<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e22b2-38a6-7ac4-b743-e2716790db19,g:5242c770-e4ca-4653-8453-0601d7f5e0ca-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e22b2-398b-7dac-91e4-9fc74a2b8130" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e22b2-398b-705b-b9ea-d6a7d1067767" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e22b2-398b-7dac-91e4-9fc74a2b8130" xlink:to="loc_us-gaap_Liabilities_019e22b2-398b-705b-b9ea-d6a7d1067767" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e22b2-398b-71a7-ba48-fa98fe20b093" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e22b2-398b-7dac-91e4-9fc74a2b8130" xlink:to="loc_us-gaap_StockholdersEquity_019e22b2-398b-71a7-ba48-fa98fe20b093" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e22b2-398b-7989-a029-bd7a070c0332" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e22b2-398b-7dac-91e4-9fc74a2b8130" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e22b2-398b-7989-a029-bd7a070c0332" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e22b2-398b-7d0e-a017-9efb158c5c00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e22b2-398b-7d0e-a017-9efb158c5c00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e22b2-398b-7335-9003-5e84bdc4781b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e22b2-398b-7335-9003-5e84bdc4781b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationLiabilityCurrent_019e22b2-398b-7db1-b288-53e66749ce05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredCompensationLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_DeferredCompensationLiabilityCurrent_019e22b2-398b-7db1-b288-53e66749ce05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e22b2-398b-7eb0-a69d-fa63924dff89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e22b2-398b-7eb0-a69d-fa63924dff89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e22b2-398b-70ca-8092-4097bb6332df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e22b2-398b-70ca-8092-4097bb6332df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_019e22b2-398b-7b90-a64b-35f0fc53aa0e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7c2d-bf83-45a479093447" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_019e22b2-398b-7b90-a64b-35f0fc53aa0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e22b2-398b-79e9-bfc3-a551cbde71ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7a33-97c5-53f84a8579f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e22b2-398b-79e9-bfc3-a551cbde71ad" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e22b2-398b-7a33-97c5-53f84a8579f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019e22b2-398b-75ff-bbbf-7fb81e35994d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e22b2-398b-79e9-bfc3-a551cbde71ad" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019e22b2-398b-75ff-bbbf-7fb81e35994d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e22b2-398b-71e2-ae1a-6fca26772fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e22b2-398b-79e9-bfc3-a551cbde71ad" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e22b2-398b-71e2-ae1a-6fca26772fb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e22b2-398b-76c2-8faf-f7e5e0b6d97b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e22b2-398b-79e9-bfc3-a551cbde71ad" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e22b2-398b-76c2-8faf-f7e5e0b6d97b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e22b2-398b-726e-aa4c-e4788a1efc62" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_AssetsCurrent_019e22b2-398b-726e-aa4c-e4788a1efc62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e22b2-398b-743d-8aca-c7d728a3cf09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e22b2-398b-743d-8aca-c7d728a3cf09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e22b2-398b-702f-978e-4ef9bd4894d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e22b2-398b-702f-978e-4ef9bd4894d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_DeferredSolutionAndOtherCostsNoncurrent_019e22b2-398b-7369-af7b-35fe4a4ec331" xlink:href="qtwo-20260630.xsd#qtwo_DeferredSolutionAndOtherCostsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_qtwo_DeferredSolutionAndOtherCostsNoncurrent_019e22b2-398b-7369-af7b-35fe4a4ec331" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_DeferredImplementationCostsNoncurrent_019e22b2-398b-7726-8c69-4342ff1bfc7a" xlink:href="qtwo-20260630.xsd#qtwo_DeferredImplementationCostsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_qtwo_DeferredImplementationCostsNoncurrent_019e22b2-398b-7726-8c69-4342ff1bfc7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e22b2-398b-748d-82b4-6b3187e28afd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e22b2-398b-748d-82b4-6b3187e28afd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e22b2-398b-762e-8e41-4a0f5d7bc007" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_Goodwill_019e22b2-398b-762e-8e41-4a0f5d7bc007" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetNoncurrent_019e22b2-398b-7c8d-8049-55c843389445" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNetNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetNoncurrent_019e22b2-398b-7c8d-8049-55c843389445" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e22b2-398b-742b-a088-c58f54a4679c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e22b2-398b-764b-9774-206d9f83fbed" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e22b2-398b-742b-a088-c58f54a4679c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_019e22b2-398b-754b-85e5-45a9361716a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:to="loc_us-gaap_CommonStockValueOutstanding_019e22b2-398b-754b-85e5-45a9361716a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019e22b2-398b-7728-9e80-99db6e51a56e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019e22b2-398b-7728-9e80-99db6e51a56e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e22b2-398b-7850-b64f-1996bc63ce3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e22b2-398b-7850-b64f-1996bc63ce3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e22b2-398b-75c5-bc0f-1a21d9db3bda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e22b2-398b-75c5-bc0f-1a21d9db3bda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValueOutstanding_019e22b2-398b-7e29-ad95-43b4f731972f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValueOutstanding"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e22b2-398b-777b-b23b-d502d0538fe8" xlink:to="loc_us-gaap_PreferredStockValueOutstanding_019e22b2-398b-7e29-ad95-43b4f731972f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e22b2-398b-77d7-b56a-bb88614275bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e22b2-398b-77d7-b56a-bb88614275bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019e22b2-398b-78b0-b8f4-74f10dcf9339" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCash"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_RestrictedCash_019e22b2-398b-78b0-b8f4-74f10dcf9339" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019e22b2-398b-7a9e-baab-c5dd6ca595a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019e22b2-398b-7a9e-baab-c5dd6ca595a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e22b2-398b-718d-8ce6-424b22ae6ab6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e22b2-398b-718d-8ce6-424b22ae6ab6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019e22b2-398b-7173-a234-597600bc56ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019e22b2-398b-7173-a234-597600bc56ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e22b2-398b-7ffb-ac1a-d4aeccde96d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e22b2-398b-7ffb-ac1a-d4aeccde96d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_DeferredSolutionAndOtherCostsCurrentPortion_019e22b2-398b-72b0-a67c-631edc26de20" xlink:href="qtwo-20260630.xsd#qtwo_DeferredSolutionAndOtherCostsCurrentPortion"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_qtwo_DeferredSolutionAndOtherCostsCurrentPortion_019e22b2-398b-72b0-a67c-631edc26de20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_DeferredImplementationCostsCurrent_019e22b2-398b-71e0-aa15-f1e90abff791" xlink:href="qtwo-20260630.xsd#qtwo_DeferredImplementationCostsCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e22b2-398b-7e4b-85ee-5f810c253bf6" xlink:to="loc_qtwo_DeferredImplementationCostsCurrent_019e22b2-398b-71e0-aa15-f1e90abff791" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e22b2-398b-793b-85c9-ec2034961c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_InterestandOtherExpenseNonoperating_019e22b2-398b-793a-9af8-351eb4f3ad05" xlink:href="qtwo-20260630.xsd#qtwo_InterestandOtherExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e22b2-398b-793b-85c9-ec2034961c8c" xlink:to="loc_qtwo_InterestandOtherExpenseNonoperating_019e22b2-398b-793a-9af8-351eb4f3ad05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndOtherIncome_019e22b2-398b-7b9f-bc5c-41930d92d38e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestAndOtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e22b2-398b-793b-85c9-ec2034961c8c" xlink:to="loc_us-gaap_InterestAndOtherIncome_019e22b2-398b-7b9f-bc5c-41930d92d38e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e22b2-398b-76bf-8847-a1dec5a7e653" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e22b2-398b-7d0c-bf47-996c47e26c91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e22b2-398b-76bf-8847-a1dec5a7e653" xlink:to="loc_us-gaap_GrossProfit_019e22b2-398b-7d0c-bf47-996c47e26c91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e22b2-398b-7e53-88a8-8e144d33724b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e22b2-398b-76bf-8847-a1dec5a7e653" xlink:to="loc_us-gaap_OperatingExpenses_019e22b2-398b-7e53-88a8-8e144d33724b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_019e22b2-398b-7fb5-b277-5f1112869d48" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_us-gaap_SellingAndMarketingExpense_019e22b2-398b-7fb5-b277-5f1112869d48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e22b2-398b-7fc7-aed1-710be5ceceb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e22b2-398b-7fc7-aed1-710be5ceceb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019e22b2-398b-7312-a9a4-c9911056d39d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019e22b2-398b-7312-a9a4-c9911056d39d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019e22b2-398b-7eb4-9e54-ffcf4ec5c540" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019e22b2-398b-7eb4-9e54-ffcf4ec5c540" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_LeaseAndOtherRestructuringCharges_019e22b2-398b-7875-9fc9-439d40040d7a" xlink:href="qtwo-20260630.xsd#qtwo_LeaseAndOtherRestructuringCharges"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_qtwo_LeaseAndOtherRestructuringCharges_019e22b2-398b-7875-9fc9-439d40040d7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e22b2-398b-78b4-bdf0-d669f0178079" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e22b2-398b-7606-abd5-5228537553a8" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019e22b2-398b-78b4-bdf0-d669f0178079" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7791-8109-21ab342b6582" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e22b2-398b-75a0-b4de-af220f87dc2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7791-8109-21ab342b6582" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e22b2-398b-75a0-b4de-af220f87dc2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e22b2-398b-75d9-aba6-7c7713a53624" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7791-8109-21ab342b6582" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e22b2-398b-75d9-aba6-7c7713a53624" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e22b2-398b-750c-9d62-49d1e8214ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e22b2-398b-71a4-a6cd-0e6cb351395a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e22b2-398b-750c-9d62-49d1e8214ed0" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e22b2-398b-71a4-a6cd-0e6cb351395a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e22b2-398b-7b93-8f88-cb933f58e4de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e22b2-398b-750c-9d62-49d1e8214ed0" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e22b2-398b-7b93-8f88-cb933f58e4de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e22b2-398b-76b0-a9ca-d84c44173ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019e22b2-398b-780a-84f6-23d621f18024" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e22b2-398b-76b0-a9ca-d84c44173ae5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019e22b2-398b-780a-84f6-23d621f18024" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7446-abc7-b3d34efc06ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e22b2-398b-76b0-a9ca-d84c44173ae5" xlink:to="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7446-abc7-b3d34efc06ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019e22b2-398b-7886-bc50-c2bbbbb439bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e22b2-398b-76b0-a9ca-d84c44173ae5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019e22b2-398b-7886-bc50-c2bbbbb439bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f8b8a-764d-71b7-b63f-f1fcd468aead" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019f8b8a-764d-7ce1-b62a-c0cf4e2d5a44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f8b8a-764d-71b7-b63f-f1fcd468aead" xlink:to="loc_us-gaap_OperatingIncomeLoss_019f8b8a-764d-7ce1-b62a-c0cf4e2d5a44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019f8b8a-764d-7024-a8fc-24959b7e6e8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019f8b8a-764d-71b7-b63f-f1fcd468aead" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019f8b8a-764d-7024-a8fc-24959b7e6e8d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-7820-bba2-dbf84658016e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019e22b2-398c-7f88-9853-0598e025c5ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-7820-bba2-dbf84658016e" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019e22b2-398c-7f88-9853-0598e025c5ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e22b2-398c-7e84-8928-9d8e82f1ab4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-7820-bba2-dbf84658016e" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e22b2-398c-7e84-8928-9d8e82f1ab4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_PaymentForMaturityOfConvertibleDebt_019f1bc2-aac0-7356-9656-96c73ec46d7d" xlink:href="qtwo-20260630.xsd#qtwo_PaymentForMaturityOfConvertibleDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-7820-bba2-dbf84658016e" xlink:to="loc_qtwo_PaymentForMaturityOfConvertibleDebt_019f1bc2-aac0-7356-9656-96c73ec46d7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e22b2-398b-7ed0-8a5f-11b6ca25af2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e22b2-398b-7ed0-8a5f-11b6ca25af2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019e22b2-398b-7837-8044-4488f2d1e014" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019e22b2-398b-7837-8044-4488f2d1e014" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_019e22b2-398b-7fa8-a700-67fbe20e0a5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_019e22b2-398b-7fa8-a700-67fbe20e0a5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_IncreaseDecreaseinDeferredSolutionandOtherCosts_019e22b2-398b-7fec-bf42-e252fe1e9e1d" xlink:href="qtwo-20260630.xsd#qtwo_IncreaseDecreaseinDeferredSolutionandOtherCosts"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_qtwo_IncreaseDecreaseinDeferredSolutionandOtherCosts_019e22b2-398b-7fec-bf42-e252fe1e9e1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e22b2-398b-73f6-9873-ec27928b200f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e22b2-398b-73f6-9873-ec27928b200f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019e22b2-398b-7150-8b56-fdaf0dbd424d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019e22b2-398b-7150-8b56-fdaf0dbd424d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7eb7-b899-6b3ff210d290" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_NetIncomeLoss_019e22b2-398b-7eb7-b899-6b3ff210d290" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e22b2-398c-7dd9-807a-03f8caf769ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019e22b2-398c-7dd9-807a-03f8caf769ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_IncreaseDecreaseinDeferredImplementationCosts_019e22b2-398c-71c7-8091-2a78edb66994" xlink:href="qtwo-20260630.xsd#qtwo_IncreaseDecreaseinDeferredImplementationCosts"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_qtwo_IncreaseDecreaseinDeferredImplementationCosts_019e22b2-398c-71c7-8091-2a78edb66994" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019e22b2-398c-7283-a8c0-7a1ec737de20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019e22b2-398c-7283-a8c0-7a1ec737de20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e22b2-398c-7715-aedd-16cf2fc2d0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e22b2-398c-7715-aedd-16cf2fc2d0a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_019e22b2-398c-7557-9aa3-7fbe9a858117" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_019e22b2-398c-7557-9aa3-7fbe9a858117" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e22b2-398c-7820-8bb5-618e3c1de6a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e22b2-398c-7820-8bb5-618e3c1de6a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_OperatingLeaseRestructuringAndImpairmentLoss_019e22b2-398c-7a7b-b433-847330bdb6da" xlink:href="qtwo-20260630.xsd#qtwo_OperatingLeaseRestructuringAndImpairmentLoss"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_qtwo_OperatingLeaseRestructuringAndImpairmentLoss_019e22b2-398c-7a7b-b433-847330bdb6da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e22b2-398c-78e3-ad8f-b8582ba6ed1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e22b2-398c-78e3-ad8f-b8582ba6ed1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e22b2-398c-7b02-822c-af362cf1ec4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_ShareBasedCompensation_019e22b2-398c-7b02-822c-af362cf1ec4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAmortizationOfDeferredCharges_019e22b2-398c-7906-87bc-7c1b108e31c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAmortizationOfDeferredCharges"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_OtherAmortizationOfDeferredCharges_019e22b2-398c-7906-87bc-7c1b108e31c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e22b2-398c-7919-a90b-fce87b6147ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e22b2-398c-7919-a90b-fce87b6147ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019e22b2-398c-73a7-9310-024d44bc5880" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398b-772e-b1d8-8b0c01e6271d" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019e22b2-398c-73a7-9310-024d44bc5880" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7738-8b41-1c4d05fbe3f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e22b2-398c-740e-b24b-18b1f8365ca5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7738-8b41-1c4d05fbe3f4" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e22b2-398c-740e-b24b-18b1f8365ca5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019e22b2-398c-712d-a0e0-233ba08124da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7738-8b41-1c4d05fbe3f4" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019e22b2-398c-712d-a0e0-233ba08124da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForSoftware_019e22b2-398c-7cc4-b3a0-866db2a9024e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForSoftware"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7738-8b41-1c4d05fbe3f4" xlink:to="loc_us-gaap_PaymentsForSoftware_019e22b2-398c-7cc4-b3a0-866db2a9024e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019e22b2-398c-75b3-876a-841d9b284262" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7738-8b41-1c4d05fbe3f4" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019e22b2-398c-75b3-876a-841d9b284262" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e22b2-398c-795e-b6c3-d158584a0837" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398c-7df8-8265-74a7831f2924" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e22b2-398c-795e-b6c3-d158584a0837" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e22b2-398c-7df8-8265-74a7831f2924" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7988-9ef6-ea80870e0f1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e22b2-398c-795e-b6c3-d158584a0837" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e22b2-398c-7988-9ef6-ea80870e0f1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-749e-9feb-37258f18c8db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e22b2-398c-795e-b6c3-d158584a0837" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e22b2-398c-749e-9feb-37258f18c8db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e22b2-398c-7293-8d77-810530c3bc6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e22b2-398c-795e-b6c3-d158584a0837" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e22b2-398c-7293-8d77-810530c3bc6f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/SummaryofSignificantAccountingPoliciesScheduleofNetIncomePerShareBasicandDilutedDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#SummaryofSignificantAccountingPoliciesScheduleofNetIncomePerShareBasicandDilutedDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/SummaryofSignificantAccountingPoliciesScheduleofNetIncomePerShareBasicandDilutedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_AdjustedNetIncomeLossAttributableToParent_019e22b2-398c-7c2f-a330-2ac5d51d293c" xlink:href="qtwo-20260630.xsd#qtwo_AdjustedNetIncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e22b2-398c-74fa-9fd1-111a3e1c9af0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_qtwo_AdjustedNetIncomeLossAttributableToParent_019e22b2-398c-7c2f-a330-2ac5d51d293c" xlink:to="loc_us-gaap_NetIncomeLoss_019e22b2-398c-74fa-9fd1-111a3e1c9af0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_ReversalOfInterestExpenseNetOfTax_019e22b2-398c-7651-b243-7caedf10f32e" xlink:href="qtwo-20260630.xsd#qtwo_ReversalOfInterestExpenseNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_qtwo_AdjustedNetIncomeLossAttributableToParent_019e22b2-398c-7c2f-a330-2ac5d51d293c" xlink:to="loc_qtwo_ReversalOfInterestExpenseNetOfTax_019e22b2-398c-7651-b243-7caedf10f32e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019edb8f-bc5a-7fcc-af0d-d543e307edd8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019edb8f-bc5a-7004-b4c8-e08e38ae3866" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019edb8f-bc5a-7fcc-af0d-d543e307edd8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019edb8f-bc5a-7004-b4c8-e08e38ae3866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019edb8f-bc5a-7dd5-bfff-e5856086fd04" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019edb8f-bc5a-7fcc-af0d-d543e307edd8" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019edb8f-bc5a-7dd5-bfff-e5856086fd04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_IncrementalCommonSharesAttributableToDilutiveEffectOfEmployeeStockPurchasePlan_019edb8f-bc5a-76e4-87e3-e940635fd2f0" xlink:href="qtwo-20260630.xsd#qtwo_IncrementalCommonSharesAttributableToDilutiveEffectOfEmployeeStockPurchasePlan"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019edb8f-bc5a-7fcc-af0d-d543e307edd8" xlink:to="loc_qtwo_IncrementalCommonSharesAttributableToDilutiveEffectOfEmployeeStockPurchasePlan_019edb8f-bc5a-76e4-87e3-e940635fd2f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_019edb8f-bc5a-78ce-b107-efcb256644a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019edb8f-bc5a-7fcc-af0d-d543e307edd8" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_019edb8f-bc5a-78ce-b107-efcb256644a0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/CashCashEquivalentsandInvestmentsScheduleofCashCashEquivalentsandInvestmentsDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CashCashEquivalentsandInvestmentsScheduleofCashCashEquivalentsandInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CashCashEquivalentsandInvestmentsScheduleofCashCashEquivalentsandInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019e22b2-3a52-7642-a841-157e4f9f2803" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e22b2-3a52-7d7d-98b7-e3b9c11cbf09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019e22b2-3a52-7642-a841-157e4f9f2803" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e22b2-3a52-7d7d-98b7-e3b9c11cbf09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e22b2-3a52-7591-bb88-49d077cd7dfe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019e22b2-3a52-7642-a841-157e4f9f2803" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e22b2-3a52-7591-bb88-49d077cd7dfe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e22b2-3a52-79f7-9151-4e04bf497832" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019e22b2-3a52-7642-a841-157e4f9f2803" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e22b2-3a52-79f7-9151-4e04bf497832" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019e22b2-3a52-7a5c-804c-2aec8c5f15d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e22b2-3a52-783e-a843-44464de74980" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValue_019e22b2-3a52-7a5c-804c-2aec8c5f15d4" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e22b2-3a52-783e-a843-44464de74980" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/CashCashEquivalentsandInvestmentsScheduleofContractualMaturitiesDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CashCashEquivalentsandInvestmentsScheduleofContractualMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CashCashEquivalentsandInvestmentsScheduleofContractualMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_019e22b2-3a52-749f-bf6b-a92b0f5a49a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_019e22b2-3a52-77c9-aa18-90faa1f484a9" xlink:href="qtwo-20260630.xsd#qtwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_019e22b2-3a52-749f-bf6b-a92b0f5a49a2" xlink:to="loc_qtwo_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_019e22b2-3a52-77c9-aa18-90faa1f484a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019e22b2-3a52-7392-abe9-3893804f544d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_019e22b2-3a52-749f-bf6b-a92b0f5a49a2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019e22b2-3a52-7392-abe9-3893804f544d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7a55-8d3f-ab88108db1af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e22b2-3a52-7e03-ab0e-6382e4c2cefe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7a55-8d3f-ab88108db1af" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e22b2-3a52-7e03-ab0e-6382e4c2cefe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e22b2-3a52-7e39-a2c3-345d297f18f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7a55-8d3f-ab88108db1af" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e22b2-3a52-7e39-a2c3-345d297f18f8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/GoodwillandIntangibleAssetsScheduleofEstimatedFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#GoodwillandIntangibleAssetsScheduleofEstimatedFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/GoodwillandIntangibleAssetsScheduleofEstimatedFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019e22b2-3a52-7b69-9009-ec74208beb2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019e22b2-3a52-7b69-9009-ec74208beb2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019e22b2-3a52-7517-829e-51aac25348cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019e22b2-3a52-7517-829e-51aac25348cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019e22b2-3a52-7bbf-8052-a20557ac6370" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019e22b2-3a52-7bbf-8052-a20557ac6370" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019e22b2-3a52-7ba0-876f-d0b0f57e95fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019e22b2-3a52-7ba0-876f-d0b0f57e95fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019e22b2-3a52-7a86-a4aa-5fc5fceba3f9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019e22b2-3a52-7a86-a4aa-5fc5fceba3f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_IntangibleAssetFiniteLivedEstimatedAmortizationExpenseAfterYearFour_019e22b2-3a52-70ef-a55f-cf326d717a9e" xlink:href="qtwo-20260630.xsd#qtwo_IntangibleAssetFiniteLivedEstimatedAmortizationExpenseAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e22b2-3a52-7266-992a-ef000fdd240b" xlink:to="loc_qtwo_IntangibleAssetFiniteLivedEstimatedAmortizationExpenseAfterYearFour_019e22b2-3a52-70ef-a55f-cf326d717a9e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7445-9840-687a07ea4221" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e22b2-3a52-7b3f-85a8-a932ea207f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7445-9840-687a07ea4221" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e22b2-3a52-7b3f-85a8-a932ea207f5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e22b2-3a52-77b0-997d-84ccc5a9aab6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7445-9840-687a07ea4221" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e22b2-3a52-77b0-997d-84ccc5a9aab6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails_1" xlink:type="simple" xlink:href="qtwo-20260630.xsd#LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/LeasesScheduleofFutureMinimumPaymentsRequiredUnderOperatingLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e22b2-3a52-7b25-85f0-1d87db9ad72a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e22b2-3a52-7b25-85f0-1d87db9ad72a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e22b2-3a52-73ff-8000-42a83572a2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e22b2-3a52-73ff-8000-42a83572a2b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e22b2-3a52-7ab2-bfd9-215cdb31cc81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e22b2-3a52-7ab2-bfd9-215cdb31cc81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e22b2-3a52-729d-aa9b-ee1b5321cb0a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e22b2-3a52-729d-aa9b-ee1b5321cb0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e22b2-3a52-7454-8b21-e3842b7afaa1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e22b2-3a52-7454-8b21-e3842b7afaa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019e22b2-3a52-7b51-ba16-2ce6b1a783ce" xlink:href="qtwo-20260630.xsd#qtwo_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e22b2-3a52-7187-b94f-70ec979a943f" xlink:to="loc_qtwo_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019e22b2-3a52-7b51-ba16-2ce6b1a783ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/CommitmentsandContingenciesScheduleofFutureMinimumContractualCommitmentsDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#CommitmentsandContingenciesScheduleofFutureMinimumContractualCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/CommitmentsandContingenciesScheduleofFutureMinimumContractualCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligation"/>
    <link:loc xlink:type="locator" xlink:label="loc_qtwo_ContractualObligationToBePaidYearFourAndThereafter_019e22b2-3a52-7b2c-9341-b51c578f5674" xlink:href="qtwo-20260630.xsd#qtwo_ContractualObligationToBePaidYearFourAndThereafter"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:to="loc_qtwo_ContractualObligationToBePaidYearFourAndThereafter_019e22b2-3a52-7b2c-9341-b51c578f5674" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_019e22b2-3a52-79ce-a687-b5b48b1059d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligationDueInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:to="loc_us-gaap_ContractualObligationDueInNextTwelveMonths_019e22b2-3a52-79ce-a687-b5b48b1059d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInThirdYear_019e22b2-3a52-77e4-959a-65ab723f4a41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligationDueInThirdYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:to="loc_us-gaap_ContractualObligationDueInThirdYear_019e22b2-3a52-77e4-959a-65ab723f4a41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationFutureMinimumPaymentsDueRemainderOfFiscalYear_019e22b2-3a52-7697-b57a-c3b902d7410f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligationFutureMinimumPaymentsDueRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:to="loc_us-gaap_ContractualObligationFutureMinimumPaymentsDueRemainderOfFiscalYear_019e22b2-3a52-7697-b57a-c3b902d7410f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligationDueInSecondYear_019e22b2-3a52-7637-94c2-5cdf6b5f7267" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractualObligationDueInSecondYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ContractualObligation_019e22b2-3a52-7008-a2cc-d7e325954c1a" xlink:to="loc_us-gaap_ContractualObligationDueInSecondYear_019e22b2-3a52-7637-94c2-5cdf6b5f7267" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/DebtScheduleofConvertibleNotesDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#DebtScheduleofConvertibleNotesDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/DebtScheduleofConvertibleNotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e22b2-3a52-7415-9e91-cb403b88ff75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_019e22b2-3a52-71bb-b1e9-5ade4a0b3e45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e22b2-3a52-7415-9e91-cb403b88ff75" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_019e22b2-3a52-71bb-b1e9-5ade4a0b3e45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e22b2-3a52-76cc-9667-3e3a181d0893" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e22b2-3a52-7415-9e91-cb403b88ff75" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019e22b2-3a52-76cc-9667-3e3a181d0893" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://q2ebanking.com/role/DebtScheduleofInterestExpenseDetails" xlink:type="simple" xlink:href="qtwo-20260630.xsd#DebtScheduleofInterestExpenseDetails"/>
  <link:calculationLink xlink:role="http://q2ebanking.com/role/DebtScheduleofInterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e22b2-3a52-7014-812f-2fc04120f88a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_019e22b2-3a52-7bf1-9b14-fadef20e24b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseNonoperating_019e22b2-3a52-7014-812f-2fc04120f88a" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_019e22b2-3a52-7bf1-9b14-fadef20e24b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_019e22b2-3a52-7754-bb29-0b08316729c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseNonoperating_019e22b2-3a52-7014-812f-2fc04120f88a" xlink:to="loc_us-gaap_InterestExpenseDebt_019e22b2-3a52-7754-bb29-0b08316729c9" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
