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Performance Based Restricted Stock Units [Member] Performance Based Restricted Stock Units [Member] Change in accrued interest relating to marketable securities held as investments. Change In Accrued Interest Relating To Marketable Securities Held As Investments Accrued interest, net of interest receivable on maturity of investments Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Weighted-Average Grant Date Fair Value, Forfeited Treasury Stock, Shares, Acquired Repurchase of common stock (in shares) Repurchase of common stock (in shares) Health Care Costs, Policy [Policy Text Block] Prepaid Clinical Trial and Preclinical Study Costs Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Number Of Milestones Achieved. Number Of Milestones Achieved Number of milestones achieved Earnings Per Share [Abstract] Net loss per share: Monthly base rent payments due next 49-60 months Base Rent Payable Due In Next Forty Nine to Sixty Months Base rent payable due in next forty nine to sixty months. Share-Based Payment Arrangement, Option, Activity [Table Text Block] Summary of Stock Option Activity Lessee, Operating Lease, Liability, to be Paid, Year Four 2030 Share Based Compensation Arrangement by Share Based Payment Award Number of Remaining Shares Vested Share based compensation arrangement by share based payment award number of remaining shares vested. Number of remaining shares vested upon achievement Plan Name [Axis] Plan Name Subsequent Event Type [Axis] Equity [Abstract] Class of Warrant or Right [Table] Equity [Text Block] Stockholders' Equity Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Cash flows from financing activities PRSU awards vesting upon the achievement of all four of the milestones over a four year period. P R S U Awards Vesting Upon Achievement Of All Four Of Milestones Over Four Year Period [Member] PRSU Awards Vesting Upon the Achievement of All Four of the Milestones Over a Four Year Period [Member] Liabilities, Noncurrent Total long-term liabilities Entity Incorporation, Date of Incorporation Date of incorporation Entity Tax Identification Number Entity Tax Identification Number Treasury stock, shares Treasury Stock, Common, Shares Equity Component [Domain] Equity Component Shares Issued, Value, Share-Based Payment Arrangement, before Forfeiture Issuance of common stock under employee stock plans Entity Address, City or Town Entity Address, City or Town 2014 Equity Incentive Plan [Member] Two Thousand Fourteen Equity Incentive Plan [Member] 2014 Equity Incentive Plan [Member] Stock Issued During Period, Value, New Issues Sale of common stock, net of issuance costs Sale of common stock Restricted cash Restricted Cash, Noncurrent Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Payments for repurchase of common stock and warrants. Payments For Repurchase Of Common Stock And Warrants Purchase of common stock and warrants Net Income (Loss) Attributable to Parent [Abstract] Numerator: Commercial Paper [Member] Commercial paper [Member] Commercial paper, available-for-sale [Member] US Government Debt Securities [Member] Government debt securities [Member] Deposits Assets, Noncurrent Deposits Share-Based Payment Arrangement, Additional Disclosure [Abstract] Antidilutive Security, Excluded EPS Calculation [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Weighted Average Number of Shares Outstanding, Diluted [Abstract] Denominator: Lessee, Operating Lease, Option to Extend Operating lease, option to extend, description Statement [Table] Statement [Table] Shares Issued, Shares, Share-Based Payment Arrangement, before Forfeiture Issuance of common stock under employee stock plans (in shares) Share-Based Payment Arrangement, Expense Stock compensation expense CALIFORNIA California [Member] Entity Shell Company Entity Shell Company Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Expected term (in years) Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash provided by investing activities Statement [Line Items] Statement [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Number of milestones to be achieved. Number Of Milestones To Be Achieved Number of milestones to be achieve AOCI, Debt Securities, Available-for-Sale, Adjustment, after Tax Accumulated other comprehensive (loss) gain Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Shares, Vested Shares vested Number of shares vested upon achievement Maximum [Member] Maximum [Member] Shelf registration statement expiry date. Shelf Registration Statement Expiry Date Shelf registration statement expiry date Proceeds from Sale of Debt Securities, Available-for-Sale Proceeds from sales of available-for-sale securities Sale of Stock [Domain] Sale of Stock Operating lease rentals annual increase percentage. Operating Lease Rentals Annual Increase Percentage Percentage of rent increase under lease Base Rent Payable Due In Next Thirty Seven Months to Forty Eight Months Base Rent Payable Due In Next Thirty Seven Months to Forty Eight Months Monthly base rent payments due next 37-48 months January two thousand twenty one member. January Two Thousand Twenty One [Member] January 2021 [Member] Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation Net (decrease) increase in cash, cash equivalents and restricted cash Subsequent Events [Abstract] Share Repurchase Program, Expiration Date Stock repurchase program, termination date Asset Class [Axis] Asset Class Investments, Debt and Equity Securities [Abstract] Operating Lease Number Of Subleases Operating lease number of subleases. Operating lease number of subleases Business description. Business Description Policy [Text Block] The Company Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted-Average Grant Date Fair Value, Granted Two thousand twenty four employee stock purchase plan. Two Thousand Twenty Four Employee Stock Purchase Plan [Member] 2024 ESPP [Member] Assets, Current [Abstract] Current assets: Leases [Abstract] Document Fiscal Year Focus Document Fiscal Year Focus Amortization of investment premiums Accretion (Amortization) of Discounts and Premiums, Investments Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Shares, Outstanding, Beginning Balance Common Stock, Shares, Outstanding, Ending Balance Equity, Including Portion Attributable to Noncontrolling Interest Balance Balance Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest, Total Financial Instruments [Domain] Financial Instruments Maximum duration of employee stock purchase plan. Maximum Duration Of Employee Stock Purchase Plan Maximum duration of employee stock purchase plan Revenue from Contract with Customer [Policy Text Block] Revenue Recognition Operating Lease, Liability, Noncurrent Lease liability, net of current portion Lessee, Operating Lease, Liability, to be Paid Total minimum lease payments Other Accrued Liabilities, Current Other accrued liabilities Additional Paid in Capital, Common Stock Additional paid-in capital Security Exchange Name Security Exchange Name Schedule of commitments and contingencies. Schedule Of Commitments And Contingencies [Table] Schedule Of Commitments And Contingencies [Table] Operating leases interest expense. Operating Leases Interest Expense Interest expense related to operating lease liability Entity Address, State or Province Entity Address, State or Province Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Weighted-average Recognition Period Operating Lease, Right-of-Use Asset Right-of-use assets Amendment Flag Amendment Flag Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Right-of-use asset obtained in exchange for lease obligation Share-Based Payment Arrangement [Text Block] Stock-Based Compensation Other Nonoperating Income (Expense) Total other income, net Total Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation, Ending Balance Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation, Beginning Balance Debt Securities, Available-for-Sale [Abstract] Available For Sale Securities [Abstract] City Area Code City Area Code Organization, Consolidation and Presentation of Financial Statements [Abstract] Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions Number of securities in unrealized loss position Operating Expenses [Abstract] Operating expenses: Number of milestones deemed as achievable. Number Of Milestones Deemed As Achievable Number of milestones deemed as achievable Common Stock, Par or Stated Value Per Share Common stock, par value Performance Target Achieved [Member] Performance Target One [Member] Performance target one. Share based compensation arrangement by share based payment award equity instruments other than options cancelled weighted average grant date fair value. Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled Weighted Average Grant Date Fair Value Weighted-Average Grant Date Fair Value, Cancelled Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted-Average Remaining Contractual Term Options exercisable, Weighted-Average Remaining Contractual Term Lessee, Leases [Policy Text Block] Leases Liabilities, Current Total current liabilities Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Cash, cash equivalents and restricted cash beginning of period Cash, cash equivalents and restricted cash at end of period Segment Reporting [Text Block] Segment Reporting Debt Securities, Available-for-Sale [Table Text Block] Summary of Investments Classified As Available-For-Sale Securities Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative Trading Symbol Trading Symbol Geographical [Axis] Geographical Percentage of common stock outstanding to increase shares reserved for issuance. Percentage Of Common Stock Outstanding To Increase Shares Reserved For Issuance Percentage of common stock outstanding to increase shares reserved for issuance Subsequent Event [Table] Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Shares, Granted Issuance of performance based award Entity Emerging Growth Company Entity Emerging Growth Company Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Foreign currency translation gain (loss) Foreign currency translation gain Additional Paid-in Capital [Member] Additional Paid-In Capital [Member] Plan Name [Domain] Plan Name Share-Based Payment Arrangement, Tranche One [Member] Tranche One [Member] Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares issued under ESPP PRSU awards vesting upon the achievement of three of the milestones over a four year period. P R S U Awards Vesting Upon Achievement Of Three Of Milestones Over Four Year Period [Member] PRSU Awards Vesting Upon the Achievement of Three of the Milestones Over a Four Year Period [Member] Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplemental disclosure of non-cash investing and financing transactions Cover [Abstract] Deferred Compensation Arrangement with Individual, Exercise Price Common stock price per share Sublease Commencement Date Sublease commencement date. Sublease commencement date Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining lease term Payments to Acquire Investments Purchases of investments Payments to Acquire Investments, Total Share-Based Compensation Arrangement by Share-Based Payment Award, Description Common stock reserved for issuance, description Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Share-Based Payment Arrangement, Noncash Expense Stock-based compensation Total stock-based compensation expense included in expenses Share-Based Payment Arrangement, Noncash Expense, Total Proceeds from maturities of investments Proceeds from Maturities, Prepayments and Calls of Short-Term Investments Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Adjustments to reconcile net loss to net cash used in operating activities Private Placement and Registered Direct Offering [Member] Private Placement And Registered Direct Offering [Member] Private placement and registered direct offering. Fair Value Disclosures [Abstract] Cash and Cash Equivalent Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value, Total Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Equity. Equity [Line Items] Equity [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Forfeited awards Forfeited, Shares Subject to Stock Options Entity Filer Category Entity Filer Category Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description Lease Contractual Term [Axis] Lease Contractual Term Employee stock purchase plan number of purchase periods. Employee Stock Purchase Plan Number Of Purchase Periods Employee stock purchase plan, number of purchase periods Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period. Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled In Period Shares, Cancelled Cancelled awards Revenue from Contract with Customer, Excluding Assessed Tax Revenues Segment Reporting [Abstract] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Statement of Financial Position [Abstract] Local Phone Number Local Phone Number