| Schedule of segment reporting |
| | | | | | | | | | | | | | | Three months ended June 30, | | Six months ended June 30, | | | 2026 | | 2025 | | 2026 | | 2025 | | | | (in thousands) | | (in thousands) | Revenue | | $ | 5,841 | | $ | 5,262 | | $ | 9,403 | | $ | 6,829 | Less: | | | | | | | | | | | | | Employee related expenses | | | (16,960) | | | (14,525) | | | (33,746) | | | (28,741) | Laboratory and development expenses | | | (17,387) | | | (15,593) | | | (32,148) | | | (31,560) | Professional fees | | | (1,756) | | | (3,124) | | | (6,263) | | | (5,181) | Information technology system costs(2) | | | (1,427) | | | (838) | | | (3,086) | | | (1,839) | Facility expenses | | | (1,437) | | | (1,704) | | | (2,984) | | | (3,371) | Other segment items(1) (2) | | | (2,511) | | | (1,804) | | | (6,024) | | | (2,773) | Segment operating loss | | | (35,637) | | | (32,326) | | | (74,848) | | | (66,636) | Reconciliation | | | | | | | | | | | | | Depreciation and amortization expense | | | (4,907) | | | (3,630) | | | (7,863) | | | (8,157) | Share-based compensation expense | | | (5,016) | | | (5,084) | | | (10,106) | | | (9,494) | Fair value (loss) / gain - contingent consideration | | | (1,256) | | | (2,254) | | | 82 | | | (3,470) | Fair value loss - Liability related to pre-funded warrants | | | (15,970) | | | — | | | (12,201) | | | — | Foreign currency (losses) / gains, net | | | (1,730) | | | 18,638 | | | (4,024) | | | 25,810 | Interest income | | | 5,051 | | | 3,524 | | | 10,280 | | | 7,651 | Interest expense - Royalty Financing Agreement | | | (12,963) | | | (13,770) | | | (25,584) | | | (27,079) | Interest expense - Hercules loan facility | | | (1,403) | | | (1,821) | | | (2,813) | | | (3,621) | Other reconciling items | | | (5,387) | | | (571) | | | (5,188) | | | 4,561 | Consolidated loss before income tax expense | | $ | (79,218) | | $ | (37,294) | | $ | (132,265) | | $ | (80,435) |
| (1) | Other segment items included in segment operating loss include costs related to intellectual property and insurance offset by income related to payments received from European authorities to subsidize the Company’s research and development in the Netherlands. |
| (2) | The comparative amounts for the three and six months ended June 30, 2025 have been adjusted to reflect the level of detail at which the CODM reviews segment operating expenses in 2026, with information technology system costs presented as a separate line item and consumables included within other segment items for all periods presented. |
|