<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e282a-b2d0-7eea-8a76-7f5400b27347,g:6faa6a07-7278-4419-8280-e4a8a093f648-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="cort-20260630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e282a-b3a3-76d8-989e-a7cd38f485ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e282a-b3a3-76d8-989e-a7cd38f485ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019e282a-b3a3-7afb-a78f-ab60e033717c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019e282a-b3a3-7afb-a78f-ab60e033717c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e282a-b3a3-7cbe-9541-cecd1a5bb47e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e282a-b3a3-7cbe-9541-cecd1a5bb47e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e282a-b3a3-779d-83d0-a0ddfb5678a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:to="loc_us-gaap_InventoryNet_019e282a-b3a3-779d-83d0-a0ddfb5678a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a3-7001-a56a-0cb402dfd738" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e282a-b3a3-7d75-9eb9-a55e51f894e2" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a3-7001-a56a-0cb402dfd738" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-784e-9ffa-2d3d02d5b770" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e282a-b3a3-7ef1-a854-3b8d1727cf17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-784e-9ffa-2d3d02d5b770" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e282a-b3a3-7ef1-a854-3b8d1727cf17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedResearchAndDevelopmentExpensesCurrent_019e282a-b3a3-76f2-8cd5-42d86eed677e" xlink:href="cort-20260630.xsd#cort_AccruedResearchAndDevelopmentExpensesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-784e-9ffa-2d3d02d5b770" xlink:to="loc_cort_AccruedResearchAndDevelopmentExpensesCurrent_019e282a-b3a3-76f2-8cd5-42d86eed677e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a3-72b6-936b-6a37ae37fa3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-784e-9ffa-2d3d02d5b770" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a3-72b6-936b-6a37ae37fa3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e282a-b3a3-748b-9210-8b60151ca0a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-784e-9ffa-2d3d02d5b770" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e282a-b3a3-748b-9210-8b60151ca0a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e282a-b3a3-79e9-bdeb-7f9792883ada" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_AssetsCurrent_019e282a-b3a3-79e9-bdeb-7f9792883ada" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019e282a-b3a3-7a3a-924e-36b44b73562c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_InventoryNoncurrent_019e282a-b3a3-7a3a-924e-36b44b73562c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e282a-b3a3-7ed5-a050-cbbf25a09204" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e282a-b3a3-7ed5-a050-cbbf25a09204" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e282a-b3a3-7151-8a01-6347f69c7c5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e282a-b3a3-7151-8a01-6347f69c7c5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_019e282a-b3a3-7798-a105-8f3e2c3a5025" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_019e282a-b3a3-7798-a105-8f3e2c3a5025" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e282a-b3a3-78a8-ba0f-c6705fbd4349" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e282a-b3a3-78a8-ba0f-c6705fbd4349" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e282a-b3a3-76a9-ab52-ffdbe152d03c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e282a-b3a3-7f45-830f-8b9d9b30668f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e282a-b3a3-76a9-ab52-ffdbe152d03c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e282a-b3a3-7ce4-8490-2d8bc2388097" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e282a-b3a3-7761-a039-3afdbffe9054" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e282a-b3a3-7ce4-8490-2d8bc2388097" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019e282a-b3a3-7761-a039-3afdbffe9054" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e282a-b3a3-77b8-a3e0-89fcc93566a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e282a-b3a3-7ce4-8490-2d8bc2388097" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e282a-b3a3-77b8-a3e0-89fcc93566a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-7e13-9c5a-3fc2981bdb0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e282a-b3a3-7ce4-8490-2d8bc2388097" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e282a-b3a3-7e13-9c5a-3fc2981bdb0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_LongTermAccruedGovernmentRebates_019e71a9-b15b-7bb4-a4bc-ec1491876f3c" xlink:href="cort-20260630.xsd#cort_LongTermAccruedGovernmentRebates"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e282a-b3a3-7ce4-8490-2d8bc2388097" xlink:to="loc_cort_LongTermAccruedGovernmentRebates_019e71a9-b15b-7bb4-a4bc-ec1491876f3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e282a-b3a3-7322-be98-83207036da3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7d2c-afe7-8f522f35a3d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e282a-b3a3-7322-be98-83207036da3f" xlink:to="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7d2c-afe7-8f522f35a3d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e282a-b3a3-7715-9902-5b4f93695509" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e282a-b3a3-7322-be98-83207036da3f" xlink:to="loc_us-gaap_Liabilities_019e282a-b3a3-7715-9902-5b4f93695509" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e282a-b3a3-71f6-bae2-34a1bcffd42d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e282a-b3a3-7322-be98-83207036da3f" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e282a-b3a3-71f6-bae2-34a1bcffd42d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019e282a-b3a3-7166-a6c5-ff8d89e99892" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_PreferredStockValue_019e282a-b3a3-7166-a6c5-ff8d89e99892" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e282a-b3a3-7d9a-897e-1c4e2fe1c972" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_CommonStockValue_019e282a-b3a3-7d9a-897e-1c4e2fe1c972" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019e282a-b3a3-7876-ba9b-52192ecb5609" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019e282a-b3a3-7876-ba9b-52192ecb5609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e282a-b3a3-77ad-b209-44d667544f6a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e282a-b3a3-77ad-b209-44d667544f6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e282a-b3a3-7dbc-a9b7-f3583a91f82d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e282a-b3a3-7dbc-a9b7-f3583a91f82d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e282a-b3a3-7eae-8c6d-9e2afe75341c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e282a-b3a3-7b61-a652-2caf2e19dce2" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e282a-b3a3-7eae-8c6d-9e2afe75341c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="cort-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e282a-b3a3-7f70-a084-46e2be097be7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e282a-b3a3-7858-b384-c839d67ecb9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e282a-b3a3-7f70-a084-46e2be097be7" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e282a-b3a3-7858-b384-c839d67ecb9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e282a-b3a3-7c39-8222-8e31ab43c1b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e282a-b3a3-7f70-a084-46e2be097be7" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e282a-b3a3-7c39-8222-8e31ab43c1b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e282a-b3a3-7c59-b8a6-258f907e9228" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e282a-b3a3-7da5-94d9-705e68637d13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e282a-b3a3-7c59-b8a6-258f907e9228" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e282a-b3a3-7da5-94d9-705e68637d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e282a-b3a3-74d1-b9eb-e7f9f81e7488" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e282a-b3a3-7c59-b8a6-258f907e9228" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e282a-b3a3-74d1-b9eb-e7f9f81e7488" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e282a-b3a3-77fc-b011-9a794d6dc840" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e282a-b3a3-7866-91d6-4763ed44904d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e282a-b3a3-77fc-b011-9a794d6dc840" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e282a-b3a3-7866-91d6-4763ed44904d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7629-a604-cc608a13e69b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e282a-b3a3-77fc-b011-9a794d6dc840" xlink:to="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7629-a604-cc608a13e69b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7f89-a149-1fb0247b466f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e282a-b3a3-7411-a493-d7263cd489db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7f89-a149-1fb0247b466f" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e282a-b3a3-7411-a493-d7263cd489db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e282a-b3a3-7696-b175-1bc1e7d38c6c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7f89-a149-1fb0247b466f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e282a-b3a3-7696-b175-1bc1e7d38c6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e282a-b3a3-739a-8bcb-b0810c0515ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e282a-b3a3-7f89-a149-1fb0247b466f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e282a-b3a3-739a-8bcb-b0810c0515ac" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="cort-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e282a-b3a3-79c0-bd16-c1bee3870fe6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e282a-b3a3-783b-9ac3-a8afaeaf34a5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e282a-b3a3-79c0-bd16-c1bee3870fe6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e282a-b3a3-783b-9ac3-a8afaeaf34a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e282a-b3a3-714e-80aa-179432775856" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e282a-b3a3-79c0-bd16-c1bee3870fe6" xlink:to="loc_us-gaap_NetIncomeLoss_019e282a-b3a3-714e-80aa-179432775856" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e282a-b3a3-78b0-981a-88e3dc4cd638" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e282a-b3a3-79c0-bd16-c1bee3870fe6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e282a-b3a3-78b0-981a-88e3dc4cd638" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="cort-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-7f33-a36c-1d1dac0818d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e282a-b3a4-79f6-81bc-4e6f8958525e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-7f33-a36c-1d1dac0818d4" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e282a-b3a4-79f6-81bc-4e6f8958525e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019e282a-b3a4-7b41-8e25-a625fcd03308" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-7f33-a36c-1d1dac0818d4" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019e282a-b3a4-7b41-8e25-a625fcd03308" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019e282a-b3a4-731e-b5ef-ef2994c8d841" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-7f33-a36c-1d1dac0818d4" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019e282a-b3a4-731e-b5ef-ef2994c8d841" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019eb581-cf7a-779b-afab-ddd2755fb33e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019eb581-cf7a-7d16-ae1f-2a287ed05296" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019eb581-cf7a-779b-afab-ddd2755fb33e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019eb581-cf7a-7d16-ae1f-2a287ed05296" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019eb581-cf7a-75dd-bff5-2f3813833370" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019eb581-cf7a-779b-afab-ddd2755fb33e" xlink:to="loc_us-gaap_RestrictedCash_019eb581-cf7a-75dd-bff5-2f3813833370" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e282a-b3a4-7daf-9b98-c7877152b532" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a4-784c-a89d-6881c4a8a929" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e282a-b3a4-7daf-9b98-c7877152b532" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a4-784c-a89d-6881c4a8a929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-78ea-a308-0e4e65fa95cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e282a-b3a4-7daf-9b98-c7877152b532" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e282a-b3a4-78ea-a308-0e4e65fa95cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7890-a8da-7b254f6eb05c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e282a-b3a4-7daf-9b98-c7877152b532" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7890-a8da-7b254f6eb05c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e282a-b3a4-7bde-b974-1da710509efb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e282a-b3a4-7daf-9b98-c7877152b532" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e282a-b3a4-7bde-b974-1da710509efb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7357-845c-1070b6d3ab08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019e282a-b3a4-75ab-bee5-07a9668bbd36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7357-845c-1070b6d3ab08" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019e282a-b3a4-75ab-bee5-07a9668bbd36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e282a-b3a4-70f3-b952-9b1f19c73aca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7357-845c-1070b6d3ab08" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e282a-b3a4-70f3-b952-9b1f19c73aca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e282a-b3a4-7c26-a837-0c9600f6e712" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7357-845c-1070b6d3ab08" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e282a-b3a4-7c26-a837-0c9600f6e712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019e282a-b3a4-7545-8b90-feab6e99ef70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e282a-b3a4-7357-845c-1070b6d3ab08" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019e282a-b3a4-7545-8b90-feab6e99ef70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccretionExpenseIncome_019e282a-b3a3-709d-944c-341b624fe477" xlink:href="cort-20260630.xsd#cort_AccretionExpenseIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_cort_AccretionExpenseIncome_019e282a-b3a3-709d-944c-341b624fe477" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e282a-b3a3-7ee4-80c3-1707cc77b8ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e282a-b3a3-7ee4-80c3-1707cc77b8ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e282a-b3a3-7fa9-8e2b-f823c7446569" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e282a-b3a3-7fa9-8e2b-f823c7446569" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e282a-b3a3-7aa0-a78d-ea7b626fa425" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e282a-b3a3-7aa0-a78d-ea7b626fa425" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e282a-b3a3-7420-8cac-316cde91af3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_ShareBasedCompensation_019e282a-b3a3-7420-8cac-316cde91af3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e282a-b3a3-71f4-a7ca-5f4f006397cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e282a-b3a3-71f4-a7ca-5f4f006397cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_019e282a-b3a3-7313-a77b-cf4ffe1232ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_019e282a-b3a3-7313-a77b-cf4ffe1232ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses_019e282a-b3a3-7d08-98b5-1c0cd90b328d" xlink:href="cort-20260630.xsd#cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_cort_IncreaseDecreaseInAccruedResearchAndDevelopmentExpenses_019e282a-b3a3-7d08-98b5-1c0cd90b328d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019e282a-b3a3-7e2d-bb46-0c8a732687bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_ProfitLoss_019e282a-b3a3-7e2d-bb46-0c8a732687bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e282a-b3a3-7d45-98d9-2247f23fc029" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e282a-b3a3-7d45-98d9-2247f23fc029" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e282a-b3a4-7324-a054-c1c8ddc8a35f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e282a-b3a3-77e4-a897-f826f9892662" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e282a-b3a4-7324-a054-c1c8ddc8a35f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7ca9-9b43-60d4f73dcf13" xlink:href="cort-20260630.xsd#cort_InventoryCurrentNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_019e282a-b3a4-73bb-a6a5-85bb138606d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7ca9-9b43-60d4f73dcf13" xlink:to="loc_us-gaap_InventoryNoncurrent_019e282a-b3a4-73bb-a6a5-85bb138606d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e282a-b3a4-7e10-8be3-b8103de7ae9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7ca9-9b43-60d4f73dcf13" xlink:to="loc_us-gaap_InventoryNet_019e282a-b3a4-7e10-8be3-b8103de7ae9d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1" xlink:type="simple" xlink:href="cort-20260630.xsd#CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofCompositionofInventoryDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7c55-bfed-793bf655a52e" xlink:href="cort-20260630.xsd#cort_InventoryCurrentNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryFinishedGoodsCurrentAndNoncurrent_019e282a-b3a4-7b7c-9274-1f2ba7a01edf" xlink:href="cort-20260630.xsd#cort_InventoryFinishedGoodsCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7c55-bfed-793bf655a52e" xlink:to="loc_cort_InventoryFinishedGoodsCurrentAndNoncurrent_019e282a-b3a4-7b7c-9274-1f2ba7a01edf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryWorkInProcessCurrentAndNoncurrent_019e282a-b3a4-7b23-a017-940c4187851c" xlink:href="cort-20260630.xsd#cort_InventoryWorkInProcessCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7c55-bfed-793bf655a52e" xlink:to="loc_cort_InventoryWorkInProcessCurrentAndNoncurrent_019e282a-b3a4-7b23-a017-940c4187851c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_InventoryRawMaterialCurrentAndNoncurrent_019e282a-b3a4-7abd-b1e0-ebfa9ad5a6b8" xlink:href="cort-20260630.xsd#cort_InventoryRawMaterialCurrentAndNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_cort_InventoryCurrentNoncurrent_019e282a-b3a4-7c55-bfed-793bf655a52e" xlink:to="loc_cort_InventoryRawMaterialCurrentAndNoncurrent_019e282a-b3a4-7abd-b1e0-ebfa9ad5a6b8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_019e282a-b3a4-7b2f-812b-5903e8f76eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_019e282a-b3a4-7b2f-812b-5903e8f76eb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_ClinicalDepositsCurrent_019e282a-b3a4-78c2-b801-a3e034f8962b" xlink:href="cort-20260630.xsd#cort_ClinicalDepositsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:to="loc_cort_ClinicalDepositsCurrent_019e282a-b3a4-78c2-b801-a3e034f8962b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidTaxes_019e282a-b3a4-78fe-8db7-00e00b9f35b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:to="loc_us-gaap_PrepaidTaxes_019e282a-b3a4-78fe-8db7-00e00b9f35b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_DeferredClinicalMaterialsCurrent_019e282a-b3a4-7a70-9c24-2ed528d781a2" xlink:href="cort-20260630.xsd#cort_DeferredClinicalMaterialsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:to="loc_cort_DeferredClinicalMaterialsCurrent_019e282a-b3a4-7a70-9c24-2ed528d781a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019f7da5-8791-70b2-9cf1-d7fb84e40ce2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e282a-b3a4-748c-bcaf-a69094b20388" xlink:to="loc_us-gaap_OtherAssetsCurrent_019f7da5-8791-70b2-9cf1-d7fb84e40ce2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/CompositionofCertainBalanceSheetItemsScheduleofOtherAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a4-7e68-a8c0-16427cdb7813" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_ShortTermAccruedGovernmentRebateCurrent_019e282a-b3a4-7aa6-834c-10368c501799" xlink:href="cort-20260630.xsd#cort_ShortTermAccruedGovernmentRebateCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a4-7e68-a8c0-16427cdb7813" xlink:to="loc_cort_ShortTermAccruedGovernmentRebateCurrent_019e282a-b3a4-7aa6-834c-10368c501799" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e282a-b3a4-72ed-b106-f5368271a8dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a4-7e68-a8c0-16427cdb7813" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e282a-b3a4-72ed-b106-f5368271a8dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_019e282a-b3a4-7853-83cd-b7f2da19ce1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a4-7e68-a8c0-16427cdb7813" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_019e282a-b3a4-7853-83cd-b7f2da19ce1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cort_AccruedCompensationCurrent_019e282a-b3a4-7b89-9be3-3d584124d4bb" xlink:href="cort-20260630.xsd#cort_AccruedCompensationCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e282a-b3a4-7e68-a8c0-16427cdb7813" xlink:to="loc_cort_AccruedCompensationCurrent_019e282a-b3a4-7b89-9be3-3d584124d4bb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/AvailableforSaleMarketableSecuritiesandFairValueMeasurementsScheduleofAvailableforSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019e282a-b3a4-7aae-ab7c-aec3e7836007" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e282a-b3a4-7cb4-8c45-15a3519d209a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019e282a-b3a4-7aae-ab7c-aec3e7836007" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e282a-b3a4-7cb4-8c45-15a3519d209a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e282a-b3a4-797a-a9f4-a2da30b456e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019e282a-b3a4-7aae-ab7c-aec3e7836007" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e282a-b3a4-797a-a9f4-a2da30b456e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019e282a-b3a4-7fbf-9a80-a70937b464d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019e282a-b3a4-7aae-ab7c-aec3e7836007" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019e282a-b3a4-7fbf-9a80-a70937b464d8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e282a-b3a4-742d-ba92-2a4fa80dbf69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e282a-b3a4-742d-ba92-2a4fa80dbf69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e282a-b3a4-77b2-b229-c48fbc01b2d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e282a-b3a4-77b2-b229-c48fbc01b2d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e282a-b3a4-73ae-a617-3f411a43994f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e282a-b3a4-73ae-a617-3f411a43994f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e282a-b3a4-7d53-87c3-5d50fc0950ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e282a-b3a4-7d53-87c3-5d50fc0950ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e282a-b3a4-7eec-95e7-403b59d6c435" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-75fe-9ca7-e140723868b1" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e282a-b3a4-7eec-95e7-403b59d6c435" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="cort-20260630.xsd#LeasesScheduleofFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/LeasesScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-73f7-9786-dc8e80569acf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e282a-b3a4-7c2d-a619-18da2c7cfa26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-73f7-9786-dc8e80569acf" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e282a-b3a4-7c2d-a619-18da2c7cfa26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e282a-b3a4-7dd7-8d99-b4f49bcd54d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e282a-b3a4-73f7-9786-dc8e80569acf" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e282a-b3a4-7dd7-8d99-b4f49bcd54d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/StockBasedCompensationDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#StockBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/StockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019e282a-b3a4-7bd4-a216-d7a30aba2a01" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_019e282a-b3a4-7ff5-a550-ff01525e611b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019e282a-b3a4-7bd4-a216-d7a30aba2a01" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_019e282a-b3a4-7ff5-a550-ff01525e611b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e282a-b3a4-7419-8d40-7261199f0617" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019e282a-b3a4-7bd4-a216-d7a30aba2a01" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019e282a-b3a4-7419-8d40-7261199f0617" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.corcept.com/role/NetIncomePerShareScheduleofComputationofNetLossIncomePerShareDetails" xlink:type="simple" xlink:href="cort-20260630.xsd#NetIncomePerShareScheduleofComputationofNetLossIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.corcept.com/role/NetIncomePerShareScheduleofComputationofNetLossIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e282a-b3a4-71a1-ab4a-97305154c1a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e282a-b3a4-7dfe-b834-4126767e4df1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e282a-b3a4-71a1-ab4a-97305154c1a0" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e282a-b3a4-7dfe-b834-4126767e4df1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e282a-b3a4-7632-b6b5-47d76f4a2024" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e282a-b3a4-71a1-ab4a-97305154c1a0" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e282a-b3a4-7632-b6b5-47d76f4a2024" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
