<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e4a69-a50c-71a8-814a-3ecdc7d7066d,g:f0a046a0-46b5-4ba9-8080-8a3f20daf043-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="simple" xlink:href="medp-20260630.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e4a69-a5e0-7848-92b5-090ef94531af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e4a69-a5e0-719c-971f-6ef008f284dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e4a69-a5e0-7848-92b5-090ef94531af" xlink:to="loc_us-gaap_Liabilities_019e4a69-a5e0-719c-971f-6ef008f284dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-74c4-8e25-7928ec9575ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e4a69-a5e0-7848-92b5-090ef94531af" xlink:to="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-74c4-8e25-7928ec9575ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-775b-95be-b54bbfea61d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e4a69-a5e0-79a4-bffd-2b5a38ed56b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-775b-95be-b54bbfea61d8" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e4a69-a5e0-79a4-bffd-2b5a38ed56b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a5e0-78d4-852c-ce9e272086dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-775b-95be-b54bbfea61d8" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a5e0-78d4-852c-ce9e272086dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e4a69-a5e0-73ff-908d-6cb59bdda77b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-775b-95be-b54bbfea61d8" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e4a69-a5e0-73ff-908d-6cb59bdda77b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019e4a69-a5e0-7ee8-820b-dbbf4a6e099f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-775b-95be-b54bbfea61d8" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019e4a69-a5e0-7ee8-820b-dbbf4a6e099f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7442-ab88-8e9ef0d5dd54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7442-ab88-8e9ef0d5dd54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e4a69-a5e0-7a86-a912-3f5ef105df79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e4a69-a5e0-7a86-a912-3f5ef105df79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e4a69-a5e0-7619-8ea4-985957848247" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e4a69-a5e0-7619-8ea4-985957848247" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e4a69-a5e0-7328-99e8-1a13391dd691" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_Goodwill_019e4a69-a5e0-7328-99e8-1a13391dd691" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e4a69-a5e0-754e-9a45-ae793815d712" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e4a69-a5e0-754e-9a45-ae793815d712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e4a69-a5e0-7e58-81ba-a66823a33c08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e4a69-a5e0-7e58-81ba-a66823a33c08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e4a69-a5e0-7b4a-af04-63b975104162" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e4a69-a5e0-7430-9c38-3c13051321d6" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e4a69-a5e0-7b4a-af04-63b975104162" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019e4a69-a5e0-7757-b164-dc6d9f0b83c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_PreferredStockValue_019e4a69-a5e0-7757-b164-dc6d9f0b83c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e4a69-a5e0-7648-ba43-0b99bbc949d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_CommonStockValue_019e4a69-a5e0-7648-ba43-0b99bbc949d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019e4a69-a5e0-7373-8966-3a9def915719" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019e4a69-a5e0-7373-8966-3a9def915719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e4a69-a5e0-7362-9eeb-28d247e6ec80" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019e4a69-a5e0-7362-9eeb-28d247e6ec80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e4a69-a5e0-75b5-b5b8-c39602206ef3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e4a69-a5e0-75b5-b5b8-c39602206ef3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e4a69-a5e0-7a87-8ad5-ceb8cc476d45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e4a69-a5e0-795b-b4fa-82331c779157" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e4a69-a5e0-7a87-8ad5-ceb8cc476d45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e4a69-a5e0-7f8e-bffa-cf6b80e5903e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-783f-8210-a49bcaeddabd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e4a69-a5e0-7f8e-bffa-cf6b80e5903e" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e4a69-a5e0-783f-8210-a49bcaeddabd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e4a69-a5e0-771b-83c3-56be0604099b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e4a69-a5e0-7f8e-bffa-cf6b80e5903e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e4a69-a5e0-771b-83c3-56be0604099b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019e4a69-a5e0-72c4-b04b-1627385c4412" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e4a69-a5e0-7f8e-bffa-cf6b80e5903e" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019e4a69-a5e0-72c4-b04b-1627385c4412" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e4a69-a5e0-7b91-adf4-50a32bf7303e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e4a69-a5e0-7f8e-bffa-cf6b80e5903e" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e4a69-a5e0-7b91-adf4-50a32bf7303e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7f57-bd1f-885040c1df66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e4a69-a5e0-735d-9e42-2b2f72995071" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7f57-bd1f-885040c1df66" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e4a69-a5e0-735d-9e42-2b2f72995071" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a5e0-7694-8cb4-9f4c4a55642a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7f57-bd1f-885040c1df66" xlink:to="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a5e0-7694-8cb4-9f4c4a55642a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e4a69-a5e0-784e-a1fb-ae6b968ca533" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e4a69-a5e0-7f57-bd1f-885040c1df66" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e4a69-a5e0-784e-a1fb-ae6b968ca533" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="simple" xlink:href="medp-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7c7e-91d7-946d26c60823" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectOperatingCosts_019e4a69-a5e0-7981-a20e-f1576c091c8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DirectOperatingCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7c7e-91d7-946d26c60823" xlink:to="loc_us-gaap_DirectOperatingCosts_019e4a69-a5e0-7981-a20e-f1576c091c8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4a69-a5e0-7422-92bc-3a76d273834e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7c7e-91d7-946d26c60823" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e4a69-a5e0-7422-92bc-3a76d273834e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019e4a69-a5e0-72c2-81b6-491813071acf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7c7e-91d7-946d26c60823" xlink:to="loc_us-gaap_Depreciation_019e4a69-a5e0-72c2-81b6-491813071acf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019e4a69-a5e0-7b1c-a0ad-a7d25df64c17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7c7e-91d7-946d26c60823" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019e4a69-a5e0-7b1c-a0ad-a7d25df64c17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e4a69-a5e0-70e0-8e2e-0486804ded35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4a69-a5e0-78ec-b0af-df2cc3f7faf4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e4a69-a5e0-70e0-8e2e-0486804ded35" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e4a69-a5e0-78ec-b0af-df2cc3f7faf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7639-810b-92eec2914aff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e4a69-a5e0-70e0-8e2e-0486804ded35" xlink:to="loc_us-gaap_CostsAndExpenses_019e4a69-a5e0-7639-810b-92eec2914aff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e4a69-a5e0-7ab6-892e-c9ae79b614d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e4a69-a5e0-7395-817a-13f02c8ab8e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e4a69-a5e0-7ab6-892e-c9ae79b614d1" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e4a69-a5e0-7395-817a-13f02c8ab8e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e4a69-a5e0-7fe7-ab85-ca697035b74d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e4a69-a5e0-7ab6-892e-c9ae79b614d1" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e4a69-a5e0-7fe7-ab85-ca697035b74d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e4a69-a5e0-75e7-96a0-23126441012f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4a69-a5e0-75a2-bd4d-176eb8a37b07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e4a69-a5e0-75e7-96a0-23126441012f" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e4a69-a5e0-75a2-bd4d-176eb8a37b07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019e4a69-a5e0-7c94-b0d3-21fe108def9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e4a69-a5e0-75e7-96a0-23126441012f" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019e4a69-a5e0-7c94-b0d3-21fe108def9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e4a69-a5e0-7d4d-80a4-d74b8b60c97c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e4a69-a5e0-733a-bec7-c34090a478c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e4a69-a5e0-7d4d-80a4-d74b8b60c97c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e4a69-a5e0-733a-bec7-c34090a478c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e4a69-a5e0-7096-bd40-341ba127a998" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e4a69-a5e0-7d4d-80a4-d74b8b60c97c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e4a69-a5e0-7096-bd40-341ba127a998" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="simple" xlink:href="medp-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e4a69-a5e0-7a23-8f26-49edf2e18ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4a69-a5e0-71a6-886f-8a289123dd5f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e4a69-a5e0-7a23-8f26-49edf2e18ce6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019e4a69-a5e0-71a6-886f-8a289123dd5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e4a69-a5e0-7068-9d19-b05396c3a9da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e4a69-a5e0-7a23-8f26-49edf2e18ce6" xlink:to="loc_us-gaap_NetIncomeLoss_019e4a69-a5e0-7068-9d19-b05396c3a9da" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="medp-20260630.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e4a69-a5e0-7e9c-8afb-d7f04c1c3a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e4a69-a5e0-7fe6-a935-b7a357790738" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e4a69-a5e0-7e9c-8afb-d7f04c1c3a3c" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e4a69-a5e0-7fe6-a935-b7a357790738" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e4a69-a5e0-7d31-b366-d5156d5609e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e4a69-a5e0-7e9c-8afb-d7f04c1c3a3c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e4a69-a5e0-7d31-b366-d5156d5609e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e4a69-a5e0-7259-88bd-16ab826be883" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e4a69-a5e0-7e9c-8afb-d7f04c1c3a3c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e4a69-a5e0-7259-88bd-16ab826be883" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e4a69-a5e0-7a0f-8a3f-e8fb01ee6f66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e4a69-a5e0-7e9c-8afb-d7f04c1c3a3c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e4a69-a5e0-7a0f-8a3f-e8fb01ee6f66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019f6749-fa58-711f-bda2-b9409803e53f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_NetIncomeLoss_019f6749-fa58-711f-bda2-b9409803e53f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019f6745-f951-7d66-be2e-01021089b960" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_Depreciation_019f6745-f951-7d66-be2e-01021089b960" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019f674b-18e4-7c04-b280-975f1cf47654" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019f674b-18e4-7c04-b280-975f1cf47654" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019f6752-1e41-788f-8a61-5690296cc353" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_ShareBasedCompensation_019f6752-1e41-788f-8a61-5690296cc353" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f6752-1e41-7b29-9a03-69529dc85eab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019f6752-1e41-7b29-9a03-69529dc85eab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019f6753-2873-774c-a2e9-59ad78b10d3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019f6753-2873-774c-a2e9-59ad78b10d3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019f6753-2873-7074-9008-6c16a30eebdd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019f6753-2873-7074-9008-6c16a30eebdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_019f6754-cca1-733a-9414-168d86615bc4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_019f6754-cca1-733a-9414-168d86615bc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019f6754-cca1-70b2-bd82-29e586b2e3b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019f6754-cca1-70b2-bd82-29e586b2e3b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f6754-cca1-7eb3-84d4-d268244ef843" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019f6754-cca1-7eb3-84d4-d268244ef843" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019f6756-9f4b-75e1-bb65-2c6bca69b265" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019f6756-9f4b-75e1-bb65-2c6bca69b265" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019f6756-9f4b-76b2-a85f-708444acfb85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019f6756-9f4b-76b2-a85f-708444acfb85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019f6756-9f4b-7870-9505-15a6bf6b0cea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019f6756-9f4b-7870-9505-15a6bf6b0cea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019f6756-9f4b-72cc-bf82-43e7ebaf879c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019f6745-f951-72d8-9c86-1dbfb3920044" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019f6756-9f4b-72cc-bf82-43e7ebaf879c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e4a69-a5e0-7a8d-b991-e390e5d106ef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e4a69-a5e0-775a-ad80-077ad0faf053" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e4a69-a5e0-7a8d-b991-e390e5d106ef" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e4a69-a5e0-775a-ad80-077ad0faf053" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019e4a69-a5e0-7238-aed6-9ca617b805a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e4a69-a5e0-7a8d-b991-e390e5d106ef" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019e4a69-a5e0-7238-aed6-9ca617b805a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e4a69-a5e0-7ded-a238-c1c881992178" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019e4a69-a5e0-73ce-bf90-17e0a274778b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e4a69-a5e0-7ded-a238-c1c881992178" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019e4a69-a5e0-73ce-bf90-17e0a274778b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e4a69-a5e0-7204-8b1e-9cf7ab738fea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e4a69-a5e0-7ded-a238-c1c881992178" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e4a69-a5e0-7204-8b1e-9cf7ab738fea" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a6a8-7318-b3f5-4f20ff773bb9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_019e4a69-a6a8-7819-9669-1e7e072b7015" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a6a8-7318-b3f5-4f20ff773bb9" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_019e4a69-a6a8-7819-9669-1e7e072b7015" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnbilledReceivablesCurrent_019e4a69-a6a8-7b89-95a7-7b2af4eef233" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_UnbilledReceivablesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a6a8-7318-b3f5-4f20ff773bb9" xlink:to="loc_us-gaap_UnbilledReceivablesCurrent_019e4a69-a6a8-7b89-95a7-7b2af4eef233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019e4a69-a6a8-7797-a557-5d6ea5f37406" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019e4a69-a6a8-7318-b3f5-4f20ff773bb9" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019e4a69-a6a8-7797-a557-5d6ea5f37406" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-7e28-973d-a77e17d3ed1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e4a69-a6a8-752c-a3e1-1e714a654c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-7e28-973d-a77e17d3ed1e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e4a69-a6a8-752c-a3e1-1e714a654c6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e4a69-a6a8-7e88-8c33-c35ce49783d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-7e28-973d-a77e17d3ed1e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e4a69-a6a8-7e88-8c33-c35ce49783d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e4a69-a6a8-74f7-aafa-d1cfe4dc9510" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-739d-877a-f92c2213f360" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e4a69-a6a8-74f7-aafa-d1cfe4dc9510" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-739d-877a-f92c2213f360" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedTradeNames_019e4a69-a6a8-7ff7-8131-d949074c3e94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedTradeNames"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e4a69-a6a8-74f7-aafa-d1cfe4dc9510" xlink:to="loc_us-gaap_IndefiniteLivedTradeNames_019e4a69-a6a8-7ff7-8131-d949074c3e94" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-72d4-9ea6-d675266c7f90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019e4a69-a6a8-7b58-a250-e614f9e7d6cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-72d4-9ea6-d675266c7f90" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019e4a69-a6a8-7b58-a250-e614f9e7d6cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019e4a69-a6a8-7dd9-bd93-fe2b52c689f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-72d4-9ea6-d675266c7f90" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019e4a69-a6a8-7dd9-bd93-fe2b52c689f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019e4a69-a6a8-7fb6-aa5b-734990c8c851" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e4a69-a6a8-72d4-9ea6-d675266c7f90" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019e4a69-a6a8-7fb6-aa5b-734990c8c851" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/AccruedExpensesScheduleofAccruedExpensesDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#AccruedExpensesScheduleofAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/AccruedExpensesScheduleofAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a6a8-7d39-9fc1-dd193805c811" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e4a69-a6a8-7d89-ab95-ed821ed5b065" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a6a8-7d39-9fc1-dd193805c811" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e4a69-a6a8-7d89-ab95-ed821ed5b065" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent_019e4a69-a6a8-74cb-9c7a-d41e8889d72e" xlink:href="medp-20260630.xsd#medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a6a8-7d39-9fc1-dd193805c811" xlink:to="loc_medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent_019e4a69-a6a8-74cb-9c7a-d41e8889d72e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e4a69-a6a8-7dc4-acc6-6d7a1673d29c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e4a69-a6a8-7d39-9fc1-dd193805c811" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e4a69-a6a8-7dc4-acc6-6d7a1673d29c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e4a69-a6a8-73eb-b523-c81865a64f60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e4a69-a6a8-7af5-96d2-f544fa4b5a50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e4a69-a6a8-73eb-b523-c81865a64f60" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e4a69-a6a8-7af5-96d2-f544fa4b5a50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e4a69-a6a8-7058-88bf-933ea1881759" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e4a69-a6a8-73eb-b523-c81865a64f60" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e4a69-a6a8-7058-88bf-933ea1881759" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="medp-20260630.xsd#LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-72ac-9e52-2a11c5cef6af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e4a69-a6a8-7bd5-946e-a42d02df2d58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-72ac-9e52-2a11c5cef6af" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e4a69-a6a8-7bd5-946e-a42d02df2d58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e4a69-a6a8-7303-afa2-67e0a9aa6246" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-72ac-9e52-2a11c5cef6af" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e4a69-a6a8-7303-afa2-67e0a9aa6246" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="medp-20260630.xsd#LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e4a69-a6a8-7f97-98fd-29fb91a85e90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e4a69-a6a8-7f97-98fd-29fb91a85e90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e4a69-a6a8-73bb-9ff3-433c39329306" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e4a69-a6a8-73bb-9ff3-433c39329306" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e4a69-a6a8-7042-90e1-a90213e14067" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e4a69-a6a8-7042-90e1-a90213e14067" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e4a69-a6a8-7b78-937d-d96e03d21c9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e4a69-a6a8-7b78-937d-d96e03d21c9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e4a69-a6a8-7d3b-9cf8-ad374b5263f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019e4a69-a6a8-7d3b-9cf8-ad374b5263f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_medp_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour_019e4a69-a6a8-70c8-b04f-95aa416874c7" xlink:href="medp-20260630.xsd#medp_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e4a69-a6a8-7562-a81f-8bd5601271c5" xlink:to="loc_medp_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour_019e4a69-a6a8-70c8-b04f-95aa416874c7" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
