FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
Ennis Riley Charles
(Last) (First) (Middle)
C/O FREENOME, INC.
51 ASTOR PLACE, 10TH FLOOR
(Street)
NEW YORK NY 10003
(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
07/20/2026 		3. Issuer Name and Ticker or Trading Symbol
Freenome, Inc. [ FRNM ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Product Officer
 5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 2,490,453
D
 
Common Stock 373,913
I
By Trust (1)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (2) 06/21/2030 Common Stock 310,958 4.85 D  
Stock Option (right to buy)   (2) 06/21/2032 Common Stock 281,369 15.91 (6) D  
Stock Option (right to buy)   (3) 02/17/2033 Common Stock 75,082 11.88 (6) D  
Stock Option (right to buy)   (4) 02/15/2034 Common Stock 118,471 18.24 (6) D  
Stock Option (right to buy)   (5) 03/10/2035 Common Stock 221,457 14 (6) D  
Explanation of Responses:
1. Represents shares held by the Riley Ennis Irrevocable Trust dated 1/14/21. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such shares for the purpose of Section 16 of the Exchange Act, or for any other purpose.
2. The shares subject to this option are fully vested.
3. 25% of the shares subject to this option shall vest and become exercisable on February 2, 2024 with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
4. The shares subject to this option shall vest and become exercisable in thirty-six (36) equal monthly installments commencing from February 16, 2024, subject to the Reporting Person's continued service on each such vesting date.
5. 25% of the shares subject to this option shall vest and become exercisable on February 15, 2026 with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.
6. This option was previously amended, pursuant to which the exercise price of the option will be automatically reduced to $8.45 upon the occurrence of certain events.
Remarks:
Exhibit 24 - Power of Attorney
/s/ Thomas Fitzpatrick, Attorney-in-Fact 07/27/2026
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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ATTACHMENTS / EXHIBITS

ATTACHMENTS / EXHIBITS

EXHIBIT 24