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  <xs:element id="smmt_CollaborativeArrangementRightsAndObligationsUpfrontPaymentPaidInShares" abstract="false" name="CollaborativeArrangementRightsAndObligationsUpfrontPaymentPaidInShares" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_PaymentsForCollaborativeArrangement" abstract="false" name="PaymentsForCollaborativeArrangement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_CollaborativeArrangementRightsAndObligationsAdditionalPotentialCommercialMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsAdditionalPotentialCommercialMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_CollaborativeArrangementRightsAndObligationsMaximumAggregateMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsMaximumAggregateMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_CollaborativeArrangementRightsAndObligationsPotentialRegulatoryMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsPotentialRegulatoryMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_CollaborativeArrangementRightsAndObligationsPotentialCommercialMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsPotentialCommercialMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_OtherIncomeNetTable" abstract="true" name="OtherIncomeNetTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="smmt_ThirdPartyMember" abstract="true" name="ThirdPartyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_OtherIncomeNetLineItems" abstract="true" name="OtherIncomeNetLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="smmt_SaleOfIntangibleAssetContingentConsiderationRegulatoryMilestonesLiability" abstract="false" name="SaleOfIntangibleAssetContingentConsiderationRegulatoryMilestonesLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_SaleOfIntangibleAssetContingentConsiderationSalesMilestonesLiability" abstract="false" name="SaleOfIntangibleAssetContingentConsiderationSalesMilestonesLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_ResearchAndDevelopmentPrepaidExpensesCurrent" abstract="false" name="ResearchAndDevelopmentPrepaidExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_AccruedResearchAndDevelopmentCurrent" abstract="false" name="AccruedResearchAndDevelopmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_OriginalDistributionAgreementMember" abstract="true" name="OriginalDistributionAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_DistributionAgreementMember" abstract="true" name="DistributionAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_SaleOfStockAggregateOfferingPrice" abstract="false" name="SaleOfStockAggregateOfferingPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_SaleOfStockAmountRemainingUnderTheOffering" abstract="false" name="SaleOfStockAmountRemainingUnderTheOffering" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_ClassOfWarrantOrRightExercisesInPeriod" abstract="false" name="ClassOfWarrantOrRightExercisesInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="smmt_ClassOfWarrantOrRightWeightedAverageExercisePriceExercisesInPeriod" abstract="false" name="ClassOfWarrantOrRightWeightedAverageExercisePriceExercisesInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="smmt_A2020StockIncentivePlanMember" abstract="true" name="A2020StockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_A2020IncrementalPoolMember" abstract="true" name="A2020IncrementalPoolMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_A2024InducementPoolMember" abstract="true" name="A2024InducementPoolMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_EmployeeStockOptionPerformanceBasedMember" abstract="true" name="EmployeeStockOptionPerformanceBasedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAllowableUnderThePlan" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAllowableUnderThePlan" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="smmt_ShareBasedPaymentArrangementCostNotYetRecognizedDueToAcceleratedVestingAmount" abstract="false" name="ShareBasedPaymentArrangementCostNotYetRecognizedDueToAcceleratedVestingAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_ShareBasedPaymentArrangementWeightedAverageRecognitionPeriod" abstract="false" name="ShareBasedPaymentArrangementWeightedAverageRecognitionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="smmt_EmployeeStockOptionTimeBasedMember" abstract="true" name="EmployeeStockOptionTimeBasedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="smmt_SubleaseAgreementFirstAmendmentMember" abstract="true" name="SubleaseAgreementFirstAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_SubleaseAgreementFirstAndThirdAmendmentMember" abstract="true" name="SubleaseAgreementFirstAndThirdAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_SubleaseAgreementSecondAmendmentMember" abstract="true" name="SubleaseAgreementSecondAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_GeniusSubleaseAgreementMember" abstract="true" name="GeniusSubleaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_InvestmentsResearchSubleaseAgreementMember" abstract="true" name="InvestmentsResearchSubleaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_GeniusSubleaseAgreementAndInvestmentsResearchSubleaseAgreementMember" abstract="true" name="GeniusSubleaseAgreementAndInvestmentsResearchSubleaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_SubleaseAgreementThirdAmendmentMember" abstract="true" name="SubleaseAgreementThirdAmendmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_AkesoSupplyAgreementMember" abstract="true" name="AkesoSupplyAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_CoChiefExecutiveOfficerMember" abstract="true" name="CoChiefExecutiveOfficerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_WilsonSonsiniGoodrichRosatiP.C.WSGRMember" abstract="true" name="WilsonSonsiniGoodrichRosatiP.C.WSGRMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_AreaOfPremisesSubleased" abstract="false" name="AreaOfPremisesSubleased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="smmt_RelatedPartyTransactionSubleaseExtensionTerm" abstract="false" name="RelatedPartyTransactionSubleaseExtensionTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="smmt_RelatedPartyTransactionPaymentsToRelatedParty" abstract="false" name="RelatedPartyTransactionPaymentsToRelatedParty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_LessorOperatingLeaseNumberOfContracts" abstract="false" name="LessorOperatingLeaseNumberOfContracts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="smmt_LessorOperatingLeaseAreaOfPremisesLeased" abstract="false" name="LessorOperatingLeaseAreaOfPremisesLeased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="smmt_LesseeOperatingLeaseProportionOfAmountPayablePercentage" abstract="false" name="LesseeOperatingLeaseProportionOfAmountPayablePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="smmt_ClassOfWarrantOrRightWeightedAverageExercisePrice" abstract="false" name="ClassOfWarrantOrRightWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="smmt_PrincetonOfficeLeaseMember" abstract="true" name="PrincetonOfficeLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_DugganFebruaryNoteMember" abstract="true" name="DugganFebruaryNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_ZanganehNoteMember" abstract="true" name="ZanganehNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_DugganSeptemberNoteMember" abstract="true" name="DugganSeptemberNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_ChiefExecutiveOfficerAndPresidentMember" abstract="true" name="ChiefExecutiveOfficerAndPresidentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="smmt_LesseeOperatingLeaseAverageAnnualLeasePayments" abstract="false" name="LesseeOperatingLeaseAverageAnnualLeasePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="smmt_IncreaseInAreaOfRealEstateProperty" abstract="false" name="IncreaseInAreaOfRealEstateProperty" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="smmt_OtherCommitmentPeriodForWhichTheMajorityOfCommitmentsAreToBePaid" abstract="false" name="OtherCommitmentPeriodForWhichTheMajorityOfCommitmentsAreToBePaid" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
