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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		6 Months Ended
	Jun. 30, 2026	Jun. 30, 2018	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025
2014 Plan
Share-based compensation
Increase in authorized shares	350,000
Ordinary shares available for issue	2,815,628		2,815,628		2,815,628
Unrecognized compensation costs	$ 40,776		$ 40,776		$ 40,776
Weighted-average remaining period for recognition (in years)					2 years 3 months 18 days
2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			5,016	$ 5,084	$ 10,106	$ 9,494
Research and development expenses \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			1,888	2,758	3,865	5,221
Selling, general and administrative expenses \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			3,128	2,326	6,241	4,273
Share options \| 2014 Plan
Share-based compensation
Unrecognized compensation costs	14,464		14,464		$ 14,464
Weighted-average remaining period for recognition (in years)					2 years 6 months 25 days
Share options \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			1,861	1,662	$ 3,668	3,299
Restricted Share Units \| 2014 Plan
Share-based compensation
Unrecognized compensation costs	25,886		25,886		$ 25,886
Weighted-average remaining period for recognition (in years)					2 years 2 months 1 day
Restricted Share Units \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			3,255	2,547	$ 6,461	4,760
Performance Share Units \| 2014 Plan
Share-based compensation
Unrecognized compensation costs	$ 427		427		$ 427
Weighted-average remaining period for recognition (in years)					10 months 13 days
Performance Share Units \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			$ (108)	$ 875	$ (46)	$ 1,435
ESPP \| Employee Share Purchase Plan
Share-based compensation
Ordinary shares available for issue	72,773	150,000	72,773	86,712	72,773	86,712
Discounted rate for purchase of shares		85.00%
Issuance of ordinary shares relating to employee stock purchase plan (in shares)					13,939	0
ESPP \| 2014 Plans and ESPP
Share-based compensation
Share-based compensation expense			$ 8		$ 23