v3.26.1
Condensed consolidated statement of comprehensive income - USD ($)
shares in Millions, $ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Condensed consolidated statement of comprehensive income        
Product Sales $ 14,510 $ 13,795 $ 28,896 $ 26,670
Alliance Revenue 874 654 1,699 1,293
Product Revenue 15,384 14,449 30,595 27,963
Collaboration Revenue   8 77 82
Total Revenue 15,384 14,457 30,672 28,045
Cost of sales (2,523) (2,473) (5,201) (4,714)
Gross profit 12,861 11,984 25,471 23,331
Distribution expense (145) (143) (286) (278)
Research and development expense (4,053) (3,548) (7,545) (6,707)
Selling, general and administrative expense (5,651) (4,864) (10,571) (9,356)
Other operating income and expense 152 79 341 192
Operating profit 3,164 3,508 7,410 7,182
Finance income 80 68 153 149
Finance expense (435) (439) (828) (785)
Share of after tax losses in associates and joint ventures (10) (10) (22) (17)
Profit before tax 2,799 3,127 6,713 6,529
Taxation (291) (679) (1,124) (1,160)
Profit for the period 2,508 2,448 5,589 5,369
Other comprehensive income:        
Remeasurement of the defined benefit pension liability 158 (81) 233 (30)
Net gains/(losses) on equity investments measured at fair value through Other comprehensive income 280 (67) 465 (125)
Tax expense on items that will not be reclassified to profit or loss 5 14 (51) (3)
Total other comprehensive income that will not be reclassified to profit and loss, net of tax 443 (134) 647 (158)
Foreign exchange arising on consolidation (148) 1,312 (699) 2,464
Foreign exchange arising on designated liabilities in net investment hedges 36 (43) 43 10
Fair value movements on cash flow hedges (2) 201 (81) 273
Fair value movements on cash flow hedges transferred to profit and loss 41 (213) 96 (315)
Fair value movements on derivatives designated in net investment hedges   (10) 4 (20)
Gains of hedging 16 18   10
Tax income/(expense) on items that may be reclassified subsequently to profit and loss   (22) 7 (52)
Total other comprehensive income that may be reclassified subsequently to profit and loss, net of tax (57) 1,243 (630) 2,370
Other comprehensive income, for the period, net of tax 386 1,109 17 2,212
Total comprehensive income for the period 2,894 3,557 5,606 7,581
Profit/(loss) attributable to:        
Owners of the Parent 2,507 2,450 5,587 5,366
Non-controlling interests 1 (2) 2 3
Profit for the period 2,508 2,448 5,589 5,369
Total comprehensive income attributable to:        
Owners of the Parent 2,893 3,556 5,606 7,574
Non-controlling interests 1 1   7
Total comprehensive income for the period $ 2,894 $ 3,557 $ 5,606 $ 7,581
Earnings per share        
Basic earnings per $0.25 Ordinary Share $ 1.61 $ 1.58 $ 3.6 $ 3.46
Diluted earnings per $0.25 Ordinary Share $ 1.61 $ 1.57 $ 3.58 $ 3.44
Weighted average number of Ordinary Shares in issue (millions) 1,551 1,550 1,550 1,550
Diluted weighted average number of Ordinary Shares in issue (millions) 1,560 1,559 1,561 1,560