0001645469 2026-07-21 2026-07-21 0001645469 1 2026-07-21 2026-07-21 iso4217:USD pure shares S-8 S-8 EX-FILING FEES 0001645469 Monopar Therapeutics N/A false S-8 Monopar Therapeutics Equity Common Stock, $0.001 par value true 600000 107.66 64596000.00 0.0001381 8920.71 64596000.00 8920.71 0.00 8920.71 (1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, this Registration Statement shall also cover any additional shares of common stock ("Common Stock") of Monopar Therapeutics Inc. (the "Registrant") that become issuable under the Registrant's 2026 Stock Incentive Plan (the "Plan"), by reason of any stock dividend, stock split, recapitalization or other similar transaction that increases the number of the outstanding shares of the Registrant's common stock. (2) Represents shares of Common Stock reserved for future grant under the Plan. (3) Estimated solely for purposes of calculating the registration fee in accordance with Rule 457(c) and Rule 457(h) of the Securities Act of 1933, as amended, by averaging the high ($110.00) and low ($105.32) sales prices of the Registrant's common stock reported on the Nasdaq Capital Market as of a date (July 16, 2026) within five business days prior to filing this Registration Statement.