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  <xs:element id="cort_NumberOfSeriesOfSelectiveCortisolModulators" abstract="false" name="NumberOfSeriesOfSelectiveCortisolModulators" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cort_NumberOfCompounds" abstract="false" name="NumberOfCompounds" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cort_InventoryRawMaterialCurrentAndNoncurrent" abstract="false" name="InventoryRawMaterialCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_InventoryWorkInProcessCurrentAndNoncurrent" abstract="false" name="InventoryWorkInProcessCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_InventoryFinishedGoodsCurrentAndNoncurrent" abstract="false" name="InventoryFinishedGoodsCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_InventoryCurrentNoncurrent" abstract="false" name="InventoryCurrentNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_ClinicalDepositsCurrent" abstract="false" name="ClinicalDepositsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_DeferredClinicalMaterialsCurrent" abstract="false" name="DeferredClinicalMaterialsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_ShortTermAccruedGovernmentRebateCurrent" abstract="false" name="ShortTermAccruedGovernmentRebateCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_AccruedCompensationCurrent" abstract="false" name="AccruedCompensationCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_MarketableSecuritiesMaximumMaturityPeriod" abstract="false" name="MarketableSecuritiesMaximumMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cort_MarketableSecuritiesShortTermMaximumMaturityPeriod" abstract="false" name="MarketableSecuritiesShortTermMaximumMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cort_MarketableSecuritiesWeightedAverageMaturityPeriod" abstract="false" name="MarketableSecuritiesWeightedAverageMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cort_PurchaseObligationAdditionalActivePharmaceuticalIngredientCommittedToPurchase" abstract="false" name="PurchaseObligationAdditionalActivePharmaceuticalIngredientCommittedToPurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cort_LesseeOperatingLeaseRentableArea" abstract="false" name="LesseeOperatingLeaseRentableArea" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="cort_OperatingLeaseLiabilityObligatedBaseRent" abstract="false" name="OperatingLeaseLiabilityObligatedBaseRent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cort_StockOptionAndRestrictedStockUnitsMember" abstract="true" name="StockOptionAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cort_HypercortisolismProductsMember" abstract="true" name="HypercortisolismProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cort_LifyorliMember" abstract="true" name="LifyorliMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cort_DavidL.MahoneyMember" abstract="true" name="DavidL.MahoneyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cort_JosephD.LyonMember" abstract="true" name="JosephD.LyonMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cort_JosephK.BelanoffM.D.Member" abstract="true" name="JosephK.BelanoffM.D.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
