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  <xs:element id="argx_DepreciationAndAmortizationExpenseSellingGeneralAndAdministrativeExpenses" abstract="false" name="DepreciationAndAmortizationExpenseSellingGeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="argx_ExecutiveDirectorsMember" abstract="true" name="ExecutiveDirectorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_MaximumTermOfOptionsGrantedForShareBasedPaymentArrangement" abstract="false" name="MaximumTermOfOptionsGrantedForShareBasedPaymentArrangement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="argx_PerformanceRequirementsForShareBasedPaymentArrangementPerformancePeriod" abstract="false" name="PerformanceRequirementsForShareBasedPaymentArrangementPerformancePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="argx_CommitmentsTable" abstract="true" name="CommitmentsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="argx_HalozymeTherapeuticsIncMember" abstract="true" name="HalozymeTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_LonzaAndFujifilmMember" abstract="true" name="LonzaAndFujifilmMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_IfrsTypeOfArrangementAndNonArrangementTransactionsAxis" abstract="true" name="IfrsTypeOfArrangementAndNonArrangementTransactionsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="argx_IfrsTypeOfArrangementAndNonArrangementTransactionsDomain" abstract="true" name="IfrsTypeOfArrangementAndNonArrangementTransactionsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_EfgartigimodMember" abstract="true" name="EfgartigimodMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="argx_CommitmentsLineItems" abstract="true" name="CommitmentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="argx_FutureMilestonePaymentsAllTargets" abstract="false" name="FutureMilestonePaymentsAllTargets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="argx_NumberOnNominatedTargetUnderAgreement" abstract="false" name="NumberOnNominatedTargetUnderAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
