currency effect on cash, cash equivalents and restricted cash (1,906) 5,052
Net increase in cash, cash equivalents and restricted cash 332,760 94,943
Cash, cash equivalents and restricted cash at the beginning of period 81,801 160,329
Cash, cash equivalents and restricted cash at the end of period 414,561 255,272
Cash and cash equivalents 413,027 253,778
Restricted cash related to leasehold and other deposits 1,534 1,494
Total cash, cash equivalents and restricted cash 414,561 255,272
Supplemental cash flow disclosures:    
Cash paid for interest $ (11,494) $ (9,652)