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number of securities to which transaction applies: As of the close of business
on July 20, 2026, the maximum number of securities of Crinetics
Pharmaceuticals, Inc. (the &#x201c;Company&#x201d;) to which this transaction applies is
estimated to be 123,242,416, which consists of (i) 106,061,721 shares of the
Company&#x2019;s common stock, par value $0.001 per share (&#x201c;Company Common Stock&#x201d;),
which may be entitled to receive the merger consideration of $85.00 per share;
(ii) 14,266,735 shares of Company Common Stock subject to outstanding options
(&#x201c;Company Stock Options&#x201d;) to purchase Company Common Stock granted under the
Company&#x2019;s 2018 Incentive Award Plan, 2015 Stock Incentive Plan and 2021
Employment Inducement Incentive Award Plan (collectively, as amended from time
to time, the &#x201c;Company Stock Plans&#x201d;), with a weighted average exercise price of
$31.38 per share; (iii) 2,813,919 shares of Company Common Stock subject to
outstanding restricted stock units of the Company granted under a Company Stock
Plan (&#x201c;Company RSUs&#x201d;); (iv) 12,041 shares of Company Common Stock subject to
RSUs that may be issued after July 20, 2026; and (v) 88,000 shares of Company
Common Stock subject to outstanding rights under the Company&#x2019;s 2018 Employee
Stock Purchase Plan (&#x201c;Company ESPP&#x201d;) that may be issued after July 20, 2026.&lt;/span&gt; &lt;/div&gt; &lt;/td&gt; &lt;/tr&gt; &lt;/table&gt;&lt;table style="font-size: 12pt; border-spacing: 0px; border-collapse: collapse; width: 100%; margin-left: auto; margin-right: auto;"&gt;
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      (2)
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      In
accordance with Rule 0-11 under the Exchange Act, the proposed maximum
aggregate value of the transaction estimated solely for the purposes of
calculating the filing fee was calculated based on the sum of: (i) the product
of 106,061,721 shares of Company Common Stock multiplied by the merger
consideration of $85.00 per share; (ii) the product of 14,266,735 shares of
Company Common Stock subject to outstanding Company Stock Options and $53.62
per share (which is the difference between the merger consideration of $85.00
per share and the weighted average exercise price of $31.38 per share); (iii)
2,813,919 shares of Company Common Stock subject to outstanding Company RSUs
multiplied by the merger consideration of $85.00 per share; (iv) 12,041 shares
of Company Common Stock subject to RSUs that may be issued after July 20, 2026
multiplied by the merger consideration of $85.00 per share; and (v) 88,000
shares of Company Common Stock subject to outstanding rights under the Company
ESPP multiplied by the merger consideration of $85.00 per share.
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      (3)
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      In
accordance with Section 14(g) of the Exchange Act, the filing fee was
determined by multiplying the sum calculated in the preceding sentence by
0.00013810.
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