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        <link:definition>9955536 - Disclosure - SUPPLEMENTAL INFORMATION - Schedule of Long-lived Assets by Location (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="nvcr_ReceivablesAndPrepaidExpenses" abstract="false" name="ReceivablesAndPrepaidExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_FieldEquipmentNetNoncurrent" abstract="false" name="FieldEquipmentNetNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_OtherAccountsPayableLeaseLiabilitiesAndAccruedExpensesCurrent" abstract="false" name="OtherAccountsPayableLeaseLiabilitiesAndAccruedExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_EmployeeRelatedLiabilitiesNonCurrent" abstract="false" name="EmployeeRelatedLiabilitiesNonCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwardForfeitures" abstract="false" name="StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwardForfeitures" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="nvcr_StockIssuedDuringPeriodValueStockOptionsExercisedAndRestrictedStockAwardForfeitures" abstract="false" name="StockIssuedDuringPeriodValueStockOptionsExercisedAndRestrictedStockAwardForfeitures" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_IncreaseDecreaseInAccountsReceivablesAndPrepaidExpenses" abstract="false" name="IncreaseDecreaseInAccountsReceivablesAndPrepaidExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_PaymentsTaxRelatedToNetSettlementOnEquityAwards" abstract="false" name="PaymentsTaxRelatedToNetSettlementOnEquityAwards" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_CashPaidDuringPeriodForAbstract" abstract="true" name="CashPaidDuringPeriodForAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nvcr_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNetOfDisposals" abstract="false" name="RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityNetOfDisposals" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_RevenueRecognizedAccordingPerformancePeriodTableTextBlock" abstract="false" name="RevenueRecognizedAccordingPerformancePeriodTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost" abstract="false" name="CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue" abstract="false" name="CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecuritiesFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities" abstract="false" name="CashCashEquivalentsAvailableForSaleAndHeldToMaturityDebtSecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_A2024CreditFacilityMember" abstract="true" name="A2024CreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_A2024CreditFacilityTrancheAMember" abstract="true" name="A2024CreditFacilityTrancheAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_A2024CreditFacilityTrancheBMember" abstract="true" name="A2024CreditFacilityTrancheBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_A2024CreditFacilityTrancheCMember" abstract="true" name="A2024CreditFacilityTrancheCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_A2024CreditFacilityTrancheDMember" abstract="true" name="A2024CreditFacilityTrancheDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_LineOfCreditFacilityNumberOfDrawings" abstract="false" name="LineOfCreditFacilityNumberOfDrawings" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="nvcr_LineOfCreditFacilityAccordionFeatureAdditionalBorrowingCapacityOption" abstract="false" name="LineOfCreditFacilityAccordionFeatureAdditionalBorrowingCapacityOption" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_LinesOfCreditFacilityNumberOfRepayments" abstract="false" name="LinesOfCreditFacilityNumberOfRepayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="nvcr_DebtCovenantFinalPaymentOfOutstandingPrincipalDueAnniversaryOfClosingYear" abstract="false" name="DebtCovenantFinalPaymentOfOutstandingPrincipalDueAnniversaryOfClosingYear" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="nvcr_OtherInternationalMarketsMember" abstract="true" name="OtherInternationalMarketsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_InternationalMarketsMember" abstract="true" name="InternationalMarketsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_RevenuePerformanceObligationPeriodObligationWasSatisfiedInAxis" abstract="true" name="RevenuePerformanceObligationPeriodObligationWasSatisfiedInAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="nvcr_RevenuePerformanceObligationPeriodObligationWasSatisfiedInDomain" abstract="true" name="RevenuePerformanceObligationPeriodObligationWasSatisfiedInDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_ReportingPeriodMember" abstract="true" name="ReportingPeriodMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_PreviousPeriodsMember" abstract="true" name="PreviousPeriodsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_AccountsReceivableExcludingUnbilledReceivables" abstract="false" name="AccountsReceivableExcludingUnbilledReceivables" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_ScheduleOfShareCapitalTable" abstract="true" name="ScheduleOfShareCapitalTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="nvcr_A2024OmnibusIncentivePlanMember" abstract="true" name="A2024OmnibusIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_TwoThousandFifteenPlanMember" abstract="true" name="TwoThousandFifteenPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_A2025EmployeeSharePurchasePlanESPPMember" abstract="true" name="A2025EmployeeSharePurchasePlanESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_PerformanceBasedShareUnitsPSUsMember" abstract="true" name="PerformanceBasedShareUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_ShareCapitalLineItems" abstract="true" name="ShareCapitalLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumPercentageOfAvailableSharePoolExemptFromVestingPeriodRequirements" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumPercentageOfAvailableSharePoolExemptFromVestingPeriodRequirements" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="nvcr_RestrictedStockUnitsRSUsAndPerformanceBasedShareUnitsPSUsMember" abstract="true" name="RestrictedStockUnitsRSUsAndPerformanceBasedShareUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_GrantedAxis" abstract="true" name="GrantedAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="nvcr_GrantedDomain" abstract="true" name="GrantedDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_AwardOneMember" abstract="true" name="AwardOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_AwardTwoMember" abstract="true" name="AwardTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_AwardThreeMember" abstract="true" name="AwardThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_AwardFourMember" abstract="true" name="AwardFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWithheldForWithholdingTaxObligationWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWithheldForWithholdingTaxObligationWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNotExpectedToVestNonvestedNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNotExpectedToVestNonvestedNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNotExpectedToVestNonvestedWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNotExpectedToVestNonvestedWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="nvcr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedAndNotExpectedToVestFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedAndNotExpectedToVestFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="nvcr_OthersCountriesMember" abstract="true" name="OthersCountriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
