75000 - Document - Document And Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
75010 - Statement - Condensed Consolidated Balance Sheet (Unaudited)
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link:calculationLink
link:definitionLink
75020 - Statement - Condensed Consolidated Balance Sheet (Unaudited) (Parentheticals)
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link:calculationLink
link:definitionLink
75030 - Statement - Condensed Consolidated Statements of Operations (Unaudited)
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link:calculationLink
link:definitionLink
75040 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss) (Unaudited)
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link:calculationLink
link:definitionLink
75050 - Statement - Consolidated Statements of Equity (Unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
75060 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)
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link:calculationLink
link:definitionLink
995455 - Disclosure - Note 1 - Business and Organization
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995465 - Disclosure - Note 2 - Foreign Exchange Rates
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995475 - Disclosure - Note 3 - Summary of Significant Accounting Policies
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995485 - Disclosure - Note 4 - Earnings (Loss) Per Share
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995495 - Disclosure - Note 5 - Composition of Certain Financial Statement Captions
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995505 - Disclosure - Note 6 - Investments
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995515 - Disclosure - Note 7 -Debt
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995525 - Disclosure - Note 8 - Accumulated Other Comprehensive Loss
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995535 - Disclosure - Note 9 - Fair Value Measurements
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995545 - Disclosure - Note 10 - Derivative Contracts
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995555 - Disclosure - Note 11 - Related Party Transactions
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995565 - Disclosure - Note 12 - Commitments and Contingencies
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995575 - Disclosure - Note 13 - Revenue Recognition
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995585 - Disclosure - Note 14 - Strategic Alliances
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995595 - Disclosure - Note 15 - Segments
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995605 - Disclosure - Note 16 - Leases
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995615 - Disclosure - Note 17 - Subsequent Events
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995625 - Disclosure - Significant Accounting Policies (Policies)
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995635 - Disclosure - Note 3 - Summary of Significant Accounting Policies (Tables)
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995645 - Disclosure - Note 4 - Earnings (Loss) Per Share (Tables)
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995655 - Disclosure - Note 5 - Composition of Certain Financial Statement Captions (Tables)
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995665 - Disclosure - Note 6 - Investments (Tables)
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link:calculationLink
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995675 - Disclosure - Note 7 - Debt (Tables)
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link:calculationLink
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995685 - Disclosure - Note 8 - Accumulated Other Comprehensive Loss (Tables)
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link:calculationLink
link:definitionLink
995695 - Disclosure - Note 9 - Fair Value Measurements (Tables)
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link:calculationLink
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995705 - Disclosure - Note 10 - Derivative Contracts (Tables)
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link:calculationLink
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995715 - Disclosure - Note 13 - Revenue Recognition (Tables)
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link:calculationLink
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995725 - Disclosure - Note 15 - Segments (Tables)
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995735 - Disclosure - Note 16 - Leases (Tables)
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995745 - Disclosure - Note 1 - Business and Organization (Details Textual)
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995755 - Disclosure - Note 2 - Foreign Exchange Rates (Details Textual)
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link:calculationLink
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995765 - Disclosure - Note 3 - Summary of Significant Accounting Policies (Details Textual)
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995775 - Disclosure - Note 3 - Summary of Significant Accounting Policies - Reconciliation of Cash (Details)
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link:calculationLink
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995785 - Disclosure - Note 4 - Earnings (Loss) Per Share (Details Textual)
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link:calculationLink
link:definitionLink
995795 - Disclosure - Note 5 - Composition of Certain Financial Statement Captions (Details Textual)
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link:calculationLink
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995805 - Disclosure - Note 5 - Composition of Certain Financial Statement Captions - Schedule of Financial Statement Information (Details)
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995815 - Disclosure - Note 5 - Composition of Certain Financial Statement Captions - Schedule of Goodwill (Details)
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995825 - Disclosure - Note 6 - Investments (Details Textual)
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995835 - Disclosure - Note 6 - Investments - Schedule of Investments (Details)
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995845 - Disclosure - Note 6 - Investments - Gains and Losses on Equity Securities (Details)
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995855 - Disclosure - Note 7 - Debt (Details Textual)
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995865 - Disclosure - Note 7 - Debt - Schedule of Debt Instruments (Details)
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link:calculationLink
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995865 - Disclosure - Note 7 - Debt - Schedule of Debt Instruments (Details) [Default]
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995875 - Disclosure - Note 7 - Debt - Schedule of 2029 Convertible Notes (Details)
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995885 - Disclosure - Note 7 - Debt - Schedule of Line of Credit Facilities (Details)
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995895 - Disclosure - Note 8 - Accumulated Other Comprehensive Loss - Schedule of changes in Accumulated Other Comprehensive Loss (Details)
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995905 - Disclosure - Note 9 - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured on a Recurring Basis (Details)
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995915 - Disclosure - Note 9 - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured on a Recurring Basis (Details) (Parentheticals)
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995925 - Disclosure - Note 9 - Fair Value Measurements - Summary of Carrying Value and Estimated Fair Value of Notes (Details)
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995935 - Disclosure - Note 10 - Derivative Contracts - Summary of Fair Values and Presentation of Derivatives Financial Instruments (Details)
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995935 - Disclosure - Note 10 - Derivative Contracts - Summary of Fair Values and Presentation of Derivatives Financial Instruments (Details) [Default]
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995945 - Disclosure - Note 10 - Derivative Contracts - Summary of Gains and Losses Recorded (Details)
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995955 - Disclosure - Note 11 - Related Party Transactions (Details Textual)
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995965 - Disclosure - Note 12 - Commitments and Contingencies (Details Textual)
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995975 - Disclosure - Note 13 - Revenue Recognition (Details Textual)
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995985 - Disclosure - Note 13 - Revenue Recognition - Composition of Revenue From Services (Details)
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995995 - Disclosure - Note 13 - Revenue Recognition - Analysis of Product Sales Allowances and Accruals (Details)
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996005 - Disclosure - Note 14 - Strategic Alliances (Details Textual)
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996015 - Disclosure - Note 15 - Segments (Details Textual)
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996025 - Disclosure - Note 15 - Segments - Operations by Segment (Details)
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996035 - Disclosure - Note 15 - Segments - Assets by Segment (Details)
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996045 - Disclosure - Note 16 - Leases (Details Textual)
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996055 - Disclosure - Note 16 - Leases - Schedule of Lease Balances (Details)
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996065 - Disclosure - Note 16 - Leases - Schedule of Lease Balances (Details) (Parentheticals)
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996075 - Disclosure - Note 16 - Leases - Schedule of Undiscounted Future Minimum Lease Payments (Details)
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996085 - Disclosure - Note 16 - Leases - Schedule of Undiscounted Future Minimum Lease Payments (Details) 2
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996095 - Disclosure - Note 16 - Leases - Schedule of Undiscounted Future Minimum Lease Payments (Details) (Parentheticals)
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996105 - Disclosure - Note 16 - Leases - Supplemental Cash Flow Information (Details)
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Line of Credit Facility [Line Items]
Related Party Transaction [Table]
Accumulated Foreign Currency Adjustment Attributable to Parent [Member]
Accumulated Foreign Currency Adjustment Attributable to Parent [Member]
Foreign Currency Translation [Member]
Scenario [Axis]
Schedule of Derivative Instruments in Statement of Financial Position, Fair Value [Table Text Block]
Summary of Fair Values and Presentation of Derivatives Financial Instruments
us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability
Embedded Derivative, Fair Value of Embedded Derivative Liability
us-gaap_GrossProfit
Gross margin
Value of collaborative arrangement.
opk_CollaborativeArrangementValue
Collaborative Arrangement, Value
Debt Conversion, Name [Domain]
Represents Chargebacks, discounts, rebates and fees.
Chargebacks, Discounts, Rebates and Fees [Member]
Gain on sale of assets
Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal
Gain on sale of assets
Debt Disclosure [Text Block]
Debt
us-gaap_OperatingLeaseLiability
Total lease liabilities, operating
us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners
Subsidiary, Ownership Percentage, Noncontrolling Owner
us-gaap_InterestExpense
Interest Expense
srt_StockRepurchaseProgramAuthorizedAmount1
Share Repurchase Program, Authorized, Amount
Minority Interest Increase Ownership Percentage By Parent
Minority interest increase ownership percentage by parent
Minority Interest Increase Ownership Percentage By Parent
us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax
Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax
Line of credit
Gain (Loss) on Disposition of Other Assets
Gain on sale of assets
Represents the Merck Agreement.
Merck Agreement [Member]
us-gaap_PurchaseObligation
Purchase Obligation
us-gaap_DebtInstrumentBasisSpreadOnVariableRate1
Debt Instrument, Basis Spread on Variable Rate
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares outstanding, diluted
Weighted average common shares outstanding, diluted
Not Designated as Hedging Instrument [Member]
Not Designated as Hedging Instrument [Member]
us-gaap_StockRepurchasedDuringPeriodShares
Stock Repurchased During Period, Shares (in shares)
Shares repurchase (in shares)
Less: Net losses realized during the period on equity securities
Equity Securities, FV-NI, Realized Gain (Loss), Total
Less: Net gains and losses realized during the period on equity securities
Less: Net gains and losses realized during the period on equity securities
Equity-based compensation expense
us-gaap_LesseeOperatingLeaseTermOfContract
Lessee, Operating Lease, Term of Contract (Year)
Minimum [Member]
SPAIN
us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures (in shares)
Debt Instrument, Redemption, Period Three [Member]
Represents LeaderMed.
LeaderMed [Member]
LeaderMed [Member]
Represents ChromaDex Corporation.
ChromaDex Corporation [Member]
ChromaDex Corporation [Member]
Relating to BCI Bank.
BCI Bank [Member]
Developed Technology Rights [Member]
Investment, Name [Axis]
us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo
2028, finance
Fair Value, Recurring [Member]
Fair Value, Recurring [Member]
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Consolidated Entities [Domain]
Amount of sales milestone payment of option in collaborative arrangement.
opk_CollaborativeAgreementOptionSalesMilestonePayments
Collaborative Agreement, Option, Sales Milestone Payments
Common Stock, Shares, Issued (in shares)
Common Stock, Shares, Issued (in shares)
Segment Reporting [Line Items]
Represents the amount of aggregate transaction price allocated to remaining performance obligations, excluding unexercised contract options.
opk_AggregateTransactionPriceAllocatedToRemainingPerformanceObligationsExcludingUnexercisedContractOptionsAmount
Aggregate Transaction Price Allocated to Remaining Performance Obligations, Excluding Unexercised Contract Options, Amount
Business Combination, Contingent Consideration, Liability
Business Combination, Contingent Consideration, Liability
Business Combination, Contingent Consideration, Liability, Total
Other receivables
Other receivables
us-gaap_DebtInstrumentFaceAmount
Debt Instrument, Face Amount
us-gaap_IncomeTaxExpenseBenefit
Income tax benefit
Goodwill, foreign exchange effect
Counterparty Name [Domain]
Significant Accounting Policies [Table]
Disclosure of significant accounting policies.
Condensed Balance Sheet Statement [Table]
us-gaap_RepaymentsOfDebt
Repayments of Debt
Related Party Transaction [Line Items]
Relating to the collaboration and license agreement with Entera.
Collaboration and License Agreement With Entera [Member]
us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)
us-gaap_RepaymentsOfLinesOfCredit
Repayments of lines of credit
The number of major customers.
opk_NumberOfMajorCustomers
Number of Major Customers
Operating Segments [Member]
Intangible Asset, Finite-Lived, Class [Domain]
us-gaap_ContractWithCustomerLiability
Contract with Customer, Liability
Credit line capacity
Income Tax Authority, Name [Axis]
us-gaap_TableTextBlock
Notes Tables
us-gaap_TreasuryStockCommonValue
Treasury Stock - 30,174,907, and 30,849,907 shares at June 30, 2026 and December 31, 2025, respectively
Nicoya Therapeutics [Member]
Nicoya Therapeutics [Member]
Nicoya Therapeutics.
Cost of Goods and Services Sold
Cost of Goods and Services Sold
Cost of revenue
Cost of Product and Service Sold, Total
us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount
Less: Difference between lease payments and discounted lease liabilities, operating
Represents the amount of commitments and contingencies included in current accrued commitments.
Commitments and contingencies
Commitments and contingencies
us-gaap_NonoperatingIncomeExpense
Other expense, net
Income Statement [Abstract]
Relating to OPKO Chile.
OPKO Chile [Member]
Comprehensive Income (Loss) Note [Text Block]
Accumulated Other Comprehensive Loss
Income Tax Jurisdiction [Axis]
us-gaap_DebtInstrumentUnamortizedDiscount
Balance, discount
Balance, discount
Debt Instrument, Unamortized Discount, Total
Debt Instrument, Unamortized Discount, Total
Fair value changes of derivative instruments, net
Relating to Bank of Chile.
Bank of Chile [Member]
CONNECTICUT
CONNECTICUT
The repayment fee percent for a debt instrument.
opk_DebtInstrumentRepaymentFeePercent
Debt Instrument, Repayment Fee, Percent
Related and Nonrelated Parties [Domain]
Loss per share, basic
Earnings Per Share, Basic, Total
Loss per share, basic
Amount of development milestone payment from collaborative arrangement.
opk_CollaborativeArrangementDevelopmentMilestonePayment
Collaborative Arrangement, Development Milestone Payment
Document Period End Date
us-gaap_FinanceLeaseInterestExpense
Finance Lease, Interest Expense
Intangible assets, net
us-gaap_FiniteLivedIntangibleAssetsNet
Derivative [Abstract]
Tax Period [Axis]
Debt Instrument [Line Items]
us-gaap_InvestmentOwnedBalanceShares
Investment Owned, Balance, Shares (in shares)
Embedded Derivative Financial Instruments [Member]
Embedded Derivative Financial Instruments [Member]
Common Stock, Shares Authorized (in shares)
Common Stock, Shares Authorized (in shares)
Statement of Stockholders' Equity [Abstract]
us-gaap_OtherPrepaidExpenseCurrent
Prepaid expenses
us-gaap_FinanceLeaseRightOfUseAsset
Finance lease assets
Other current assets and prepaid expenses
Other current assets and prepaid expenses
Other current assets and prepaid expenses
Loss from investments in investees
Losses from investments in investees
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign currency translation
Debt Conversion Description [Axis]
Corporate Joint Venture [Member]
Represents Pharmsynthez.
Pharmsynthez [Member]
Pharmsynthez [Member]
Represents Beckman Coulter.
Beckman Coulter [Member]
us-gaap_DebtInstrumentInterestRateStatedPercentage
Debt Instrument, Interest Rate, Stated Percentage
us-gaap_CostsAndExpenses
Total costs and expenses
Disaggregation of Revenue [Table]
Disposal Group, Including Discontinued Operation, Goodwill
Disposal Group, Including Discontinued Operation, Goodwill
SUPPLEMENTAL INFORMATION:
us-gaap_Assets
Assets
Total assets
Title of 12(b) Security
Schedule of Equity Method Investments [Line Items]
Goodwill
Goodwill
Goodwill
us-gaap_LitigationSettlementAmountAwardedToOtherParty
Litigation Settlement, Amount Awarded to Other Party
us-gaap_PaymentsForRepurchaseOfCommonStock
Share repurchase
Related Party Transaction [Axis]
Earnout consideration receivable
Earnout Consideration Receivable
Earnout consideration receivable.
Vehicles [Member]
us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree
2029, finance
Derivative, Value of contracts
Derivative, Notional Amount
Customer Concentration Risk [Member]
Operating cash out flows from operating leases
Represents reimbursement of travel expenses.
Reimbursement of Travel Expenses [Member]
Segment Reporting, Reconciliation of Asset by Segment to Consolidated [Table Text Block]
Reconciliation of Assets from Segment to Consolidated
us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear
July 1, 2026 through December 31, 2026, operating
Interest paid
Interest paid
Product [Member]
Gross to net provision
Represents the amount of net provision costs gross included in accrued liabilities.
Gross to net provision
Represents Common Stock options/warrants.
Common Stock Options/ Warrants [Member]
Common Stock Options/ Warrants [Member]
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
2027, operating
Represent the Germany price approval by the local sick fund association.
Germany Price Approval by Local Sick Fund Association [Member]
us-gaap_TreasuryStockValueAcquiredCostMethod
Shares repurchase
Treasury Stock, Value, Acquired, Cost Method
Location, Statement of Financial Position, Balance [Axis]
The name for the particular debt instrument or borrowing that distinguishes it from other debt instruments or borrowings, including draws against credit facilities.
The 2025 Convertible Notes [Member]
The 2025 Convertible Notes [Member]
Relating to individual patients.
Individual Patients [Member]
Taxes recoverable
Taxes recoverable
Health Care Organization, Revenue Sources [Axis]
Other comprehensive income (loss), net of tax:
Other comprehensive income (loss), net of tax:
Customer Relationships [Member]
Customer Relationships [Member]
us-gaap_PaymentsToAcquireInterestInJointVenture
Payments to Acquire Interest in Joint Venture
Disaggregation of Revenue [Table Text Block]
Disaggregation of Revenue
Segment Reporting [Table Text Block]
Schedule of Segment Reporting Information, by Segment
us-gaap_ValuationAllowancesAndReservesDeductions
Credits or payments made
Related to debt.
Debt Principal Amount After July 17, 2029 [Member]
Unusual or Infrequent Items, or Both, Disclosure [Text Block]
Foreign Exchange Rates
Represents COCP.
COCP [Member]
COCP [Member]
Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member]
Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member]
us-gaap_StockholdersEquity
Total shareholders’ equity
Beginning Balance
Ending Balance
Treasury Stock, Common [Member]
Amount of variable interest entities included equity method investments.
opk_EquityMethodInvestmentVariableInterestEntity
Variable interest entity, equity method
Other assets
Other assets
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Fair Value, by Balance Sheet Grouping [Table Text Block]
Summary of Carrying Value and Estimated Fair Value of Notes
Pertains to ownership interest in the aggregate principal amount.
opk_DebtInstrumentOwnershipInterest
Debt Instrument, Ownership Interest
Earnings Per Share [Text Block]
Earnings (Loss) Per Share
us-gaap_NotesPayableFairValueDisclosure
Notes
Estimate of Fair Value Measurement [Member]
Estimate of Fair Value Measurement [Member]
us-gaap_NumberOfReportableSegments
Number of reportable segments
Derivative Instruments, Gain (Loss) [Table]
Revenue Benchmark [Member]
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Increase in Share Repurchase Program Authorized Amount
Increase in share repurchase program authorized amount.
Israel Tax Authority [Member]
Israel Tax Authority [Member]
us-gaap_LongTermDebt
Balance, total
Balance, total
Long-Term Debt
Total
2044 Notes
Segment Reporting, Reconciling Item, Corporate Nonsegment [Member]
Relating to Santander Bank.
Santander Bank [Member]
us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount
Less: Difference between lease payments and discounted lease liabilities, finance
us-gaap_ProvisionForDoubtfulAccounts
Credit loss expense
Represents maximum regulatory milestone payments under collaborative agreement.
opk_CollaborativeArrangementMaximumRegulatoryMilestonePayments
Collaborative Arrangement, Maximum Regulatory Milestone Payments
Inventory, Policy [Policy Text Block]
Inventories
Investment [Table Text Block]
Schedule of Investments
Restricted Stock [Member]
Restricted Stock [Member]
Litigation Case [Axis]
Consorcio Bank [Member]
Represents Consorcio Bank.
us-gaap_LongTermDebtPercentageBearingVariableInterestRate
Long-Term Debt, Percentage Bearing Variable Interest, Percentage Rate
Geographical [Domain]
Amount after tax of income (loss) from continuing operations, after deduction of income tax expense (benefit), but before income (loss) attributable to noncontrolling interest, and addition of income (loss) from equity method investments.
opk_IncomeLossFromContinuingOperationsNetOfTaxBeforeEquityMethodInvestmentsAndNoncontrollingInterestTotal
Net loss before investment losses
Relating to BioReference.
BioReference [Member]
us-gaap_EquitySecuritiesFvNi
Equity securities
Litigation Status [Domain]
Relating to Series A-2 Preferred Stock.
Series A-2 Preferred Stock [Member]
Series A-2 Preferred Stock [Member]
Statistical Measurement [Axis]
us-gaap_AreaOfRealEstateProperty
Area of Real Estate Property (Acre)
Relating to the 2033 Senior Notes.
The 2033 Senior Notes [Member]
The 2033 Senior Notes [Member]
Consumable supplies
Consumable supplies
Relating to Santander Bank 2.
Santander Bank 2 [Member]
Entity Interactive Data Current
Equity Securities Without Readily Determinable Fair Value Underlying Equity in Net Assets
Equity securities without readily determinable fair value underlying equity in net assets.
Equity securities with no readily determinable fair value, underlying value
Gain (Loss) on Extinguishment of Debt
Gain (Loss) on Extinguishment of Debt, Total
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree
2029, operating
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Common Stock - $0.01 par value, 1,250,000,000 shares authorized; 776,128,402 and 789,917,433 shares issued at June 30, 2026 and December 31, 2025, respectively
Common Stock - $0.01 par value, 1,250,000,000 shares authorized; 776,128,402 and 789,917,433 shares issued at June 30, 2026 and December 31, 2025, respectively
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Computation of Basic and Diluted Income (Loss) Per Share
Taxes payable
Taxes payable
Property, Plant, and Equipment [Policy Text Block]
Property, plant and equipment
Raw materials
Raw materials
Proceeds from the sale of property, plant and equipment
Liabilities
Liabilities
Total liabilities
us-gaap_ForeignCurrencyTransactionGainLossBeforeTax
Foreign currency transaction (losses) gain
Ownership [Domain]
Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage. Excludes amount for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.
Cash, cash equivalents and current restricted cash
Cash, cash equivalents and current restricted cash
Restricted cash, current
Note 16 - Leases
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets and Liabilities Measured on a Recurring Basis
Product and Service [Axis]
Accumulated deficit
Accumulated deficit
Represents EirGen.
EirGen [Member]
EirGen [Member]
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
Relating to Itau Bank.
Itau Bank [Member]
Adjustments To Additional Paid In Capital Repurchase Of Convertible Debt
Adjustments to additional paid in capital repurchase of convertible debt.
Repurchase of 2029 Convertible Notes
Represents Healthcare insurers.
Healthcare Insurers [Member]
us-gaap_CashAndCashEquivalentsFairValueDisclosure
Money market funds
us-gaap_IncreaseDecreaseInAccountsPayable
Accounts payable
us-gaap_EquityMethodInvestmentOwnershipPercentage
Equity Method Investment, Ownership Percentage
Revenues:
Fair Value, by Balance Sheet Grouping [Table]
Represents information pertaining to CAMP4 Therapeutics Corporation.
CAMP4 Therapeutics Corporation [Member]
CAMP4 Therapeutics Corporation [Member]
us-gaap_DebtInstrumentConvertibleThresholdTradingDays
Debt Instrument, Convertible, Threshold Trading Days
Amount of monthly payments in year five for operating lease.
opk_OperatingLeasesMonthlyPaymentsYearFive
Operating Leases, Monthly Payments, Year Five
Condensed Balance Sheet Statements, Captions [Line Items]
Disaggregation of Revenue [Line Items]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Business and Organization
NGENLA [Member]
NGENLA .
NGENLA
Changes in assets and liabilities:
us-gaap_GoodwillImpairedAccumulatedImpairmentLoss
Goodwill, impairment
Represents client payers.
Client Payers [Member]
Relating to OPKO diagnostics.
OPKO Diagnostics [Member]
Interest rate under litigation settlement.
opk_LitigationSettlementInterestRate
Litigation Settlement, Interest Rate
The percent of principal amount required to be paid for early extinguishment of debt instrument.
opk_DebtInstrumentEarlyExtinguishmentPercentOfPrincipalAmount
Debt Instrument, Early Extinguishment, Percent of Principal Amount
Tabular disclosure of supplemental cash information related to leases.
Schedule of Supplemental Cash Flow Information of Leases [Table Text Block]
Supplemental Cash Flow Information
Deferred tax liabilities
Deferred tax liabilities
Represents the set of legal entities associated with a report.
Opko [Member]
us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization
Less: accumulated amortization
Relating to FineTech.
FineTech [Member]
us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger
Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger
us-gaap_StockRepurchasedDuringPeriodValue
Stock Repurchased During Period, Value
Shares repurchase
Unrealized net gains and losses recognized during the period on equity securities still held at the reporting date
Unrealized net gains and losses recognized during the period on equity securities still held at the reporting date
Unrealized net gains and losses recognized during the period on equity securities still held at the reporting date
Noncompete Agreements [Member]
Covenants not to compete [Member]
Forward contracts
Derivative Liability
Derivative Liability, Total
Related Party Transactions [Abstract]
us-gaap_OperatingLeaseCost
Operating Lease, Cost
Nicoya [Member]
Nicoya.
Nicoya
Derivative Liability, Statement of Financial Position [Extensible Enumeration]
Tabular disclosure of product sales allowances and accruals.
Schedule of Product Sales Allowances and Accruals [Table Text Block]
Schedule of Product Sales Allowances and Accruals
Long-Lived Asset, Class [Axis]
Information pertaining to the increase (decrease) in revenue.
opk_IncreaseDecreaseRevenueFromContractWithCustomerExcludingAssessedTax
Increase (Decrease), Revenue from Contract with Customer, Excluding Assessed Tax
Income Tax, Policy [Policy Text Block]
Income taxes
Subsequent Events [Text Block]
Subsequent Events
Effect of exchange rate changes on cash, cash equivalents and restricted cash
Fair Value Hierarchy and NAV [Axis]
Represents Frost Real Estate Holdings, LLC.
Frost Real Estate Holdings, LLC [Member]
Intangible Asset, Indefinite-Lived, Class [Axis]
Self-Pay [Member]
Escrow receivable
Escrow Deposit
Escrow receivable
Relating to Entera.
Entera [Member]
Represents NIMS.
NIMS [Member]
NIMS [Member]
Current maturities of operating leases
Operating lease liabilities
Current maturities of operating leases
Tabular disclosure of lessee's assets and liabilities.
Assets and Liabilities, Lessee [Table Text Block]
Schedule of Lease Balances
Concentration Risk Type [Domain]
Litigation Case [Domain]
Customer [Domain]
Amount of each milestone payment under collaborative agreements.
opk_CollaborativeAgreementsEachMilestonePayment
Collaborative Agreements, Each Milestone Payment
us-gaap_DebtInstrumentConvertibleConversionRatio1
Debt Instrument, Convertible, Conversion Ratio
Pertains to the event of default.
Scenario, Event of Default [Member]
us-gaap_LiabilitiesAndStockholdersEquity
Total liabilities and equity
MEXICO
Represents select assets of BioReference.
Select Assets of BioReference [Member]
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo
2028, operating
Research and development
Research and development
Intangible Asset, Finite-Lived, Class [Axis]
Lessee, Lease, Description [Table]
Document Fiscal Period Focus
us-gaap_RevenueRemainingPerformanceObligation
Revenue, Remaining Performance Obligation, Amount
Derivatives, Fair Value [Line Items]
HealthSnap, Inc. [Member]
HealthSnap, Inc. [Member]
Relating to HealthSnap, Inc.
Royalties
Royalties
Accumulated Other Comprehensive Income (Loss) [Line Items]
Subsegments [Domain]
Represents tax year 2014 through tax year 2020.
Tax Year 2014 Through Tax Year 2020 [Member]
Tax Year 2014 Through Tax Year 2020 [Member]
Currency [Axis]
us-gaap_FiniteLivedIntangibleAssetUsefulLife
Finite-Lived Intangible Asset, Useful Life (Year)
Estimated useful lives
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
Net (decrease) increase in cash, cash equivalents and restricted cash
Entity Current Reporting Status
Use of Estimates, Policy [Policy Text Block]
Use of estimates
Represents Pfizer Inc.
Pfizer Inc. [Member]
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Class of Stock [Domain]
Revenue from Contract with Customer Benchmark [Member]
Accounts payable
Accounts payable
us-gaap_AssetsFairValueDisclosure
Total assets
Document Transition Report
Commitments and Contingencies Disclosure [Abstract]
us-gaap_IncreaseDecreaseInInventories
Inventory, net
Amount of lessee's undiscounted obligation for lease payment for finance lease to be paid after fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).
opk_FinanceLeaseLiabilityPaymentsDueAfterYearFour
Thereafter, finance
Liabilities, Current [Abstract]
Current liabilities:
Disposal Group Name [Axis]
Conversion of Stock, Shares Converted
Repurchase of 2029 Convertible Notes (in shares)
Represents the development costs related to collaborative arrangements.
opk_CollaborativeArrangementDevelopmentCosts
Collaborative Arrangement, Development Costs
Settled Litigation [Member]
Settled Litigation [Member]
Represents the first marketing approval of Rayaldee in Europe.
First Marketing Approval of Rayaldee in Europe [Member]
us-gaap_DebtWeightedAverageInterestRate
Debt, Weighted Average Interest Rate
Common Stock [Member]
Derivative Instruments and Hedging Activities Disclosure [Text Block]
Derivative Contracts
Information pertaining to the debt.
The 2029 Convertible Affiliate Notes [Member]
Borrowings on lines of credit
Investment [Text Block]
Investments
Statistical Measurement [Domain]
Other income and (expense), net:
Other income (expense), net:
Represents Eloxx.
Eloxx [Member]
Finite lived intangible assets, gross
Intangible assets, Gross
Equity Securities, FV-NI, Gain (Loss)
Net gains and losses recognized during the period on equity securities
Net gains and losses recognized during the period on equity securities
Equity:
Equity:
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted average common shares outstanding, basic (in shares)
Weighted average common shares outstanding, basic
SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain]
us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear
July 1, 2026 through December 31, 2026, finance
ASSETS
Assets [Abstract]
Entity Central Index Key
Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table]
us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss
Income Tax Examination, Estimate of Possible Loss
Income tax assessment
Represents the Pfizer Agreement.
Pfizer Agreement [Member]
Line of Credit Facility [Table]
Represent Rayaldee.
Rayaldee [Member]
Consolidation Items [Axis]
Current Fiscal Year End Date
Notes To Financial Statements [Abstract]
Notes To Financial Statements Abstract
Document Quarterly Report
Represents the amount of minority interest shares acquired.
opk_MinorityInterestSharesIssued
Minority Interest, Shares Issued (in shares)
Health Care Organization, Revenue Sources [Domain]
Interest rate
Disposal Group Name [Domain]
Information by business combination or series of individually immaterial business combinations.
ModeX Therapeutics, Inc [Member]
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Relating to Banco De Sabadell.
Banco De Sabadell [Member]
The additional authorized amount for debt instrument.
opk_DebtInstrumentAdditionalAuthorizedAmount
Debt Instrument, Additional Authorized Amount
us-gaap_NetCashProvidedByUsedInOperatingActivities
Net cash used in operating activities
Entity Incorporation, State or Country Code
Loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Loss per share, diluted
Disposal Group, Held-for-Sale or Disposed of by Sale, Not Discontinued Operations [Member]
Stockholders' Equity, Policy [Policy Text Block]
Stock Repurchase Program
us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent
Operating leases
Net loss
Net loss
Variable interest Entity Underlying Equity In Net Assets
Variable interest entity underlying equity in net assets.
Variable interest Entity, equity method, Underlying Equity In Net Assets
Represents the amount of goodwill and intangible assets acquired as part of a business combination.
opk_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedGoodwillAndIntangibleAssets
Business combination, assets acquired and liabilities assumed
Ownership [Axis]
us-gaap_IncreaseDecreaseInOtherOperatingAssets
Other assets
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
us-gaap_DisposalGroupIncludingDiscontinuedOperationConsideration
Cash consideration
Long-Lived Asset, Class [Domain]
Restricted cash, long-term
us-gaap_GainLossOnDispositionOfAssets1
Realized gain on disposal of fixed assets and sales of equity securities
Building and Building Improvements [Member]
Buildings and Improvements [Member]
Amount of inventory not yet billed included in accrued liabilities.
Inventory received but not invoiced
Inventory received but not invoiced
Note 15 - Segments - Assets by Segment (Details)
Goodwill and Intangible Assets, Policy [Policy Text Block]
Goodwill and intangible assets
Composition of Certain Financial Statement Captions
upplemental Balance Sheet Disclosures [Text Block]
Lease Contractual Term [Domain]
Other comprehensive income
Other comprehensive income
Other comprehensive loss
us-gaap_DebtConversionConvertedInstrumentSharesIssued1
Debt Conversion, Converted Instrument, Shares Issued (in shares)
us-gaap_ComprehensiveIncomeNetOfTax
Comprehensive loss
Technology-Based Intangible Assets [Member]
Technologies [Member]
CHILE
Percentage of gross sales for provision for sales allowance.
opk_ProvisionForSalesAllowanceAsPercentOfGrossSales
Provision for Rayaldee sales allowances and accruals as a percentage of gross Rayaldee sales
Provision for Rayaldee sales allowances and accruals as a percentage of gross Rayaldee sales
Income Tax Jurisdiction [Domain]
Measurement Frequency [Domain]
Scenario [Domain]
Equity Components [Axis]
Cash flows from investing activities:
Represents GeneDx Holdings.
GeneDx Holdings [Member]
GeneDx Holdings [Member]
Common Stock Options, Warrants, and Restricted Stock Units Surrendered in Net Exercise
Common stock options, warrants, and restricted stock units surrendered in net exercise.
Common stock options, warrants, and restricted stock units surrendered in net exercise
Collaborative Arrangement Disclosure [Text Block]
Strategic Alliances
Statement of Cash Flows [Abstract]
Represents other countries.
Other Countries [Member]
Fair Value Hierarchy and NAV [Domain]
The entire disclosure for finance and operating leases of lessee. Includes, but is not limited to, description of lessee's finance and operating lease and maturity analysis of finance and operating lease liability.
Lessee, Leases [Text Block]
Leases
Represents governmental.
Governmental [Member]
Condensed Financial Information Disclosure [Abstract]
Equity securities with no readily determinable fair value
Equity securities with no readily determinable fair value
us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Other current assets and prepaid expenses
Intangible assets, net
Intangible assets, net
Note To Financial Statement Details Textual
Fair Value Disclosures [Text Block]
Fair Value Measurements
The net cash inflow or outflow resulting from exercise of stock options and warrants.
Proceeds from the exercise of common stock options
Finance leases long-term
Other long-term liabilities
Finance leases long-term
Condensed Balance Sheet [Table Text Block]
Schedule of Financial Statement Information
Relating to BARDA Agreement.
BARDA Agreement [Member]
BARDA Agreement [Member]
Equity securities, underlying value
Equity Method Investment, Underlying Equity in Net Assets
Depreciation and amortization
Depreciation and amortization
Equity securities
Equity securities
Chief Executive Officer [Member]
Chief Executive Officer [Member]
Machinery and Equipment [Member]
Machinery, Medical and Other Equipment [Member]
Investments [Abstract]
Investments
Investments
Total carrying value of investments
us-gaap_GoodwillGross
Goodwill, gross
Relating to project registration.
Project Registration [Member]
Product registrations [Member]
us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
Loss before income taxes and investment losses
Derivative Contract [Domain]
Amount of liability related to reimbursements for payor overpayments.
opk_AccruedExpensePayorOverpaymentReimbursementLiability
Accrued Expense, Payor Overpayment Reimbursement, Liability
Class of Stock [Axis]
Derivative Instruments, Gain (Loss) [Table Text Block]
Summary of Gains and Losses Recorded
us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)
Counterparty Name [Axis]
Information pertaining to the debt.
The 2029 Convertible 144A Notes [Member]
Overall Value of Collaboration
Overall value of the collaboration.
Overall value of the collaboration
AOCI Attributable to Parent [Member]
Intellectual Property and Other [Member]
Intellectual property and other.
Intellectual Property and Other [Member]
Compensation Related Costs, Policy [Policy Text Block]
Equity-based compensation
us-gaap_DebtInstrumentRedemptionPricePercentage
Debt Instrument, Redemption Price, Percentage
Inventory, Net
Inventory, net
Inventory, net
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Variable interest entities
Segment Reporting, Policy [Policy Text Block]
Segment reporting
Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]
Concentration Risk Benchmark [Domain]
Accrued expenses and other liabilities
us-gaap_DebtInstrumentConvertibleConversionPrice1
Debt Instrument, Convertible, Conversion Price (in dollars per share)
Represents CURNA, OPKO Diagnostics and OPKO Renal.
CURNA, OPKO Diagnostics and OPKO Renal [Member]
Accrued Liabilities, Current
Accrued Liabilities, Current
Accrued expenses
The price per share of stock repurchased during the period and has not been retired and is not held in treasury. Some state laws may mandate the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.
opk_StockRepurchasedDuringPeriodPricePerShare
Stock Repurchased During Period, Price Per Share (in dollars per share)
Represents BioCardia.
BioCardia [Member]
BioCardia [Member]
Current portion of notes payable
Customer [Axis]
Hedging Designation [Axis]
Work in-process
Work in-process
Hedging Designation [Domain]
Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]
Research and Development Expense, Policy [Policy Text Block]
Research and development expenses
Document Type
Convertible Debt [Member]
Convertible Debt [Member]
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, cash equivalents and restricted cash
Cash flows from operating activities:
LIABILITIES AND EQUITY
Liabilities and Equity [Abstract]
Equity Method Investment [Table]
us-gaap_PaymentsToAcquireProductiveAssets
Capital expenditures
Lessee, Lease, Description [Line Items]
Represents Diagnostics.
Diagnostics [Member]
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
us-gaap_OperatingIncomeLoss
Segment operating loss
Operating loss
Lender Name [Axis]
Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]
Schedule of Changes in Accumulated Other Comprehensive Loss
Disposal Group Classification [Axis]
Service [Member]
Amount of sales milestone payment in collaborative arrangement.
opk_CollaborativeArrangementSalesMilestonePayment
Collaborative Arrangement, Sales Milestone Payment
Segment Reporting [Table]
Entity File Number
Finished products
Finished products
Revenue from Contract with Customer [Text Block]
Revenue Recognition
Represents the amount of clinical trial costs included in accrued liabilities.
Clinical trials
Clinical trials
Long-Lived Asset, Excluding Intangible Asset and Goodwill, Impairment and Disposal [Policy Text Block]
Impairment of long-lived assets
Retained Earnings [Member]
Equity Underlying Equity in Net Assets
Equity underlying equity in net assets.
Equity Method Underlying Equity in Net Assets
Accrued interest
Accrued interest
Entity Registrant Name
Accounting Policies [Abstract]
us-gaap_Depreciation
Depreciation expense
us-gaap_ProfitLoss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Selling, general and administrative
Selling, general and administrative
2044 Royalty Financing [Member]
2044 Royalty financing.
2044 Royalty Financing
us-gaap_TreasuryStockAcquiredAverageCostPerShare
Shares Acquired, Average Cost Per Share (in dollars per share)
Related to Entera Bio Ltd.
Entera Bio Ltd. [Member]
Entera Bio Ltd. [Member]
Intersegment Eliminations [Member]
Trade Names [Member]
Trade Names [Member]
Entity Address, Address Line One
us-gaap_DerivativeNumberOfInstrumentsHeld
Derivative, Number of Instruments Held
UNITED STATES
UNITED STATES
Relating to CURNA.
CURNA [Member]
Relating to Chilean and Spanish Lines of Credit.
Chilean and Spanish Lines of Credit [Member]
Chilean and Spanish Lines of Credit [Member]
Exercise of common stock options (in shares)
Exercise of common stock options and warrants (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)
All Currencies [Domain]
Treasury Stock, Shares, Retired (in shares)
Treasury Stock, Shares, Retired
us-gaap_DebtInstrumentIssuedPrincipal
Debt Instrument, Issued, Principal
us-gaap_AssetsCurrent
Total current assets
Total current assets
Furniture and Fixtures [Member]
Income Tax Jurisdiction, Foreign [Member]
Foreign Tax Jurisdiction [Member]
Warrants And Options Underlying Equity in Net Asset
Warrants and options underlying equity in net asset.
Warrants And Options Underlying Equity in Net Asset
Segments [Axis]
Income Tax Authority, Name [Domain]
Derivatives, Policy [Policy Text Block]
Derivative financial instruments
us-gaap_ProceedsFromDivestitureOfBusinesses
Proceeds from Labcorp sale
Proceeds from divestiture of businesses
Loss Contingencies [Line Items]
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Payments to Acquire Interest in Subsidiaries and Affiliates
Investments in investees
Payments to Acquire Interest in Subsidiaries and Affiliates, Total
Investments in investees
Deferred income tax benefit
Deferred income tax (benefit) provision
Entity Small Business
Long term portion of notes payable
Relating to Security Bank.
Security Bank [Member]
In Process Research and Development [Member]
Investment, Name [Domain]
us-gaap_InventoryValuationReserves
Less: inventory reserve
Long-Term Debt, Type [Axis]
Represents Development and License Agreement.
Development and License Agreement [Member]
Significant Accounting Policies [Text Block]
Summary of significant accounting policies
Related to the Oncology Transaction.
Oncology Transaction [Member]
Represents NICOYA Macau Limited.
NICOYA Macau Limited [Member]
Accounts receivable, net
Accounts receivable, net
Accounts receivable, net
Consolidation Items [Domain]
us-gaap_TreasuryStockSharesAcquired
Shares repurchase (in shares)
us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
Debt Instrument, Convertible, Threshold Consecutive Trading Days
us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour
2030, finance
Relating to OPKO Mexico.
OPKO Mexico [Member]
Earnings Per Share [Abstract]
Loss per share:
Investment, Policy [Policy Text Block]
Investments
us-gaap_DerivativeAssets
Derivative Asset, Total
Common stock options/warrants
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour
2030, operating
Represents Merck Sharp & Dohme LLC.
Merck Sharp & Dohme LLC [Member]
Represents the percentage of future royalties payments that would be considered a fee for repayment of a debt instrument.
opk_DebtInstrumentRepaymentFeeRoyaltyPercentage
Debt Instrument, Repayment Fee, Royalty Percentage
Represents upfront payments under collaborative agreement.
opk_CollaborativeArrangementUpfrontPayments
Collaborative Arrangement, Upfront Payments
Provision related to current period sales
Provision related to current period sales
Product and Service [Domain]
us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent
Less: allowance for credit losses
Allowance for credit losses
Issuance of 3.00% convertible senior notes, net (including related parties)
Proceeds from Convertible Debt
Relating to Transition Therapeutics.
Transition Therapeutics [Member]
Measurement Frequency [Axis]
Cash flows from financing activities:
Amortization of debt discount
Eli Lilly and Company [Member]
Eli Lilly and Company.
Eli Lilly and Company [Member]
Intangible Asset, Indefinite-Lived, Class [Domain]
Line of Credit Facility, Lender [Domain]
Liabilities, Noncurrent
Total long-term liabilities
Consolidated Entities [Axis]
Office Space [Member]
Represents office space.
us-gaap_InterestPayableCurrentAndNoncurrent
Interest Payable
Entity Tax Identification Number
Treasury Stock, Common, Shares (in shares)
Treasury Stock, Common, Shares (in shares)
Treasury Stock Beginning Balance (in shares)
Treasury Stock Ending Balance (in shares)
Accounts Receivable [Member]
Amount Recognized in Income Due to Inflationary Accounting
Decreasein foreign currency exchange rate
Derivative Instrument [Axis]
Equity Component [Domain]
us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill
Net intangible assets other than goodwill
Represents the capitalized costs for research and development in process.
In-process research and development
In-process research and development
Worldwide License Agreement With Eli Lilly [Member]
Worldwide License Agreement With Eli Lilly [Member]
Worldwide license agreement with Eli Lilly.
Entity Address, City or Town
Tax Period [Domain]
Period following from first commercial sale for collaborative arrangement.
opk_CollaborativeArrangementPeriodFollowingFirstCommercialSale
Collaborative Arrangement, Period Following First Commercial Sale (Year)
Business Combination [Axis]
Income taxes paid, net of refunds
Income taxes paid (refunded), net
Segments [Domain]
Entity Common Stock, Shares Outstanding
Equity Method Investments
Equity Method
Concentration Risk Type [Axis]
us-gaap_InventoryWriteDown
Inventory obsolescence expense
Schedule of Debt [Table Text Block]
Schedule of debt instrument
Settlement of Convertible Notes
Settlement of convertible notes.
Settlement of convertible notes
Entity [Domain]
Relating to Eloxx Pharmaceuticals, Inc.
Eloxx Pharmaceuticals, Inc. [Member]
Eloxx Pharmaceuticals, Inc. [Member]
Measurement Basis [Axis]
Related to litigation case settlement wit the Office of the Attorney General for the State of Texas.
Settlement With the Office of the Attorney General for the State of Texas [Member]
Settlement With the Office of the Attorney General for the State of Texas [Member]
Employee severance
Employee severance
Represents government contract, BARDA.
Government Contract, BARDA [Member]
BARDA Contract [Member]
Statement [Table]
Software, In-Development, Internally Developed, and Purchased [Member]
Software [Member]
Royalty [Member]
Royalty [Member]
Revenue from Receipt of Equity
Revenue from the receipt of equity.
Revenue from the receipt of equity
Entity Shell Company
us-gaap_NetCashProvidedByUsedInInvestingActivities
Net cash (used in) provided by investing activities
Statement [Line Items]
Maximum [Member]
Relating to Entera ordinary shares.
Entera Ordinary Shares [Member]
us-gaap_DebtConversionOriginalDebtAmount1
Debt Conversion, Original Debt, Amount
Repurchase
Debt Disclosure [Abstract]
us-gaap_FinanceLeaseLiabilityPaymentsDue
Total undiscounted future minimum lease payments, finance
Represents the 2023 Convertible Notes.
The 2023 Convertible Notes [Member]
The 2023 Convertible Notes [Member]
Interest income
Interest income
us-gaap_OtherLiabilitiesAndDeferredRevenueNoncurrent
Other
us-gaap_DebtConversionConvertedInstrumentAmount1
Debt Conversion, Converted Instrument, Amount
Business Combination [Domain]
Disclosure Text Block Supplement [Abstract]
Exercise of Common Stock Options and Vested Restricted Stock Units Value
Exercise of Common Stock Options and Vested Restricted Stock Units Value
Exercise of common stock options and vested restricted stock units
Licensing Agreements [Member]
Licenses [Member]
Concentration Risk Benchmark [Axis]
us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
U.S. federal statutory rate, Percent
us-gaap_OpenTaxYear
Foreign tax years
Relating to Internacional Bank.
Internacional Bank [Member]
Debt Instrument, Redemption, Period [Domain]
Consolidation, Policy [Policy Text Block]
Principles of consolidation
Subsequent Events [Abstract]
ISRAEL
Foreign Exchange Forward [Member]
Foreign Exchange Forward [Member]
Forward Contracts [Member]
Collaborative Arrangement, Aggregate Milestone Payments
Amount of product selection payments, clinical and regulatory milestone payments, and commercial milestone payment eligible to be received.
Product selection, clinical and regulatory milestone and commercial milestone payments
Collaborative Arrangement, Aggregate Milestone Payments
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Amortization of debt issuance cost
Amortization of deferred financing costs
Adjustments to reconcile net loss to net cash used in operating activities:
us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet
Embedded Derivative, Gain (Loss) on Embedded Derivative, Net
Current assets:
Current assets:
us-gaap_DeferredFinanceCostsNet
Balance, debt issuance cost
Balance, debt issuance cost
Debt Issuance Costs, Net, Total
Debt Issuance Costs, Net, Total
Finance leases short-term
Accrued expenses
Finance leases short-term
Liabilities, Fair Value Disclosure
Total liabilities
Professional fees
Professional fees
us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued
Uncertain tax positions
Related Party Transaction [Domain]
Line of Credit [Member]
Leases [Abstract]
Other Intangible Assets [Member]
Other [Member]
Document Fiscal Year Focus
Represents Integrated DNA Technologies Inc.
Integrated DNA Technologies Inc. [Member]
Represents Xenetic.
Xenetic [Member]
Represents LeaderMed joint venture.
LeaderMed Joint Venture [Member]
LeaderMed Joint Venture [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Niagen [Member]
Niagen [Member]
Senior secured notes
Senior secured royalty financing
Statement of Comprehensive Income [Abstract]
Convertible Debt [Table Text Block]
Schedule of 2029 Convertible Notes
Revenue from Contract with Customer [Policy Text Block]
Revenue recognition
Foreign Currency Contract, Asset, Fair Value Disclosure
Forward contracts
Forecast [Member]
us-gaap_ContractWithCustomerPerformanceObligationSatisfiedInPreviousPeriod
Contract with Customer, Performance Obligation Satisfied in Previous Period
The 2044 Convertible Notes [Member]
The 2044 Convertible Notes.
The 2044 Convertible Notes [Member]
Stock Repurchased and Retired During Period, Shares
Shares retired
Represents the amount of shares of an investment purchased.
opk_InvestmentOwnedSharesPurchased
Investment Owned, Shares Purchased (in shares)
Operating lease liabilities
Operating lease liabilities
Operating lease liabilities
us-gaap_ContractWithCustomerLiabilityRevenueRecognized
Contract with Customer, Liability, Revenue Recognized
Schedule of Line of Credit Facilities [Table Text Block]
Schedule of Lines of Credit
Relating to OPKO Health Europe.
OPKO Health Europe [Member]
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue
Total undiscounted future minimum lease payments, operating
us-gaap_MinorityInterestOwnershipPercentageByParent
Subsidiary, Ownership Percentage, Parent
SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis]
us-gaap_OtherAccruedLiabilitiesCurrent
Other
Security Exchange Name
Percentage of Equity Interest
Percentage of equity interest.
Percentage of equity interest
us-gaap_Revenues
Revenues
Revenues, Total
Revenue
Amount of increase (decrease) in foreign currency measurement.
Foreign currency measurement
us-gaap_FinanceLeaseWeightedAverageDiscountRatePercent
Finance leases
Related and Nonrelated Parties [Axis]
New Accounting Pronouncements, Policy [Policy Text Block]
Accounting standards yet to be adopted
us-gaap_DerivativeGainLossOnDerivativeNet
Derivative gain (loss)
Debt Instrument, Redemption, Period Two [Member]
Entity Address, State or Province
us-gaap_RelatedPartyTransactionAmountsOfTransaction
Related Party Transaction, Amounts of Transaction
us-gaap_AccountsReceivableNet
Accounts receivable
Non-cash interest
us-gaap_DisclosureTextBlockAbstract
Notes to Financial Statements
Operating lease right-of-use assets
Operating lease assets
Operating lease right-of-use assets
Exercise of Common Stock Options and Vested Restricted Stock Units Shares
Exercise of common stock options and vested restricted stock units shares.
Exercise of common stock options and vested restricted stock units (in shares)
Amendment Flag
Loss Contingencies [Table]
Goodwill [Table Text Block]
Schedule of Goodwill
Amount of delayed payment under collaborative agreement.
opk_CollaborativeAgreementDelayedPayment
Collaborative Agreement, Delayed Payment
Amount of lessee's undiscounted obligation for lease payment for operating lease due after fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).
opk_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour
Thereafter, operating
The name for the particular debt instrument or borrowing that distinguishes it from other debt instruments or borrowings, including draws against credit facilities.
The 2029 Convertible Notes [Member]
The 2029 Convertible Notes [Member]
us-gaap_ConcentrationRiskPercentage1
Concentration risk, percentage
Amended and restated collaboration and license agreement of Entera.
Amended and Restated Entera Collaboration and License Agreement [Member]
Amended and Restated Entera Collaboration and License Agreement [Member]
Debt Instrument [Axis]
Other income, net
Other income (expense), net
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
Total cash, cash equivalents, and restricted cash shown in the Condensed Consolidated Statements of Cash Flows
Mortgages and other debts payable
Mortgages and other debts payable
Scotiabank [Member]
SCOTIABANK [Member]
City Area Code
Represents government payers.
Government Payers [Member]
us-gaap_InterestExpenseNonoperating
Interest expense
Reported Value Measurement [Member]
Reported Value Measurement [Member]
Represents Vifor Fresenius Medical Care Renal Pharma Ltd.
Vifor Fresenius Medical Care Renal Pharma Ltd. [Member]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Represents GeneDx.
GeneDx [Member]
Regeneron Collaboration Agreement [Member]
Regeneron Collaboration Agreement.
Regeneron Collaboration Agreement [Member]
Unrealized Gain (Loss) on Investments [Table Text Block]
Schedule of Gains and Losses on Equity Securities
Commissions
Commissions
Change in foreign currency translation and other comprehensive income (loss)
Change in foreign currency translation and other comprehensive income (loss)
Royalty percent
Royalty Percentage
Royalty percentage.
Costs and expenses:
Disclosure of the company's policy regarding shipping and handling costs.
Shipping and Handling Costs [Policy Text Block]
Shipping and handling costs
Amount of cash outflow for leases.
opk_PaymentsForLeases
Total
Proceeds from sale of equity securities
Proceeds from Sale of Equity Securities, FV-NI
Debt Instrument, Redemption, Period [Axis]
Represents the price per share of shares purchased
opk_SharesPurchasedPricePerShare
Shares Purchased, Price Per Share (in dollars per share)
Variable Interest Entity, Not Primary Beneficiary [Member]
Variable Interest Entity, Not Primary Beneficiary [Member]
Employee benefits and severance
Employee benefits and severance
Common Stock, Par or Stated Value (in dollars per share)
Common Stock, Par or Stated Value (in dollars per share)
Common Stock Par Value
Legal Entity [Axis]
Note Exchange Transactions [Member]
Note exchange transactions.
us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths
2027, finance
Equity Security, FV-NI, Ownership Percent
opk_EquitySecurityFvniOwnershipPercent
Represents the amount of equity security ownership percent.
Litigation Status [Axis]
IRELAND
Ireland [Member]
us-gaap_LiabilitiesCurrent
Total current liabilities
Noncash Investing and Financing Items [Abstract]
Non-cash financing:
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Represents Zebra.
Zebra [Member]
Zebra [Member]
Represents Labcorp.
Labcorp [Member]
Represents information pertaining to La Caixa Bank.
La Caixa Bank [Member]
us-gaap_VariableLeaseCost
Variable Lease, Cost
Segment Reporting [Text Block]
Segments
Relating to Entera discontinuing funding.
Entera Discontinuing Funding [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Operating cash out flows from finance leases
Nicoya Therapeutics Cayman [Member]
Nicoya therapeutics cayman.
Nicoya Therapeutics Cayman [Member]
Other Currency [Member]
Current portion of lines of credit and notes payable
Current portion of lines of credit and notes payable
Trading Symbol
us-gaap_FinanceLeaseWeightedAverageRemainingLeaseTerm1
Finance leases (in years) (Year)
Equity Method Investment, Nonconsolidated Investee [Domain]
Geographical [Axis]
Amortization of debt discount and debt issuance costs, total
Amortization of debt discount and debt issuance costs, total
Fair Value Measurement, Policy [Policy Text Block]
Fair value measurements
Amount of unrealized gain (loss) on investment in equity securities and derivative instruments measured at fair value with change in fair value recognized in net income.
opk_ChangesInFairValueGainLossInEquitySecuritiesFvniAndDerivativeInstruments
Change in fair value of equity securities and derivative instruments
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]
Tabular disclosure of undiscounted cash flows of operating and finance lease liability.
Lessee, Lease Liability, Maturity [Table Text Block]
Schedule of Undiscounted Future Minimum Lease Payments
Represents the carrying value of equity instruments held as part of equity investments.
Warrants and options
Warrants and options
Entity Emerging Growth Company
Subsegments [Axis]
Additional Paid-in Capital [Member]
Relating to OPKO Biologics.
OPKO Biologics [Member]
us-gaap_DerivativeFairValueOfDerivativeNet
Derivative financial instruments
us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture (in shares)
Fair Value Measurement [Domain]
us-gaap_DebtInstrumentCarryingAmount
Balance
Balance
Disposal Group Classification [Domain]
Amount of supplement for advance of development under the arrangement.
opk_CollaborativeArrangementSupplementForAdvanceOfDevelopment
Collaborative Arrangement, Supplement for Advance of Development
Other Liabilities, Noncurrent
Other long-term liabilities
Other long-term liabilities
Portion at Fair Value Measurement [Member]
Portion at Fair Value Measurement [Member] [Default]
Prepaid insurance
Prepaid insurance
us-gaap_FinanceLeaseLiability
Total lease liabilities, finance
Represents the 2029 Convertible Notes.
The 2029 Convertible Notes 1 [Member]
The 2029 Convertible Notes 1 [Member]
Notes
Executive Officer [Member]
Relating to medicare and medicaid.
Medicare and Medicaid [Member]
Represents currency concentration risk.
Currency Concentration Risk [Member]
Amount of cumulative delayed payment received under collaborative agreement.
opk_CollaborativeAgreementDelayedPaymentReceivedCumulative
Collaborative Agreement, Delayed Payment Received, Cumulative
Cover [Abstract]
Schedule of Cash and Cash Equivalents [Table Text Block]
Summary of Reconciliation of Cash, Cash Equivalents and Restricted Cash for Balance Sheets and Cash Flows
Represents Pharmaceutical.
Pharmaceutical [Member]
Other segment items
Segment Reporting, Other Segment Item, Amount
Amount of monthly rent expense under operating lease.
opk_OperatingLeaseMonthlyRentExpense
Operating Lease, Monthly Rent Expense
Accounts receivable
Accounts receivable
The 2024 Convertible Notes [Member]
The 2024 convertible notes.
The 2024 Convertible Notes [Member]
us-gaap_DebtInstrumentRepurchaseAmount
Debt Instrument, Repurchase Amount
Represents sales returns.
Sales Returns [Member]
us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1
Operating leases (in years) (Year)
Revenue from Contract with Customer [Abstract]
us-gaap_PaymentsToAcquireInvestments
Payments to Acquire Investments
Investments in investees
Payments to Acquire Investments, Total
Long term portion of convertible notes
Long term portion of convertible notes
Long-Term Debt, Type [Domain]
Accumulated other comprehensive loss
Accumulated other comprehensive loss
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of credit risk and allowance for credit losses
Eli Lilly and Regeneron
Eli Lilly and Regeneron [Member]
Eli Lilly and Regeneron.
Relating to BICE Bank.
BICE Bank [Member]
us-gaap_PropertyPlantAndEquipmentUsefulLife
Property, Plant and Equipment, Useful Life (Year)
Estimated useful lives
Amortization of intangible assets
Amortization of intangible assets
Amortization expense
Equity-based compensation – employees and non-employees
Equity-based compensation expense
Represents information pertaining to Xenetic Biosciences, Inc.
Xenetic Biosciences, Inc. [Member]
Xenetic Biosciences, Inc. [Member]
Additional paid-in capital
Additional paid-in capital
opk_OwnershipPercentage
Ownership, Percentage
The percentage of ownership of common stock or equity participation in the investee.
Fair Value Disclosures [Abstract]
Cash and cash equivalents
Stock Repurchased and Retired During Period, Value
Shares retired, Value
Represents Leica Microsystems Inc.
Leica Microsystems Inc. [Member]
Relating to notes and other debt.
Notes and Other Debt [Member]
Equity Method Investment, Nonconsolidated Investee [Axis]
Amount of monthly payments in first year for operating lease.
opk_OperatingLeasesMonthlyPaymentsYearOne
Operating Leases, Monthly Payments, Year One
Accumulated Other Comprehensive Income (Loss) [Table]
us-gaap_ValuationAllowancesAndReservesBalance
Balance at end
Balance at beginning
us-gaap_NetCashProvidedByUsedInFinancingActivities
Net cash used in financing activities
Debt Instrument, Redemption, Period One [Member]
Relating to Estado Bank.
Estado Bank [Member]
us-gaap_EquityMethodInvestmentQuotedMarketValue
Equity Method Investment, Quoted Market Value
Derivative Instruments, Gain (Loss) [Line Items]
Entity Filer Category
Significant Accounting Policy [Line Item]
Disclosure of significant accounting policy.
Debt Instrument, Name [Domain]
Affiliate Purchasers [Member]
Affiliate purchaser.
Lease Contractual Term [Axis]
Induced Conversion of Convertible Debt Expense
Inducement expense and loss on debt conversion
us-gaap_IncreaseDecreaseInAccountsReceivable
Accounts receivable, net
Property, Plant, and Equipment, after Accumulated Depreciation, Depletion, and Amortization
Property, plant and equipment, net
Represents transfer of intellectual property and other.
Transfer of Intellectual Property and Other [Member]
Transfer of Intellectual Property and Other [Member]
Revenues
Total gross Rayaldee sales
Revenues
Total revenues
us-gaap_SharesOutstanding
Ending Balance (in shares)
Beginning Balance (in shares)
Represents Commonwealth.
Commonwealth [Member]
Commonwealth [Member]
Value of collaborative arrangement including milestones.
opk_CollaborativeArrangementValueIncludingMilestones
Collaborative Arrangement, Value, Including Milestones
Segment Reporting [Abstract]
us-gaap_OtherAssetsCurrent
Other
Entity Address, Postal Zip Code
Statement of Financial Position [Abstract]
Financing cash out flows from finance leases
Local Phone Number